References
- van der Poll T, Opal SM. Pathogenesis, treatment, and prevention of pneumococcal pneumonia. Lancet 2009; 374:1543-56; PMID:19880020; https://doi.org/https://doi.org/10.1016/S0140-6736(09)61114-4
- Bogaert D, De Groot R, Hermans PW. Streptococcus pneumoniae colonisation: the key to pneumococcal disease. Lancet Infect Dis 2004; 4:144-54; PMID:14998500; https://doi.org/https://doi.org/10.1016/S1473-3099(04)00938-7
- World Health Organization. Pneumococcal vaccines WHO position paper - 2012. Wkly Epidemiol Rec 2012; 87:129-44; PMID:24340399
- O'Brien KL, Wolfson LJ, Watt JP, Henkle E, Deloria-Knoll M, McCall N, Lee E, Mulholland K, Levine OS, Cherian T, et al. Burden of disease caused by Streptococcus pneumoniae in children younger than 5 years: global estimates. Lancet 2009; 374:893-902; PMID:19748398; https://doi.org/https://doi.org/10.1016/S0140-6736(09)61204-6
- Kadioglu A, Weiser JN, Paton JC, Andrew PW. The role of Streptococcus pneumoniae virulence factors in host respiratory colonization and disease. Nat Rev Microbiol 2008; 6:288-301; PMID:18340341; https://doi.org/https://doi.org/10.1038/nrmicro1871
- Koppe U, Suttorp N, Opitz B. Recognition of Streptococcus pneumoniae by the innate immune system. Cell Microbiol 2012; 14:460-6; PMID:22212419; https://doi.org/https://doi.org/10.1111/j.1462-5822.2011.01746.x
- Aberdein JD, Cole J, Bewley MA, Marriott HM, Dockrell DH. Alveolar macrophages in pulmonary host defence the unrecognized role of apoptosis as a mechanism of intracellular bacterial killing. Clin Exp Immunol 2013; 174:193-202; PMID:23841514
- van Rossum AM, Lysenko ES, Weiser JN. Host and bacterial factors contributing to the clearance of colonization by Streptococcus pneumoniae in a murine model. Infect Immun 2005; 73:7718-26; PMID:16239576; https://doi.org/https://doi.org/10.1128/IAI.73.11.7718-7726.2005
- Malley R, Henneke P, Morse SC, Cieslewicz MJ, Lipsitch M, Thompson CM, Kurt-Jones E, Paton JC, Wessels MR, Golenbock DT. Recognition of pneumolysin by Toll-like receptor 4 confers resistance to pneumococcal infection. Proc Natl Acad Sci U S A 2003; 100:1966-71; PMID:12569171; https://doi.org/https://doi.org/10.1073/pnas.0435928100
- Albiger B, Dahlberg S, Sandgren A, Wartha F, Beiter K, Katsuragi H, Akira S, Normark S, Henriques-Normark B. Toll-like receptor 9 acts at an early stage in host defence against pneumococcal infection. Cell Microbiol 2007; 9:633-44; PMID:17004992; https://doi.org/https://doi.org/10.1111/j.1462-5822.2006.00814.x
- Fang R, Tsuchiya K, Kawamura I, Shen Y, Hara H, Sakai S, Yamamoto T, Fernandes-Alnemri T, Yang R, Hernandez-Cuellar E, et al. Critical roles of ASC inflammasomes in caspase-1 activation and host innate resistance to Streptococcus pneumoniae infection. J Immunol (Baltimore, Md: 1950) 2011; 187:4890-9; PMID:21957143; https://doi.org/https://doi.org/10.4049/jimmunol.1100381
- McNeela EA, Burke A, Neill DR, Baxter C, Fernandes VE, Ferreira D, Smeaton S, El-Rachkidy R, McLoughlin RM, Mori A, et al. Pneumolysin activates the NLRP3 inflammasome and promotes proinflammatory cytokines independently of TLR4. PLoS Pathog 2010; 6:e1001191; PMID:21085613; https://doi.org/https://doi.org/10.1371/journal.ppat.1001191
- Linden SK, Sutton P, Karlsson NG, Korolik V, McGuckin MA. Mucins in the mucosal barrier to infection. Mucosal Immunol 2008; 1:183-97; PMID:19079178; https://doi.org/https://doi.org/10.1038/mi.2008.5
- McGuckin MA, Lindén SK, Sutton P, Florin TH. Mucin dynamics and enteric pathogens. Nat Rev Micro 2011; 9:265-78; https://doi.org/https://doi.org/10.1038/nrmicro2538
- Linden SK, Sheng YH, Every AL, Miles KM, Skoog EC, Florin TH, Sutton P, McGuckin MA. MUC1 limits Helicobacter pylori infection both by steric hindrance and by acting as a releasable decoy. PLoS Pathogens 2009; 5:e1000617; PMID:19816567; https://doi.org/https://doi.org/10.1371/journal.ppat.1000617
- Ueno K, Koga T, Kato K, Golenbock DT, Gendler SJ, Kai H, Kim KC. MUC1 mucin is a negative regulator of toll-like receptor signaling. Am J Respir Cell Mol Biol 2008; 38:263-8; PMID:18079492; https://doi.org/https://doi.org/10.1165/rcmb.2007-0336RC
- McGuckin MA, Every AL, Skene CD, Linden SK, Chionh YT, Swierczak A, McAuley J, Harbour S, Kaparakis M, Ferrero R, et al. Muc1 mucin limits both Helicobacter pylori colonization of the murine gastric mucosa and associated gastritis. Gastroenterology 2007; 133:1210-8; PMID:17919495; https://doi.org/https://doi.org/10.1053/j.gastro.2007.07.003
- Ng GZ, Menheniott TR, Every AL, Stent A, Judd LM, Chionh YT, Dhar P, Komen JC, Giraud AS, Wang TC, et al. The MUC1 mucin protects against Helicobacter pylori pathogenesis in mice by regulation of the NLRP3 inflammasome. Gut 2016; 65:1087-99; PMID:26079943; https://doi.org/https://doi.org/10.1136/gutjnl-2014-307175
- Lu W, Hisatsune A, Koga T, Kato K, Kuwahara I, Lillehoj EP, Chen W, Cross AS, Gendler SJ, Gewirtz AT, et al. Cutting edge: enhanced pulmonary clearance of Pseudomonas aeruginosa by Muc1 knockout mice. J Immunol 2006; 176:3890-4; https://doi.org/https://doi.org/10.4049/jimmunol.176.7.3890
- Kyo Y, Kato K, Park YS, Gajghate S, Umehara T, Lillehoj EP, Suzaki H, Kim KC. Antiinflammatory role of MUC1 mucin during infection with nontypeable Haemophilus influenzae. Am J Respir Cell Mol Biol 2012; 46:149-56; PMID:22298528; https://doi.org/https://doi.org/10.1165/rcmb.2011-0142OC
- Lillehoj EP, Kim BT, Kim KC. Identification of Pseudomonas aeruginosa flagellin as an adhesin for Muc1 mucin. Am J Physiol Lung Cell Mol Physiol 2002; 282:L751-6; PMID:11880301; https://doi.org/https://doi.org/10.1152/ajplung.00383.2001
- Kato K, Lillehoj EP, Kai H, Kim KC. MUC1 expression by human airway epithelial cells mediates pseudomonas aeruginosa adhesion. Front Biosci (Elite edition) 2010; 2:68-77; PMID:20036855
- Kato K, Uchino R, Lillehoj EP, Knox K, Lin Y, Kim KC. Membrane-Tethered MUC1 Mucin Counter-Regulates the Phagocytic Activity of Macrophages. Am J Respir Cell Mol Biol 2016; 54:515-23; PMID:26393683; https://doi.org/https://doi.org/10.1165/rcmb.2015-0177OC
- Harvey RM, Stroeher UH, Ogunniyi AD, Smith-Vaughan HC, Leach AJ, Paton JC. A variable region within the genome of Streptococcus pneumoniae contributes to strain-strain variation in virulence. PLoS One 2011; 6:e19650; PMID:21573186; https://doi.org/https://doi.org/10.1371/journal.pone.0019650
- Hughes CE, Harvey RM, Plumptre CD, Paton JC. Development of primary invasive pneumococcal disease caused by serotype 1 pneumococci is driven by early increased type I interferon response in the lung. Infect Immun 2014; 82:3919-26; PMID:25001606; https://doi.org/https://doi.org/10.1128/IAI.02067-14
- Melin M, Trzciński K, Antonio M, Meri S, Adegbola R, Kaijalainen T, Käyhty H, Väkeväinen M. Serotype-Related Variation in Susceptibility to Complement Deposition and Opsonophagocytosis among Clinical Isolates of Streptococcus pneumoniae. Infect Immun 2010; 78:5252-61; PMID:20855517; https://doi.org/https://doi.org/10.1128/IAI.00739-10
- Dockrell DH, Marriott HM, Prince LR, Ridger VC, Ince PG, Hellewell PG, Whyte MK. Alveolar macrophage apoptosis contributes to pneumococcal clearance in a resolving model of pulmonary infection. J Immunol (Baltimore, Md: 1950) 2003; 171:5380-8; PMID:14607941; https://doi.org/https://doi.org/10.4049/jimmunol.171.10.5380
- Knapp S, Leemans JC, Florquin S, Branger J, Maris NA, Pater J, van Rooijen N, van der Poll T. Alveolar macrophages have a protective antiinflammatory role during murine pneumococcal pneumonia. Am J Respir Critical Care Med 2003; 167:171-9; PMID:12406830; https://doi.org/https://doi.org/10.1164/rccm.200207-698OC
- Deniset JF, Surewaard BG, Lee WY, Kubes P. Splenic Ly6Ghigh mature and Ly6Gint immature neutrophils contribute to eradication of S. pneumoniae. J Exp Med 2017; 214:1333-50; PMID:28424248; https://doi.org/https://doi.org/10.1084/jem.20161621
- McAuley JL, Linden SK, Png CW, King RM, Pennington HL, Gendler SJ, Florin TH, Hill GR, Korolik V, McGuckin MA. MUC1 cell surface mucin is a critical element of the mucosal barrier to infection. J Clin Invest 2007; 117:2313-24; PMID:17641781; https://doi.org/https://doi.org/10.1172/JCI26705
- Spicer AP, Rowse GJ, Lidner TK, Gendler SJ. Delayed mammary tumor progression in Muc-1 null mice. J Biol Chem 1995; 270:30093-101; PMID:8530414; https://doi.org/https://doi.org/10.1074/jbc.270.50.30093
- Chionh YT, Ng GZ, Ong L, Arulmuruganar A, Stent A, Saeed MA, Wee JL, Sutton P. Protease-activated receptor 1 suppresses Helicobacter pylori gastritis via the inhibition of macrophage cytokine secretion and interferon regulatory factor 5. Mucosal Immunol 2015; 8:68-79; PMID:24866378; https://doi.org/https://doi.org/10.1038/mi.2014.43
- Misharin AV, Morales-Nebreda L, Mutlu GM, Budinger GR, Perlman H. Flow cytometric analysis of macrophages and dendritic cell subsets in the mouse lung. Am J Respir Cell Mol Biol 2013; 49:503-10; PMID:23672262; https://doi.org/https://doi.org/10.1165/rcmb.2013-0086MA
- Zaynagetdinov R, Sherrill TP, Kendall PL, Segal BH, Weller KP, Tighe RM, Blackwell TS. Identification of myeloid cell subsets in murine lungs using flow cytometry. Am J Respir Cell Mol Biol 2013; 49:180-9; PMID:23492192; https://doi.org/https://doi.org/10.1165/rcmb.2012-0366MA
- Hsu PD, Scott DA, Weinstein JA, Ran FA, Konermann S, Agarwala V, Li Y, Fine EJ, Wu X, Shalem O, et al. DNA targeting specificity of RNA-guided Cas9 nucleases. Nat Biotechnol 2013; 31:827-32; PMID:23873081; https://doi.org/https://doi.org/10.1038/nbt.2647