Leptospira interrogans outer membrane protein LipL21 is a potent inhibitor of neutrophil myeloperoxidase

References

• Faine S, Adler B, Bolin C, et al. Leptospira and Leptospirosis. Melbourne, Australia: MediSci; 1999. p. 259.
   Google Scholar
• Plank R, Dean D. Overview of the epidemiology, microbiology, and pathogenesis of Leptospira spp. in humans. Microbes Infect. 2000;2:1265–76. doi:10.1016/S1286-4579(00)01280-6.
   PubMed Web of Science ®Google Scholar
• Levett PN. Leptospirosis. Clin Microbiol Rev. 2001;14:296–326. doi:10.1128/CMR.14.2.296-326.2001.
   PubMed Web of Science ®Google Scholar
• Vinetz JM. Leptospirosis. Current opinion in infectious diseases. 2001;14:527–38. doi:10.1097/00001432-200110000-00005.
   PubMed Web of Science ®Google Scholar
• Toyokawa T, Ohnishi M, Koizumi N. Diagnosis of acute leptospirosis. Expert Rev Anti Infect Ther. 2011;9:111–21. doi:10.1586/eri.10.151.
   PubMed Web of Science ®Google Scholar
• Burg ND, Pillinger MH. The neutrophil: function and regulation in innate and humoral immunity. Clin Immunol. 2001;99:7–17. doi:10.1006/clim.2001.5007.
   PubMed Web of Science ®Google Scholar
• Crockett-Torabi E. Selectins and mechanisms of signal transduction. Journal of leukocyte biology. 1998;63:1–14.
   PubMed Web of Science ®Google Scholar
• Ley K. Integration of inflammatory signals by rolling neutrophils. Immunol Rev. 2002;186:8–18. doi:10.1034/j.1600-065X.2002.18602.x.
   PubMed Web of Science ®Google Scholar
• Wahl SM, Feldman GM, McCarthy JB. Regulation of leukocyte adhesion and signaling in inflammation and disease. Journal of leukocyte biology. 1996;59:789–96.
   PubMed Web of Science ®Google Scholar
• Sheshachalam A, Srivastava N, Mitchell T, Lacy P, Eitzen G. Granule protein processing and regulated secretion in neutrophils. Front Immunol. 2014;5:448. doi:10.3389/fimmu.2014.00448.
   PubMed Web of Science ®Google Scholar
• Hampton MB, Kettle AJ, Winterbourn CC. Inside the neutrophil phagosome: oxidants, myeloperoxidase, and bacterial killing. Blood. 1998;92:3007–17.
   PubMed Web of Science ®Google Scholar
• Ravnsborg T, Houen G, Hojrup P. The glycosylation of myeloperoxidase. Biochim Biophys Acta. 2010;1804:2046–53. doi:10.1016/j.bbapap.2010.07.001.
   PubMed Web of Science ®Google Scholar
• Van Antwerpen P, Slomianny MC, Boudjeltia KZ, et al. Glycosylation pattern of mature dimeric leukocyte and recombinant monomeric myeloperoxidase: glycosylation is required for optimal enzymatic activity. J Biol Chem. 2010;285:16351–9. doi:10.1074/jbc.M109.089748.
   PubMed Web of Science ®Google Scholar
• Segal AW. How neutrophils kill microbes. Annu Rev Immunol. 2005;23:197–223. doi:10.1146/annurev.immunol.23.021704.115653.
   PubMed Web of Science ®Google Scholar
• Klebanoff SJ. Myeloperoxidase: friend and foe. J Leukoc Biol. 2005;77:598–625. doi:10.1189/jlb.1204697.
   PubMed Web of Science ®Google Scholar
• Arnhold J, Flemmig J. Human myeloperoxidase in innate and acquired immunity. Arch Biochem Biophys. 2010;500:92–106. doi:10.1016/j.abb.2010.04.008.
   PubMed Web of Science ®Google Scholar
• Nicholls SJ, Hazen SL. Myeloperoxidase, modified lipoproteins, and atherogenesis. J Lipid Res. 2009;50 Suppl:S346–51. doi:10.1194/jlr.R800086-JLR200.
   PubMed Web of Science ®Google Scholar
• Murgia R, Garcia R, Cinco M. Leptospires are killed in vitro by both oxygen-dependent and -independent reactions. Infect Immun. 2002;70:7172–5. doi:10.1128/IAI.70.12.7172-7175.2002.
   PubMed Web of Science ®Google Scholar
• Wang B, Sullivan J, Sullivan GW, Mandell GL. Interaction of leptospires with human polymorphonuclear neutrophils. Infect Immun. 1984;44:459–64.
   PubMed Web of Science ®Google Scholar
• Wang B, Sullivan JA, Sullivan GW, Mandell GL. Role of specific antibody in interaction of leptospires with human monocytes and monocyte-derived macrophages. Infect Immun. 1984;46:809–13.
   PubMed Web of Science ®Google Scholar
• Cunningham TM, Walker EM, Miller JN, et al. Selective release of the Treponema pallidum outer membrane and associated polypeptides with Triton X-114. J Bacteriol. 1988;170:5789–96. doi:10.1128/jb.170.12.5789-5796.1988.
   PubMed Web of Science ®Google Scholar
• Ramos CR, Abreu PA, Nascimento AL, et al. A high-copy T7 Escherichia coli expression vector for the production of recombinant proteins with a minimal N-terminal His-tagged fusion peptide. Braz J Med Biol Res. 2004;37:1103–9. doi:10.1590/S0100-879X2004000800001.
   PubMed Web of Science ®Google Scholar
• Vieira ML, Pimenta DC, de Morais ZM, et al. Proteome analysis of Leptospira interrogans virulent strain. Open Microbiol J. 2009;3:69–74. doi:10.2174/1874285800903010069.
   PubMedGoogle Scholar
• Nauseef WM, Volpp BD, McCormick S, et al. Assembly of the neutrophil respiratory burst oxidase. Protein kinase C promotes cytoskeletal and membrane association of cytosolic oxidase components. J Biol Chem. 1991;266:5911–7.
   PubMed Web of Science ®Google Scholar
• Singh V, Yeoh BS, Xiao X, et al. Interplay between enterobactin, myeloperoxidase and lipocalin 2 regulates E. coli survival in the inflamed gut. Nat Commun. 2015;6:7113. doi:10.1038/ncomms8113.
   PubMed Web of Science ®Google Scholar
• Louvel H, Bommezzadri S, Zidane N, et al. Comparative and functional genomic analyses of iron transport and regulation in Leptospira spp. J Bacteriol. 2006;188:7893–904. doi:10.1128/JB.00711-06.
   PubMed Web of Science ®Google Scholar
• Sritharan M, Asuthkar S, Sridhar V. Understanding iron acquisition by pathogenic leptospires: a review. Indian J Med Microbiol. 2006;24:311–6. doi:10.4103/0255-0857.29406.
   PubMedGoogle Scholar
• Matsunaga J, Young TA, Barnett JK, et al. Novel 45-kilodalton leptospiral protein that is processed to a 31-kilodalton growth-phase-regulated peripheral membrane protein. Infect Immun. 2002;70:323–34. doi:10.1128/IAI.70.1.323-334.2002.
   PubMed Web of Science ®Google Scholar
• Cullen PA, Haake DA, Bulach DM, et al. LipL21 is a novel surface-exposed lipoprotein of pathogenic Leptospira species. Infect Immun. 2003;71:2414–21. doi:10.1128/IAI.71.5.2414-2421.2003.
   PubMed Web of Science ®Google Scholar
• Cullen PA, Xu X, Matsunaga J, et al. Surfaceome of Leptospira spp. Infect Immun. 2005;73:4853–63. doi:10.1128/IAI.73.8.4853-4863.2005.
   PubMed Web of Science ®Google Scholar
• Vieira ML, de Morais ZM, Goncales AP, et al. Lsa63, a newly identified surface protein of Leptospira interrogans binds laminin and collagen IV. J Infect. 2010;60:52–64. doi:10.1016/j.jinf.2009.10.047.
   PubMed Web of Science ®Google Scholar
• Hyslop PA, Hinshaw DB, Scraufstatter IU, et al. Hydrogen peroxide as a potent bacteriostatic antibiotic: implications for host defense. Free Radic Biol Med. 1995;19:31–7. doi:10.1016/0891-5849(95)00005-I.
   PubMed Web of Science ®Google Scholar
• Klebanoff SJ. Myeloperoxidase: Contribution to the microbicidal activity of intact leukocytes. Science. 1970;169:1095–7. doi:10.1126/science.169.3950.1095.
   PubMed Web of Science ®Google Scholar
• Klebanoff SJ. Myeloperoxidase-halide-hydrogen peroxide antibacterial system. J Bacteriol. 1968;95:2131–8.
   PubMed Web of Science ®Google Scholar
• Nascimento AL, Verjovski-Almeida S, Van Sluys MA, et al. Genome features of Leptospira interrogans serovar Copenhageni. Braz J Med Biol Res. 2004;37:459–77. doi:10.1590/S0100-879X2004000400003.
   PubMed Web of Science ®Google Scholar
• Stewart PE, Carroll JA, Dorward DW, et al. Characterization of the Bat proteins in the oxidative stress response of Leptospira biflexa. BMC Microbiol. 2012;12:290. doi:10.1186/1471-2180-12-290.
   PubMed Web of Science ®Google Scholar
• Picardeau M. Virulence of the zoonotic agent of leptospirosis: still terra incognita? Nat Rev Microbiol. 2017;15:297–307. doi:10.1038/nrmicro.2017.5.
   PubMed Web of Science ®Google Scholar
• Eshghi A, Lourdault K, Murray GL, et al. Leptospira interrogans catalase is required for resistance to H2O2 and for virulence. Infect Immun. 2012;80:3892–9. doi:10.1128/IAI.00466-12.
   PubMed Web of Science ®Google Scholar
• Malmstrom J, Beck M, Schmidt A, et al. Proteome-wide cellular protein concentrations of the human pathogen Leptospira interrogans. Nature. 2009;460:762–5. doi:10.1038/nature08184.
   PubMed Web of Science ®Google Scholar
• Nally JE, Whitelegge JP, Bassilian S, et al. Characterization of the outer membrane proteome of Leptospira interrogans expressed during acute lethal infection. Infect Immun. 2007;75:766–73. doi:10.1128/IAI.00741-06.
   PubMed Web of Science ®Google Scholar
• Craig SB, Collet TA, Wynwood SJ, et al. Neutrophil counts in leptospirosis patients infected with different serovars. Trop Biomed. 2013;30:579–83.
   PubMed Web of Science ®Google Scholar
• Craig SB, Graham GC, Burns MA, et al. Haematological and clinical-chemistry markers in patients presenting with leptospirosis: A comparison of the findings from uncomplicated cases with those seen in the severe disease. Ann Trop Med Parasitol. 2009;103:333–41. doi:10.1179/136485909X435058.
   PubMed Web of Science ®Google Scholar
• Araujo AM, Reis EA, Athanazio DA, et al. Oxidative stress markers correlate with renal dysfunction and thrombocytopenia in severe leptospirosis. Am J Trop Med Hyg. 2014;90:719–23. doi:10.4269/ajtmh.13-0667.
   PubMed Web of Science ®Google Scholar
• Scharrig E, Carestia A, Ferrer MF, et al. Neutrophil Extracellular Traps are Involved in the Innate Immune Response to Infection with Leptospira. PLoS Negl Trop Dis. 2015;9:e0003927. doi:10.1371/journal.pntd.0003927.
   PubMed Web of Science ®Google Scholar
• Chen X, Li SJ, Ojcius DM, et al. Mononuclear-macrophages but not neutrophils act as major infiltrating anti-leptospiral phagocytes during leptospirosis. PLoS One. 2017;12:e0181014. doi:10.1371/journal.pone.0181014.
   PubMed Web of Science ®Google Scholar