B Cells Protect T Cell-deficient mice from Cryptococcal Brain Invasion

References

• Dufaud C, Rivera J, Rohatgi S, Pirofski LA. Naive B cells reduce fungal dissemination in Cryptococcus neoformans infected Rag1-/- mice. Virulence. 2017;1–12. PMID:28837391
   PubMed Web of Science ®Google Scholar
• Rajasingham R, Smith RM, Park BJ, Jarvis JN, Govender NP, Chiller TM, Denning DW, Loyse A, Boulware DR. Global burden of disease of HIV-associated cryptococcal meningitis: an updated analysis. Lancet Infect Dis. 2017;17:873–81. doi:10.1016/S1473-3099(17)30243-8. PMID:28483415
   PubMed Web of Science ®Google Scholar
• Olszewski MA, Zhang Y, Huffnagle GB. Mechanisms of cryptococcal virulence and persistence. Future Microbiol. 2010;5:1269–88. doi:10.2217/fmb.10.93. PMID:20722603
   PubMed Web of Science ®Google Scholar
• Rohatgi S, Pirofski LA. Molecular characterization of the early B cell response to pulmonary Cryptococcus neoformans infection. J Immunol. 2012;189:5820–30. doi:10.4049/jimmunol.1201514. PMID:23175699
   PubMed Web of Science ®Google Scholar
• Subramaniam KS, Datta K, Quintero E, Manix C, Marks MS, Pirofski LA. The absence of serum IgM enhances the susceptibility of mice to pulmonary challenge with Cryptococcus neoformans. J Immunol. 2010;184:5755–67. doi:10.4049/jimmunol.0901638. PMID:20404271
   PubMed Web of Science ®Google Scholar
• Szymczak WA, Davis MJ, Lundy SK, Dufaud C, Olszewski M, Pirofski LA. X-linked immunodeficient mice exhibit enhanced susceptibility to Cryptococcus neoformans Infection. MBio. 2013;4. PMID:23820392
   PubMed Web of Science ®Google Scholar
• Chen GH, McNamara DA, Hernandez Y, Huffnagle GB, Toews GB, Olszewski MA. Inheritance of immune polarization patterns is linked to resistance versus susceptibility to Cryptococcus neoformans in a mouse model. Infect Immun. 2008;76:2379–91. doi:10.1128/IAI.01143-07. PMID:18391002
   PubMed Web of Science ®Google Scholar
• Weber GF, Chousterman BG, Hilgendorf I, Robbins CS, Theurl I, Gerhardt LM, Iwamoto Y, Quach TD, Ali M, Chen JW, et al. Pleural innate response activator B cells protect against pneumonia via a GM-CSF-IgM axis. J Exp Med. 2014;211:1243–56. doi:10.1084/jem.20131471. PMID:24821911
   PubMed Web of Science ®Google Scholar
• Messina JA, Maziarz EK, Spec A, Kontoyiannis DP, Perfect JR. Disseminated Cryptococcosis With Brain Involvement in Patients With Chronic Lymphoid Malignancies on Ibrutinib. Open Forum Infect Dis. 2017;4:ofw261. PMID:28480254
   PubMed Web of Science ®Google Scholar
• Lionakis MS, Dunleavy K, Roschewski M, Widemann BC, Butman JA, Schmitz R, Yang Y, Cole DE, Melani C, Higham CS, et al. Inhibition of B Cell Receptor Signaling by Ibrutinib in Primary CNS Lymphoma. Cancer Cell. 2017;31:833–43 e5.
   Web of Science ®Google Scholar
• Hoffman W, Lakkis FG, Chalasani G. B Cells, Antibodies, and More. Clin J Am Soc Nephrol. 2016;11:137–54. doi:10.2215/CJN.09430915. PMID:26700440
   PubMed Web of Science ®Google Scholar
• Parra D, Rieger AM, Li J, Zhang YA, Randall LM, Hunter CA, Barreda DR, Sunyer JO. Pivotal advance: peritoneal cavity B-1 B cells have phagocytic and microbicidal capacities and present phagocytosed antigen to CD4+ T cells. J Leukoc Biol. 2012;91:525–36. doi:10.1189/jlb.0711372. PMID:22058420
   PubMed Web of Science ®Google Scholar
• Popi AF, Longo-Maugeri IM, Mariano M. An Overview of B-1 Cells as Antigen-Presenting Cells. Front Immunol. 2016;7:138. PMID:27148259
   PubMed Web of Science ®Google Scholar
• Osterholzer JJ, Chen GH, Olszewski MA, Zhang YM, Curtis JL, Huffnagle GB, Toews GB. Chemokine receptor 2-mediated accumulation of fungicidal exudate macrophages in mice that clear cryptococcal lung infection. Am J Pathol. 2011;178:198–211. doi:10.1016/j.ajpath.2010.11.006. PMID:21224057
   PubMed Web of Science ®Google Scholar
• Feldmesser M, Kress Y, Novikoff P, Casadevall A. Cryptococcus neoformans is a facultative intracellular pathogen in murine pulmonary infection. Infect Immun. 2000;68:4225–37. doi:10.1128/IAI.68.7.4225-4237.2000. PMID:10858240
   PubMed Web of Science ®Google Scholar
• Santiago-Tirado FH, Onken MD, Cooper JA, Klein RS, Doering TL. Trojan Horse Transit Contributes to Blood-Brain Barrier Crossing of a Eukaryotic Pathogen. MBio. 2017;8.
   PubMed Web of Science ®Google Scholar
• Ngamskulrungroj P, Chang Y, Sionov E, Kwon-Chung KJ. The primary target organ of Cryptococcus gattii is different from that of Cryptococcus neoformans in a murine model. MBio. 2012;3. PMID:22570277
   PubMed Web of Science ®Google Scholar