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Editorial

Escherichia coli K1 meningitis: Analysis of the effects of CNF1 toxin in newborn mice questions its virulence function

Pages 754-755 | Received 29 Jun 2016, Accepted 08 Jul 2016, Published online: 10 Aug 2016

References

  • Chang AC, Krishnan S, Prasadarao NV. The effects of cytotoxic necrotizing factor 1 expression in the uptake of Escherichia coli K1 by macrophages and the onset of meningitis in newborn mice. Virulence 2016; 7(7):806-818; http://dx.doi.org/10.1080/21505594.2016.1192730
  • Kaper JB, Nataro JP, Mobley HL. Pathogenic Escherichia coli. Nat Rev Microbiol 2004; 2:123-40; PMID:15040260; http://dx.doi.org/10.1038/nrmicro818
  • Etienne-Manneville S, Hall A. Rho GTPases in cell biology. Nature 2002; 420:629-35; PMID:12478284; http://dx.doi.org/10.1038/nature01148
  • Bokoch GM. Regulation of innate immunity by Rho GTPases. Trends Cell Biol 2005; 15:163-71; PMID:15752980; http://dx.doi.org/10.1016/j.tcb.2005.01.002
  • Boquet P, Lemichez E. Bacterial virulence factors targeting Rho GTPases: parasitism or symbiosis? Trends Cell Biol 2003; 13:238-46; PMID:12742167; http://dx.doi.org/10.1016/S0962-8924(03)00037-0
  • Boyer L, Magoc L, Dejardin S, Cappillino M, Paquette N, Hinault C, Charriere GM, Ip WK, Fracchia S, Hennessy E, et al. Pathogen-derived effectors trigger protective immunity via activation of the Rac2 enzyme and the IMD or Rip kinase signaling pathway. Immunity 2011; 35:536-49; PMID:22018470; http://dx.doi.org/10.1016/j.immuni.2011.08.015
  • Stuart, LM, Paquette, N, Boyer, L. Effector-triggered versus pattern-triggered immunity: how animals sense pathogens. Nat Rev Immunol 2013; 13(3):199-206; PMID:23411798
  • Diabate M, Munro P, Garcia E, Jacquel A, Michel G, Obba S, Goncalves D, Luci C, Marchetti S, Demon D, et al. escherichia coli alpha-hemolysin counteracts the anti-virulence innate immune response triggered by the Rho GTPase activating toxin CNF1 during bacteremia. PLoS Pathog 2015; 11:e1004732; PMID:25781937
  • Prasadarao, NV, Wass, CA, Weiser, JN, Stins, MF, Huang, SH, Kim, KS. Outer membrane protein A of Escherichia coli contributes to invasion of brain microvascular endothelial cells. Infect Immun 1996; 64:146-53; PMID:8557332
  • Mittal R, Sukumaran SK, Selvaraj SK, Wooster DG, Babu MM, Schreiber AD, Verbeek JS, Prasadarao NV. Fcγ receptor I alpha chain (CD64) expression in macrophages is critical for the onset of meningitis by Escherichia coli K1. PLoS Pathog 2010; 6:e1001203.
  • Shames SR, Finlay BB. Bacterial effector interplay: a new way to view effector function. Trends Microbiol 2012; 20:214-9; PMID:22425230; http://dx.doi.org/10.1016/j.tim.2012.02.007
  • Khan NA, Wang Y, Kim KJ, Chung JW, Wass CA, Kim KS. Cytotoxic necrotizing factor-1 contributes to Escherichia coli K1 invasion of the central nervous system. J Biol Chem 2002; 277:15607-12; PMID:11877402; http://dx.doi.org/10.1074/jbc.M112224200
  • Khan NA, Shin S, Chung JW, Kim KJ, Elliott S, Wang Y, Kim KS. Outer membrane protein A and cytotoxic necrotizing factor-1 use diverse signaling mechanisms for Escherichia coli K1 invasion of human brain microvascular endothelial cells. Microb Pathog 2003; 35:35-42; PMID:12860457; http://dx.doi.org/10.1016/S0882-4010(03)00090-1
  • Xie Y, Kim KJ, Kim KS. Current concepts on Escherichia coli K1 translocation of the blood-brain barrier. FEMS Immunol Med Microbiol 2004; 42:271-9; PMID:15477040; http://dx.doi.org/10.1016/j.femsim.2004.09.001
  • Doye A, Mettouchi A, Bossis G, Clément R, Buisson-Touati C, Flatau G, Gagnoux L, Piechaczyk M, Boquet P, Lemichez E. CNF1 exploits the ubiquitin-proteasome machinery to restrict Rho GTPase activation for bacterial host cell invasion. Cell 2002; 111:553-64; PMID:12437928; http://dx.doi.org/10.1016/S0092-8674(02)01132-7

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