Mutation of G234 amino acid residue in Candida albicans drug-resistance-related protein Rta2p is associated with fluconazole resistance and dihydrosphingosine transport

References

• Gow NA, van de Veerdonk FL, Brown AJ, Netea MG. Candida albicans morphogenesis and host defence: discriminating invasion from colonization. Nat Rev Microbiol 2011; 12:112-22; PMID:22158429
   PubMed Web of Science ®Google Scholar
• Williams DW, Jordan RP, Wei XQ, Alves CT, Wise MP, Wilson MJ, Lewis MA. Interactions of Candida albicans with host epithelial cells. J Oral Microbiol 2013; 21:5:1-8.
   Google Scholar
• Perea S, Patterson TF. Antifungal Resistance in Pathogenic Fungi. Clin Infect Dis 2002; 35:1073-80; PMID:12384841; http://dx.doi.org/10.1086/344058
   PubMed Web of Science ®Google Scholar
• Chandra J, Kuhn DM, Mulherjee PK, Hoyer LL, McCormick T, Ghannoum MA. Biofilm formation by the fungal pathogen Candida albicans: development, architecture, and drug resistance. J Bacteriol 2001; 183:5385-94; PMID:11514524; http://dx.doi.org/10.1128/JB.183.18.5385-5394.2001
   PubMed Web of Science ®Google Scholar
• White TC. Increased mRNA levels of ERG16, CDR, and MDR1 correlate with increases in azole resistance in Candida albicans isolates from a patient infected with human immunodeficiency virus. Antimicrob Agents Chemother 1997; 41:1482-87; PMID:9210670
   PubMed Web of Science ®Google Scholar
• Prasad R, De Wergifosse P, Goffeau A, Balzi E. Molecular cloning and characterization of a novel gene of Candida albicans, CDR1, conferring multiple resistance to drugs and antifungals. Curr Genet 1995; 27:320-9; PMID:7614555; http://dx.doi.org/10.1007/BF00352101
   PubMed Web of Science ®Google Scholar
• Sanglard D, Ischer F, Monod M, Bille J. Cloning of Candida albicans genes conferring resistance to azole antifungal agents: characterization of CDR2, a new multidrug ABC transporter gene. Microbiology 1997; 143:405-16; PMID:9043118; http://dx.doi.org/10.1099/00221287-143-2-405
   PubMed Web of Science ®Google Scholar
• Marichal P, Koymans L, Willemsens S, Bellens D, Verhasselt P, Luyten W, Borgers M, Ramaekers FC, Odds FC, Bossche HV. Contribution of mutations in the cytochrome P450 14alpha-demethylase (Erg11p, Cyp51p) to azole resistance in Candida albicans. Microbiology 1999; 145:2701-13; PMID:10537192
   PubMed Web of Science ®Google Scholar
• Cruz MC, Goldstein AL, Blankenship JR, Del Poeta M, Davis D, Cardenas ME, Perfect JR, McCusker JH, Heitman J. Calcineurin is essential for survival during membrane stress in Candida albicans. EMBO J 2002; 21:546-59; PMID:11847103; http://dx.doi.org/10.1093/emboj/21.4.546
   PubMed Web of Science ®Google Scholar
• Bader T, Schröppel K, Bentink S, Agabian N, Köhler G, Morschhäuser J. Role of calcineurin in stress resistance, morphogenesis, and virulence of a Candida albicans wild-type strain. Infect Immun 2006; 74:4366-9; PMID:16790813; http://dx.doi.org/10.1128/IAI.00142-06
   PubMed Web of Science ®Google Scholar
• White TC, Holleman S, Dy F, Mirels LF, Stevens DA. Resistance mechanisms in clinical isolates of Candida albicans. Antimicrob Agents Chemother 2002; 46:1704-13; PMID:12019079; http://dx.doi.org/10.1128/AAC.46.6.1704-1713.2002
   PubMed Web of Science ®Google Scholar
• Jia XM, Ma ZP, Jia Y, Gao PH, Zhang JD, Wang Y, Xu YG, Wang L, Cao YY, Cao YB, et al. RTA2, a novel gene involved in azole resistance in Candida albicans. Biochem Biophys Res Commun 2008; 373:631-6; PMID:18601908; http://dx.doi.org/10.1016/j.bbrc.2008.06.093
   PubMed Web of Science ®Google Scholar
• Jia XM, Wang Y, Jia Y, Gao PH, Xu YG, Wang L, Cao YY, Cao YB, Zhang LX, Jiang YY. RTA2 is involved in calcineurin-mediated azole resistance and sphingoid long-chain base release in Candida albicans. Cell Mol Life Sci 2009; 66:122-34; PMID:19002381; http://dx.doi.org/10.1007/s00018-008-8409-3
   PubMed Web of Science ®Google Scholar
• Feng Q, Summers E, Guo B, Fink G. Ras signaling is required for serum-induced hyphal differentiation in Candida albicans. J Bacteriol 1999; 181:6339-46; PMID:10515923
   PubMed Web of Science ®Google Scholar
• Espinel-Ingroff A, Rodríguez-Tudela JL, Martínez-Suárez JV. Comparison of two alternative microdilution procedures with the National Committee for Clinical Laboratory Standards reference macrodilution method M27-P for in vitro testing of fluconazole-resistant and-susceptible isolates of Candida albicans. J Clin Microbiol 1995; 33:3154-8; PMID:8586692
   PubMed Web of Science ®Google Scholar
• Hamza OJ, van den Bout-van den Beukel CJ, Matee MI, Moshi MJ, Mikx FH, Selemani HO, Mbwambo ZH, Van der Ven AJ, Verweij PE. Antifungal activity of some Tanzanian plants used traditionally for the treatment of fungal infections. J Ethnopharmacol 2006; 108:124-32; PMID:16829001; http://dx.doi.org/10.1016/j.jep.2006.04.026
   PubMed Web of Science ®Google Scholar
• Klepser ME, Wolfe EJ, Jones RN, Nightingale CH, Pfaller MA. Antifungal pharmacodynamic characteristics of fluconazole and amphotericin B tested against Candida albicans. Antimicrob Agents Chemother 1997; 41:1392-5; PMID:9174207
   PubMed Web of Science ®Google Scholar
• Zhang L, Yan K, Zhang Y, Huang R, Bian J, Zheng C, Sun H, Chen Z, Sun N, An R, et al. High-throughput synergy screening identifies microbial metabolites as combination agents for the treatment of fungal infections. Proc Natl Acad Sci USA 2007; 104:4606-11.
   PubMed Web of Science ®Google Scholar
• Nielsen M, Lundegaard C, Lund O, Petersen TN. CPHmodels-3.0-remote homology modeling using structure-guided sequence profiles. Nucleic Acids Res 2010;38:W576-81; PMID:20542909; http://dx.doi.org/10.1093/nar/gkq535
   PubMed Web of Science ®Google Scholar
• Wang H, Wang X, Li X, Zhang Y, Dai Y, Guo C, Zheng H. QSAR study and the hydrolysis activity prediction of three alkaline lipases from different lipase-producing microorganisms. Lipids Health Dis 2012; 11:124; PMID:23016923; http://dx.doi.org/10.1186/1476-511X-11-124
   PubMed Web of Science ®Google Scholar
• Raba M, Baumgartner T, Hilger D, Klempahn K, Härtel T, Jung K, Jung H. Function of transmembrane domain IX in the Na+/proline transporter PutP. J Mol Biol 2008; 382:884-93; PMID:18692508; http://dx.doi.org/10.1016/j.jmb.2008.07.070
   PubMed Web of Science ®Google Scholar
• Jia Y, Tang RJ, Wang L, Zhang X, Wang Y, Jia XM, Jiang YY. Calcium-Activated-Calcineurin Reduces the In Vitro and In Vivo Sensitivity of Fluconazole to Candida albicans via Rta2p. PLoS One 2012; 7:1-9; PMID:23118995; http://dx.doi.org/10.1371/annotation/7de63575-e5c9-4f1d-bb45-fc6420e92c71
   PubMed Web of Science ®Google Scholar
• Blankenship JR, Wormley FL, Boyce MK, Schell WA, Filler SG, Perfect JR, Heitman J. Calcineurin is essential for Candida albicans survival in serum and virulence. Eukaryot Cell 2003; 2:422-30; PMID:12796287; http://dx.doi.org/10.1128/EC.2.3.422-430.2003
   PubMed Web of Science ®Google Scholar
• Kihara A, Igarashi Y. Identification and Characterization of a Saccharomyces cerevisiae Gene, RSB1, Involved in Sphingoid Long-chain Base Release. J Biol Chem 2002; 277:30048-54; PMID:12034738; http://dx.doi.org/10.1074/jbc.M203385200
   PubMed Web of Science ®Google Scholar
• Mao C, Saba JD, Obeid LM. The dihydrosphingosine-1-phosphate phosphatases of Saccharomyces cerevisiae are important regulators of cell proliferation and heat stress responses. Biochem J 1999; 342:667-75; PMID:10477278; http://dx.doi.org/10.1042/0264-6021:3420667
   PubMed Web of Science ®Google Scholar
• Shukla S, Saini P, Smriti, Jha S, Ambudkar SV, Prasad R. Functional characterization of Candida albicans ABC transporter Cdr1p. Eukaryotic cell 2003; 2:1362-75; PMID:14665469; http://dx.doi.org/10.1128/EC.2.6.1361-1375.2003
   PubMed Web of Science ®Google Scholar
• de Micheli M, Bille J, Schueller C, Sanglard D. A common drug-responsive element mediates the upregulation of the Candida albicans ABC transporters CDR1 and CDR2, two genes involved in antifungal drug resistance. Mol Microbiol 2002; 43:1197-214; PMID:11918807; http://dx.doi.org/10.1046/j.1365-2958.2002.02814.x
   PubMed Web of Science ®Google Scholar
• Egner R, Bauer BE, Kuchler K. The transmembrane domain 10 of the yeast Pdr5p ABC antifungal efflux pump determination both substrate specificity and inhibitor susceptibility. Mol Microbiol 2000; 35:1255-63; PMID:10712705; http://dx.doi.org/10.1046/j.1365-2958.2000.01798.x
   PubMed Web of Science ®Google Scholar
• Jha S, Karnani N, Lynn AM, Prasad R. Covalent modification of cysteine 193 impairs ATPase function of nucleotide-binding domain of a Candida drug efflux pump. Biochem Biophys Res Commun 2003; 310:869-75; PMID:14550284; http://dx.doi.org/10.1016/j.bbrc.2003.09.094
   PubMed Web of Science ®Google Scholar
• Jha S, Dabas N, Karnani N, Saini P, Prasad R. ABC multidrug transporter Cdr1p of Candida albicans has divergent nucleotide-binding domains which display functional asymmetry. FEMS Yeast Res 2004; 5:63-72; PMID:15381123; http://dx.doi.org/10.1016/j.femsyr.2004.07.002
   PubMed Web of Science ®Google Scholar
• Krishnamurthy S, Gupta V, Snehlata P, Prasad P. Characterization of human steroid hormone transport mediated by Cdr1p, multidrug transporte of Candida albicans, belonging to the ATP binding cassette super family. FEMS Microbiol Lett 1998; 158:69-74; PMID:9453158; http://dx.doi.org/10.1111/j.1574-6968.1998.tb12802.x
   PubMed Web of Science ®Google Scholar
• Dogra S, Krishnamurthy S, Gupta V, Dixit BL, Gupta CM, Sanglard D, Prasad R. Asymmetric distribution of phosphatidylethanolamine in C. albicans: possible mediation by CDR1, a multidrug transporter belonging to ATP binding cassette (ABC) superfamily. Yeast 1999; 15:111-21; PMID:10029989; http://dx.doi.org/10.1002/(SICI)1097-0061(19990130)15:2%3c111::AID-YEA350%3e3.0.CO;2-E
   PubMed Web of Science ®Google Scholar
• Steinbach W, Reedy J, Cramer R, Perfect J, Heitman J. Harnessing calcineurin as a novel anti-infective agent against invasive fungal infections. Nat Rev Microbiol 2007; 5:418-30; PMID:17505522; http://dx.doi.org/10.1038/nrmicro1680
   PubMed Web of Science ®Google Scholar