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Letter to the Editor

Phenotypic switching of Candida tropicalis is associated with cell damage in epithelial cells and virulence in Galleria mellonella model

, , , , &
Pages 379-386 | Received 30 Oct 2015, Accepted 04 Jan 2016, Published online: 22 Feb 2016

References

  • Pfaller MA, Rhomberg PR, Messer SA, Jones RN, Castanheira M. Isavuconazole, micafungin, and 8 comparator antifungal agents´ susceptibility profiles for common and uncommon opportunistic fungi collected in 2013: temporal analysis of antifungal drug resistance using CLSI species-specific clinical breakpoints and proposed epidemiological cutoff values. Diag Microbiol Infect Dis 2015; 82:303-13; http://dx.doi.org/10.1016/j.diagmicrobio.2015.04.008
  • Soll DR. Candida commensalism and virulence: the evolution of phenotypic plasticity. Acta Trop 2002; 81:101-10; PMID:11801217; http://dx.doi.org/10.1016/S0001-706X(01)00200-5
  • Soll DR. High-frequency switching in Candida albicans. Clin Microbiol Rev 1992; 5:183-203; PMID:1576587
  • França EJG, Andrade CGTJ, Furlaneto-Maia L, Serpa R, Oliveira MT, Quesada RMB, Furlaneto MC. Ultrastructural architecture of colonies of different morphologies and biofilm produced by phenotypes switching of Candida tropicalis. Micron 2011; 42:726-32; http://dx.doi.org/10.1016/j.micron.2011.03.008
  • Moralez ATP, França EJG, Furlaneto-Maia L, Quesada MB, Furlaneto MC. Phenotypic switching in Candida tropicalis: association with modification of putative virulence attributes and antifungal drug sensitivity. Med Mycol 2014; 52:106-14; PMID:23971864
  • Soll DR, Staebell M, Langtimm C, Pfaller M, Hicks J, Rao TV. Multiple Candida strains in the course of a single systemic. J Clin Microbiol 1988; 26:1448-59; PMID:3049653
  • Porman AM, Alby K, Hirakawa MP, Bennett RJ. Discovery of a phenotypic switch regulating sexual mating in the opportunistic fungal pathogen Candida tropicalis. Proc Nat Acad Sci 2011; 108:21158-63; http://dx.doi.org/10.1073/pnas.1112076109
  • Porman AM, Hirakawa MP, Jones SK, Wang N, Bennett RJ. MTL-Independent phenotypic switching in Candida tropicalis and a dual role for Wor1 in regulating switching and filamentation. Plos Genet 2013; 9:e1003369; PMID:23555286; http://dx.doi.org/10.1371/journal.pgen.1003369
  • Xie J, Du H, Guan G, Tong Y, Kourkoumpetis TK, Zhang L, Bai FY, Huang G. N-acetylglucosamine induces white-to-opaque switching and mating in Candida tropicalis, providing new insights into adaptation and fungal sexual evolution. Eukaryot Cell 2012; 11:773-82; PMID:22544905; http://dx.doi.org/10.1128/EC.00047-12
  • Jones SK, Jr, Hirakawa MP, Bennett RJ. Sexual biofilm formation in Candida tropicalis opaque cells. Mol Microbiol 2014; 92:383-98; PMID:24612417; http://dx.doi.org/10.1111/mmi.12565
  • Zhang XB, Yu SJ, Yu JX, Gong YL, Feng W, Sun FJ. Retrospective analysis of epidemiology and prognostic factors for candidemia at a hospital in China, 2000-2009. Jpn J Infect Dis 2012; 65:510-5; PMID:23183203; http://dx.doi.org/10.7883/yoken.65.510
  • Nucci M, Queiroz-Telles F, Alvarado-Matute T, Tiraboschi IR, Cortes J, Zurita J, Guzman-Blanco M, Santolaya ME, Thompson L, Sifuentes-Osornio J, et al. American Invasive Mycosis Network. Epidemiology of candidemia in Latin America: A laboratory-based survey. Plos One 2013; 8:e59373; PMID:23527176; http://dx.doi.org/10.1371/journal.pone.0059373
  • Costa VG, Quesada RMB, Stipp-Abe AT, Furlaneto-Maia L, Furlaneto MC. Nosocomial bloodstream Candida infections in a tertiary-care hospital in South Brazil: a 4-year survey. Mycopathologia 2014; 178:243-50; PMID:25103140; http://dx.doi.org/10.1007/s11046-014-9791-z
  • Kontoyiannis DP, Vaziri I, Hanna HA, Boktour M, Thornby J, Hachem R, Bodey GP, Raad II. Risk factors for Candida tropicalis fungemia in patients with cancer. Clin Infect Dis 2001; 33:1676-81; PMID:11568858; http://dx.doi.org/10.1086/323812
  • Colombo AL, Guimarães T, Silva LRBF, Monfardini LPA, Cunha AKB, Rady P, Alves T, Rosas RC. Prospective observational study of candidemia in São Paulo, Brazil: Incidence rate, epidemiology, and predictors of mortality. Infect Control Hosp Ep 2007; 28:570-6; http://dx.doi.org/10.1086/513615
  • Mylonakis E, Moreno R, El Khoury JB, Idnurm A, Heitman J, Calderwood SB, Ausubel FM, Diener A. Galleria mellonella as a model system to study Cryptococcus neoformans pathogenesis. Infect Immun 2005; 73:3842-50; PMID:15972469; http://dx.doi.org/10.1128/IAI.73.7.3842-3850.2005
  • Kvaal C, Srikantha T, Soll DR. Misexpression of the white-phase-specific gene WH11 in the opaque phase of Candida albicans affects switching and virulence. Infect Immun 1997; 65:4469-75
  • Kvaal C, Lachke SA, Srikantha T, Daniels K, McCoy J, Soll DR. Misexpression of the opaque-phase-specific gene PEP1 (SAP1) in the white phase of Candida albicans confers increased virulence in a mouse model of cutaneous infection. Infect Immun 1999; 67:6652-62; PMID:10569787
  • Tao L, Du H, Guan G, Dai Y, Nobile CJ, Liang W, Cao C, Zhang Q, Zhong J, Huang G. Discovery of a “white-gray-opaque” tristable phenotypic switching system in Candida albicans: roles of non-genetic diversity in host adaptation. Plos Biol 2014; 12:e 1001830; http://dx.doi.org/10.1371/journal.pbio.1001830
  • Slutsky B, Staebell M, Anderson J, Risen L, Pfaller M, Soll DR. White-Opaque transition: a second high-frequency switching system in Candida albicans. J Bacteriol 1987; 169:189-97; PMID:3539914
  • Furlaneto MC, Andrade CGTJ, Aragão PHA, França EJGF, Moralez ATP, Ferreira LCS. Scanning electron microscopy as a tool for the analysis of colony architecture produced by phenotypic switching of a human pathogenic yeast Candida tropicalis. J Phys: Conf Ser 2012; 371:012022
  • Negri M, Gonçalves V, Silva S, Henriques M, Azeredo J, Oliveira R. Crystal violet staining to quantify Candida adhesion to epithelial cells. Brit J Biomed Sci 2010; 67:120-5
  • Negri M, Botelho N, Silva S, Lopes LMRH, Henriques M, Azeredo J, Oliveira R. An in vitro evaluation of Candida tropicalis infectivity using human cell monolayers. J Med Microbiol 2011; 60:1270-5; PMID:21566089; http://dx.doi.org/10.1099/jmm.0.031195-0
  • Mesa-Arango AC, Forastiero A, Bernal-Martínez L, Cuenca Estrella M, Mellado E, Zaragoza O. The non-mammalian host Galleria mellonella can be used to study the virulence of the fungal pathogen Candida tropicalis and the efficacy of antifungal drugs during infection by this pathogenic yeast. Med Mycol 2013; 51:461-72; PMID:23170962; http://dx.doi.org/10.3109/13693786.2012.737031

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