Alpha lipoic acid and diabetes mellitus: potential effects on peripheral neuropathy and different metabolic parameters

References

• Bruschi LKM, Rocha DA, Filho ELG, et al. Diabetes mellitus and diabetic peripheral neuropathy. Open J Endocr Metabol Dis. 2017;7(1):12–21
   Google Scholar
• Boulton AJ, Vinik AI, Arezzo JC, et al. Diabetic neuropathies: a statement by the American diabetes association. Diabetes Care. 2005;28(4):956–962.
   PubMed Web of Science ®Google Scholar
• D’ Souza M, Kulkarni V, Bhaskaran U, et al. Diabetic peripheral neuropathy and its determinants among patients attending a tertiary health care centre in Mangalore, India. J Public Health Res. 2015;4:450.
   Google Scholar
• Li N, Yan W, Hu X, et al. Effects of oral α-lipoic acid administration on body weight in overweight or obese subjects: a crossover randomized, double-blind, placebo-controlled trial. Clin Endocrinol (Oxf). 2017 May;86(5):680–687.
   Web of Science ®Google Scholar
• Ziegler D, Low PA, Litchy WJ, et al. Efficacy and safety of antioxidant treatment with α-Lipoic acid over 4 years in diabetic polyneuropathy. Diabetes Care. 2011;34(9):2054–2060.
   PubMed Web of Science ®Google Scholar
• Han T, Bai J, Liu W, et al. THERAPY OF ENDOCRINE DISEASE: a systematic review and meta-analysis of α-lipoic acid in the treatment of diabetic peripheral neuropathy. Eur J Endocrinol. 2012;167(4):465–471.
   PubMed Web of Science ®Google Scholar
• Okanovid A, Prnjavorac B, Jusufovid E, et al. Alpha-lipoic acid reduces body weight and regulates triglycerides in obese patients with diabetes mellitus. Med Glas. 2015;12:2.
   Google Scholar
• Sun Y-D, Dong Y-D, Fan R, et al. Effect of (R)-α-lipoic acid supplementation on serum lipids and antioxidative ability in patients with age-related macular degeneration. Ann Nutr Metab. 2012;60(4):293–297.
   Web of Science ®Google Scholar
• Kamenova P. Improvement of insulin sensitivity in patients with type 2 diabetes mellitus after oral administration of alpha-lipoic acid. Hormones (Athens). 2006 Oct-Dec;5(4):251–258.
   PubMedGoogle Scholar
• As L, Bosch JP, Lewis JB, et al. A more accurate method to estimate glomerular filtration rate from serum creatinine: a new prediction equation. modification of diet in renal disease study group. Ann Inter Med. 1999;130(6):461–470.
   Web of Science ®Google Scholar
• Ma B, Afify HE, Sabri N, et al. Comparative Study of Vitamin B complex combined with alpha Lipoic acid versus Vitamin B complex in treatment of diabetic polyneuropathy in type 2 diabetic patients. Clin Exp Pharmacol. 2017;7(4):241.
   Google Scholar
• Agathos E, Tentolouris A, Eleftheriadou I, et al. Effect of α-lipoic acid on symptoms and quality of life in patients with painful diabetic neuropathy. J Int Med Res. 2018 May;46(5):1779–1790; Epub 2018 Mar 8. PMID: 29517942; PMCID: PMC5991249.
   PubMed Web of Science ®Google Scholar
• Ziegler D, Ametov A, Barinov A, et al. Oral treatment With -Lipoic acid improves symptomatic diabetic polyneuropathy: the SYDNEY 2 trial. Diabetes Care. 2006 Nov;29(11):2365–2370. PMID: 17065669
   PubMed Web of Science ®Google Scholar
• Mijnhout GS, Kollen BJ, Alkhalaf A, et al. Alpha lipoic Acid for symptomatic peripheral neuropathy in patients with diabetes: a meta-analysis of randomized controlled trials. Int J Endocrinol. 2012; Epub 2012 Jan 26:456279. DOI:https://doi.org/10.1155/2012/456279. PMID: 22331979; PMCID: PMC3272801.
   Google Scholar
• Haak E, Usadel KH, Kusterer K, et al. Effects of alpha-lipoic acid on microcirculation in patients with peripheral diabetic neuropathy. Exp Clin Endocrinol Diabetes. 2000;108(3):168–174. PMID: 10926311
   Web of Science ®Google Scholar
• Heitzer T, Finckh B, Albers S, et al. Beneficial effects of alpha-lipoic acid and ascorbic acid on endothelium-dependent, nitric oxide-mediated vasodilation in diabetic patients: relation to parameters of oxidative stress. Free Radic Biol Med. 2001 Jul 1;31(1):53–61. PMID: 11425490.
   PubMed Web of Science ®Google Scholar
• Stevens MJ, Obrosova I, Cao X, et al. Effects of DL-alpha-lipoic acid on peripheral nerve conduction, blood flow, energy metabolism, and oxidative stress in experimental diabetic neuropathy. Diabetes. 2000 Jun;49(6):1006–1015. PMID: 10866054
   PubMed Web of Science ®Google Scholar
• Nagamatsu M, Nickander KK, Schmelzer JD, et al. Lipoic acid improves nerve blood flow, reduces oxidative stress, and improves distal nerve conduction in experimental diabetic neuropathy. Diabetes Care. 1995 Aug;18(8):1160–1167. PMID: 7587852
   Web of Science ®Google Scholar
• Mohammadi V, Khalili M, Eghtesadi S, et al. The effect of alpha-lipoic acid (ALA) supplementation on cardiovascular risk factors in men with chronic spinal cord injury: a clinical trial. Spinal Cord. 2015 Aug;53(8):621–624; Epub 2015 Mar 10. PMID: 25753493.
   PubMed Web of Science ®Google Scholar
• Koh EH, Lee WJ, Lee SA, et al. Effects of alpha-lipoic acid on body weight in obese subjects. Am J Med. 2011 Jan;124(1):85.e1-8.
   Web of Science ®Google Scholar
• Li N, Yan W, Hu X, et al. Effects of oral α-lipoic acid administration on body weight in overweight or obese subjects: a crossover randomized, double-blind, placebo-controlled trial. Clin Endocrinol (Oxf). 2017 May;86(5):680–687; Epub 2017 Feb 26. PMID: 28239907.
   Web of Science ®Google Scholar
• Udupa AS, Nahar PS, Shah SH, et al. Study of comparative effects of antioxidants on insulin sensitivity in type 2 diabetes mellitus. J Clin Diagn Res. 2012;6(9):1469–1473.
   PubMedGoogle Scholar
• Tabrizi R, Borhani-Haghighi A, Mirhosseini N, et al. The effects of alpha-lipoic acid supplementation on fasting glucose and lipid profiles among patients with stroke: a systematic review and meta-analysis of randomized controlled trials. J Diabetes Metab Disord. 2019 Jul 29;18(2):585–595. PMID: 31890685; PMCID: PMC6915248.
   Web of Science ®Google Scholar
• Karadağ C, Yoldemir T, Yavuz DG. Effects of vitamin D supplementation on insulin sensitivity and androgen levels in vitamin-D-deficient polycystic ovary syndrome patients. J Obstet Gynaecol Res. 2018 Feb 2; Epub 2017 Nov 2. 44(2):270–277. PMID: 29094433.
   PubMed Web of Science ®Google Scholar
• Hoseini R, Damirchi A, Babaei P. Vitamin D increases PPARγ expression and promotes beneficial effects of physical activity in metabolic syndrome. Nutrition. 2017 Apr;36:54–59. PMID: 28336108. Epub 2016 Jun 29.
   PubMed Web of Science ®Google Scholar
• Mirmasoumi G, Fazilati M, Foroozanfard F, et al. The effects of flaxseed oil omega-3 fatty acids supplementation on metabolic status of patients with polycystic ovary syndrome: a randomized, double-blind, placebo-controlled trial. Exp Clin Endocrinol Diabetes. 2018 Apr;126(4):222–228; Epub 2017 Nov 8. PMID: 29117618.
   PubMed Web of Science ®Google Scholar
• Szkudelski T, Szkudelska K. The relevance of AMP-activated protein kinase in insulin-secreting β cells: a potential target for improving β cell function? J Physiol Biochem. 2019 Nov;75(4):423–432; Epub 2019 Nov 5. PMID: 31691163; PMCID: PMC6920233.
   Web of Science ®Google Scholar
• Saengsirisuwan V, Kinnick TR, Schmit MB, et al. Interactions of exercise training and lipoic acid on skeletal muscle glucose transport in obese Zucker rats. 1985;2001(91):145e53. J Appl Physiol.
   Google Scholar
• Lee WJ, Song KH, Koh EH, et al. α-Lipoic acid increases insulin sensitivity by activating AMPK in skeletal muscle. Biochem Biophys Res Commun. 2005 Jul 8;332(3):885–891. PMID: 15913551.
   PubMed Web of Science ®Google Scholar
• Bast A, Haenen GR. Lipoic acid: a multifunctional antioxidant. Biofactors. 2003;17(1–4):207–213. PMID: 12897442
   PubMed Web of Science ®Google Scholar
• Singh U, Jialal I. Retracted: alpha-lipoic acid supplementation and diabetes. Nutr Rev. 2008 Nov;66(11):646–657. PMID: 19019027; PMCID: PMC2657658
   PubMed Web of Science ®Google Scholar
• Kim E, Park DW, Choi SH, et al. A preliminary investigation of α-Lipoic acid treatment of antipsychotic drug-induced weight gain in patients with schizophrenia. J Clin Psychopharmacol. 2008 Apr;28(2):138–146. PMID: 18344723
   PubMed Web of Science ®Google Scholar
• Khabbazi T, Mahdavi R, Safa J, et al. Effects of alpha-lipoic acid supplementation on inflammation, oxidative stress, and serum lipid profile levels in patients with end-stage renal disease on hemodialysis. J Ren Nutr. 2012 Mar;22(2):244–250; Epub 2011 Sep 10. PMID: 21908204.
   PubMed Web of Science ®Google Scholar
• Sun YD, Dong YD, Fan R, et al. Effect of (R)-α-lipoic acid supplementation on serum lipids and antioxidative ability in patients with age-related macular degeneration. Ann Nutr Metab. 2012;60(4):293–297. Epub 2012 Jun 1. PMID: 22678104.
   Web of Science ®Google Scholar
• Chen W-L, Kang C-H, Wang S-G, et al. α-Lipoic acid regulates lipid metabolism through induction of sirtuin 1 (SIRT1) and activation of AMP-activated protein kinase. Diabetologia. 2012;55(6):1824–1835.
   PubMed Web of Science ®Google Scholar
• Ansar H, Mazloom Z, Kazemi F, et al. Effect of alpha-lipoic acid on blood glucose, insulin resistance and glutathione peroxidase of type 2 diabetic patients. Saudi Med J. 2011;32(6):584–588.
   Web of Science ®Google Scholar
• Seo EY, Ha AW, Kim WK. α-Lipoic acid reduced weight gain and improved the lipid profile in rats fed with high fat diet. Nutr Res Pract. 2012;6(3):195–200.
   PubMed Web of Science ®Google Scholar
• Ichikawa T, Liang J, Kitajima S, et al. Macrophage-derived lipoprotein lipase increases aortic atherosclerosis in cholesterol-fed Tg rabbits. Atherosclerosis. 2005;179(1):87–95.
   PubMed Web of Science ®Google Scholar
• Vidovic B, Milovanovic S, Stefanovic A, et al. Effects of Alpha-Lipoic acid supplementation on plasma adiponectin levels and some metabolic risk factors in patients with schizophrenia. J Med Food. 2017;20(1):79–85.
   Web of Science ®Google Scholar
• Singh K, Gupta K, Kaur S. High resolution ultrasonography of the tibial nerve in diabetic peripheral neuropathy. J Ultrason. 2017 Dec;17(71):246–252; Epub 2017 Dec 29. PMID: 29375899; PMCID: PMC5769664.
   PubMed Web of Science ®Google Scholar
• Watanabe H, Ito A, Morita Y, et al. Sonographic evaluation of the median nerve in diabetic patients, comparison with nerve conduction studies. J Ultrasound Med. 2009;28(6):727–734.
   Web of Science ®Google Scholar
• Riazi S, Bril V, Perkins BA, et al. Can ultrasound of the tibial nerve detect diabetic peripheral neuropathy?: a cross-sectional study. Diabetes Care. 2012;35(12):2575–2579.
   Web of Science ®Google Scholar