Epigenomic mediation after adverse childhood experiences: a systematic review and meta-analysis

References

• Felitti VJ, Anda RF, Nordenberg D, et al. Relationship of childhood abuse and household dysfunction to many of the leading causes of death in adults. The adverse childhood experiences (ACE) study. Am J Prev Med. 1998;14:245–258.
   PubMed Web of Science ®Google Scholar
• Hughes K, Bellis MA, Hardcastle KA, et al. The effect of multiple adverse childhood experiences on health: a systematic review and meta-analysis. Lancet Publ Health. 2017;2:e356–e366.
   PubMed Web of Science ®Google Scholar
• McCrory E, De Brito SA, Viding E. The link between child abuse and psychopathology: a review of neurobiological and genetic research. J R Soc Med. 2012;105:151–156.
   PubMed Web of Science ®Google Scholar
• Rich-Edwards JW, Mason S, Rexrode K, et al. Physical and sexual abuse in childhood as predictors of early-onset cardiovascular events in women. Circulation. 2012;126:920–927.
   PubMed Web of Science ®Google Scholar
• Dube SR, Fairweather D, Pearson WS, et al. Cumulative childhood stress and autoimmune diseases in adults. Psychosom Med. 2009;71:243–250.
   PubMed Web of Science ®Google Scholar
• Holman DM, Ports KA, Buchanan ND, et al. The association between adverse childhood experiences and risk of cancer in adulthood: a systematic review of the literature. Pediatrics. 2016;138:S81–S91.
   PubMed Web of Science ®Google Scholar
• Miller GE, Chen E, Parker KJ. Psychological stress in childhood and susceptibility to the chronic diseases of aging: moving toward a model of behavioral and biological mechanisms. Psychol Bull. 2011;137:959–997.
   PubMed Web of Science ®Google Scholar
• Oral R, Ramirez M, Coohey C, et al. Adverse childhood experiences and trauma informed care: The future of health care. Pediatr Res. 2016;79:227–233.
   PubMed Web of Science ®Google Scholar
• Morris MC, Compas BE, Garber J. Relations among posttraumatic stress disorder, comorbid major depression, and HPA function: a systematic review and meta-analysis. Clinical Psychol Rev. 2012;32:301–315.
   PubMed Web of Science ®Google Scholar
• Tozzi L, Farrell C, Booij L, et al. Epigenetic changes of FKBP5 as a link connecting genetic and environmental risk factors with structural and functional brain changes in major depression. Neuropsychopharmacology. 2018;43:1138–1145.
   PubMed Web of Science ®Google Scholar
• McGowan PO, Sasaki A, Huang TCT, et al. Promoter-wide hypermethylation of the ribosomal RNA gene promoter in the suicide brain. Plos One. 2008;3:e2085.
   PubMed Web of Science ®Google Scholar
• Nemeroff CB. Paradise lost: the neurobiological and clinical consequences of child abuse and neglect. Neuron. 2016;89:892–909.
   PubMed Web of Science ®Google Scholar
• Weaver ICG, Cervoni N, Champagne FA, et al. Epigenetic programming by maternal behavior. Nat Neurosci. 2004;7:847.
   PubMed Web of Science ®Google Scholar
• Lutz P-E, Turecki G. DNA methylation and childhood maltreatment: from animal models to human studies. Neuroscience. 2014;264:142–156.
   PubMed Web of Science ®Google Scholar
• Alexander N, Kirschbaum C, Wankerl M, et al. Glucocorticoid receptor gene methylation moderates the association of childhood trauma and cortisol stress reactivity. Psychoneuroendocrinology. 2018;90:68–75.
   PubMed Web of Science ®Google Scholar
• Klengel T, Binder EB. Epigenetics of stress-related psychiatric disorders and gene × environment interactions. Neuron. 2015;86:1343–1357.
   PubMed Web of Science ®Google Scholar
• Szyf M. The early life social environment and DNA methylation: DNA methylation mediating the long-term impact of social environments early in life. Epigenetics. 2011;6:971–978.
   PubMed Web of Science ®Google Scholar
• Yang B-Z, Zhang H, Ge W, et al. Child abuse and epigenetic mechanisms of disease risk. Am J Prevent Med. 2013;44:101–107.
   PubMed Web of Science ®Google Scholar
• Argentieri MA, Nagarajan S, Seddighzadeh B, et al. Epigenetic pathways in human disease: the impact of DNA methylation on stress-related pathogenesis and current challenges in biomarker development. EBioMedicine. 2017;18:327–350.
   PubMed Web of Science ®Google Scholar
• Nugent NR, Goldberg A, Uddin M. Topical review: the emerging field of epigenetics: informing models of pediatric trauma and physical health. J Pediatr Psychol. 2016;41:55–64.
   Web of Science ®Google Scholar
• Provençal NB, Elisabeth B. The effects of early life stress on the epigenome: from the womb to adulthood and even before. Exp Neurol. 2015;268:10–20.
   Web of Science ®Google Scholar
• Vaiserman AM, Koliada AK. Early-life adversity and long-term neurobehavioral outcomes: epigenome as a bridge? Hum Genom. 2017;11:34.
   Web of Science ®Google Scholar
• Groger N, Matas E, Gos T, et al. The transgenerational transmission of childhood adversity: behavioral, cellular, and epigenetic correlates. J Neural Transm. 2016;123:1037–1052.
   Web of Science ®Google Scholar
• Chu SH, Loucks EB, Kelsey KT, et al. Sex-specific epigenetic mediators between early life social disadvantage and adulthood BMI. Epigenomics. 2018;10:707–722.
   PubMed Web of Science ®Google Scholar
• Kumsta R, Marzi SJ, Viana J, et al. Severe psychosocial deprivation in early childhood is associated with increased DNA methylation across a region spanning the transcription start site of CYP2E1. Transl Psychiatry. 2016;6:e830.
   PubMed Web of Science ®Google Scholar
• Liberati A, Altman DG, Tetzlaff J, et al. The PRISMA statement for reporting systematic reviews and meta-analyses of studies that evaluate healthcare interventions: explanation and elaboration. BMJ. 2009;339:b2700.
   PubMed Web of Science ®Google Scholar
• Wells G, Shea B, O'Connell D, et al. The Newcastle–Ottawa Scale (NOS) for assessing the quality of nonrandomised studies in meta-analyses. Available from: http://www.ohri.ca/programs/clinical_epidemiology/oxford.asp [last accessed on April 7, 2019].
   Google Scholar
• Willer CJ, Li Y, Abecasis GR. METAL: fast and efficient meta-analysis of genomewide association scans. Bioinformatics. 2010;26:2190–2191.
   PubMed Web of Science ®Google Scholar
• Kamburov A, Wierling C, Lehrach H, et al. ConsensusPathDB—a database for integrating human functional interaction networks. Nucl Acids Res. 2009;37:D623–D628.
   PubMed Web of Science ®Google Scholar
• Labonté B, Suderman M, Maussion G, et al. Genome-wide epigenetic regulation by early-life trauma. Arch Gen Psychiatry. 2012;69:722–731.
   PubMed Web of Science ®Google Scholar
• O'Donnell KJ, Chen L, Mac Isaac JL, et al. DNA methylome variation in a perinatal nurse-visitation program that reduces child maltreatment: a 27-year follow-up. Transl Psychiatry. 2018;8:15.
   Web of Science ®Google Scholar
• Mehta D, Klengel T, Conneely KN, et al. Childhood maltreatment is associated with distinct genomic and epigenetic profiles in posttraumatic stress disorder. Proc Natl Acad Sci USA. 2013;110:8302–8307.
   PubMed Web of Science ®Google Scholar
• Lawn RB, Anderson EL, Suderman M, et al. Psychosocial adversity and socioeconomic position during childhood and epigenetic age: analysis of two prospective cohort studies. Hum Mol Genet. 2018;27:1301–1308.
   PubMed Web of Science ®Google Scholar
• Zhang H, Wang F, Kranzler HR, et al. Profiling of childhood adversity-associated DNA methylation changes in alcoholic patients and healthy controls. PLoS One. 2013;8:e65648.
   PubMed Web of Science ®Google Scholar
• Marinova Z, Maercker A, Küffer A, et al. DNA methylation profiles of elderly individuals subjected to indentured childhood labor and trauma. BMC Med Genet. 2017;18:1–10.
   Web of Science ®Google Scholar
• Cecil CA, Smith RG, Walton E, et al. Epigenetic signatures of childhood abuse and neglect: implications for psychiatric vulnerability. J Psychiatr Res. 2016;83:184–194.
   PubMed Web of Science ®Google Scholar
• Houtepen LC, Vinkers CH, Carrillo-Roa T, et al. Genome-wide DNA methylation levels and altered cortisol stress reactivity following childhood trauma in humans. Nat Commun. 2016;7:10967.
   PubMed Web of Science ®Google Scholar
• Smith AK, Conneely KN, Kilaru V, et al. Differential immune system DNA methylation and cytokine regulation in post-traumatic stress disorder. Am J Med Genet Part B. 2011;156B:700–708.
   PubMed Web of Science ®Google Scholar
• Labonté B, Yerko V, Gross J, et al. Differential glucocorticoid receptor exon 1B, 1C, and 1H expression and methylation in suicide completers with a history of childhood abuse. Biol Psychiatry. 2012;72:41–48.
   PubMed Web of Science ®Google Scholar
• McGowan PO, Sasaki A, D'Alessio AC, et al. Epigenetic regulation of the glucocorticoid receptor in human brain associates with childhood abuse. Nat Neurosci. 2009;12:342–348.
   PubMed Web of Science ®Google Scholar
• Bustamante AC, Aiello AE, Galea S, et al. Glucocorticoid receptor DNA methylation, childhood maltreatment and major depression. J Affect Disord. 2016;206:181–188.
   PubMed Web of Science ®Google Scholar
• Farrell C, Doolin K, O’ Leary N, et al. DNA methylation differences at the glucocorticoid receptor gene in depression are related to functional alterations in hypothalamic–pituitary–adrenal axis activity and to early life emotional abuse. Psychiatry Res. 2018;265:341–348.
   PubMed Web of Science ®Google Scholar
• Tyrka AR, Price LH, Marsit C, et al. Childhood adversity and epigenetic modulation of the leukocyte glucocorticoid receptor: preliminary findings in healthy adults. PloS One. 2012;7:e30148.
   PubMed Web of Science ®Google Scholar
• Tyrka AR, Parade SH, Welch ES, et al. Methylation of the leukocyte glucocorticoid receptor gene promoter in adults: associations with early adversity and depressive, anxiety and substance-use disorders. Transl Psychiatry. 2016;6:e848.
   Web of Science ®Google Scholar
• Steiger H, Labonté B, Groleau P, et al. Methylation of the glucocorticoid receptor gene promoter in bulimic women: associations with borderline personality disorder, suicidality, and exposure to childhood abuse. Int J Eat Disord. 2013;46:246–255.
   PubMed Web of Science ®Google Scholar
• Vangeel E, Van Den Eede F, Hompes T, et al. Chronic fatigue syndrome and DNA hypomethylation of the glucocorticoid receptor gene promoter 1F region: associations with HPA axis hypofunction and childhood trauma. Psychosom Med. 2015;77:853–862.
   Web of Science ®Google Scholar
• Bustamante AC, Aiello AE, Guffanti G, et al. FKBP5 DNA methylation does not mediate the association between childhood maltreatment and depression symptom severity in the Detroit Neighborhood Health Study. J Psychiatric Res. 2018;96:39–48.
   PubMed Web of Science ®Google Scholar
• Klengel T, Mehta D, Anacker C, et al. Allele-specific FKBP5 DNA demethylation mediates gene-childhood trauma interactions. Nat Neurosci. 2013;16:33–41.
   PubMed Web of Science ®Google Scholar
• Beach SRH, Brody GH, Lei MK, et al. Impact of child sex abuse on adult psychopathology: a genetically and epigenetically informed investigation. J Family Psychol. 2013;27:3–11.
   PubMed Web of Science ®Google Scholar
• Okada S, Morinobu S, Fuchikami M, et al. The potential of SLC6A4 gene methylation analysis for the diagnosis and treatment of major depression. J Psychiatric Res. 2014;53:47–53.
   PubMed Web of Science ®Google Scholar
• Booij L, Szyf M, Carballedo A, et al. DNA methylation of the serotonin transporter gene in peripheral cells and stress-related changes in hippocampal volume: a study in depressed patients and healthy controls. PLoS One. 2015;10:e0119061.
   PubMed Web of Science ®Google Scholar
• Perroud N, Salzmann A, Prada P, et al. Response to psychotherapy in borderline personality disorder and methylation status of the BDNF gene. Transl Psychiatry. 2013;3:e207.
   PubMed Web of Science ®Google Scholar
• Thaler L, Gauvin L, Joober R, et al. Methylation of BDNF in women with bulimic eating syndromes: associations with childhood abuse and borderline personality disorder. Prog Neuropsychopharmacol Biol Psychiatry. 2014;54:43–49.
   PubMed Web of Science ®Google Scholar
• Groleau P, Joober R, Israel M, et al. Methylation of the dopamine D2 receptor (DRD2) gene promoter in women with a bulimia-spectrum disorder: associations with borderline personality disorder and exposure to childhood abuse. J Psychiatr Res. 2014;48:121–127.
   Web of Science ®Google Scholar
• Janusek LW, Tell D, Gaylord-Harden N, et al. Relationship of childhood adversity and neighborhood violence to a proinflammatory phenotype in emerging adult African American men: an epigenetic link. Brain Behav Immun. 2017;60:126–135.
   PubMed Web of Science ®Google Scholar
• Checknita D, Ekstrom T, Comasco E, et al. Associations of monoamine oxidase A gene first exon methylation with sexual abuse and current depression in women. J Neural Transm. 2018;125:1053–1064.
   Web of Science ®Google Scholar
• Lutz PE, Gross JA, Dhir SK, et al. Epigenetic regulation of the kappa opioid receptor by child abuse. Biol Psychiatry. 2018;84:751–761.
   PubMed Web of Science ®Google Scholar
• Smearman EL, Almli LM, Conneely KN, et al. Oxytocin receptor genetic and epigenetic variations: association with child abuse and adult psychiatric symptoms. Child Develop. 2016;87:122–134.
   PubMed Web of Science ®Google Scholar
• Boks MP, Rutten BPF, Geuze E, et al. SKA2 methylation is involved in cortisol stress reactivity and predicts the development of post-traumatic stress disorder (PTSD) after military deployment. Neuropsychopharmacology. 2016;41:1350–1356.
   PubMed Web of Science ®Google Scholar
• Berent D, Pogórski M, Kulczycka-Wojdala D, et al. Childhood adversities are not a predictors of SSTR4met in alcoholics. Transl Neurosci. 2017;8:127–138.
   PubMed Web of Science ®Google Scholar
• Lapp HE, Ahmed S, Moore CL, et al. Toxic stress history and hypothalamic-pituitary-adrenal axis function in a social stress task: genetic and epigenetic factors. Neurotoxicol Teratol. 2019;71:41–49.
   PubMed Web of Science ®Google Scholar
• Misiak B, Szmida E, Karpiński P, et al. Lower LINE-1 methylation in first-episode schizophrenia patients with the history of childhood trauma. Epigenomics. 2015;7:1275–1285.
   PubMed Web of Science ®Google Scholar
• O'Leary NA, Wright MW, Brister JR, et al. Reference sequence (RefSeq) database at NCBI: current status, taxonomic expansion, and functional annotation. Nucl Acids Res. 2016;44:D733–D745.
   PubMed Web of Science ®Google Scholar
• Nanni V, Uher R, Danese A. Childhood maltreatment predicts unfavorable course of illness and treatment outcome in depression: a meta-analysis. AJP. 2012;169:141–151.
   Web of Science ®Google Scholar
• Grayson DR, Kundakovic M, Sharma RP. Is there a future for histone deacetylase inhibitors in the pharmacotherapy of psychiatric disorders? Mol Pharmacol. 2010;77:126–135.
   PubMed Web of Science ®Google Scholar
• Davies MN, Volta M, Pidsley R, et al. Functional annotation of the human brain methylome identifies tissue-specific epigenetic variation across brain and blood. Genome Biol. 2012;13:R43.
   PubMed Web of Science ®Google Scholar