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Editorial

A glimpse into the future – new therapeutic targets could transform the way we treat staphylococcal infections

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References

  • Lister JL, Horswill AR. Staphylococcus aureus biofilms: recent developments in biofilm dispersal. Front Cell Infect Microbiol [Internet]. 2014;4:1–9.
  • Brady RA, Leid JG, Calhoun JH, Costerton JW, Shirtliff ME. Osteomyelitis and the role of biofilms in chronic infection. FEMS Immunol Med Microbiol. 2008;52:13–22.
  • Lewis K. Multidrug tolerance of biofilms and persister cells. Curr Top Microbiol Immunol Immunol. 2008;322:107–31.
  • Pendleton JN, Gorman SP, Gilmore BF. Clinical relevance of the ESKAPE pathogens. Expert Rev Anti Infect Ther. 2013;11:297–308.
  • Anonymous. Antibiotic resistance threats in the United States, 2013. Centers for Disease Control and Prevenation. 2013; http://www.cdc.gov/drugresistance/threat-report-2013/index.html
  • Köck R, Becker K, Cookson B, van Gemert-Pijnem JE, Harbarth S, Kluytmans JAJW, Mielke M, Peters G, Skov RL, Struelens MJ, et al. Methicillin-resistant Staphylococcus aureus (MRSA): burden of disease and control challenges in Europe. Euro Surveill. 2010;15:1–9.
  • Maura D, Ballok AE, Rahme LG. Considerations and caveats in anti-virulence drug development. Curr Opin Microbiol. 2016;33:41–6
  • Conlon BP, Nakayasu ES, Fleck LE, LaFleur MD, Isabella VM, Coleman K, Leonard SN, Smith RD, Adkins JN, Lewis K. Activated ClpP kills persisters and eradicates a chronic biofilm infection. Nature. 2013;503:365–70
  • Atwood DN, Beenken KE, Lantz TL, Meeker DG, Lynn WB, Mills WB, Spencer HJ, Smeltzer MS. Regulatory mutations impacting antibiotic susceptibility in an established Staphylococcus aureus biofilm. Antimicrob Agents Chemother. 2016;60:1826–29
  • Atwood DN, Loughran AJ, Courtney AP, Anthony AC, Meeker DG, Spencer HJ, Gupta RK, Lee CY, Beenken KE, Smeltzer MS. Comparative impact of diverse regulatory loci on Staphylococcus aureus biofilm formation. Microbiologyopen. 2015;4:436–51.
  • Rom JS, Atwood DN, Beenken KE, Meeker DG, Loughran AJ, Spencer HJ, Lantz TL, Smeltzer MS. Impact of Staphylococcus aureus regulatory mutations that modulate biofilm formation in the USA300 strain LAC on virulence in a murine bacteremia model. Virulence. 2017;14:1–15.
  • Balamurugan P, Hema M, Kaur G, Sridharan V, Prabu PC, Sumana MN, Princy SA. Development of a biofilm inhibitor molecule against multidrug resistant Staphylococcus aureus associated with gestational urinary tract infections. Front Microbiol. 2015;6:1–13.
  • Arya R, Ravikumar R, Santhosh RS, Princy SA. SarA based novel therapeutic candidate against Staphylococcus aureus associated with vascular graft infections. Front Microbiol. 2015;6:1–12.
  • Gray B, Hall P, Gresham H. Targeting agr- and agr-like quorum sensing systems for development of common therapeutics to treat multiple gram-positive bacterial infections. Sensors. 2013;13:5130–66.
  • Beenken KE, Beenken KE, Blevins JS, Blevins JS, Smeltzer MS, Smeltzer MS. Mutation of sarA in Staphylococcus aureus limits biofilm formation. Society. 2003;71:4206–11.
  • Sihto H-M, Budi Susilo Y, Tasara T, Rådström P, Stephan R, Schelin J, Johler S. Effect of sodium nitrite and regulatory mutations Δagr, ΔsarA, and ΔsigB on the mRNA and protein levels of staphylococcal enterotoxin D. Food Control. 2016;65:37–45.
  • Blevins JS, Beenken KE, Elasri MO, Hurlburt BK, Smeltzer MS. Strain-dependent differences in the regulatory roles of sarA and agr in Staphylococcus aureus. Infect Immun. 2002;70:470–80.
  • Cassat J, Dunman PM, Murphy E, Projan SJ, Beenken KE, Palm KJ, Yang S-J, Rice KC, Bayles KW, Smeltzer MS. Transcriptional profiling of a Staphylococcus aureus clinical isolate and its isogenic agr and sarA mutants reveals global differences in comparison to the laboratory strain RN6390. Microbiology. 2006;152:3075–90.
  • Nagarajan V, Smeltzer MS, Elasri MO. Genome-scale transcriptional profiling in Staphylococcus aureus: bringing order out of chaos. FEMS Microbiol Lett. 2009;295:204–10.

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