Decreased expression of 14-3-3 in Paracoccidioides brasiliensis confirms its involvement in fungal pathogenesis

References

• Lacaz CS. Historical evolution of the knowledge on Paracoccidioides brasiliensis. 1994.
   Google Scholar
• Brummer E, Castaneda E, Restrepo A. Paracoccidioidomycosis: an update. Clin Microbiol Rev 1993; 6:89-117; PMID:8472249
   PubMed Web of Science ®Google Scholar
• Restrepo A, McEwen JG, Castañeda E. The habitat of Paracoccidioides brasiliensis: how far from solving the riddle? Med Mycol 2001; 39:233-41; PMID:11446526; http://dx.doi.org/10.1080/714031028
   PubMed Web of Science ®Google Scholar
• Colombo AL, Tobón A, Restrepo A, Queiroz-Telles F, Nucci M. Epidemiology of endemic systemic fungal infections in Latin America. Med Mycol 2011; 49:785-98; PMID:21539506
   PubMed Web of Science ®Google Scholar
• Bocca AL, Amaral AC, Teixeira MM, Sato PK, Sato P, Shikanai-Yasuda MA, Soares Felipe MS. Paracoccidioidomycosis: eco-epidemiology, taxonomy and clinical and therapeutic issues. Future Microbiol 2013; 8:1177-91; PMID:24020744; http://dx.doi.org/10.2217/fmb.13.68
   PubMed Web of Science ®Google Scholar
• San-Blas G, Niño-Vega G, Iturriaga T. Paracoccidioides brasiliensis and paracoccidioidomycosis: molecular approaches to morphogenesis, diagnosis, epidemiology, taxonomy and genetics. Med Mycol 2002; 40:225-42; PMID:12146752; http://dx.doi.org/10.1080/mmy.40.3.225.242
   PubMed Web of Science ®Google Scholar
• Hube B, Naglik J. Candida albicans proteinases: resolving the mystery of a gene family. Microbiology 2001; 147:1997-2005; PMID:11495978; http://dx.doi.org/10.1099/00221287-147-8-1997
   PubMed Web of Science ®Google Scholar
• Franco M. Host-parasite relationships in paracoccidioidomycosis. J Med Vet Mycol 1987; 25:5-18; PMID:3553526; http://dx.doi.org/10.1080/02681-218780000021
   PubMed Web of Science ®Google Scholar
• Kurokawa CS, Sugizaki MF, Peraçoli MT. Virulence factors in fungi of systemic mycoses. Rev Inst Med Trop Sao Paulo 1998; 40:125-35; PMID:9830725; http://dx.doi.org/10.1590/S0036-46651998000300001
   PubMedGoogle Scholar
• VAN DE, Wouw AP, Howlett BJ. Fungal pathogenicity genes in the age of ‘omics’;. Mol Plant Pathol 2011; 12:507-14; PMID:21535355; http://dx.doi.org/10.1111/j.1364-3703.2010.00680.x
   PubMed Web of Science ®Google Scholar
• Filler SG, Sheppard DC. Fungal invasion of normally non-phagocytic host cells. PLoS Pathog 2006; 2:e129; PMID:17196036; http://dx.doi.org/10.1371/journal.ppat.0020129
   PubMed Web of Science ®Google Scholar
• Amenta PS, Gil J, Martinez-Hernandez A. Connective tissue of rat lung. II: Ultrastructural localization of collagen types III, IV, and VI. J Histochem Cytochem 1988; 36:1167-73; PMID:3403967; http://dx.doi.org/10.1177/36.9.3403967
   PubMed Web of Science ®Google Scholar
• Schwartz MA. Integrins and extracellular matrix in mechanotransduction. Cold Spring Harb Perspect Biol 2010; 2:a005066; PMID:21084386; http://dx.doi.org/10.1101/cshperspect.a005066
   PubMed Web of Science ®Google Scholar
• Geiger B, Yamada KM. Molecular architecture and function of matrix adhesions. Cold Spring Harb Perspect Biol 2011; 3:pii: a005033; PMID:21441590; http://dx.doi.org/10.1101/cshperspect.a005033
   PubMed Web of Science ®Google Scholar
• Sohn K, Senyürek I, Fertey J, Königsdorfer A, Joffroy C, Hauser N, Zelt G, Brunner H, Rupp S. An in vitro assay to study the transcriptional response during adherence of Candida albicans to different human epithelia. FEMS Yeast Res 2006; 6:1085-93; PMID:17042758; http://dx.doi.org/10.1111/j.1567-1364.2006.00130.x
   PubMed Web of Science ®Google Scholar
• Bhavsar AP, Auweter SD, Finlay BB. Proteomics as a probe of microbial pathogenesis and its molecular boundaries. Future Microbiol 2010; 5:253-65; PMID:20143948; http://dx.doi.org/10.2217/fmb.09.114
   PubMed Web of Science ®Google Scholar
• Vicentini AP, Gesztesi JL, Franco MF, de Souza W, de Moraes JZ, Travassos LR, Lopes JD. Binding of Paracoccidioides brasiliensis to laminin through surface glycoprotein gp43 leads to enhancement of fungal pathogenesis. Infect Immun 1994; 62:1465-9; PMID:8132354
   PubMed Web of Science ®Google Scholar
• Hanna SA, Monteiro da Silva JL, Giannini MJ. Adherence and intracellular parasitism of Paracoccidioides brasiliensis in Vero cells. Microbes Infect 2000; 2:877-84; PMID:10962270; http://dx.doi.org/10.1016/S1286-4579(00)00390-7
   PubMed Web of Science ®Google Scholar
• Barbosa MS, Báo SN, Andreotti PF, de Faria FP, Felipe MS, dos Santos Feitosa L, Mendes-Giannini MJ, Soares CM. Glyceraldehyde-3-phosphate dehydrogenase of Paracoccidioides brasiliensis is a cell surface protein involved in fungal adhesion to extracellular matrix proteins and interaction with cells. Infect Immun 2006; 74:382-9; PMID:16368993; http://dx.doi.org/10.1128/IAI.74.1.382-389.2006
   PubMed Web of Science ®Google Scholar
• Pereira LA, Báo SN, Barbosa MS, da Silva JL, Felipe MS, de Santana JM, Mendes-Giannini MJ, de Almeida Soares CM. Analysis of the Paracoccidioides brasiliensis triosephosphate isomerase suggests the potential for adhesin function. FEMS Yeast Res 2007; 7:1381-8; PMID:17714474; http://dx.doi.org/10.1111/j.1567-1364.2007.00292.x
   PubMed Web of Science ®Google Scholar
• Donofrio FC, Calil AC, Miranda ET, Almeida AM, Benard G, Soares CP, Veloso SN, Soares CM, Mendes Giannini MJ. Enolase from Paracoccidioides brasiliensis: isolation and identification as a fibronectin-binding protein. J Med Microbiol 2009; 58:706-13; PMID:19429745; http://dx.doi.org/10.1099/jmm.0.003830-0
   PubMed Web of Science ®Google Scholar
• Marcos CM, de Fátima da Silva J, de Oliveira HC, Moraes da Silva RA, Mendes-Giannini MJ, Fusco-Almeida AM. Surface-expressed enolase contributes to the adhesion of Paracoccidioides brasiliensis to host cells. FEMS Yeast Res 2012; 12:557-70; PMID:22443156; http://dx.doi.org/10.1111/j.1567-1364.2012.00806.x
   PubMed Web of Science ®Google Scholar
• González A, Gómez BL, Diez S, Hernández O, Restrepo A, Hamilton AJ, Cano LE. Purification and partial characterization of a Paracoccidioides brasiliensis protein with capacity to bind to extracellular matrix proteins. Infect Immun 2005; 73:2486-95; http://dx.doi.org/10.1128/IAI.73.4.2486-2495.2005
   PubMed Web of Science ®Google Scholar
• Hernández O, Almeida AJ, Gonzalez A, Garcia AM, Tamayo D, Cano LE, Restrepo A, McEwen JG. A 32-kilodalton hydrolase plays an important role in Paracoccidioides brasiliensis adherence to host cells and influences pathogenicity. Infect Immun 2010; 78:5280-6; http://dx.doi.org/10.1128/IAI.00692-10
   PubMed Web of Science ®Google Scholar
• da Silva Neto BR, de Fátima da Silva J, Mendes-Giannini MJ, Lenzi HL, de Almeida Soares CM, Pereira M. The malate synthase of Paracoccidioides brasiliensis is a linked surface protein that behaves as an anchorless adhesin. BMC Microbiol 2009; 9:272; PMID:20034376; http://dx.doi.org/10.1186/1471-2180-9-272
   PubMed Web of Science ®Google Scholar
• Zambuzzi-Carvalho PF, Cruz AH, Santos-Silva LK, Goes AM, Soares CM, Pereira M. The malate synthase of Paracoccidioides brasiliensis Pb01 is required in the glyoxylate cycle and in the allantoin degradation pathway. Med Mycol 2009; 47:734-44; PMID:19888806; http://dx.doi.org/10.3109/13693780802609620
   PubMed Web of Science ®Google Scholar
• Andreotti PF, Monteiro da Silva JL, Bailão AM, Soares CM, Benard G, Soares CP, Mendes-Giannini MJ. Isolation and partial characterization of a 30 kDa adhesin from Paracoccidioides brasiliensis. Microbes Infect 2005; 7:875-81; PMID:15862780; http://dx.doi.org/10.1016/j.micinf.2005.02.005
   PubMed Web of Science ®Google Scholar
• da Silva JEF, de Oliveira HC, Marcos CM, da Silva RA, da Costa TA, Calich VL, Almeida AM, Mendes-Giannini MJ. Paracoccidoides brasiliensis 30 kDa adhesin: identification as a 14-3-3 protein, cloning and subcellular localization in infection models. PLoS One 2013; 8:e62533; PMID:23638109; http://dx.doi.org/10.1371/journal.pone.0062533
   PubMed Web of Science ®Google Scholar
• Menino JF, Almeida AJ, Rodrigues F. Gene knockdown in Paracoccidioides brasiliensis using antisense RNA. Methods Mol Biol 2012; 845:187-98; PMID:22328375; http://dx.doi.org/10.1007/978-1-61779-539-8_12
   PubMedGoogle Scholar
• Hernández O, Almeida AJ, Tamayo D, Torres I, Garcia AM, López A, Restrepo A, McEwen JG. The hydrolase PbHAD32 participates in the adherence of Paracoccidioides brasiliensis conidia to epithelial lung cells. Med Mycol 2012; 50:533-7; http://dx.doi.org/10.3109/13693786.2011.619583
   PubMed Web of Science ®Google Scholar
• Tamayo D, Muñoz JF, Torres I, Almeida AJ, Restrepo A, McEwen JG, Hernández O. Involvement of the 90 kDa heat shock protein during adaptation of Paracoccidioides brasiliensis to different environmental conditions. Fungal Genet Biol 2013; 51:34-41; PMID:23207691; http://dx.doi.org/10.1016/j.fgb.2012.11.005
   PubMed Web of Science ®Google Scholar
• Peraçoli MT, Sugizaki MF, Mendes RP, Naiff R, Montenegro MR. Paracoccidioides brasiliensis isolated from armadillos is virulent to Syrian hamsters. Mycopathologia 1999; 148:123-30; http://dx.doi.org/10.1023/A:1007119403572
   PubMed Web of Science ®Google Scholar
• Svidzinski TI, Miranda Neto MH, Santana RG, Fischman O, Colombo AL. Paracoccidioides brasilienses isolates obtained from patients with acute and chronic disease exhibit morphological differences after animal passage. Rev Inst Med Trop Sao Paulo 1999; 41:279-83; PMID:10602541; http://dx.doi.org/10.1590/S0036-46651999000500003
   PubMedGoogle Scholar
• Borges-Walmsley MI, Chen D, Shu X, Walmsley AR. The pathobiology of Paracoccidioides brasiliensis. Trends Microbiol 2002; 10:80-7; PMID:11827809; http://dx.doi.org/10.1016/S0966-842X(01)02292-2
   PubMed Web of Science ®Google Scholar
• San-Blas G, Niño-Vega G. Paracoccidioides brasiliensis: virulence and host response. In Cihlar, RL and Calderone, RA (ed.). Fungal pathogenesis: principles and clinical applications. pp. 205–226. New York, NY. 2001.
   Google Scholar
• Rooney PJ, Klein BS. Linking fungal morphogenesis with virulence. Cell Microbiol 2002; 4:127-37; PMID:11906450; http://dx.doi.org/10.1046/j.1462-5822.2002.00179.x
   PubMed Web of Science ®Google Scholar
• Böhmer M, Colby T, Böhmer C, Bräutigam A, Schmidt J, Bölker M. Proteomic analysis of dimorphic transition in the phytopathogenic fungus Ustilago maydis. Proteomics 2007; 7:675-85; PMID:17340586; http://dx.doi.org/10.1002/pmic.200600900
   PubMed Web of Science ®Google Scholar
• Hurtado CA, Rachubinski RA. YlBMH1 encodes a 14-3-3 protein that promotes filamentous growth in the dimorphic yeast Yarrowia lipolytica. Microbiology 2002; 148:3725-35; PMID:12427962; http://dx.doi.org/10.1099/00221287-148-11-3725
   PubMed Web of Science ®Google Scholar
• Aristizabal BH, Clemons KV, Stevens DA, Restrepo A. Morphological transition of Paracoccidioides brasiliensis conidia to yeast cells: in vivo inhibition in females. Infect Immun 1998; 66:5587-91; PMID:9784579
   PubMed Web of Science ®Google Scholar
• Roberts RL, Mösch HU, Fink GR. 14-3-3 proteins are essential for RAS/MAPK cascade signaling during pseudohyphal development in S. cerevisiae. Cell 1997; 89:1055-65; PMID:9215628; http://dx.doi.org/10.1016/S0092-8674(00)80293-7
   PubMed Web of Science ®Google Scholar
• Kraus PR, Hofmann AF, Harris SD. Characterization of the Aspergillus nidulans 14-3-3 homologue, ArtA. FEMS Microbiol Lett 2002; 210:61-6; PMID:12023078; http://dx.doi.org/10.1111/j.1574-6968.2002.tb11160.x
   PubMed Web of Science ®Google Scholar
• Palmer GE, Johnson KJ, Ghosh S, Sturtevant J. Mutant alleles of the essential 14-3-3 gene in Candida albicans distinguish between growth and filamentation. Microbiology 2004; 150:1911-24; PMID:15184577; http://dx.doi.org/10.1099/mic.0.26910-0
   PubMed Web of Science ®Google Scholar
• Almeida AJ, Cunha C, Carmona JA, Sampaio-Marques B, Carvalho A, Malavazi I, Steensma HY, Johnson DI, Leão C, Logarinho E, et al. Cdc42p controls yeast-cell shape and virulence of Paracoccidioides brasiliensis. Fungal Genet Biol 2009; 46:919-26; PMID:19686860; http://dx.doi.org/10.1016/j.fgb.2009.08.004
   PubMed Web of Science ®Google Scholar
• Almeida AJ, Cunha C, Carmona JA, Sampaio-Marques B, Carvalho A, Malavazi I, Steensma HY, Johnson DI, Leão C, Logarinho E, et al. Cdc42p controls yeast-cell shape and virulence of Paracoccidioides brasiliensis. Fungal Genet Biol 2009; 46:919-26; PMID:19686860; http://dx.doi.org/10.1016/j.fgb.2009.08.004
   PubMed Web of Science ®Google Scholar
• Okagaki LH, Strain AK, Nielsen JN, Charlier C, Baltes NJ, Chrétien F, Heitman J, Dromer F, Nielsen K. Cryptococcal cell morphology affects host cell interactions and pathogenicity. PLoS Pathog 2010; 6:e1000953; PMID:20585559; http://dx.doi.org/10.1371/journal.ppat.1000953
   PubMed Web of Science ®Google Scholar
• Lengeler KB, Davidson RC, D'souza C, Harashima T, Shen WC, Wang P, Pan X, Waugh M, Heitman J. Signal transduction cascades regulating fungal development and virulence. Microbiol Mol Biol Rev 2000; 64:746-85; PMID:11104818; http://dx.doi.org/10.1128/MMBR.64.4.746-785.2000
   PubMed Web of Science ®Google Scholar
• Mendes-Giannini MJ, Andreotti PF, Vincenzi LR, da Silva JL, Lenzi HL, Benard G, Zancopé-Oliveira R, de Matos Guedes HL, Soares CP. Binding of extracellular matrix proteins to Paracoccidioides brasiliensis. Microbes Infect 2006; 8:1550-9; PMID:16698299; http://dx.doi.org/10.1016/j.micinf.2006.01.012
   PubMed Web of Science ®Google Scholar
• André DC, Lopes JD, Franco MF, Vaz CA, Calich VL. Binding of laminin to Paracoccidioides brasiliensis induces a less severe pulmonary paracoccidioidomycosis caused by virulent and low-virulence isolates. Microbes Infect 2004; 6:549-58; http://dx.doi.org/10.1016/j.micinf.2004.02.010
   PubMed Web of Science ®Google Scholar
• Kurokawa CS, Lopes CR, Sugizaki MF, Kuramae EE, Franco MF, Peraçoli MT. Virulence profile of ten Paracoccidioides brasiliensis isolates: association with morphologic and genetic patterns. Rev Inst Med Trop Sao Paulo 2005; 47:257-62; PMID:16302108; http://dx.doi.org/10.1590/S0036-46652005000500004
   PubMedGoogle Scholar
• de Oliveira HC, da Silva JeF, Scorzoni L, Marcos CM, Rossi SA, de Paula E, Silva AC, Assato PA, da Silva RA, Fusco-Almeida AM, Mendes-Giannini MJ. Importance of adhesins in virulence of Paracoccidioides spp. Front Microbiol 2015; 6:303; PMID:25914695
   PubMed Web of Science ®Google Scholar
• Fàbrega A, Vila J. Salmonella enterica serovar Typhimurium skills to succeed in the host: virulence and regulation. Clin Microbiol Rev 2013; 26:308-41; http://dx.doi.org/10.1128/CMR.00066-12
   PubMed Web of Science ®Google Scholar
• Fuchs BB, Eby J, Nobile CJ, El Khoury JB, Mitchell AP, Mylonakis E. Role of filamentation in Galleria mellonella killing by Candida albicans. Microbes Infect 2010; 12:488-96; PMID:20223293; http://dx.doi.org/10.1016/j.micinf.2010.03.001
   PubMed Web of Science ®Google Scholar
• Lev S, Desmarini D, Li C, Chayakulkeeree M, Traven A, Sorrell TC, Djordjevic JT. Phospholipase C of Cryptococcus neoformans regulates homeostasis and virulence by providing inositol trisphosphate as a substrate for Arg1 kinase. Infect Immun 2013; 81:1245-55; PMID:23381992; http://dx.doi.org/10.1128/IAI.01421-12
   PubMed Web of Science ®Google Scholar
• Mesa-Arango AC, Forastiero A, Bernal-Martínez L, Cuenca-Estrella M, Mellado E, Zaragoza O. The non-mammalian host Galleria mellonella can be used to study the virulence of the fungal pathogen Candida tropicalis and the efficacy of antifungal drugs during infection by this pathogenic yeast. Med Mycol 2013; 51:461-72; PMID:23170962; http://dx.doi.org/10.3109/13693786.2012.737031
   PubMed Web of Science ®Google Scholar
• Jacobsen ID. Galleria mellonella as a model host to study virulence of Candida. Virulence 2014; 5:237-9; PMID:24384470; http://dx.doi.org/10.4161/viru.27434
   PubMed Web of Science ®Google Scholar
• Firacative C, Duan S, Meyer W. Galleria mellonella model identifies highly virulent strains among all major molecular types of Cryptococcus gattii. PLoS One 2014; 9:e105076; PMID:25133687; http://dx.doi.org/10.1371/journal.pone.0105076
   PubMed Web of Science ®Google Scholar
• Thomaz L, García-Rodas R, Guimarães AJ, Taborda CP, Zaragoza O, Nosanchuk JD. Galleria mellonella as a model host to study Paracoccidioides lutzii and Histoplasma capsulatum. Virulence 2013; 4:139-46; PMID:23302787; http://dx.doi.org/10.4161/viru.23047
   PubMed Web of Science ®Google Scholar
• Cotter G, Doyle S, Kavanagh K. Development of an insect model for the in vivo pathogenicity testing of yeasts. FEMS Immunol Med Microbiol 2000; 27:163-9; PMID:10640612; http://dx.doi.org/10.1111/j.1574-695X.2000.tb01427.x
   PubMed Web of Science ®Google Scholar
• Salamitou S, Ramisse F, Brehélin M, Bourguet D, Gilois N, Gominet M, Hernandez E, Lereclus D. The plcR regulon is involved in the opportunistic properties of Bacillus thuringiensis and Bacillus cereus in mice and insects. Microbiology 2000; 146 (Pt 11):2825-32; PMID:11065361; http://dx.doi.org/10.1099/00221287-146-11-2825
   PubMed Web of Science ®Google Scholar
• Trevijano-Contador N, Herrero-Fernández I, García-Barbazán I, Scorzoni L, Rueda C, Rossi SA, García-Rodas R, Zaragoza O. Cryptococcus neoformans induces antimicrobial responses and behaves as a facultative intracellular pathogen in the non mammalian model Galleria mellonella. Virulence 2015; 6:66-74; PMID:25531532; http://dx.doi.org/10.4161/21505594.2014.986412
   PubMed Web of Science ®Google Scholar
• Tojo S, Naganuma F, Arakawa1 K, Yokoo1 S. Involvement of both granular cells and plasmatocytes in phagocytic reactions in the greater wax moth, Galleria mellonella. J Insect Physiol 2000; 46:1129-35; PMID:10817839; http://dx.doi.org/10.1016/S0022-1910(99)00223-1
   PubMed Web of Science ®Google Scholar
• Mowlds P, Barron A, Kavanagh K. Physical stress primes the immune response of Galleria mellonella larvae to infection by Candida albicans. Microbes Infect 2008; 10:628-34; PMID:18457977; http://dx.doi.org/10.1016/j.micinf.2008.02.011
   PubMed Web of Science ®Google Scholar
• Vogel H, Altincicek B, Glöckner G, Vilcinskas A. A comprehensive transcriptome and immune-gene repertoire of the lepidopteran model host Galleria mellonella. BMC Genomics 2011; 12:308; PMID:21663692; http://dx.doi.org/10.1186/1471-2164-12-308
   PubMed Web of Science ®Google Scholar
• Kelly MN, Johnston DA, Peel BA, Morgan TW, Palmer GE, Sturtevant JE. Bmh1p (14-3-3) mediates pathways associated with virulence in Candida albicans. Microbiology 2009; 155:1536-46; PMID:19372164; http://dx.doi.org/10.1099/mic.0.027532-0
   PubMed Web of Science ®Google Scholar
• Butt AQ, Ahmed S, Maratha A, Miggin SM. 14-3-3ε and 14-3-3σ inhibit Toll-like receptor (TLR)-mediated proinflammatory cytokine induction. J Biol Chem 2012; 287:38665-79; PMID:22984265; http://dx.doi.org/10.1074/jbc.M112.367490
   PubMed Web of Science ®Google Scholar
• Qi H, Denning TL, Soong L. Differential induction of interleukin-10 and interleukin-12 in dendritic cells by microbial toll-like receptor activators and skewing of T-cell cytokine profiles. Infect Immun 2003; 71:3337-42; PMID:12761116; http://dx.doi.org/10.1128/IAI.71.6.3337-3342.2003
   PubMed Web of Science ®Google Scholar
• Bonfim CV, Mamoni RL, Blotta MH. TLR-2, TLR-4 and dectin-1 expression in human monocytes and neutrophils stimulated by Paracoccidioides brasiliensis. Med Mycol 2009; 47:722-33; PMID:19888805; http://dx.doi.org/10.3109/13693780802641425
   PubMed Web of Science ®Google Scholar
• Beijersbergen A, Dulk-Ras AD, Schilperoort RA, Hooykaas PJ. Conjugative Transfer by the Virulence System of Agrobacterium tumefaciens. Science 1992; 256:1324-7; PMID:17736763; http://dx.doi.org/10.1126/science.256.5061.1324
   PubMed Web of Science ®Google Scholar
• Sambrook J, Fritsch EF, Maniatis T. Molecular Cloning: A Laboratory Manual. 2nd edn. Cold Spring Harbor Laboratory Press. 1,626 pp. New York, NY. 1989.
   Google Scholar
• Almeida AJ, Carmona JA, Cunha C, Carvalho A, Rappleye CA, Goldman WE, Hooykaas PJ, Leão C, Ludovico P, Rodrigues F. Towards a molecular genetic system for the pathogenic fungus Paracoccidioides brasiliensis. Fungal Genet Biol 2007; 44:1387-98; PMID:17512227; http://dx.doi.org/10.1016/j.fgb.2007.04.004
   PubMed Web of Science ®Google Scholar
• Ruiz OH, Gonzalez A, Almeida AJ, Tamayo D, Garcia AM, Restrepo A, McEwen JG. Alternative oxidase mediates pathogen resistance in Paracoccidioides brasiliensis infection. PLoS Negl Trop Dis 2011; 5:e1353; PMID:22039556; http://dx.doi.org/10.1371/journal.pntd.0001353
   PubMed Web of Science ®Google Scholar
• Rappleye CA, Engle JT, Goldman WE. RNA interference in Histoplasma capsulatum demonstrates a role for alpha-(1,3)-glucan in virulence. Mol Microbiol 2004; 53:153-65; PMID:15225311; http://dx.doi.org/10.1111/j.1365-2958.2004.04131.x
   PubMed Web of Science ®Google Scholar
• van Burik JA, Schreckhise RW, White TC, Bowden RA, Myerson D. Comparison of six extraction techniques for isolation of DNA from filamentous fungi. Med Mycol 1998; 36:299-303; PMID:10075499; http://dx.doi.org/10.1080/02681219880000471
   PubMed Web of Science ®Google Scholar
• Goldman GH, dos Reis Marques E, Duarte Ribeiro DC, de Souza Bernardes LA, Quiapin AC, Vitorelli PM, Savoldi M, Semighini CP, de Oliveira RC, Nunes LR, et al. Expressed sequence tag analysis of the human pathogen Paracoccidioides brasiliensis yeast phase: identification of putative homologues of Candida albicans virulence and pathogenicity genes. Eukaryot Cell 2003; 2:34-48; PMID:12582121; http://dx.doi.org/10.1128/EC.2.1.34-48.2003
   PubMed Web of Science ®Google Scholar
• Livak KJ, Schmittgen TD. Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method. Methods 2001; 25:402-8; http://dx.doi.org/10.1006/meth.2001.1262
   PubMed Web of Science ®Google Scholar
• Laemmli UK. Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature 1970; 227:680-5; PMID:5432063; http://dx.doi.org/10.1038/227680a0
   PubMed Web of Science ®Google Scholar
• Menino JF, Saraiva M, Gomes-Rezende J, Sturme M, Pedrosa J, Castro AG, Ludovico P, Goldman GH, Rodrigues F. P. brasiliensis virulence is affected by SconC, the negative regulator of inorganic sulfur assimilation. PLoS One 2013; 8:e74725; PMID:24066151; http://dx.doi.org/10.1371/journal.pone.0074725
   PubMed Web of Science ®Google Scholar
• Meshulam T, Levitz SM, Christin L, Diamond RD. A simplified new assay for assessment of fungal cell damage with the tetrazolium dye, (2,3)-bis-(2-methoxy-4-nitro-5-sulphenyl)-(2H)-tetrazolium-5-carboxanil ide (XTT). J Infect Dis 1995; 172:1153-6; PMID:7561202; http://dx.doi.org/10.1093/infdis/172.4.1153
   PubMed Web of Science ®Google Scholar
• Chandra J, Mukherjee PK, Leidich SD, Faddoul FF, Hoyer LL, Douglas LJ, Ghannoum MA. Antifungal resistance of candidal biofilms formed on denture acrylic in vitro. J Dent Res 2001; 80:903-8; PMID:11379893; http://dx.doi.org/10.1177/00220345010800031101
   PubMed Web of Science ®Google Scholar
• Strober, W. 2001. Trypan Blue Exclusion Test of Cell Viability. Current Protocols in Immunology. 21:3B:A.3B.1–A.3B.2
   Google Scholar
• Prado RS, Bailão AM, Silva LC, de Oliveira CM, Marques MF, Silva LP, Silveira-Lacerda EP, Lima AP, Soares CM, Pereira M. Proteomic profile response of Paracoccidioides lutzii to the antifungal argentilactone. Front Microbiol 2015; 6:616; PMID:26150808
   PubMed Web of Science ®Google Scholar
• do Carmo Silva L, Tamayo Ossa DP, Castro SV, Bringel Pires L, Alves de Oliveira CM, Conceição da Silva C, Coelho NP, Bailão AM, Parente-Rocha JA, Soares CM, et al. Transcriptome Profile of the Response of Paracoccidioides spp. to a Camphene Thiosemicarbazide Derivative. PLoS One 2015; 10:e0130703; PMID:26114868; http://dx.doi.org/10.1371/journal.pone.0130703
   PubMed Web of Science ®Google Scholar
• Nunes LR, Costa de Oliveira R, Leite DB, da Silva VS, dos Reis Marques E, da Silva Ferreira ME, Ribeiro DC, de Souza Bernardes LA, Goldman MH, Puccia R, et al. Transcriptome analysis of Paracoccidioides brasiliensis cells undergoing mycelium-to-yeast transition. Eukaryot Cell 2005; 4:2115-28; PMID:16339729; http://dx.doi.org/10.1128/EC.4.12.2115-2128.2005
   PubMed Web of Science ®Google Scholar
• Bernardino S, Pina A, Felonato M, Costa TA, Frank de Araújo E, Feriotti C, Bazan SB, Keller AC, Leite KR, Calich VL. TNF-α and CD8+ T cells mediate the beneficial effects of nitric oxide synthase-2 deficiency in pulmonary paracoccidioidomycosis. PLoS Negl Trop Dis 2013; 7:e2325; http://dx.doi.org/10.1371/journal.pntd.0002325
   PubMed Web of Science ®Google Scholar
• Scorzoni L, de Lucas MP, Mesa-Arango AC, Fusco-Almeida AM, Lozano E, Cuenca-Estrella M, Mendes-Giannini MJ, Zaragoza O. Antifungal efficacy during Candida krusei infection in non-conventional models correlates with the yeast in vitro susceptibility profile. PLoS One 2013; 8:e60047; PMID:23555877; http://dx.doi.org/10.1371/journal.pone.0060047
   PubMed Web of Science ®Google Scholar