Tackling tuberculosis: Insights from an international TB Summit in London

References

• Maitra A, Bhakta S. Mycobacterium tuberculosis… Can we beat it? Report from a Euroscicon conference 2013. Virulence 2013; 4:499-503; PMID:23863609; http://dx.doi.org/10.4161/viru.25397
   PubMed Web of Science ®Google Scholar
• Maitra A, Bhakta S. TB Summit 2014: prevention, diagnosis, and treatment of tuberculosis-a meeting report of a Euroscicon conference. Virulence 2014; 5:638-44; PMID:25003368; http://dx.doi.org/10.4161/viru.29803
   PubMed Web of Science ®Google Scholar
• WHO. Global Tuberculosis Report 2014. World Health Organization; 2014
   Google Scholar
• Bhakta S. An integration of interdisciplinary translational research in anti-TB drug discovery: out of the university research laboratories to combat mycobacterium tuberculosis. Mol Biol 2013; 2:e108; http://dx.doi.org/10.4172/2168-9547.1000e108
   Google Scholar
• da Costa C, Walker B, Bonavia A. Tuberculosis Vaccines–state of the art, and novel approaches to vaccine development. Int J Infect Dis 2015; 32:5-12; PMID:25809749; http://dx.doi.org/10.1016/j.ijid.2014.11.026
   PubMed Web of Science ®Google Scholar
• Russell DG. Mycobacterium tuberculosis: here today, and here tomorrow. Nat Rev Mol Cell Biol 2001; 2:569-77; PMID:11483990; http://dx.doi.org/10.1038/35085034
   PubMed Web of Science ®Google Scholar
• McNerney R, Cunningham J, Hepple P, Zumla A. New tuberculosis diagnostics and rollout. Int J Infect Dis 2015; 32:81-6; PMID:25809761; http://dx.doi.org/10.1016/j.ijid.2015.01.012
   PubMed Web of Science ®Google Scholar
• Lawn SD, Mwaba P, Bates M, Piatek A, Alexander H, Marais BJ, Cuevas LE, McHugh TD, Zijenah L, Kapata N, et al. Advances in tuberculosis diagnostics: the Xpert MTB/RIF assay and future prospects for a point-of-care test. Lancet Infect Dis 2013; 13:349-61; PMID:23531388; http://dx.doi.org/10.1016/S1473-3099(13)70008-2
   PubMed Web of Science ®Google Scholar
• Hershberg R, Lipatov M, Small PM, Sheffer H, Niemann S, Homolka S, Roach JC, Kremer K, Petrov DA, Feldman MW. High functional diversity in Mycobacterium tuberculosis driven by genetic drift and human demography. PLoS Biol 2008; 6:e311; PMID:19090620; http://dx.doi.org/10.1371/journal.pbio.0060311
   PubMed Web of Science ®Google Scholar
• Wirth T, Hildebrand F, Allix-Beguec C, Wolbeling F, Kubica T, Kremer K, van Soolingen D, Rusch-Gerdes S, Locht C, Brisse S, et al. Origin, spread and demography of the Mycobacterium tuberculosis complex. PLoS Pathog 2008; 4:e1000160; PMID:18802459; http://dx.doi.org/10.1371/journal.ppat.1000160
   PubMed Web of Science ®Google Scholar
• McKee M. The health consequences of the collapse of the Soviet Union. Poverty, inequality and health: an international perspective. New York: Oxford UP 2001; 1:138-45.
   Google Scholar
• Parwati I, van Crevel R, van Soolingen D. Possible underlying mechanisms for successful emergence of the Mycobacterium tuberculosis Beijing genotype strains. Lancet Infect Dis 2010; 10:103-11; PMID:20113979; http://dx.doi.org/10.1016/S1473-3099(09)70330-5
   PubMed Web of Science ®Google Scholar
• Ford CB, Shah RR, Maeda MK, Gagneux S, Murray MB, Cohen T, Johnston JC, Gardy J, Lipsitch M, Fortune SM. Mycobacterium tuberculosis mutation rate estimates from different lineages predict substantial differences in the emergence of drug-resistant tuberculosis. Nat Genet 2013; 45:784-90; PMID:23749189; http://dx.doi.org/10.1038/ng.2656
   PubMed Web of Science ®Google Scholar
• Panaiotov S, Bachiyska E, Yordanova S, Atanasova Y, Brankova N, Levterova V, Sengstake S, Anthony R, Bergval I, Sola C, et al. Beijing lineage of MDR Mycobacterium tuberculosis in Bulgaria, 2007-2011. Emerg Infect Dis 2014; 20:1899-901; PMID:25340498; http://dx.doi.org/10.3201/eid2011.140468
   PubMed Web of Science ®Google Scholar
• Sengstake S, Bablishvili N, Schuitema A, Bzekalava N, Abadia E, de Beer J, Tadumadze N, Akhalaia M, Tuin K, Tukvadze N, et al. Optimizing multiplex SNP-based data analysis for genotyping of Mycobacterium tuberculosis isolates. BMC Genomics 2014; 15:572; PMID:25001491; http://dx.doi.org/10.1186/1471-2164-15-572
   PubMed Web of Science ®Google Scholar
• Barnett M, Bushby SR, Mitchison DA. Isoniazid-resistant strains of tubercle bacili; their development and stability. Lancet 1953; 1:314-20; PMID:13012073; http://dx.doi.org/10.1016/S0140-6736(53)90993-3
   PubMedGoogle Scholar
• Niemann S, Diel R, Khechinashvili G, Gegia M, Mdivani N, Tang Y-W. Mycobacterium tuberculosis beijing lineage favors the spread of multidrug-resistant tuberculosis in the republic of Georgia. J Clin Microbiol 2010; 48:3544-50; PMID:20702677; http://dx.doi.org/10.1128/JCM.00715-10
   PubMed Web of Science ®Google Scholar
• den Hertog AL, Menting S, van Soolingen D, Anthony RM. Mycobacterium tuberculosis Beijing genotype resistance to transient rifampin exposure. Emerging infectious diseases 2014; 20:1932-3; PMID:25340553; http://dx.doi.org/10.3201/eid2011.130560
   PubMed Web of Science ®Google Scholar
• Fonseca JD, Knight GM, McHugh TD. The complex evolution of antibiotic resistance in Mycobacterium tuberculosis. Int J Infect Dis 2015; 32:94-100; PMID:25809763; http://dx.doi.org/10.1016/j.ijid.2015.01.014
   PubMed Web of Science ®Google Scholar
• Yimer SA, Norheim G, Namouchi A, Zegeye ED, Kinander W, Tønjum T, Bekele S, Mannsåker T, Bjune G, Aseffa A. Mycobacterium tuberculosis lineage 7 strains are associated with prolonged patient delay in seeking treatment for pulmonary tuberculosis in amhara region, Ethiopia. J Clin Microbiol 2015; 53:1301-9; PMID:25673798; http://dx.doi.org/10.1128/JCM.03566-14
   PubMed Web of Science ®Google Scholar
• Tessema B, Beer J, Merker M, Emmrich F, Sack U, Rodloff AC, Niemann S. Molecular epidemiology and transmission dynamics of Mycobacterium tuberculosis in Northwest Ethiopia: new phylogenetic lineages found in Northwest Ethiopia. BMC Infect Dis 2013; 13:131; PMID:23496968; http://dx.doi.org/10.1186/1471-2334-13-131
   PubMed Web of Science ®Google Scholar
• Hong Kong Chest Service/British Medical Research C. Controlled trial of four thrice-weekly regimens and a daily regimen all given for 6 months for pulmonary tuberculosis. Lancet 1981; 317:171-4
   Google Scholar
• Zhang Y, Mitchison D. The curious characteristics of pyrazinamide: a review. Int J Tuberc Lung Dis 2003; 7:6-21; PMID:12701830
   PubMed Web of Science ®Google Scholar
• Zhang Y, Shi W, Zhang W, Mitchison D. Mechanisms of pyrazinamide action and resistance. Microbiol Spectr 2013; 2:1-12; PMID:25530919
   PubMedGoogle Scholar
• Systems BD. BACTEC™ MGIT™ 960 PZA Kit System Product and Procedure Manual.
   Google Scholar
• Wayne LG. Simple pyrazinamidase and urease tests for routine identification of mycobacteria. Am Rev Respir Dis 1974; 109:147-51; PMID:4203284
   PubMed Web of Science ®Google Scholar
• Karim SSA, Churchyard GJ, Karim QA, Lawn SD. HIV infection and tuberculosis in South Africa: an urgent need to escalate the public health response. Lancet 2009; 374:921-33; http://dx.doi.org/10.1016/S0140-6736(09)60916-8
   PubMed Web of Science ®Google Scholar
• Root HF. Diabetic coma and pulmonary tuberculosis. Trans Am Clin Climatol Assoc 1934; 50:210-7; PMID:21407479
   PubMedGoogle Scholar
• Baker MA, Harries AD, Jeon CY, Hart JE, Kapur A, Lonnroth K, Ottmani SE, Goonesekera SD, Murray MB. The impact of diabetes on tuberculosis treatment outcomes: a systematic review. BMC Med 2011; 9:81-96; PMID:21722362; http://dx.doi.org/10.1186/1741-7015-9-81
   PubMed Web of Science ®Google Scholar
• Whiting DR, Guariguata L, Weil C, Shaw J. IDF Diabetes Atlas: Global estimates of the prevalence of diabetes for 2011 and 2030. Diabetes Res Clin Pract 2011; 94:311-21; PMID:22079683; http://dx.doi.org/10.1016/j.diabres.2011.10.029
   PubMed Web of Science ®Google Scholar
• Digman C, Borto D, Nasraway SA, Jr. Hyperglycemia in the critically ill. Nutr Clin Care 2005; 8:93-101; PMID:16013228
   PubMedGoogle Scholar
• Dungan KM, Braithwaite SS, Preiser JC. Stress hyperglycaemia. Lancet 2009; 373:1798-807; PMID:19465235; http://dx.doi.org/10.1016/S0140-6736(09)60553-5
   PubMed Web of Science ®Google Scholar
• Stevenson CR, Forouhi NG, Roglic G, Williams BG, Lauer JA, Dye C, Unwin N. Diabetes and tuberculosis: the impact of the diabetes epidemic on tuberculosis incidence. BMC Public Health 2007; 7:234; PMID:17822539; http://dx.doi.org/10.1186/1471-2458-7-234
   PubMed Web of Science ®Google Scholar
• Restrepo B, Fisher-Hoch S, Crespo J, Whitney E, Perez A, Smith B, McCormick J. Type 2 diabetes and tuberculosis in a dynamic bi-national border population. Epidemiol Infect 2007; 135:483-91; PMID:16863600; http://dx.doi.org/10.1017/S0950268806006935
   PubMed Web of Science ®Google Scholar
• Dooley KE, Chaisson RE. Tuberculosis and diabetes mellitus: convergence of two epidemics. Lancet Infect Dis 2009; 9:737-46; PMID:19926034; http://dx.doi.org/10.1016/S1473-3099(09)70282-8
   PubMed Web of Science ®Google Scholar
• Cadena J, Hartzler A, Hsue G, Longfield RN. Coccidioidomycosis and tuberculosis coinfection at a tuberculosis hospital: clinical features and literature review. Medicine 2009; 88:66-76; PMID:19352301; http://dx.doi.org/10.1097/MD.0b013e318194757a
   PubMed Web of Science ®Google Scholar
• Brown GD, Denning DW, Gow NA, Levitz SM, Netea MG, White TC. Hidden killers: human fungal infections. Sci Transl Med 2012; 4:165rv13; PMID:23253612; http://dx.doi.org/10.1126/scitranslmed.3004404
   PubMed Web of Science ®Google Scholar
• Wasay M, Farooq S, Khowaja ZA, Bawa ZA, Ali SM, Awan S, Beg MA, Mehndiratta MM. Cerebral infarction and tuberculoma in central nervous system tuberculosis: frequency and prognostic implications. J Neurol Neurosurg Psychiatry 2014; 85:1260-4; PMID:24623792; http://dx.doi.org/10.1136/jnnp-2013-307178
   PubMed Web of Science ®Google Scholar
• Anuradha HK, Garg RK, Sinha MK, Agarwal A, Verma R, Singh MK, Shukla R. Intracranial tuberculomas in patients with tuberculous meningitis: predictors and prognostic significance. Int J Tuberc Lung Dis 2011; 15:234-9; PMID:21219687
   PubMed Web of Science ®Google Scholar
• Misra U, Kalita J, Nair P. Role of aspirin in tuberculous meningitis: a randomized open label placebo controlled trial. J Neurol Sci 2010; 293:12-7; PMID:20421121; http://dx.doi.org/10.1016/j.jns.2010.03.025
   PubMed Web of Science ®Google Scholar
• Schoeman JF, van Rensburg AJ, Laubscher JA, Springer P. The role of aspirin in childhood tuberculous meningitis. J Child Neurol 2011; 26:956-62; PMID:21628697; http://dx.doi.org/10.1177/0883073811398132
   PubMed Web of Science ®Google Scholar
• de Kantor IN, LoBue PA, Thoen CO. Human tuberculosis caused by Mycobacterium bovis in the United States, Latin America and the Caribbean. Int J Tuberc Lung Dis 2010; 14:1369-73; PMID:20937174
   PubMed Web of Science ®Google Scholar
• Grange JM. Mycobacterium bovis infection in human beings. Tuberculosis 2001; 81:71-7; PMID:11463226; http://dx.doi.org/10.1054/tube.2000.0263
   PubMed Web of Science ®Google Scholar
• Department of Environment, Food and Rural Affairs. The incidence of Tuberculosis (TB) in Cattle to end March 2015 for Great Britain. 2015;1-9; Available at https://www.gov.uk/government/uploads/system/uploads/attachment_data/file/433673/bovinetb-statsnotice-10jun15.pdf
   Google Scholar
• Murhead RH, Burns KJ. Tuberculosis in wild badgers in Gloucestershire: epidemiology. Vet Rec 1974; 95:552-5; PMID:4462735; http://dx.doi.org/10.1136/vr.95.24.552
   PubMed Web of Science ®Google Scholar
• Department of Environment, Food and Rural Affairs. Badgers Act 1973. 1973. 57:1-7; Available at http://www.legislation.gov.uk/ukpga/1973/57/pdfs/ukpga_19730057_en.pdf
   Google Scholar
• Department of Environment, Food and Rural Affairs. Protection of Badgers Act. 1992. 1992; 51:1-16; Available at: http://www.legislation.gov.uk/ukpga/1992/51/pdfs/ukpga_19920051_en.pdf
   Google Scholar
• Department of Environment, Food and Rural Affairs. The strategy for achieving officially bovine tuberculosis free status for England. 2014: 1-85.
   Google Scholar
• Lesellier S, Palmer S, Gowtage-Sequiera S, Ashford R, Dalley D, Dave D, Weyer U, Salguero FJ, Nunez A, Crawshaw T, et al. Protection of Eurasian badgers (Meles meles) from tuberculosis after intra-muscular vaccination with different doses of BCG. Vaccine 2011; 29:3782-90; PMID:21440035; http://dx.doi.org/10.1016/j.vaccine.2011.03.028
   PubMed Web of Science ®Google Scholar
• Garrod A. Report on the Indian elephant which died in the society's gardens on July 7th, 1875. Proc Zool Soc Lond 1875; 1875:542-543.
   Google Scholar
• Landolfi JA, Terio KA, Miller M, Junecko BF, Reinhart T. Pulmonary Tuberculosis in Asian Elephants (Elephas maximus): Histologic Lesions With Correlation to Local Immune Responses. Vet Pathol 2014; PMID:25228055; 1875:542-543.
   PubMed Web of Science ®Google Scholar
• Landolfi JA, Schultz SA, Mikota SK, Terio KA. Development and validation of cytokine quantitative, real time RT-PCR assays for characterization of Asian elephant immune responses. Vet Immunol Immunopathol 2009; 131:73-8; PMID:19368977; http://dx.doi.org/10.1016/j.vetimm.2009.03.012
   PubMed Web of Science ®Google Scholar
• Landolfi JA, Mikota SK, Chosy J, Lyashchenko KP, Giri K, Gairhe K, Terio KA. Comparison of systemic cytokine levels in Mycobacterium spp. seropositive and seronegative Asian elephants (Elephas maximus). J Zoo Wildl Med 2010; 41:445-55; PMID:20945642; http://dx.doi.org/10.1638/2009-0163.1
   PubMed Web of Science ®Google Scholar
• Landolfi JA, Miller M, Maddox C, Zuckermann F, Langan JN, Terio KA. Differences in immune cell function between tuberculosis positive and negative Asian elephants. Tuberculosis 2014; 94:374-82; PMID:24836563; http://dx.doi.org/10.1016/j.tube.2014.03.001
   PubMed Web of Science ®Google Scholar
• Nazish Fatima; Mohammad Shameem; Nabeela; Khan HM. Changes in serum levels of TNF-α & IL-4 among new, under-treatment & MDR TB patients. Br Microbiol Res J 2015; 7:159-66; http://dx.doi.org/10.9734/BMRJ/2015/14798
   Google Scholar
• Das PK, Rambukkana A, Baas JG, Groothuis DG, Halperin M. Enzyme-linked immunosorbent assay for distinguishing serological responses of lepromatous and tuberculoid leprosies to the 29/33-kilodalton doublet and 64-kilodalton antigens of Mycobacterium tuberculosis. J Clin Microbiol 1990; 28:379-82; PMID:2107205
   PubMed Web of Science ®Google Scholar
• van der Werf TS, Koeter GH, Das PK, Yong S. Monoclonal ELISA to detect active tuberculosis. Lancet 1990; 336:1516; PMID:1979131; http://dx.doi.org/10.1016/0140-6736(90)93230-M
   PubMed Web of Science ®Google Scholar
• Layre E, Sweet L, Hong S, Madigan CA, Desjardins D, Young DC, Cheng TY, Annand JW, Kim K, Shamputa IC, et al. A comparative lipidomics platform for chemotaxonomic analysis of Mycobacterium tuberculosis. Chemis Biol 2011; 18:1537-49; PMID:22195556; http://dx.doi.org/10.1016/j.chembiol.2011.10.013
   PubMed Web of Science ®Google Scholar
• Layre E, Paepe DC, Larrouy-Maumus G, Vaubourgeix J, Mundayoor S, Lindner B, Puzo G, Gilleron M. Deciphering sulfoglycolipids of Mycobacterium tuberculosis. J Lipid Res 2011; 52:1098-110; PMID:21482713; http://dx.doi.org/10.1194/jlr.M013482
   PubMed Web of Science ®Google Scholar
• ter Horst B, Feringa BL, Minnaard AJ. Iterative strategies for the synthesis of deoxypropionates. Chem Commun 2010; 46:2535-47; PMID:20449305; http://dx.doi.org/10.1039/b926265b
   PubMed Web of Science ®Google Scholar
• Geerdink D, ter Horst B, Lepore M, Mori L, Puzo G, Hirsch AK, Gilleron M, de Libero G, Minnaard AJ. Total synthesis, stereochemical elucidation and biological evaluation of Ac 2 SGL; a 1, 3-methyl branched sulfoglycolipid from Mycobacterium tuberculosis. Chem Sci 2013; 4:709-16; http://dx.doi.org/10.1039/C2SC21620E
   Web of Science ®Google Scholar
• Geerdink D, Minnaard AJ. Total synthesis of sulfolipid-1. Chem Commun 2014; 50:2286-8; PMID:24441014; http://dx.doi.org/10.1039/C3CC48087A
   PubMed Web of Science ®Google Scholar
• Layre E, Lee HJ, Young DC, Martinot AJ, Buter J, Minnaard AJ, Annand JW, Fortune SM, Snider BB, Matsunaga I, et al. Molecular profiling of Mycobacterium tuberculosis identifies tuberculosinyl nucleoside products of the virulence-associated enzyme Rv3378c. Proc Natl Acad Sci U S A 2014; 111:2978-83; PMID:24516143; http://dx.doi.org/10.1073/pnas.1315883111
   PubMed Web of Science ®Google Scholar
• Pethe K, Swenson DL, Alonso S, Anderson J, Wang C, Russell DG. Isolation of Mycobacterium tuberculosis mutants defective in the arrest of phagosome maturation. Proc Natl Acad Sci U S A 2004; 101:13642-7; PMID:15340136; http://dx.doi.org/10.1073/pnas.0401657101
   PubMed Web of Science ®Google Scholar
• Sakula A. Carlo Forlanini, inventor of artificial pneumothorax for treatment of pulmonary tuberculosis. Thorax 1983; 38:326-32; PMID:6348993; http://dx.doi.org/10.1136/thx.38.5.326
   PubMed Web of Science ®Google Scholar
• Murray CJ, Ortblad KF, Guinovart C, Lim SS, Wolock TM, Roberts DA, Dansereau EA, Graetz N, Barber RM, Brown JC. Global, regional, and national incidence and mortality for HIV, tuberculosis, and malaria during 1990–2013: a systematic analysis for the Global Burden of Disease Study 2013. Lancet 2014; 384:1005-70; http://dx.doi.org/10.1016/S0140-6736(14)60844-8
   PubMed Web of Science ®Google Scholar
• Cain KP, Marano N, Kamene M, Sitienei J, Mukherjee S, Galev A, Burton J, Nasibov O, Kioko J, De Cock KM. The movement of multidrug-resistant tacross borders in East Africa needs a regional and global solution. PLoS Med 2015; 12:e1001791; PMID:25710472; http://dx.doi.org/10.1371/journal.pmed.1001791
   PubMed Web of Science ®Google Scholar
• Pietersen E, Ignatius E, Streicher EM, Mastrapa B, Padanilam X, Pooran A, Badri M, Lesosky M, van Helden P, Sirgel FA, et al. Long-term outcomes of patients with extensively drug-resistant tuberculosis in South Africa: a cohort study. Lancet 2014; 383:1230-9; PMID:24439237; http://dx.doi.org/10.1016/S0140-6736(13)62675-6
   PubMed Web of Science ®Google Scholar
• Marais E, Mlambo CK, Lewis JJ, Rastogi N, Zozio T, Grobusch MP, Duse A, Victor T, Warren RW. Treatment outcomes of multidrug-resistant tuberculosis patients in Gauteng, South Africa. Infection 2014; 42:405-13; PMID:24363208; http://dx.doi.org/10.1007/s15010-013-0572-2
   PubMed Web of Science ®Google Scholar
• Collins FS, Varmus H. A New Initiative on Precision Medicine. N Engl J Med 2015; 372:793-5; PMID:25635347; http://dx.doi.org/10.1056/NEJMp1500523
   PubMed Web of Science ®Google Scholar
• Alffenaar J, Akkerman O, Bolhuis M, Boeree M, de Lange W, van der Werf T. Breakpoints and drug exposure are inevitably closely linked. Antimicrob Agents Chemother 2015; 59:1384-; PMID:25628393; http://dx.doi.org/10.1128/AAC.04485-14
   PubMed Web of Science ®Google Scholar
• Gupta A, Kaul A, Tsolaki AG, Kishore U, Bhakta S. Mycobacterium tuberculosis: immune evasion, latency and reactivation. Immunobiology 2012; 217:363-74; PMID:21813205; http://dx.doi.org/10.1016/j.imbio.2011.07.008
   PubMed Web of Science ®Google Scholar
• Keane J, Gershon S, Wise RP, Mirabile-Levens E, Kasznica J, Schwieterman WD, Siegel JN, Braun MM. Tuberculosis associated with infliximab, a tumor necrosis factor alpha-neutralizing agent. N Engl J Med 2001; 345:1098-104; PMID:11596589; http://dx.doi.org/10.1056/NEJMoa011110
   PubMed Web of Science ®Google Scholar
• Wallis RS, Broder MS, Wong JY, Hanson ME, Beenhouwer DO. Granulomatous infectious diseases associated with tumor necrosis factor antagonists. Clin Infect Dis 2004; 38:1261-5; PMID:15127338; http://dx.doi.org/10.1086/383317
   PubMed Web of Science ®Google Scholar
• Dixon WG, Hyrich KL, Watson KD, Lunt M, Galloway J, Ustianowski A, Consortium BSRBRCC, Symmons DP, Register BSRB. Drug-specific risk of tuberculosis in patients with rheumatoid arthritis treated with anti-TNF therapy: results from the British Society for Rheumatology Biologics Register (BSRBR). Ann Rheum Dis 2010; 69:522-8; PMID:19854715; http://dx.doi.org/10.1136/ard.2009.118935
   PubMed Web of Science ®Google Scholar
• de Leon DP, Acevedo-Vasquez E, Sanchez-Torres A, Cucho M, Alfaro J, Perich R, Pastor C, Harrison J, Sanchez-Schwartz C. Attenuated response to purified protein derivative in patients with rheumatoid arthritis: study in a population with a high prevalence of tuberculosis. Ann Rheum Dis 2005; 64:1360-1; PMID:16100342; http://dx.doi.org/10.1136/ard.2004.029041
   PubMed Web of Science ®Google Scholar
• Vergne AF, Walz AJ, Miller MJ. Iron chelators from mycobacteria (1954-1999) and potential therapeutic applications. Nat Prod Rep 2000; 17:99-116; PMID:10714901; http://dx.doi.org/10.1039/a809397k
   PubMed Web of Science ®Google Scholar
• Snow G. Mycobactins: iron-chelating growth factors from mycobacteria. Bacteriol Rev 1970; 34:99; PMID:4918634
   PubMedGoogle Scholar
• Miller MJ, Zhu H, Xu Y, Wu C, Walz AJ, Vergne A, Roosenberg JM, Moraski G, Minnick AA, McKee-Dolence J. Utilization of microbial iron assimilation processes for the development of new antibiotics and inspiration for the design of new anticancer agents. Biometals 2009; 22:61-75; PMID:19130268; http://dx.doi.org/10.1007/s10534-008-9185-0
   PubMed Web of Science ®Google Scholar
• Miller MJ, Walz AJ, Zhu H, Wu C, Moraski G, Mollmann U, Tristani EM, Crumbliss AL, Ferdig MT, Checkley L, et al. Design, synthesis, and study of a mycobactin-artemisinin conjugate that has selective and potent activity against tuberculosis and malaria. J Am Chem Soc 2011; 133:2076-9; PMID:21275374; http://dx.doi.org/10.1021/ja109665t
   PubMed Web of Science ®Google Scholar
• Moraski GC, Chang M, Villegas-Estrada A, Franzblau SG, Mollmann U, Miller MJ. Structure-activity relationship of new anti-tuberculosis agents derived from oxazoline and oxazole benzyl esters. Eur J Med Chem 2010; 45:1703-16; PMID:20116900; http://dx.doi.org/10.1016/j.ejmech.2009.12.074
   PubMed Web of Science ®Google Scholar
• Cheng Y, Moraski GC, Cramer J, Miller MJ, Schorey JS. Bactericidal activity of an imidazo[1, 2-a]pyridine using a mouse M. tuberculosis infection model. PloS One 2014; 9:e87483; PMID:24498115; http://dx.doi.org/10.1371/journal.pone.0087483
   PubMed Web of Science ®Google Scholar
• Menendez C, Rodriguez F, Ribeiro AL, Zara F, Frongia C, Lobjois V, Saffon N, Pasca MR, Lherbet C, Baltas M. Synthesis and evaluation of alpha-ketotriazoles and alpha,beta-diketotriazoles as inhibitors of Mycobacterium tuberculosis. Eur J Med Chem 2013; 69:167-73; PMID:24016834; http://dx.doi.org/10.1016/j.ejmech.2013.06.042
   PubMed Web of Science ®Google Scholar
• Matviiuk T, Mori G, Lherbet C, Rodriguez F, Pasca MR, Gorichko M, Guidetti B, Voitenko Z, Baltas M. Synthesis of 3-heteryl substituted pyrrolidine-2,5-diones via catalytic Michael reaction and evaluation of their inhibitory activity against InhA and Mycobacterium tuberculosis. Eur J Med Chem 2014; 71:46-52; PMID:24269516; http://dx.doi.org/10.1016/j.ejmech.2013.10.069
   PubMed Web of Science ®Google Scholar
• Guzman JD, Gupta A, Bucar F, Gibbons S, Bhakta S. Antimycobacterials from natural sources: ancient times, antibiotic era and novel scaffolds. Front Biosci 2012; 17:1861-81; http://dx.doi.org/10.2741/4024
   PubMed Web of Science ®Google Scholar
• Guzman JD, Evangelopoulos D, Gupta A, Prieto JM, Gibbons S, Bhakta S. Antimycobacterials from lovage root (Ligusticum officinale Koch). Phytother Res 2013; 27:993-8; PMID:22899555; http://dx.doi.org/10.1002/ptr.4823
   PubMed Web of Science ®Google Scholar
• O'Donnell G, Poeschl R, Zimhony O, Gunaratnam M, Moreira JB, Neidle S, Evangelopoulos D, Bhakta S, Malkinson JP, Boshoff HI, et al. Bioactive pyridine-N-oxide disulfides from Allium stipitatum. J Nat Prod 2009; 72:360-5; PMID:19093848; http://dx.doi.org/10.1021/np800572r
   PubMed Web of Science ®Google Scholar
• Osman K, Evangelopoulos D, Basavannacharya C, Gupta A, McHugh TD, Bhakta S, Gibbons S. An antibacterial from Hypericum acmosepalum inhibits ATP-dependent MurE ligase from Mycobacterium tuberculosis. Int J Antimicrob Agents 2012; 39:124-9; PMID:22079533; http://dx.doi.org/10.1016/j.ijantimicag.2011.09.018
   PubMed Web of Science ®Google Scholar
• Wube A, Guzman JD, Hufner A, Hochfellner C, Blunder M, Bauer R, Gibbons S, Bhakta S, Bucar F. Synthesis and antibacterial evaluation of a new series of N-Alkyl-2-alkynyl/(E)-alkenyl-4-(1H)-quinolones. Molecules 2012; 17:8217-40; PMID:22777190; http://dx.doi.org/10.3390/molecules17078217
   PubMed Web of Science ®Google Scholar
• Gibbons S. Phytochemicals for bacterial resistance–strengths, weaknesses and opportunities. Planta Med 2008; 74:594-602; PMID:18446673; http://dx.doi.org/10.1055/s-2008-1074518
   PubMed Web of Science ®Google Scholar
• Guzman JD, Evangelopoulos D, Gupta A, Birchall K, Mwaigwisya S, Saxty B, McHugh TD, Gibbons S, Malkinson J, Bhakta S. Antitubercular specific activity of ibuprofen and the other 2-arylpropanoic acids using the HT-SPOTi whole-cell phenotypic assay. BMJ Open 2013; 3; PMID:23794563; http://dx.doi.org/10.1136/bmjopen-2013-002672
   PubMed Web of Science ®Google Scholar
• Vilaplana C, Marzo E, Tapia G, Diaz J, Garcia V, Cardona PJ. Ibuprofen therapy resulted in significantly decreased tissue bacillary loads and increased survival in a new murine experimental model of active tuberculosis. J Infect Dis 2013; 208:199-202; PMID:23564636; http://dx.doi.org/10.1093/infdis/jit152
   PubMed Web of Science ®Google Scholar
• Yin Z, Wang Y, Whittell LR, Jergic S, Liu M, Harry E, Dixon NE, Kelso MJ, Beck JL, Oakley AJ. DNA replication is the target for the antibacterial effects of nonsteroidal anti-inflammatory drugs. Chem Biol 2014; 21:481-7; PMID:24631121; http://dx.doi.org/10.1016/j.chembiol.2014.02.009
   PubMed Web of Science ®Google Scholar
• Gold B, Pingle M, Brickner SJ, Shah N, Roberts J, Rundell M, Bracken WC, Warrier T, Somersan S, Venugopal A, et al. Nonsteroidal anti-inflammatory drug sensitizes Mycobacterium tuberculosis to endogenous and exogenous antimicrobials. Proc Natl Acad Sci U S A 2012; 109:16004-11; PMID:23012453; http://dx.doi.org/10.1073/pnas.1214188109
   PubMed Web of Science ®Google Scholar
• Maitra A, Bates S, Kolvekar T, Devarajan PV, Guzman JD, Bhakta S. Repurposing-a ray of hope in tackling extensively drug resistance in tuberculosis. Int J Infect Dis 2015; 32:50-5; PMID:25809756; http://dx.doi.org/10.1016/j.ijid.2014.12.031
   PubMed Web of Science ®Google Scholar
• VanderVen BC, Fahey RJ, Lee W, Liu Y, Abramovitch RB, Memmott C, Crowe AM, Eltis LD, Perola E, Deininger DD, et al. Novel inhibitors of cholesterol degradation in Mycobacterium tuberculosis reveal how the bacterium's metabolism is constrained by the intracellular environment. PLoS Pathog 2015; 11:e1004679; PMID:25675247; http://dx.doi.org/10.1371/journal.ppat.1004679
   PubMed Web of Science ®Google Scholar
• Rengarajan J, Bloom BR, Rubin EJ. Genome-wide requirements for Mycobacterium tuberculosis adaptation and survival in macrophages. Proc Nat Acad Sci U S A 2005; 102:8327-32; PMID:15928073; http://dx.doi.org/10.1073/pnas.0503272102
   PubMed Web of Science ®Google Scholar
• Ryan A, Keany S, Eleftheriadou O, Ballet R, Cheng HY, Sim E. Mechanism-based inhibition of HsaD: a C-C bond hydrolase essential for survival of Mycobacterium tuberculosis in macrophage. FEMS Microbiol Lett 2014; 350:42-7; PMID:24164668; http://dx.doi.org/10.1111/1574-6968.12302
   PubMed Web of Science ®Google Scholar
• Evans DA, Manley KA, Mc KV. Genetic control of isoniazid metabolism in man. Br Med J 1960; 2:485-91; PMID:13820968; http://dx.doi.org/10.1136/bmj.2.5197.485
   PubMed Web of Science ®Google Scholar
• Bhakta S, Besra GS, Upton AM, Parish T, Sholto-Douglas-Vernon C, Gibson KJ, Knutton S, Gordon S, DaSilva RP, Anderton MC, et al. Arylamine N-acetyltransferase is required for synthesis of mycolic acids and complex lipids in Mycobacterium bovis BCG and represents a novel drug target. J Exp Med 2004; 199:1191-9; PMID:15117974; http://dx.doi.org/10.1084/jem.20031956
   PubMed Web of Science ®Google Scholar
• Brooke EW, Davies SG, Mulvaney AW, Pompeo F, Sim E, Vickers RJ. An approach to identifying novel substrates of bacterial arylamine N-acetyltransferases. Bioorg Med Chem 2003; 11:1227-34; PMID:12628650; http://dx.doi.org/10.1016/S0968-0896(02)00642-9
   PubMed Web of Science ®Google Scholar
• Westwood IM, Bhakta S, Russell AJ, Fullam E, Anderton MC, Kawamura A, Mulvaney AW, Vickers RJ, Bhowruth V, Besra GS, et al. Identification of arylamine N-acetyltransferase inhibitors as an approach towards novel anti-tuberculars. Protein Cell 2010; 1:82-95; PMID:21204000; http://dx.doi.org/10.1007/s13238-010-0006-1
   PubMed Web of Science ®Google Scholar
• Dodd PJ, Gardiner E, Coghlan R, Seddon JA. Burden of childhood tuberculosis in 22 high-burden countries: a mathematical modelling study. Lancet Glob Health 2014; 2:e453-9; PMID:25103518; http://dx.doi.org/10.1016/S2214-109X(14)70245-1
   PubMed Web of Science ®Google Scholar
• Talukder K, Salim MA, Jerin I, Sharmin F, Talukder MQ, Marais BJ, Nandi P, Cooreman E, Rahman MA. Intervention to increase detection of childhood tuberculosis in Bangladesh. Int J Tuberc Lung Dis 2012; 16:70-5; PMID:22236849; http://dx.doi.org/10.5588/ijtld.11.0060
   PubMed Web of Science ®Google Scholar
• Head MG, Fitchett JR, Cooke MK, Wurie FB, Hayward AC, Lipman MC, Atun R. Investments in respiratory infectious disease research 1997-2010: a systematic analysis of UK funding. BMJ Open 2014; 4:e004600; PMID:24670431; http://dx.doi.org/10.1136/bmjopen-2013-004600
   PubMed Web of Science ®Google Scholar
• McShane H. Tuberculosis vaccines: beyond bacille Calmette–Guérin. Philos Trans Royal Soc B Biol Sci 2011; 366:2782-9; http://dx.doi.org/10.1098/rstb.2011.0097
   PubMed Web of Science ®Google Scholar
• Organization WH. Stop TB new diagnostics working group: strategic plan 2006-2015. Geneva: WHO; 2006.
   Google Scholar
• Dorman SE. New diagnostic tests for tuberculosis: bench, bedside, and beyond. Clin Infect Dis 2010; 50:S173-S7; PMID:20397945; http://dx.doi.org/10.1086/651488
   PubMed Web of Science ®Google Scholar
• Zumla A, Nahid P, Cole ST. Advances in the development of new tuberculosis drugs and treatment regimens. Nat Rev Drug Discov 2013; 12:388-404; PMID:23629506; http://dx.doi.org/10.1038/nrd4001
   PubMed Web of Science ®Google Scholar