Clinical and laboratory considerations for the rapid detection of carbapenem-resistant Enterobacteriaceae

References

• Rhomberg PR, Jones RN. Summary trends for the Meropenem Yearly Susceptibility Test Information Collection Program: a 10-year experience in the United States (1999–2008). Diagn Microbiol Infect Dis 2009; 65:414-26; PMID:19833471; https://doi.org/10.1016/j.diagmicrobio.2009.08.020
   PubMed Web of Science ®Google Scholar
• Hidron AI, Edwards JR, Patel J, Horan TC, Sievert DM, Pollock DA, Fridkin SK. National Healthcare Safety Network T, Participating National Healthcare Safety Network F. NHSN annual update: antimicrobial-resistant pathogens associated with healthcare-associated infections: annual summary of data reported to the National Healthcare Safety Network at the Centers for Disease Control and Prevention, 2006–2007. Infect Control Hosp Epidemiol 2008; 29:996-1011; PMID:18947320; https://doi.org/10.1086/591861
   PubMed Web of Science ®Google Scholar
• Sievert DM, Ricks P, Edwards JR, Schneider A, Patel J, Srinivasan A, Kallen A, Limbago B, Fridkin S. National Healthcare Safety Network T. Antimicrobial-resistant pathogens associated with healthcare-associated infections: summary of data reported to the National Healthcare Safety Network at the Centers for Disease Control and Prevention, 2009–2010. Infect Control Hosp Epidemiol 2013; 34:1-14; PMID:23221186; https://doi.org/10.1086/668770
   PubMed Web of Science ®Google Scholar
• Centers for Disease Control and Prevention (CDC). Antibiotic resistance threats in the United States. 2013. 2013: Accessed January 2:2016
   Google Scholar
• World Health Organization (WHO). Antimicrobial Resistance Global Report on Surveillance. http://appswhoint/iris/bitstream/10665/112642/1/9789241564748_engpdf?ua=1 2014
   Google Scholar
• Nordmann P, Mammeri H. Extended-spectrum cephalosporinases: structure, detection and epidemiology. Future Microbiol 2007; 2:297-307; PMID:17661704; https://doi.org/10.2217/17460913.2.3.297
   PubMed Web of Science ®Google Scholar
• Kitchel B, Rasheed JK, Patel JB, Srinivasan A, Navon-Venezia S, Carmeli Y, Brolund A, Giske CG. Molecular epidemiology of KPC-producing Klebsiella pneumoniae isolates in the United States: clonal expansion of multilocus sequence type 258. Antimicrob Agents Chemother 2009; 53:3365-70; PMID:19506063; https://doi.org/10.1128/AAC.00126-09
   PubMed Web of Science ®Google Scholar
• Munoz-Price LS, Poirel L, Bonomo RA, Schwaber MJ, Daikos GL, Cormican M, Cornaglia G, Garau J, Gniadkowski M, Hayden MK, et al. Clinical epidemiology of the global expansion of Klebsiella pneumoniae carbapenemases. Lancet Infect Dis 2013; 13:785-96; PMID:23969216; https://doi.org/10.1016/S1473-3099(13)70190-7
   PubMed Web of Science ®Google Scholar
• Albiger B, Glasner C, Struelens MJ, Grundmann H, Monnet DL. European Survey of Carbapenemase-Producing Enterobacteriaceae working g. Carbapenemase-producing Enterobacteriaceae in Europe: assessment by national experts from 38 countries May 2015. Euro Surveill 2015:20; PMID:26675038; https://doi.org/10.2807/1560-7917.ES.2015.20.45.30062
   PubMedGoogle Scholar
• Temkin E, Adler A, Lerner A, Carmeli Y. Carbapenem-resistant Enterobacteriaceae: biology, epidemiology, and management. Ann N Y Acad Sci 2014; 1323:22-42; PMID:25195939; https://doi.org/10.1111/nyas.12537
   PubMed Web of Science ®Google Scholar
• Lin MY, Lyles-Banks RD, Lolans K, Hines DW, Spear JB, Petrak R, Trick WE, Weinstein RA, Hayden MK, Centers for Disease C. The importance of long-term acute care hospitals in the regional epidemiology of Klebsiella pneumoniae carbapenemase-producing Enterobacteriaceae. Clin Infect Dis 2013; 57:1246-52; PMID:23946222; https://doi.org/10.1093/cid/cit500
   PubMed Web of Science ®Google Scholar
• Leclercq R, Canton R, Brown DF, Giske CG, Heisig P, MacGowan AP, Mouton JW, Nordmann P, Rodloff AC, Rossolini GM, et al. EUCAST expert rules in antimicrobial susceptibility testing. Clin Microbiol Infect 2013; 19:141-60; PMID:22117544; https://doi.org/10.1111/j.1469-0691.2011.03703.x
   PubMed Web of Science ®Google Scholar
• Clinical Laboratory Sciences Institute (CLSI). Performance Standards for Antimicrobial Susceptibilty Testing. 26th ed. CLSI Supplement M100S. Wayne, PA: Clinical and Laboratory Standards Institute 2016
   Google Scholar
• Kaase M, Szabados F, Wassill L, Gatermann SG. Detection of carbapenemases in Enterobacteriaceae by a commercial multiplex PCR. J Clin Microbiol 2012; 50:3115-8; PMID:22785190; https://doi.org/10.1128/JCM.00991-12
   PubMed Web of Science ®Google Scholar
• Hemarajata P, Yang S, Hindler JA, Humphries RM. Development of a Novel Real-Time PCR assay with high-resolution melt analysis to detect and differentiate OXA-48-like β-lactamases in carbapenem-resistant enterobacteriaceae. Antimicrob Agents Chemother 2015; 59:5574-80; PMID:26124164; https://doi.org/10.1128/AAC.00425-15
   PubMed Web of Science ®Google Scholar
• Evans SR, Hujer AM, Jiang H, Hujer KM, Hall T, Marzan C, Jacobs MR, Sampath R, Ecker DJ, Manca C, et al. Rapid molecular diagnostics, antibiotic treatment decisions, and developing approaches to inform empiric therapy: PRIMERS I and II. Clin Infect Dis 2016; 62:181-9; PMID:26409063; https://doi.org/10.1093/cid/civ837
   PubMed Web of Science ®Google Scholar
• Kitchel B, Rasheed JK, Endimiani A, Hujer AM, Anderson KF, Bonomo RA, Patel JB. Genetic factors associated with elevated carbapenem resistance in KPC-producing Klebsiella pneumoniae. Antimicrob Agents Chemother 2010; 54:4201-7; PMID:20660684; https://doi.org/10.1128/AAC.00008-10
   PubMed Web of Science ®Google Scholar
• Kahlmeter G. Breakpoints for intravenously used cephalosporins in Enterobacteriaceae–EUCAST and CLSI breakpoints. Clin Microbiol Infect 2008; 14 Suppl 1:169-74; PMID:18154542; https://doi.org/10.1111/j.1469-0691.2007.01856.x
   PubMed Web of Science ®Google Scholar
• Rodel J, Karrasch M, Edel B, Stoll S, Bohnert J, Loffler B, Saupe A, Pfister W. Antibiotic treatment algorithm development based on a microarray nucleic acid assay for rapid bacterial identification and resistance determination from positive blood cultures. Diagn Microbiol Infect Dis 2015; 84(3):252-7; PMID:26712265; https://doi.org/10.1016/j.diagmicrobio.2015.10.021
   PubMed Web of Science ®Google Scholar
• Salimnia H, Fairfax MR, Lephart PR, Schreckenberger P, DesJarlais SM, Johnson JK, Robinson G, Carroll KC, Greer A, Morgan M, et al. Evaluation of the film array(R) Blood Culture Identification Panel: Results of a Multi-Center Controlled Trial. J Clin Microbiol 2016; 687-698; PMID:26739158
   PubMed Web of Science ®Google Scholar
• Mico M, Navarro F, de Miniac D, Gonzalez Y, Brell A, Lopez C, Sanchez-Reus F, Mirelis B, Coll P. Efficacy of the FilmArray blood culture identification panel for direct molecular diagnosis of infectious diseases from samples other than blood. J Med Microbiol 2015; 64:1481-8; PMID:26432445; https://doi.org/10.1099/jmm.0.000180
   PubMed Web of Science ®Google Scholar
• Lyman M, Walters M, Lonsway D, Rasheed K, Limbago B, Kallen A. Notes from the Field: Carbapenem-resistant enterobacteriaceae producing OXA-48-like Carbapenemases - United States, 2010–2015. MMWR Morb Mortal Wkly Rep 2015; 64:1315-6; PMID:26633574; https://doi.org/10.15585/mmwr.mm6447a3
   PubMed Web of Science ®Google Scholar
• Ledeboer NA, Lopansri BK, Dhiman N, Cavagnolo R, Carroll KC, Granato P, Thomson R, Jr, Butler-Wu SM, Berger H, Samuel L, et al. Identification of gram-negative bacteria and genetic resistance determinants from positive blood culture broths by use of the verigene gram-negative blood culture multiplex microarray-based molecular assay. J Clin Microbiol 2015; 53:2460-72; PMID:25994165; https://doi.org/10.1128/JCM.00581-15
   PubMed Web of Science ®Google Scholar
• Uno N, Suzuki H, Yamakawa H, Yamada M, Yaguchi Y, Notake S, Tamai K, Yanagisawa H, Misawa S, Yanagihara K. Multicenter evaluation of the Verigene Gram-negative blood culture nucleic acid test for rapid detection of bacteria and resistance determinants in positive blood cultures. Diagn Microbiol Infect Dis 2015; 83:344-8; PMID:26361710; https://doi.org/10.1016/j.diagmicrobio.2015.08.004
   PubMed Web of Science ®Google Scholar
• Kunze N, Moerer O, Steinmetz N, Schulze MH, Quintel M, Perl T. Point-of-care multiplex PCR promises short turnaround times for microbial testing in hospital-acquired pneumonia–an observational pilot study in critical ill patients. Ann Clin Microbiol Antimicrob 2015; 14:33; PMID:26071191; https://doi.org/10.1186/s12941-015-0091-3
   PubMed Web of Science ®Google Scholar
• Tato M, Ruiz-Garbajosa P, Traczewski M, Dodgson A, McEwan A, Humphries R, Hindler J, Veltman J, Wang G, Canton R. Multisite evaluation of Cepheid Xpert Carba-R Assay for the detection of carbapenemase-producing organisms in rectal swabs. J Clin Microbiol 2016; in press; PMID:27122379
   PubMed Web of Science ®Google Scholar
• Lowman W, Marais M, Ahmed K, Marcus L. Routine active surveillance for carbapenemase-producing Enterobacteriaceae from rectal swabs: diagnostic implications of multiplex polymerase chain reaction. J Hosp Infect 2014; 88:66-71; PMID:25082751; https://doi.org/10.1016/j.jhin.2014.06.009
   PubMed Web of Science ®Google Scholar
• Lau AF, Fahle GA, Kemp MA, Jassem AN, Dekker JP, Frank KM. Clinical Performance of Check-Direct CPE, a Multiplex PCR for Direct Detection of blaKPC, blaNDM/VIM, and blaOXA48 from Perirectal Swabs. J Clin Microbiol 2015; 53(12):3729-37; PMID:26338860
   PubMed Web of Science ®Google Scholar
• Burnham CA, Frobel RA, Herrera ML, Wickes BL. Rapid ertapenem susceptibility testing and Klebsiella pneumoniae carbapenemase phenotype detection in Klebsiella pneumoniae isolates by use of automated microscopy of immobilized live bacterial cells. J Clin Microbiol 2014; 52:982-6; PMID:24391202; https://doi.org/10.1128/JCM.03255-13
   PubMed Web of Science ®Google Scholar
• Nordmann P, Poirel L, Dortet L. Rapid detection of carbapenemase-producing Enterobacteriaceae. Emerg Infect Dis 2012; 18:1503-7; PMID:22932472; https://doi.org/10.3201/eid1809.120355
   PubMed Web of Science ®Google Scholar
• Yusuf E, Van Der Meeren S, Schallier A, Pierard D. Comparison of the Carba NP test with the Rapid CARB Screen Kit for the detection of carbapenemase-producing Enterobacteriaceae and Pseudomonas aeruginosa. Eur J Clin Microbiol Infect Dis 2014; 33:2237-40; PMID:25008570; https://doi.org/10.1007/s10096-014-2199-3
   PubMed Web of Science ®Google Scholar
• Dortet L, Agathine A, Naas T, Cuzon G, Poirel L, Nordmann P. Evaluation of the RAPIDEC(R) CARBA NP, the Rapid CARB Screen(R) and the Carba NP test for biochemical detection of carbapenemase-producing Enterobacteriaceae. J Antimicrob Chemother 2015; 70:3014-22; PMID:26260131; https://doi.org/10.1093/jac/dkv213
   PubMed Web of Science ®Google Scholar
• Osterblad M, Hakanen AJ, Jalava J. Evaluation of the Carba NP test for carbapenemase detection. Antimicrob Agents Chemother 2014; 58:7553-6; PMID:25246404; https://doi.org/10.1128/AAC.02761-13
   PubMed Web of Science ®Google Scholar
• Hombach M, von Gunten B, Castelberg C, Bloemberg GV. Evaluation of the Rapidec Carba NP Test for detection of carbapenemases in enterobacteriaceae. J Clin Microbiol 2015; 53:3828-33; PMID:26424840
   PubMed Web of Science ®Google Scholar
• Pantel A, Souzy D, Sotto A, Lavigne JP. Evaluation of two phenotypic screening tests for carbapenemase-producing enterobacteriaceae. J Clin Microbiol 2015; 53:3359-62; PMID:26224841; https://doi.org/10.1128/JCM.01211-15
   PubMed Web of Science ®Google Scholar
• Bogaerts P, Yunus S, Massart M, Huang TD, Glupczynski Y. Evaluation of the BYG carba test, a new electrochemical assay for rapid laboratory detection of carbapenemase-producing enterobacteriaceae. J Clin Microbiol 2016; 54:349-58; PMID:26637378; https://doi.org/10.1128/JCM.02404-15
   PubMed Web of Science ®Google Scholar
• Hrabak J, Walkova R, Studentova V, Chudackova E, Bergerova T. Carbapenemase activity detection by matrix-assisted laser desorption ionization-time of flight mass spectrometry. J Clin Microbiol 2011; 49:3222-7; PMID:21775535; https://doi.org/10.1128/JCM.00984-11
   PubMed Web of Science ®Google Scholar
• Mirande C, Canard I, Buffet Croix Blanche S, Charrier JP, van Belkum A, Welker M, Chatellier S. Rapid detection of carbapenemase activity: benefits and weaknesses of MALDI-TOF MS. Eur J Clin Microbiol Infect Dis 2015; 34:2225-34; PMID:26337432; https://doi.org/10.1007/s10096-015-2473-z
   PubMed Web of Science ®Google Scholar
• Johansson A, Ekelof J, Giske CG, Sundqvist M. The detection and verification of carbapenemases using ertapenem and matrix assisted laser desorption ionization-time of flight. BMC Microbiol 2014; 14:89; PMID:24720586; https://doi.org/10.1186/1471-2180-14-89
   PubMed Web of Science ®Google Scholar
• Lange C, Schubert S, Jung J, Kostrzewa M, Sparbier K. Quantitative matrix-assisted laser desorption ionization-time of flight mass spectrometry for rapid resistance detection. J Clin Microbiol 2014; 52:4155-62; PMID:25232164; https://doi.org/10.1128/JCM.01872-14
   PubMed Web of Science ®Google Scholar
• van Belkum A, Dunne WM. Next-generation antimicrobial susceptibility testing. J Clin Microbiol 2013; 51:2018-24; PMID:23486706; https://doi.org/10.1128/JCM.00313-13
   PubMed Web of Science ®Google Scholar
• Pulido MR, Garcia-Quintanilla M, Martin-Pena R, Cisneros JM, McConnell MJ. Progress on the development of rapid methods for antimicrobial susceptibility testing. J Antimicrob Chemother 2013; 68:2710-7; PMID:23818283; https://doi.org/10.1093/jac/dkt253
   PubMed Web of Science ®Google Scholar
• Ben-David D, Maor Y, Keller N, Regev-Yochay G, Tal I, Shachar D, Zlotkin A, Smollan G, Rahav G. Potential role of active surveillance in the control of a hospital-wide outbreak of carbapenem-resistant Klebsiella pneumoniae infection. Infect Cont Hosp Epid 2010; 31:620-6; https://doi.org/10.1086/652528
   PubMed Web of Science ®Google Scholar
• Patel G, Huprikar S, Factor S, Jenkins S, Calfee D. Outcomes of carbapenem-resistant Klebsiella pneumoniae infection and the impact of antimicrobial and adjunctive therapies. Infect Cont Hosp Epid 2008; 29:1099-106; https://doi.org/10.1086/592412
   PubMed Web of Science ®Google Scholar
• Satlin M, Calfee D, Chen L, Fauntleroy K, Wilson S, Jenkins S, Feldman E, Roboz G, Shore T, Helfgott D, et al. Emergence of carbapenem-resistant Enterobacteriaceae as causes of bloodstream infections in patients with hematologic malignancies. Leuk Lymphoma 2013; 54:799-806; PMID:22916826; https://doi.org/10.3109/10428194.2012.723210
   PubMed Web of Science ®Google Scholar
• Guh A, Bulens S, Mu Y, Jacob J, Reno J, Scott J, Wilson L, Vaeth E, Lynfield R, Shaw K, et al. Epidemiology of carbapenem-resistant enterobacteriaceae in 7 US Communities, 2012–2013. JAMA 2015; 314:1479-87; PMID:26436831; https://doi.org/10.1001/jama.2015.12480
   PubMed Web of Science ®Google Scholar
• Viale P, Giannella M, Lewis R, Trecarichi E, Petrosillo N, Tumbarello M. Predictors of mortality in multidrug-resistant Klebsiella pneumoniae bloodstream infections. Expert Rev Anti Infect Ther 2013; 11:1053-63; PMID:24073806; https://doi.org/10.1586/14787210.2013.836057
   PubMed Web of Science ®Google Scholar
• Zarkotou O, Pournaras S, Tselioti P, Dragoumanos V, Pitiriga V, Ranellou K, Prekates A, Themeli-Digalaki K, Tsakris A. Predictors of mortality in patients with bloodstream infections caused by KPC-producing Klebsiella pneumoniae and impact of appropriate antimicrobial treatment. Clin Microbiol Infect 2011; 17:1789-803; https://doi.org/10.1111/j.1469-0691.2011.03514.x
   Web of Science ®Google Scholar
• Kumar A, Roberts D, Wood K, Light B, Parrillo J, Sharma S, Suppes R, Feinstein D, Zanotti S, Taiberg L, et al. Duration of hypotension before initiation of effective antimicrobial therapy is the critical determinant of survival in human septic shock. Crit Care Med 2006; 34:1589-96; PMID:16625125; https://doi.org/10.1097/01.CCM.0000217961.75225.E9
   PubMed Web of Science ®Google Scholar
• Fowler VJ, Sanders L, Sexton D, Kong L, Marr K, Gopal A, Gottlieb G, McClelland R, Corey G. Outcome of Staphylococcus aureus bacteremia according to compliance with recommendations of infectious diseases specialists: experience with 244 patients. Clin Infect Dis 1998; 27:478-86; PMID:9770144; https://doi.org/10.1086/514686
   PubMed Web of Science ®Google Scholar
• Jenkins T, Price C, Sabel A, Mehler P, Burman W. Impact of routine infectious diseases service consultation on the evaluation, management, and outcomes of Staphylococcus aureus bacteremia. Clin Infect Dis 2008; 46:1000-8; PMID:18444816; https://doi.org/10.1086/529190
   PubMed Web of Science ®Google Scholar
• Qureshi Z, Paterson D, Potoski B, Kilayko M, Sandovsky G, Sordillo E, Polsky B, Adams-Haduch J, Doi Y. Treatment outcome of bacteremia due to KPC-producing Klebsiella pneumoniae: superiority of combination antimicrobial regimens. Antimicrob Agents Chemother 2012; 56:2108-13; PMID:22252816; https://doi.org/10.1128/AAC.06268-11
   PubMed Web of Science ®Google Scholar
• Tumbarello M, Viale P, Viscoli C, Trecarichi E, Tumietto F, Marchese A, Spanu T, Ambretti S, Ginocchio F, Cristini F, et al. Predictors of mortality in bloodstream infections caused by Klebsiella pneumoniae carbapenemase-producing K. pneumoniae: importance of combination therapy. Clin Infect Dis 2012; 55:943-50; PMID:22752516; https://doi.org/10.1093/cid/cis588
   PubMed Web of Science ®Google Scholar
• Daikos GL TS, Tzouvelekis LS, Anyfantis I, Psichogiou M, Argyropoulou A, Stefanou I, Sypsa V, Miriagou V, Nepka M, Georgiadou S, Markogiannakis A, Goukos D, Skoutelis A. Carbapenemase-producing Klebsiella pneumoniae bloodstream infections: lowering mortality by antibiotic combination schemes and the role of carbapenems. Antimicrob Agents Chemother 2014; 58:2322-8; PMID:24514083; https://doi.org/10.1128/AAC.02166-13
   PubMed Web of Science ®Google Scholar
• Falagas M, Lourida P, Poulikakos P, Rafailidis P, Tansarli G. Antimicrob Agents Chemother 2014; 58:654-63; PMID:24080646; https://doi.org/10.1128/AAC.01222-13
   PubMed Web of Science ®Google Scholar
• Balkan I, Aygün G, Aydın S, Mutcalı S, Kara Z, Kuşkucu M, Midilli K, Şemen V, Aras S, Yemişen M, et al. Blood stream infections due to OXA-48-like carbapenemase-producing Enterobacteriaceae: treatment and survival. Int J Infect Dis 2014; 26:51-6; PMID:24998423; https://doi.org/10.1016/j.ijid.2014.05.012
   PubMed Web of Science ®Google Scholar
• Sader H, Castanheira M, Flamm R, Farrell D, Jones R. Antimicrobial activity of ceftazidime-avibactam against Gram-negative organisms collected from US medical centers in 2012. Antimicrob Agents Chemother 2014; 58:1684-92; PMID:24379201; https://doi.org/10.1128/AAC.02429-13
   PubMed Web of Science ®Google Scholar
• Bercot B, Poirel L, Dortet L, Nordmann P. In vitro evaluation of antibiotic syndergy for NDM-1-producing Enterobacteriaceae. J Antimicrob Chemother 2011; 66:2295-7; PMID:21807739; https://doi.org/10.1093/jac/dkr296
   PubMed Web of Science ®Google Scholar
• Rogers B, Sidjabat H, Silvey A, Anderson T, Perera S, Li J, Paterson DL. Treatment options for New Delhi metallo-β-lactamase-harboring Enterobacteriaceae. Microb Drug Resist 2013; 19:100-3; PMID:23330550; https://doi.org/10.1089/mdr.2012.0063
   PubMed Web of Science ®Google Scholar
• Urban C, Mariano N, Rahal J. In vitro double and triple bactericidal activities of doripenem, polymyxin B, and rifampin against multidrug-resistant Acinetobacter baumannii, Pseudomonas aeruginosa, Klebsiella pneumoniae, and Escherichia coli. Antimicrob Agents Chemother 2010; 54:2732-4; PMID:20368401; https://doi.org/10.1128/AAC.01768-09
   PubMed Web of Science ®Google Scholar
• Tängdén T, Hickman R, Forsberg P, Lagerbäck P, Giske C, Cars O. Evaluation of double- and triple-antibiotic combinations for VIM- and NDM-producing Klebsiella pneumoniae by in vitro time-kill experiments. Antimicrob Agents Chemother 2014; 58:1757-62; https://doi.org/10.1128/AAC.00741-13
   PubMed Web of Science ®Google Scholar
• Poirel L, Kieffer N, Nordmann P. In vitro evaluation of dual carbapenem combinations against carbapenemase-producing Enterobacteriaceae. J Antimicrob Chemother 2016; 71:156-61; PMID:26416781; https://doi.org/10.1093/jac/dkv294
   PubMed Web of Science ®Google Scholar
• Tzouvelekis L, Markogiannakis A, Psichogiou M, Tassios P, Daikos G. Carbapenemases in Klebsiella pneumoniae and other Enterobacteriaceae: an evolving crisis of global dimensions. Clin Microbiol Rev 2012; 25:682-707; PMID:23034326; https://doi.org/10.1128/CMR.05035-11
   PubMed Web of Science ®Google Scholar
• Liu Y, Wang Y, Walsh T, Yi L, Zhang R, Spencer J, Doi Y, Tian G, Dong B, Huang X, et al. Emergence of plasmid-mediated colistin resistance mechanism MCR-1 in animals and human beings in China: a microbiological and molecular biological study. Lancet Infect Dis 2016; 16:161-8; PMID:26603172; https://doi.org/10.1016/S1473-3099(15)00424-7
   PubMed Web of Science ®Google Scholar
• Parisi S, Bartolini A, Santacatterina E, Castellani E, Ghirardo R, Berto A, Franchin E, Menegotto N, De Canale E, Tommasini T, et al. Prevalence of Klebsiella pneumoniae strains producing carbapenemases and increase of resistance to colistin in an Italian teaching hospital from January 2012 To December 2014. BMC Infect Dis 2015; 15:244; PMID:26116560; https://doi.org/10.1186/s12879-015-0996-7
   PubMed Web of Science ®Google Scholar
• Weterings V, Zhou K, Rossen J, van Stenis D, Thewessen E, Kluytmans J, Veenemans J. An outbreak of colistin-resistant Klebsiella pneumoniae carbapenemase-producing Klebsiella pneumoniae in the Netherlands (July to December 2013), with inter-institutional spread. Eur J Clin Microbiol Infect Dis 2015; 34:1647-55; PMID:26067658; https://doi.org/10.1007/s10096-015-2401-2
   PubMed Web of Science ®Google Scholar
• Mavroidi A, Katsiari M, Likousi S, Palla E, Roussou Z, Nikolaou C, Maguina A, Platsouka E. Characterization of ST258 Colistin-Resistant, blaKPC-producing Klebsiella pneumoniae in a Greek Hospital. Microb Drug Resist 2016; Feb 3 Epub ahead of print; PMID:26840950
   PubMed Web of Science ®Google Scholar
• Marchaim D, Chopra T, Pogue J, Perez F, Hujer A, Rudin S, Endimiani A, Navon-Venezia S, Hothi J, Slim J, et al. Outbreak of colistin-resistant, carbapenem-resistant Klebsiella pneumoniae in metropolitan Detroit, Michigan. Antimicrob Agents Chemother 2011; 55:593-9; PMID:21115786; https://doi.org/10.1128/AAC.01020-10
   PubMed Web of Science ®Google Scholar
• Wang X, Zhang F, Zhao C, Wang Z, Nichols W, Testa R, Li H, Chen H, He W, Wang Q, et al. In vitro activities of ceftazidime-avibactam and aztreonam-avibactam against 372 Gram-negative bacilli collected in 2011 and 2012 from 11 teaching hospitals in China. Antimicrob Agents Chemother 2014; 58:1774-8; PMID:24342639; https://doi.org/10.1128/AAC.02123-13
   PubMed Web of Science ®Google Scholar
• Navarro-San Francisco C, Mora-Rillo M, Romero-Gómez M, Moreno-Ramos F, Rico-Nieto A, Ruiz-Carrascoso G, Gómez-Gil R, Arribas-López J, Mingorance J, Paño-Pardo J. Bacteraemia due to OXA-48-carbapenemase-producing Enterobacteriaceae: a major clinical challenge. Clin Microbiol Infect 2013; 19:E72-9; PMID:23231088; https://doi.org/10.1111/1469-0691.12091
   PubMed Web of Science ®Google Scholar
• Lowman W, Schleicher G. Antimicrobial treatment and outcomes of critically ill patients with OXA-48-like carbapenemase-producing Enterobacteriaceae infections. Diagn Microbiol Infect Dis 2015; 81:138-40; PMID:25497419; https://doi.org/10.1016/j.diagmicrobio.2014.09.023
   PubMed Web of Science ®Google Scholar
• Zasowski EJ, Rybak JM, Rybak MJ. The β-Lactams Strike Back: Ceftazidime-Avibactam. Pharmacotherapy 2015; 35:755-70; PMID:26289307; https://doi.org/10.1002/phar.1622
   PubMed Web of Science ®Google Scholar
• Humphries RM, Yang S, Hemarajata P, Ward KW, Hindler JA, MIller SA, Gregson A. First report of ceftazidime-avibactam resistance in a KPC-3 expressing Klebsiella pneumoniae. Antimicrobial Agents Chemotherapy 2015; 59(10):6605-7; in press; PMID:26195508; https://doi.org/10.1128/AAC.01165-15
   PubMed Web of Science ®Google Scholar
• Perez F, El Chakhtoura N, Papp-Wallace K, Wilson B, Bonomo R. Treatment Options for Infections Caused by Carbapenem-resistant Enterobacteriaceae: Can We Apply “Precision Medicine” to Antimicrobial Chemotherapy? Expert Opin Pharmacother 2016; Jan 22; 17(6):761-81; PMID:26799840; https://doi.org/10.1517/14656566.2016.1145658
   PubMed Web of Science ®Google Scholar
• Hsu A, Tamma P. Treatment of multidrug-resistant Gram-negative infections in children. Clin Infect Dis 2014; 58:1439-48; PMID:24501388; https://doi.org/10.1093/cid/ciu069
   PubMed Web of Science ®Google Scholar
• Morrill HJ PJ, Kaye KS, LaPlante KL. Treatment Options for Carbapenem-Resistant Enterobacteriaceae Infections. Open Forum Infect Dis 2015; 2:ofv050; PMID:26125030; https://doi.org/10.1093/ofid/ofv050
   PubMed Web of Science ®Google Scholar
• Schwaber M, Carmeli Y. An ongoing national intervention to contain the spread of carbapenem-resistant Enterobacteriaceae. Clin Infect Dis 2013; 58:697-703; PMID:24304707; https://doi.org/10.1093/cid/cit795
   PubMed Web of Science ®Google Scholar
• Won S, Munoz-Price L, Lolans K, Hota B, Weinstein R, Hayden M. Emergence and rapid regional spread of Klebsiella pneumoniae carbapenemase-producing Enterobacteriaceae. Clin Infect Dis 2011; 53:532-40; PMID:21865189; https://doi.org/10.1093/cid/cir482
   PubMed Web of Science ®Google Scholar
• Kochar S, Sheard T, Sharma R, Hui A, Tolentino E, Allen G, Landman D, Bratu S, Augenbraun M, Quale J. Success of an infection control program to reduce the spread of carbapenem-resistant Klebsiella pneumoniae. Infect Control Hosp Epidemiol 2009; 30:447-52; PMID:19301985; https://doi.org/10.1086/596734
   PubMed Web of Science ®Google Scholar
• Palmore T, Henderson D. Managing transmission of carbapenem-resistant Enterobacteriaceae in healthcare settings: a view from the trenches. Clin Infect Dis 2013; 57:1593-9; PMID:23934166; https://doi.org/10.1093/cid/cit531
   PubMed Web of Science ®Google Scholar
• Snitkin E, Zelazny A, Thomas P, Stock F, Henderson D, Palmore T, Segre J, Group NCSP. Tracking a hospital outbreak of carbapenem-resistant Klebsiella pneumoniae with whole-genome sequencing. Sci Transl Med 2012; 4:148; https://doi.org/10.1126/scitranslmed.3004129
   Web of Science ®Google Scholar
• Emerging Infections Network (EIN). Routine contact precautions for MRSA, VRE, and CRE. Infect Dis Society Am 2014
   Google Scholar
• Vasoo S, Madigan T, Cunningham S, Mandrekar J, Porter S, Johnston B, Sampathkumar P, Tosh P, Johnson J, Patel R, et al. Prevalence of rectal colonization with multidrug-resistant Enterobacteriaceae among international patients hospitalized at Mayo Clinic, Rochester, Minnesota. Infect Cont Hosp Epid 2014; 35:182-6; https://doi.org/10.1086/674853
   PubMed Web of Science ®Google Scholar
• Banerjee R, Teng C, Cunningham S, Ihde S, Steckelberg J, Moriarty J, Shah N, Mandrekar J, Patel R. Randomized Trial of Rapid Multiplex Polymerase Chain Reaction-Based Blood Culture Identification and Susceptibility Testing. Clin Infect Dis 2015; 61:1071-80; PMID:26197846; https://doi.org/10.1093/cid/civ447
   PubMed Web of Science ®Google Scholar
• Rhoads D, Sintchenko V, Rauch C, Pantanowitz L. Clinical Microbiology Informatics. Clin Microbiol Rev 2014; 27:1025-47; PMID:25278581; https://doi.org/10.1128/CMR.00049-14
   PubMed Web of Science ®Google Scholar
• Wilson J, Oyen L, Ou N, McMahon M, Thompson R, Manahan J, Graner K, Lovely J, Estes L. Hospital rules-based system: the next generation of medical informatics for patient safety. Am J Health Syst Pharm 2005; 62:499-505; PMID:15745913; https://doi.org/10.2146/ajhp050287
   PubMed Web of Science ®Google Scholar
• Schurink C, Lucas P, Hoepelman I, Bonten M. Computer-assisted decision support for the diagnosis and treatment of infectious diseases in intensive care units. Lancet Infect Dis 2005; 5:305-12; PMID:15854886; https://doi.org/10.1016/S1473-3099(05)70115-8
   PubMed Web of Science ®Google Scholar
• Evans R, Pestotnik S, Classen D, Clemmer T, Weaver L, Orme J, Lloyd J, Burke J. A computer assisted management program for antibiotics and other anti-infective agents. New Engl J Med 1998; 338:232-8; PMID:9435330; https://doi.org/10.1056/NEJM199801223380406
   PubMed Web of Science ®Google Scholar
• Samore M, Bateman K, Alder S, Hannah E, Donnelly S, Stoddard G, Haddadin B, Rubin M, Williamson J, Stults B, et al. Clinical decision support and appropriateness of antimicrobial prescribing: a randomized trial. JAMA 2005; 294:2305-14; PMID:16278358; https://doi.org/10.1001/jama.294.18.2305
   PubMed Web of Science ®Google Scholar
• Forrest G, Mehta S, Weekes E, Lincalis D, Johnson J, Venezia R. Impact of rapid in situ hybridization testing on coagulase-negative staphylococci positive blood cultures. J Anti Microb Chemother 2006; 58:154-8; https://doi.org/10.1093/jac/dkl146
   PubMed Web of Science ®Google Scholar
• Forrest GN, Roghmann MC, Toombs L, Johnson J, Weekes E, Lincalis DP, Venezia RA. Peptide nucleic acid fluorescent in situ hybridization for hospital-acquired enterococcal bacteremia: delivering earlier effective antimicrobial therapy. Antimicrob Agents Chemother 2008; 52:3558-63; PMID:18663022; https://doi.org/10.1128/AAC.00283-08
   PubMed Web of Science ®Google Scholar
• Forrest GN, Mankes K, Jabra-Rizk M, Weekes E, Johnson JK, Lincalis DP, Venezia RA. Peptide nucleic acid fluorescence in situ hybridization-based identification of Candida albicans and its impact on mortality and antifungal therapy costs. J Clin Microbiol 2006; 44:3381-3; PMID:16954279; https://doi.org/10.1128/JCM.00751-06
   PubMed Web of Science ®Google Scholar
• Perez KK, Olsen RJ, Musick WL, Cernoch PL, Davis JR, Peterson L, Musser JM. Integrating rapid diagnostics and antimicrobial stewardship improves outcomes in patients with antibiotic-resistant Gram-negative bacteremia. J Infect 2014; 69:216-25; PMID:24841135; https://doi.org/10.1016/j.jinf.2014.05.005
   PubMed Web of Science ®Google Scholar
• Perez K, Olsen R, Musick W, Cernoch P, Davis J, Land G, LE P, Musser J. Integrating rapid pathogen identification and antimicrobial stewardship significantly decreases hospital costs. Arch Pathol Lab Med 2012; 137:1247-54; PMID:23216247; https://doi.org/10.5858/arpa.2012-0651-OA
   PubMed Web of Science ®Google Scholar
• Nguyen D, Yeh E, Perry S, Luo R, Pinsky B, Lee B, Sisodiya D, Baron E, Banaei N. Real-time PCR testing for mecA reduces vancomycin usage and length of hospitalization for patients infected with methicillin-sensitive Staphylococci. J Clin Microbiol 2010; 48:785-90; PMID:20071556; https://doi.org/10.1128/JCM.02150-09
   PubMed Web of Science ®Google Scholar
• Bauer K, West J, Balada-Llasat JM, Pancholi P, Stevenson K, Goff D. An antimicrobial stewardship program's impact with rapid polymerase chain reaction methicillin-resistant Staphylococcus aureus/S. aureus blood culture test in patients with S. aureus bacteremia. Clin Infect Dis 2010; 51:1074-80; PMID:20879856; https://doi.org/10.1086/656623
   PubMed Web of Science ®Google Scholar
• Huang A, Newton D, Kunapuli A, Gandhi T, Washer L, Isip J, Collins C, Nagel J. Impact of rapid organism identification via matrix-assisted laser desorption/ionization time-of-flight combined with antimicrobial stewardship team intervention in adult patients with bacteremia and candidemia. Clin Infect Dis 2013; 57:1237-45; PMID:23899684; https://doi.org/10.1093/cid/cit498
   PubMed Web of Science ®Google Scholar
• Forrest G, Van Schooneveld T, Kullar R, Schulz L, Duong P, Postelnick M. Use of electronic health records and clinical decision support systems for antimicrobial stewardship. Clin Infect Dis 2014; 59:S122-33; PMID:25261539; https://doi.org/10.1093/cid/ciu565
   PubMed Web of Science ®Google Scholar