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Brief Report

The mycobacterial P55 efflux pump is required for optimal growth on cholesterol

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Pages 444-448 | Received 13 Feb 2015, Accepted 16 Apr 2015, Published online: 09 Jul 2015

References

  • Gatfield J, Pieters J. Essential role for cholesterol in entry of mycobacteria into macrophages. Science (2000); 288:1647-50; PMID:10834844
  • Van der Geize R, Yam K, Heuser T, Wilbrink MH, Hara H, Anderton MC, Sim E, Dijkhuizen L, Davies JE, Mohn WW, et al. A gene cluster encoding cholesterol catabolism in a soil actinomycete provides insight into Mycobacterium tuberculosis survival in macrophages. Proc Natl Acad Sci U S A (2007); 104:1947-52; PMID:17264217; http://dx.doi.org/10.1073/pnas.0605728104
  • Mohn WW, van der Geize R, Stewart GR, Okamoto S, Liu J, Dijkhuizen L, Eltis LD. The actinobacterial mce4 locus encodes a steroid transporter. J Biol Chem (2008); 283:35368-74; PMID:18955493; http://dx.doi.org/10.1074/jbc.M805496200
  • Klepp LI, Forrellad MA, Osella AV, Blanco FC, Stella EJ, Bianco MV, Santangelo Mde L, Sassetti C, Jackson M, Cataldi AA, et al. Impact of the deletion of the six mce operons in Mycobacterium smegmatis. Microbes Infect (2012); 14:590-9; PMID:22353253; http://dx.doi.org/10.1016/j.micinf.2012.01.007
  • Pandey AK, Sassetti CM. Mycobacterial persistence requires the utilization of host cholesterol. Proc Natl Acad Sci U S A (2008); 105:4376-80.
  • Sassetti CM, Rubin EJ. Genetic requirements for mycobacterial survival during infection. Proc Natl Acad Sci U S A (2003); 100:12989-94; PMID:14569030; http://dx.doi.org/10.1073/pnas.2134250100
  • Joshi SM, Pandey AK, Capite N, Fortune SM, Rubin EJ, Sassetti CM. Characterization of mycobacterial virulence genes through genetic interaction mapping. Proc Natl Acad Sci U S A (2006); 103:11760-5; PMID:16868085; http://dx.doi.org/10.1073/pnas.0603179103
  • Chang JC, Miner MD, Pandey AK, Gill WP, Harik NS, Sassetti CM, Sherman DR. igr genes and Mycobacterium tuberculosis cholesterol metabolism. J Bacteriol (2009); 191:5232-9; PMID:19542286; http://dx.doi.org/10.1128/JB.00452-09
  • De Rossi E, Arrigo P, Bellinzoni M, Silva PA, Martín C, Aínsa JA, Guglierame P, Riccardi G. The multidrug transporters belonging to major facilitator superfamily in Mycobacterium tuberculosis. Mol Med (2002); 8:714-24; PMID:12520088
  • Ramon-Garcia S, Martin C, Thompson CJ, Ainsa JA. Role of the Mycobacterium tuberculosis P55 efflux pump in intrinsic drug resistance, oxidative stress responses, and growth. Antimicrob Agents Chemother (2009); 53:3675-82; PMID:19564371; http://dx.doi.org/10.1128/AAC.00550-09
  • Gaur RL, Ren K, Blumenthal A, Bhamidi S, Gibbs S, Jackson M, Zare RN, Ehrt S, Ernst JD, Banaei N. LprG-mediated surface expression of lipoarabinomannan is essential for virulence of Mycobacterium tuberculosis. PLoS Pathog (2014); 10:e1004376; PMID:25232742; http://dx.doi.org/10.1371/journal.ppat.1004376
  • Farrow MF, Rubin EJ. Function of a mycobacterial major facilitator superfamily pump requires a membrane-associated lipoprotein. J Bacteriol (2008); 190:1783-91; PMID:18156250; http://dx.doi.org/10.1128/JB.01046-07
  • Bianco MV, Blanco FC, Imperiale B, Forrellad MA, Rocha RV, Klepp LI, Cataldi AA, Morcillo N, Bigi F. Role of P27 -P55 operon from Mycobacterium tuberculosis in the resistance to toxic compounds. BMC Infect Dis (2011); 11:195; PMID:21762531; http://dx.doi.org/10.1186/1471-2334-11-195
  • Bigi F, Gioffré A, Klepp L, Santangelo MP, Alito A, Caimi K, Meikle V, Zumárraga M, Taboga O, Romano MI, et al. The knockout of the lprG-Rv1410 operon produces strong attenuation of Mycobacterium tuberculosis. Microbes Infect (2004); 6:182-7; PMID:14998516; http://dx.doi.org/10.1016/j.micinf.2003.10.010
  • Rengarajan J, Bloom BR, Rubin EJ. Genome-wide requirements for Mycobacterium tuberculosis adaptation and survival in macrophages. Proc Natl Acad Sci U S A (2005); 102:8327-32; PMID:15928073; http://dx.doi.org/10.1073/pnas.0503272102
  • Brzostek A, Pawelczyk J, Rumijowska-Galewicz A, Dziadek B, Dziadek J. Mycobacterium tuberculosis is able to accumulate and utilize cholesterol. J Bacteriol (2009); 191:6584-91; PMID:19717592; http://dx.doi.org/10.1128/JB.00488-09
  • Griffin JE, Gawronski JD, Dejesus MA, Ioerger TR, Akerley BJ, Sassetti CM. High-resolution phenotypic profiling defines genes essential for mycobacterial growth and cholesterol catabolism. PLoS Pathog (2011); 7:e1002251; PMID:21980284; http://dx.doi.org/10.1371/journal.ppat.1002251
  • de Carvalho LP, Fischer SM, Marrero J, Nathan C, Ehrt S, Rhee KY. Metabolomics of Mycobacterium tuberculosis reveals compartmentalized co-catabolism of carbon substrates. Chem Biol (2010); 17:1122-31; PMID:21035735; http://dx.doi.org/10.1016/j.chembiol.2010.08.009
  • Piddock LJ. Multidrug-resistance efflux pumps - not just for resistance. Nat Rev Microbiol (2006); 4:629-36; PMID:16845433; http://dx.doi.org/10.1038/nrmicro1464
  • Shukla S, Richardson ET, Athman JJ, Shi L, Wearsch PA, McDonald D, Banaei N, Boom WH, Jackson M, Harding CV. Mycobacterium tuberculosis lipoprotein LprG binds lipoarabinomannan and determines its cell envelope localization to control phagolysosomal fusion. PLoS Pathog (2014); 10:e1004471; PMID:25356793; http://dx.doi.org/10.1371/journal.ppat.1004471
  • Yang X, Nesbitt NM, Dubnau E, Smith I, Sampson NS. Cholesterol metabolism increases the metabolic pool of propionate in Mycobacterium tuberculosis. Biochemistry (2009); 48:3819-21; PMID:19364125; http://dx.doi.org/10.1021/bi9005418

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