1,170
Views
1
CrossRef citations to date
0
Altmetric
Editorial

Emerging roles of inositol pyrophosphates as key modulators of fungal pathogenicity

Pages 563-565 | Received 29 Nov 2017, Accepted 30 Nov 2017, Published online: 27 Feb 2018

References

  • Wundenberg T, Mayr GW. Synthesis and biological actions of diphosphoinositol phosphates (inositol pyrophosphates), regulators of cell homeostasis. Biol Chem. 2012;393:979–98. doi:10.1515/hsz-2012-0133
  • Thota SG, Unnikannan CP, Thampatty SR, et al. Inositol pyrophosphates regulate RNA polymerase I-mediated rRNA transcription in Saccharomyces cerevisiae. Biochem J. 2015;466:105–14. doi:10.1042/BJ20140798
  • Dubois E, Scherens B, Vierendeels F, et al. In Saccharomyces cerevisiae, the inositol polyphosphate kinase activity of Kcs1p is required for resistance to salt stress, cell wall integrity, and vacuolar morphogenesis. J Biol Chem. 2002;277:23755–63. doi:10.1074/jbc.M202206200
  • Saiardi A, Sciambi C, McCaffery JM, et al. Inositol pyrophosphates regulate endocytic trafficking. Proc Natl Acad Sci USA. 2002;99:14206–11. doi:10.1073/pnas.212527899
  • Saiardi A, Bhandari R, Resnick AC, et al. Phosphorylation of proteins by inositol pyrophosphates. Science. 2004;306:2101–5. doi:10.1126/science.1103344
  • Onnebo SM, Saiardi A. Inositol pyrophosphates modulate hydrogen peroxide signalling. Biochem J. 2009;423:109–118. doi:10.1042/BJ20090241
  • Worley J, Luo X, Capaldi AP. Inositol pyrophosphates regulate cell growth and the environmental stress response by activating the HDAC Rpd3L. Cell Rep. 2013;3:1476–82. doi:10.1016/j.celrep.2013.03.043
  • Park BJ, Wannemuehler KA, Marston BJ, et al. Estimation of the current global burden of cryptococcal meningitis among persons living with HIV/AIDS. Aids. 2009;23:525–530. doi:10.1097/QAD.0b013e328322ffac
  • Rajasingham R, Smith RM, Park BJ, et al. Global burden of disease of HIV-associated cryptococcal meningitis: an updated analysis. Lancet Infect Dis. 2017;17:873–81. doi:10.1016/S1473-3099(17)30243-8
  • Lev S, Desmarini D, Li C, et al. Phospholipase C of Cryptococcus neoformans regulates homeostasis and virulence by providing inositol trisphosphate as a substrate for Arg1 kinase. Infect Immun. 2013;81:1245–55. doi:10.1128/IAI.01421-12
  • Lev S, Li C, Desmarini D, et al. Fungal inositol pyrophosphate IP7 is crucial for metabolic adaptation to the host environment and pathogenicity. MBio. 2015;6:e00531–00515. doi:10.1128/mBio.00531-15
  • Li C, Lev S, Saiardi A, et al. Identification of a major IP5 kinase in Cryptococcus neoformans confirms that PP-IP5/IP7, not IP6, is essential for virulence. Sci Rep. 2016;6:23927. doi:10.1038/srep23927
  • Li C, Lev S, Desmarini D, et al. IP3-4 kinase Arg1 regulates cell wall homeostasis and surface architecture to promote clearance of Cryptococcus neoformans infection in a mouse model. Virulence. 2017;8:1833–48. doi: 10.1080/21505594.2017.1385692
  • Kozubowski L, Lee SC, Heitman J. Signalling pathways in the pathogenesis of Cryptococcus. Cell Microbiol. 2009;11:370–80. doi:10.1111/j.1462-5822.2008.01273.x
  • Cordeiro CD, Saiardi A, Docampo R. The inositol pyrophosphate synthesis pathway in Trypanosoma brucei is linked to polyphosphate synthesis in acidocalcisomes. Mol Microbiol. 2017;106:319–33. doi:10.1111/mmi.13766
  • Saiardi A, Azevedo C, Desfougères Y, et al. Microbial inositol polyphosphate metabolic pathway as drug development target. Adv Biol Regul. 2017;S2212-4926:30154–9