Biguanides enhance antifungal activity against Candida glabrata

References

• Rodrigues CF, Silva S, Henriques M. Candida glabrata: a review of its features and resistance. Eur J Clin Microbiol. 2014 May;33(5):673–688. PubMed PMID: 24249283.
   Google Scholar
• Silva S, Henriques M, Hayes A, et al. Candida glabrata and Candida albicans co-infection of an in vitro oral epithelium. J Oral Pathol Med. 2011 May;40(5):421–427. PubMed PMID: 21158929.
   PubMed Web of Science ®Google Scholar
• Sardi JC, Scorzoni L, Bernardi T, et al. Candida species: current epidemiology, pathogenicity, biofilm formation, natural antifungal products and new therapeutic options. J Med Microbiol. 2013 Jan;62(Pt 1):10–24. PubMed PMID: 23180477.
   PubMed Web of Science ®Google Scholar
• Henry KW, Nickels JT, Edlind TD. Upregulation of ERG genes in Candida species by azoles and other sterol biosynthesis inhibitors. Antimicrob Agents Chemother. 2000 Oct;44(10):2693–2700. PubMed PMID: 10991846; PubMed Central PMCID: PMC90137.
   PubMed Web of Science ®Google Scholar
• Pfaller MA, Messer SA, Hollis RJ, et al. Variation in susceptibility of bloodstream isolates of Candida glabrata to fluconazole according to patient age and geographic location in the United States in 2001 to 2007. J Clin Microbiol. 2009 Oct;47(10):3185–3190. PubMed PMID: 19656983; PubMed Central PMCID: PMC2756923.
   PubMed Web of Science ®Google Scholar
• Fidel PL Jr., Vazquez JA, Sobel JD. Candida glabrata: review of epidemiology, pathogenesis, and clinical disease with comparison to C. albicans. Clin Microbiol Rev. 1999 Jan;12(1):80–96. PubMed PMID: 9880475; PubMed Central PMCID: PMC88907.
   PubMed Web of Science ®Google Scholar
• Masia Canuto M, Gutierrez Rodero F. Antifungal drug resistance to azoles and polyenes. Lancet Infect Dis. 2002 Sep;2(9):550–563. PubMed PMID: 12206971.
   PubMed Web of Science ®Google Scholar
• Pfaller MA, Diekema DJ. Epidemiology of invasive candidiasis: a persistent public health problem. Clin Microbiol Rev. 2007 Jan;20(1):133–163. PubMed PMID: 17223626; PubMed Central PMCID: PMC1797637.
   PubMed Web of Science ®Google Scholar
• Cross SA, Scott LJ. Micafungin: a review of its use in adults for the treatment of invasive and oesophageal candidiasis, and as prophylaxis against Candida infections. Drugs. 2008;68(15):2225–2255. PubMed PMID: 18840009.
   PubMed Web of Science ®Google Scholar
• Spreghini E, Orlando F, Sanguinetti M, et al. Comparative effects of micafungin, caspofungin, and anidulafungin against a difficult-to-treat fungal opportunistic pathogen, Candida glabrata. Antimicrob Agents Chemother. 2012 Mar;56(3):1215–1222. PubMed PMID: 22203604; PubMed Central PMCID: PMC3294882.
   PubMed Web of Science ®Google Scholar
• Alexander BD, Johnson MD, Pfeiffer CD, et al. Increasing echinocandin resistance in Candida glabrata: clinical failure correlates with presence of FKS mutations and elevated minimum inhibitory concentrations. Clin Infect Dis. 2013 Jun;56(12):1724–1732. PubMed PMID: 23487382; PubMed Central PMCID: PMC3658363.
   PubMed Web of Science ®Google Scholar
• Cruciani M, Serpelloni G. Management of Candida infections in the adult intensive care unit. Expert Opin Pharmacother. 2008 Feb;9(2):175–191. PubMed PMID: 18201143.
   PubMed Web of Science ®Google Scholar
• Horn DL, Neofytos D, Anaissie EJ, et al. Epidemiology and outcomes of candidemia in 2019 patients: data from the prospective antifungal therapy alliance registry. Clin Infect Dis. 2009 Jun 15;48(12):1695–1703. PubMed PMID: 19441981.
   PubMed Web of Science ®Google Scholar
• Kojic EM, Darouiche RO. Candida infections of medical devices. Clin Microbiol Rev. 2004 Apr;17(2):255–267. PubMed PMID: 15084500; PubMed Central PMCID: PMC387407.
   PubMed Web of Science ®Google Scholar
• Shoham S, Marr KA. Invasive fungal infections in solid organ transplant recipients. Future Microbiol. 2012 May;7(5):639–655. PubMed PMID: 22568718; PubMed Central PMCID: PMC4222063.
   PubMed Web of Science ®Google Scholar
• Bennett JE, Izumikawa K, Marr KA. Mechanism of increased fluconazole resistance in Candida glabrata during prophylaxis. Antimicrob Agents Chemother. 2004 May;48(5):1773–1777. PubMed PMID: 15105134; PubMed Central PMCID: PMC400565.
   PubMed Web of Science ®Google Scholar
• Biguanides SG. A review of history, pharmacodynamics and therapy. Diabete Metab. 1983 May-Jun;9(2):148–163. PubMed PMID: 6352352.
   PubMed Web of Science ®Google Scholar
• Romero R, Erez O, Huttemann M, et al. Metformin, the aspirin of the 21st century: its role in gestational diabetes mellitus, prevention of preeclampsia and cancer, and the promotion of longevity. Am J Obstet Gynecol. 2017 Sep;217(3):282–302. PubMed PMID: 28619690.
   PubMed Web of Science ®Google Scholar
• Strack T. Metformin: a review. Drugs Today. 2008 Apr;44(4):303–314. PubMed PMID: 18536788.
   PubMed Web of Science ®Google Scholar
• Bridges HR, Jones AJ, Pollak MN, et al. Effects of metformin and other biguanides on oxidative phosphorylation in mitochondria. Biochem J. 2014 Sep 15;462(3):475–487. PubMed PMID: 25017630; PubMed Central PMCID: PMC4148174.
   PubMed Web of Science ®Google Scholar
• Viollet B, Guigas B, Sanz Garcia N, et al. Cellular and molecular mechanisms of metformin: an overview. Clin Sci. 2012 Mar;122(6):253–270. PubMed PMID: 22117616; PubMed Central PMCID: PMC3398862.
   PubMed Web of Science ®Google Scholar
• Pryor R, Cabreiro F. Repurposing metformin: an old drug with new tricks in its binding pockets. Biochem J. 2015 Nov 1;471(3):307–322. PubMed PMID: 26475449; PubMed Central PMCID: PMC4613459.
   PubMed Web of Science ®Google Scholar
• Gong J, Kelekar G, Shen J, et al. The expanding role of metformin in cancer: an update on antitumor mechanisms and clinical development. Target Oncol. 2016 Aug;11(4):447–467. 10.1007/s11523-016-0423-z. PubMed PMID: 26864078.
   PubMed Web of Science ®Google Scholar
• Kasznicki J, Sliwinska A, Drzewoski J. Metformin in cancer prevention and therapy. Ann Transl Med. 2014 Jun;2(6):57. PubMed PMID: 25333032; PubMed Central PMCID: PMC4200668.
   PubMedGoogle Scholar
• Coyle C, Cafferty FH, Vale C, et al. Metformin as an adjuvant treatment for cancer: a systematic review and meta-analysis. Ann Oncol. 2016 Dec;27(12):2184–2195. PubMed PMID: 27681864; PubMed Central PMCID: PMC5178140.
   PubMed Web of Science ®Google Scholar
• Chiang GG, Abraham RT. Targeting the mTOR signaling network in cancer. Trends Mol Med. 2007 Oct;13(10):433–442. PubMed PMID: 17905659.
   PubMed Web of Science ®Google Scholar
• Wu L, Zhou B, Oshiro-Rapley N, et al. An ancient, unified mechanism for metformin growth inhibition in C. elegans and cancer. Cell. 2016 Dec 15;167(7):1705–1718 e13. PubMed PMID: 27984722; PubMed Central PMCID: PMC5390486.
   PubMed Web of Science ®Google Scholar
• Orhan G, Bayram A, Zer Y, et al. Synergy tests by E test and checkerboard methods of antimicrobial combinations against Brucella melitensis. J Clin Microbiol. 2005 Jan;43(1):140–143. PubMed PMID: 15634962; PubMed Central PMCID: PMC540140.
   PubMed Web of Science ®Google Scholar
• Meletiadis J, Pournaras S, Roilides E, et al. Defining fractional inhibitory concentration index cutoffs for additive interactions based on self-drug additive combinations, Monte Carlo simulation analysis, and in vitro-in vivo correlation data for antifungal drug combinations against Aspergillus fumigatus. Antimicrob Agents Chemother. 2010 Feb;54(2):602–609. PubMed PMID: 19995928; PubMed Central PMCID: PMC2812160.
   PubMed Web of Science ®Google Scholar
• Lalau JD, Lemaire-Hurtel AS, Lacroix C. Establishment of a database of metformin plasma concentrations and erythrocyte levels in normal and emergency situations. Clin Drug Investig. 2011;31(6):435–438. PubMed PMID: 21401215.
   PubMed Web of Science ®Google Scholar
• Kajbaf F, De Broe ME, Lalau JD. Therapeutic concentrations of metformin: a systematic review. Clin Pharmacokinet. 2016 Apr;55(4):439–459. PubMed PMID: 26330026.
   PubMed Web of Science ®Google Scholar
• He L, Wondisford FE. Metformin action: concentrations matter. Cell Metab. 2015 Feb 3;21(2):159–162. PubMed PMID: 25651170.
   PubMed Web of Science ®Google Scholar
• Chandel NS, Avizonis D, Reczek CR, et al. Are metformin doses used in murine cancer models clinically relevant? Cell Metab. 2016 Apr 12;23(4):569–570. PubMed PMID: 27076070.
   PubMed Web of Science ®Google Scholar
• Chien HC, Zur AA, Maurer TS, et al. Rapid method to determine intracellular drug concentrations in cellular uptake assays: application to metformin in organic cation transporter 1-transfected human embryonic kidney 293 cells. Drug Metab Dispos. 2016 Mar;44(3):356–364. PubMed PMID: 26700958.
   PubMed Web of Science ®Google Scholar
• Owen MR, Doran E, Halestrap AP. Evidence that metformin exerts its anti-diabetic effects through inhibition of complex 1 of the mitochondrial respiratory chain. Biochem J. 2000 Jun 15;348(Pt 3):607–614. PubMed PMID: 10839993; PubMed Central PMCID: PMC1221104.
   PubMed Web of Science ®Google Scholar
• Hinke SA, Martens GA, Cai Y, et al. Methyl succinate antagonises biguanide-induced AMPK-activation and death of pancreatic beta-cells through restoration of mitochondrial electron transfer. Br J Pharmacol. 2007 Apr;150(8):1031–1043. PubMed PMID: 17339833; PubMed Central PMCID: PMC2013909.
   PubMed Web of Science ®Google Scholar
• Goberdhan DC, Wilson C, Harris AL. Amino acid sensing by mTORC1: intracellular transporters mark the spot. Cell Metab. 2016 Apr 12;23(4):580–589. PubMed PMID: 27076075; PubMed Central PMCID: PMC5067300.
   PubMed Web of Science ®Google Scholar
• Dowling RJ, Topisirovic I, Fonseca BD, et al. Dissecting the role of mTOR: lessons from mTOR inhibitors. Biochim Biophys Acta. 2010 Mar;1804(3):433–439. PubMed PMID: 20005306.
   PubMed Web of Science ®Google Scholar
• Hur KY, Lee MS. New mechanisms of metformin action: focusing on mitochondria and the gut. J Diabetes Investig. 2015 Nov;6(6):600–609. PubMed PMID: 26543531; PubMed Central PMCID: PMC4627534.
   PubMed Web of Science ®Google Scholar
• Laplante M, Sabatini DM. mTOR signaling in growth control and disease. Cell. 2012 Apr 13;149(2):274–293. PubMed PMID: 22500797; PubMed Central PMCID: PMC3331679.
   PubMed Web of Science ®Google Scholar
• Bastidas RJ, Shertz CA, Lee SC, et al. Rapamycin exerts antifungal activity in vitro and in vivo against Mucor circinelloides via FKBP12-dependent inhibition of Tor. Eukaryot Cell. 2012 Mar;11(3):270–281. PubMed PMID: 22210828; PubMed Central PMCID: PMC3294450.
   PubMedGoogle Scholar
• Johnson LB, Kauffman CA. Voriconazole: a new triazole antifungal agent. Clin Infect Dis. 2003 Mar 01;36(5):630–637. PubMed PMID: 12594645.
   PubMed Web of Science ®Google Scholar
• Zervos M, Meunier F. Fluconazole (Diflucan): a review. Int J Antimicrob Agents. 1993;3(3):147–170. PubMed PMID: 18611557.
   PubMedGoogle Scholar
• Prasad R, Rawal MK. Efflux pump proteins in antifungal resistance. Front Pharmacol. 2014;5:202. PubMed PMID: 25221515; PubMed Central PMCID: PMC4148622.
   PubMed Web of Science ®Google Scholar
• Cannon RD, Lamping E, Holmes AR, et al. Efflux-mediated antifungal drug resistance. Clin Microbiol Rev. 2009 Apr;22(2):291–321. Table of Contents. PubMed PMID: 19366916; PubMed Central PMCID: PMC2668233.
   PubMed Web of Science ®Google Scholar
• Kaufmann SHE, Dorhoi A, Hotchkiss RS, et al. Host-directed therapies for bacterial and viral infections. Nat Rev Drug Discov. 2017 Sep 22;(17):35–56. PubMed PMID: 28935918.
   PubMed Web of Science ®Google Scholar
• Singhal A, Jie L, Kumar P, et al. Metformin as adjunct antituberculosis therapy. Sci Transl Med. 2014 Nov 19;6(263):263ra159. PubMed PMID: 25411472.
   PubMed Web of Science ®Google Scholar
• Alastruey-Izquierdo A, Melhem MS, Bonfietti LX, et al. Susceptibility test for fungi: clinical and laboratorial correlations in medical mycology. Rev Inst Med Trop Sao Paulo. 2015 Sep;57(Suppl 19):57–64. PubMed PMID: 26465371; PubMed Central PMCID: PMC4711191.
   PubMed Web of Science ®Google Scholar
• Chapin KC, Musgnug MC. Evaluation of Sensititre automated reading and incubation system for automated reading of Sensititre broth microdilution susceptibility plates. J Clin Microbiol. 2004 Feb;42(2):909–911. PubMed PMID: 14766887; PubMed Central PMCID: PMC344475.
   PubMed Web of Science ®Google Scholar
• Seider K, Brunke S, Schild L, et al. The facultative intracellular pathogen Candida glabrata subverts macrophage cytokine production and phagolysosome maturation. J Immunology. 2011 Sep 15;187(6):3072–3086. PubMed PMID: 21849684.
   PubMed Web of Science ®Google Scholar
• Mansour MK, Tam JM, Khan NS, et al. Dectin-1 activation controls maturation of beta-1,3-glucan-containing phagosomes. J Biol Chem. 2013 May 31;288(22):16043–16054. PubMed PMID: 23609446; PubMed Central PMCID: PMC3668760.
   PubMed Web of Science ®Google Scholar