Modulatory upregulation of an insulin peptide gene by different pathogens in C. elegans

References

• Shivers RP, Youngman MJ, Kim DH. Transcriptional responses to pathogens in Caenorhabditis elegans. Curr Opin Microbiol. 2008;11:251–6. doi:10.1016/j.mib.2008.05.014
   PubMed Web of Science ®Google Scholar
• Kim DH, Ewbank JJ. Signaling in the innate immune response. In: ed The C. elegans Research Community, ed. WormBook. http://www.wormbook.org, 2015:1–51.
   Google Scholar
• Wong D, Bazopoulou D, Pujol N, et al. Genome-wide investigation reveals pathogen-specific and shared signatures in the response of Caenorhabditis elegans to infection. Genome Biol. 2007;8:R194. doi:10.1186/gb-2007-8-9-r194
   PubMed Web of Science ®Google Scholar
• Engelmann I, Griffon A, Tichit L, et al. A comprehensive analysis of gene expression changes provoked by bacterial and fungal infection in C. elegans PLoS One. 2011;6:e19055. doi:10.1371/journal.pone.0019055
   PubMed Web of Science ®Google Scholar
• Ewbank JJ, Pujol N. Local and long-range activation of innate immunity by infection and damage in C. elegans Curr Opin Immunol. 2016;38:1–7. doi:10.1016/j.coi.2015.09.005
   PubMed Web of Science ®Google Scholar
• Chikka MR, Anbalagan C, Dvorak K, et al. The Mitochondria-Regulated Immune Pathway Activated in the C. elegans Intestine Is Neuroprotective. Cell Rep. 2016;16:2399–414. doi:10.1016/j.celrep.2016.07.077
   PubMed Web of Science ®Google Scholar
• Zugasti O, Thakur N, Belougne J, et al. A quantitative genome-wide RNAi screen in C. elegans for antifungal innate immunity genes. BMC Biol. 2016;14:35. doi:10.1186/s12915-016-0256-3
   PubMed Web of Science ®Google Scholar
• E. LZ, T., Koh, S., Chuang, M., et al. An antimicrobial peptide and its neuronal receptor regulate dendrite degeneration in aging and infection. Neuron. 2018; 97:125–38. doi:10.1016/j.neuron.2017.12.001. PMID: 29301098.
   PubMed Web of Science ®Google Scholar
• Murphy CT, Hu PJ. Insulin/insulin-like growth factor signaling in C. elegans. In: Community The C. elegans Research Community, ed. WormBook, 2013:1–43.
   Google Scholar
• Tullet JM. DAF-16 target identification in C. elegans: past, present and future. Biogerontology. 2015;16:221–34. doi:10.1007/s10522-014-9527-y
   PubMed Web of Science ®Google Scholar
• Kawli T, Tan MW. Neuroendocrine signals modulate the innate immunity of Caenorhabditis elegans through insulin signaling. Nat Immunol. 2008;9:1415–24. doi:10.1038/ni.1672
   PubMed Web of Science ®Google Scholar
• Evans EA, Kawli T, Tan MW. Pseudomonas aeruginosa suppresses host immunity by activating the DAF-2 insulin-like signaling pathway in Caenorhabditis elegans. PLoS Pathog. 2008;4:e1000175. doi:10.1371/journal.ppat.1000175
   PubMed Web of Science ®Google Scholar
• Lee K, Mylonakis E. An Intestine-Derived Neuropeptide Controls Avoidance Behavior in Caenorhabditis elegans. Cell reports. 2017;20:2501–12. doi:10.1016/j.celrep.2017.08.053
   PubMed Web of Science ®Google Scholar
• Yang W, Dierking K, Esser D, et al. Overlapping and unique signatures in the proteomic and transcriptomic responses of the nematode Caenorhabditis elegans toward pathogenic Bacillus thuringiensis. Dev Comp Immunol. 2015;51:1–9. doi:10.1016/j.dci.2015.02.010
   PubMed Web of Science ®Google Scholar
• Shapira M, Hamlin BJ, Rong J, et al. A conserved role for a GATA transcription factor in regulating epithelial innate immune responses. Proc Natl Acad Sci U S A. 2006;103:14086–91. doi:10.1073/pnas.0603424103
   PubMed Web of Science ®Google Scholar
• Troemel ER, Chu SW, Reinke V, et al. p38 MAPK regulates expression of immune response genes and contributes to longevity in C. elegans. PLoS Genet. 2006;2:e183. doi:10.1371/journal.pgen.0020183
   PubMed Web of Science ®Google Scholar
• Visvikis O, Ihuegbu N, Labed SA, et al. Innate Host Defense Requires TFEB-Mediated Transcription of Cytoprotective and Antimicrobial Genes. Immunity. 2014;40:896–909. doi:10.1016/j.immuni.2014.05.002
   PubMed Web of Science ®Google Scholar
• Bakowski MA, Desjardins CA, Smelkinson MG, et al. Ubiquitin-mediated response to microsporidia and virus infection in C. elegans. PLoS Pathog. 2014;10:e1004200. doi:10.1371/journal.ppat.1004200
   PubMed Web of Science ®Google Scholar
• Pierce SB, Costa M, Wisotzkey R, et al. Regulation of DAF-2 receptor signaling by human insulin and ins-1, a member of the unusually large and diverse C. elegans insulin gene family. Genes Dev. 2001;15:672–86. doi:10.1101/gad.867301
   PubMed Web of Science ®Google Scholar
• Ritter AD, Shen Y, Fuxman Bass J, et al. Complex expression dynamics and robustness in C. elegans insulin networks. Genome Res. 2013;23:954–65.
   PubMed Web of Science ®Google Scholar
• Couillault C, Pujol N, Reboul J, et al. TLR-independent control of innate immunity in Caenorhabditis elegans by the TIR domain adaptor protein TIR-1, an ortholog of human SARM. Nat Immunol. 2004;5:488–94. doi:10.1038/ni1060
   PubMed Web of Science ®Google Scholar
• Labed SA, Omi S, Gut M, et al. The pseudokinase NIPI-4 is a novel regulator of antimicrobial peptide gene expression. PLoS One. 2012;7:e33887. doi:10.1371/journal.pone.0033887
   PubMed Web of Science ®Google Scholar
• Ziegler K, Kurz CL, Cypowyj S, et al. Antifungal innate immunity in C. elegans: PKCdelta links G protein signaling and a conserved p38 MAPK cascade. Cell Host Microbe. 2009;5:341–52. doi:10.1016/j.chom.2009.03.006
   PubMed Web of Science ®Google Scholar
• Dierking K, Polanowska J, Omi S, et al. Unusual regulation of a STAT protein by an SLC6 family transporter in C. elegans epidermal innate immunity. Cell Host Microbe. 2011;9:425–35. doi:10.1016/j.chom.2011.04.011
   PubMed Web of Science ®Google Scholar
• Arbibe L, Kim DW, Batsche E, et al. An injected bacterial effector targets chromatin access for transcription factor NF-kappaB to alter transcription of host genes involved in immune responses. Nat Immunol. 2007;8:47–56. doi:10.1038/ni1423
   PubMed Web of Science ®Google Scholar
• Nicholas HR, Hodgkin J. The ERK MAP kinase cascade mediates tail swelling and a protective response to rectal infection in C. elegans. Curr Biol. 2004;14:1256–61. doi:10.1016/j.cub.2004.07.022
   PubMed Web of Science ®Google Scholar
• Irazoqui JE, Troemel ER, Feinbaum RL, et al. Distinct pathogenesis and host responses during infection of C. elegans by P. aeruginosa and S. aureus. PLoS Pathog. 2010;6:e1000982. doi:10.1371/journal.ppat.1000982
   PubMed Web of Science ®Google Scholar
• Zugasti O, Ewbank JJ. Neuroimmune regulation of antimicrobial peptide expression by a noncanonical TGF-beta signaling pathway in Caenorhabditis elegans epidermis. Nat Immunol. 2009;10:249–56. doi:10.1038/ni.1700
   PubMed Web of Science ®Google Scholar
• Pujol N, Cypowyj S, Ziegler K, et al. Distinct innate immune responses to infection and wounding in the C. elegans epidermis. Curr Biol. 2008;18:481–9. doi:10.1016/j.cub.2008.02.079
   PubMed Web of Science ®Google Scholar
• Zou CG, Tu Q, Niu J, et al. The DAF-16/FOXO transcription factor functions as a regulator of epidermal innate immunity. PLoS Pathog. 2013;9:e1003660. doi:10.1371/journal.ppat.1003660
   PubMed Web of Science ®Google Scholar
• Jansson HB. Adhesion of conidia of Drechmeria coniospora to Caenorhabditis elegans wild typemutants. J Nematol. 1994;26:430–5.
   PubMed Web of Science ®Google Scholar
• Henderson ST, Johnson TE. daf-16 integrates developmental and environmental inputs to mediate aging in the nematode Caenorhabditis elegans. Curr Biol. 2001;11:1975–80. doi:10.1016/S0960-9822(01)00594-2
   PubMed Web of Science ®Google Scholar
• Patel DS, Garza-Garcia A, Nanji M, et al. Clustering of genetically defined allele classes in the Caenorhabditis elegans DAF-2 insulin/IGF-1 receptor. Genetics. 2008;178:931–46. doi:10.1534/genetics.107.070813
   PubMed Web of Science ®Google Scholar
• Ewald CY, Landis JN, Porter Abate J, et al. Dauer-independent insulin/IGF-1-signalling implicates collagen remodelling in longevity. Nature. 2015;519:97–101. doi:10.1038/nature14021
   PubMed Web of Science ®Google Scholar
• Rouger V, Bordet G, Couillault C, et al. Independent Synchronized Control and Visualization of Interactions between Living Cells and Organisms. Biophys J. 2014;106:2096–104. doi:10.1016/j.bpj.2014.03.044
   PubMed Web of Science ®Google Scholar
• Pujol N, Davis PA, Ewbank JJ. The Origin and Function of Anti-Fungal Peptides in C. elegans: Open Questions. Front Immunol. 2012;3:237. doi:10.3389/fimmu.2012.00237
   PubMed Web of Science ®Google Scholar
• Ward JD, Mullaney B, Schiller BJ, et al. Defects in the C. elegans acyl-CoA Synthase, acs-3, and Nuclear Hormone Receptor, nhr-25, Cause Sensitivity to Distinct, but Overlapping Stresses. PLoS One. 2014;9:e92552. doi:10.1371/journal.pone.0092552
   PubMed Web of Science ®Google Scholar
• Ding W, Smulan LJ, Hou NS, et al. s-Adenosylmethionine Levels Govern Innate Immunity through Distinct Methylation-Dependent Pathways. Cell Metab. 2015;22:633–45. doi:10.1016/j.cmet.2015.07.013
   PubMed Web of Science ®Google Scholar
• Tong A, Lynn G, Ngo V, et al. Negative regulation of Caenorhabditis elegans epidermal damage responses by death-associated protein kinase. Proc Natl Acad Sci U S A. 2009;106:1457–61. doi:10.1073/pnas.0809339106
   PubMed Web of Science ®Google Scholar
• Lee SH, Wong RR, Chin CY, et al. Burkholderia pseudomallei suppresses Caenorhabditis elegans immunity by specific degradation of a GATA transcription factor. P Natl Acad Sci USA. 2013;110:15067–72. doi:10.1073/pnas.1311725110
   PubMed Web of Science ®Google Scholar
• Rohlfing AK, Miteva Y, Hannenhalli S, et al. Genetic and physiological activation of osmosensitive gene expression mimics transcriptional signatures of pathogen infection in C. elegans. PLoS One. 2010;5:e9010. doi:10.1371/journal.pone.0009010
   PubMed Web of Science ®Google Scholar
• Spencer WC, Zeller G, Watson JD, et al. A spatial and temporal map of C. elegans gene expression. Genome Res. 2011;21:325–41. doi:10.1101/gr.114595.110
   PubMed Web of Science ®Google Scholar
• Lebrigand K, He LD, Thakur N, et al. Comparative Genomic Analysis of Drechmeria coniospora Reveals Core and Specific Genetic Requirements for Fungal Endoparasitism of Nematodes. PLoS Genet. 2016;12:e1006017. doi:10.1371/journal.pgen.1006017
   PubMed Web of Science ®Google Scholar
• Cao J, Packer JS, Ramani V, et al. Comprehensive single-cell transcriptional profiling of a multicellular organism. Science. 2017;357:661–7. doi:10.1126/science.aam8940
   PubMed Web of Science ®Google Scholar
• Pukkila-Worley R, Feinbaum RL, McEwan DL, et al. The Evolutionarily Conserved Mediator Subunit MDT-15/MED15 Links Protective Innate Immune Responses and Xenobiotic Detoxification. PLoS Pathog. 2014;10:e1004143. doi:10.1371/journal.ppat.1004143
   PubMed Web of Science ®Google Scholar
• Bolz DD, Tenor JL, Aballay A. A conserved PMK-1/p38 MAPK is required in Caenorhabditis elegans tissue-specific immune response to Yersinia pestis infection. J Biol Chem. 2010;285:10832–40. doi:10.1074/jbc.M109.091629
   PubMed Web of Science ®Google Scholar
• Hattori A, Mizuno T, Akamatsu M, et al. The Caenorhabditis elegans JNK signaling pathway activates expression of stress response genes by derepressing the Fos/HDAC repressor complex. PLoS Genet. 2013;9:e1003315. doi:10.1371/journal.pgen.1003315
   PubMed Web of Science ®Google Scholar
• Pukkila-Worley R, Feinbaum R, Kirienko NV, et al. Stimulation of host immune defenses by a small molecule protects C. elegans from bacterial infection. PLoS Genet. 2012;8:e1002733. doi:10.1371/journal.pgen.1002733
   PubMed Web of Science ®Google Scholar
• Mallo GV, Kurz CL, Couillault C, et al. Inducible antibacterial defense system in C. elegans. Curr Biol. 2002;12:1209–14. doi:10.1016/S0960-9822(02)00928-4
   PubMed Web of Science ®Google Scholar
• Marsh EK, van den Berg MC, May RC. A two-gene balance regulates Salmonella typhimurium tolerance in the nematode Caenorhabditis elegans. PLoS One. 2011;6:e16839. doi:10.1371/journal.pone.0016839
   PubMed Web of Science ®Google Scholar
• Pukkila-Worley R, Ausubel FM. Immune defense mechanisms in the Caenorhabditis elegans intestinal epithelium. Curr Opin Immunol. 2012;24:3–9. doi:10.1016/j.coi.2011.10.004
   PubMed Web of Science ®Google Scholar
• Kawano T, Nagatomo R, Kimura Y, et al. Disruption of ins-11, a Caenorhabditis elegans insulin-like gene, and phenotypic analyses of the gene-disrupted animal. Biosci Biotechnol Biochem. 2006;70:3084–7. doi:10.1271/bbb.60472
   PubMed Web of Science ®Google Scholar
• Maures TJ, Booth LN, Benayoun BA, et al. Males shorten the life span of C. elegans hermaphrodites via secreted compounds. Science. 2014;343:541–4. doi:10.1126/science.1244160
   PubMed Web of Science ®Google Scholar
• Boone E, Colombani J, Andersen DS, et al. The Hippo signalling pathway coordinates organ growth and limits developmental variability by controlling dilp8 expression. Nat Commun. 2016;7:13505. doi:10.1038/ncomms13505
   PubMed Web of Science ®Google Scholar
• Pradel E, Zhang Y, Pujol N, et al. Detection and avoidance of a natural product from the pathogenic bacterium Serratia marcescens by Caenorhabditis elegans. Proc Natl Acad Sci U S A. 2007;104:2295–300. doi:10.1073/pnas.0610281104
   PubMed Web of Science ®Google Scholar
• Stiernagle T. Maintenance of C. elegans. WormBook. http://www.wormbook.org: The C. elegans Research Community ed, 2006:1551–8507.
   Google Scholar
• Vallin E, Gallagher J, Granger L, et al. A Genome-Wide Collection of Mos1 Transposon Insertion Mutants for the C. elegans Research Community. PLoS One. 2012;7:e30482. doi:10.1371/journal.pone.0030482
   PubMed Web of Science ®Google Scholar
• Frokjaer-Jensen C, Davis MW, Hopkins CE, et al. Single-copy insertion of transgenes in Caenorhabditis elegans. Nat Genet. 2008;40:1375–83. doi:10.1038/ng.248
   PubMed Web of Science ®Google Scholar
• Dickinson DJ, Pani AM, Heppert JK, et al. Streamlined Genome Engineering with a Self-Excising Drug Selection Cassette. Genetics. 2015;200:1035–49. doi:10.1534/genetics.115.178335
   PubMed Web of Science ®Google Scholar
• Pujol N, Link EM, Liu LX, et al. A reverse genetic analysis of components of the Toll signalling pathway in Caenorhabditis elegans. Curr Biol. 2001;11:809–21. doi:10.1016/S0960-9822(01)00241-X
   PubMed Web of Science ®Google Scholar
• Pujol N, Zugasti O, Wong D, et al. Anti-fungal innate immunity in C. elegans is enhanced by evolutionary diversification of antimicrobial peptides. PLoS Pathog. 2008;4:e1000105. doi:10.1371/journal.ppat.1000105
   PubMed Web of Science ®Google Scholar
• Oliveros JC. Venny. An interactive tool for comparing lists with Venn's diagrams. http://bioinfogp.cnb.csic.es/tools/venny/index.html 2007;
   Google Scholar