Regulatory T cells in paracoccidioidomycosis

References

• Sakaguchi S, Sakaguchi N, Shimizu J, et al. Immunologic tolerance maintained by CD25 + CD4 + regulatory T cells: their common role in controlling autoimmunity, tumor immunity, and transplantation tolerance. Immunol Rev. 2001;182:18–32. 14.
   PubMed Web of Science ®Google Scholar
• Sakaguchi S, Yamaguchi T, Nomura T, et al. Regulatory T cells and immune tolerance. Cell. 2008;133(5):775–787.
   PubMed Web of Science ®Google Scholar
• Belkaid Y, Rouse BT. Natural regulatory T cells in infectious diseases. Nature Immunol. 2011;6:353–360.
   Google Scholar
• Rudensky AY. Regulatory T cells and Foxp3. Immunol Rev. 2011;241:260–269.
   PubMed Web of Science ®Google Scholar
• Lu L, Barbi J, Pan F. The regulation of immune tolerance by Foxp3. Nat Rev Immunol. 2017;17:703–717.
   PubMed Web of Science ®Google Scholar
• Hori S, Nomura T, Sakaguchi S. Control of regulatory T cell development by the transcription factor Foxp3. Science. 2003;299:1057–1061.
   PubMed Web of Science ®Google Scholar
• Fontenot JD, Gavin MA, Rudensky AY. Foxp3 programs the development and function of CD4+CD25+ regulatory T cells. Nature Immunol. 2003;4:330–336.
   PubMed Web of Science ®Google Scholar
• Bennett CL, Christie J, Ramsdell F, et al. The immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome (IPEX) is caused by mutations of FOXP3. Nature Genet. 2001;27:20–21.
   PubMed Web of Science ®Google Scholar
• Wildin RS, Ramsdell F, Peake J, et al. X-linked neonatal diabetes mellitus, enteropathy and endocrinopathy syndrome is the human equivalent of mouse scurfy. Nature Genet. 2001;27:18–20.
   PubMed Web of Science ®Google Scholar
• Brunkow ME, Jeffery EW, Hjerrild KA, et al. Disruption of a new forkhead/winged-helix protein, scurfin, results in the fatal lymphoproliferative disorder of the scurfy mouse. Nature Genet. 2001;27:68–73.
   PubMed Web of Science ®Google Scholar
• Josefowicz SZ, Lu LF, Rudensky AY. Regulatory T cells: mechanisms of differentiation and function. Annu Rev Immunol. 2012;30:531–564.
   PubMed Web of Science ®Google Scholar
• Ohkura N, Kitagawa Y, Sakaguchi S. Development and maintenance of regulatory T cells. Immunity. 2013;38(3):414–423.
   PubMed Web of Science ®Google Scholar
• Allan SE, Crome SQ, Crellin NK, et al. Activation-induced FOXP3 in human T effector cells does not suppress proliferation or cytokine production. Int Immunol. 2007;19(4):345–354.
   PubMed Web of Science ®Google Scholar
• Rubtsov YP, Niec RE, Josefowicz S, et al. Stability of the regulatory T cell lineage in vivo. Science. 2010;329:1667–1671.
   PubMed Web of Science ®Google Scholar
• Ohkura N, Hamaguchi M, Morikawa H, et al. T cell receptor stimulation-induced epigenetic changes and Foxp3 expression are independent and complementary events required for Treg cell development. Immunity. 2012;37:785–799.
   PubMed Web of Science ®Google Scholar
• Chen W, Jin W, Hardegen N, et al. Conversion of peripheral CD4+CD25- naive T cells to CD4+CD25+ regulatory T cells by TGF-beta induction of transcription factor Foxp3. J Exp Med. 2003;198(12):1875–1886.
   PubMed Web of Science ®Google Scholar
• Coombes JL, Siddiqui KR, Arancibia-Cárcamo CV, et al. A functionally specialized population of mucosal CD103+ DCs induces Foxp3+ regulatory T cells via a TGF-beta and retinoic acid-dependent mechanism. J Exp Med. 2007;204(8):1757–1764.
   PubMed Web of Science ®Google Scholar
• Roncarolo MG, Gregori S, Battaglia M, et al. Interleukin-10-secreting type 1 regulatory T cells in rodents and humans. Immunol Rev. 2006;212:28–50.
   PubMed Web of Science ®Google Scholar
• Yamaguchi T, Hirota K, Nagahama K, et al. Control of immune responses by antigen-specific regulatory T cells expressing the folate receptor. Immunity. 2007;24:145–159.
   Google Scholar
• Shevach EM, Stephens GL. The GITR-GITRL interaction: costimulation or contrasuppression of regulatory activity? Nat Rev Immunol. 2006;6:613–618.
   PubMed Web of Science ®Google Scholar
• Deaglio S, Dwyer KM, Gao W, et al. Adenosine generation catalyzed by CD39 and CD73 expressed on regulatory T cells mediates immune suppression. J Exp Med. 2007;204:1257–1265.
   PubMed Web of Science ®Google Scholar
• Yadav M, Louvet C, Davini D, et al. Neuropilin-1 distinguishes natural and inducible regulatory T cells among regulatory T cell subsets in vivo. J Exp Med. 2012;209(10):1713–1722.
   PubMed Web of Science ®Google Scholar
• Antonioli L, Pacher P, Vizi ES, et al. CD39 and CD73 in immunity and inflammation. Trends Mol Med. 2013;19(6):355–367.
   PubMed Web of Science ®Google Scholar
• Kursar M, Koch M, Mittrücker HW, et al. Cutting Edge: regulatory T cells prevent efficient clearance of Mycobacterium tuberculosis. J Immunol. 2007;178:2661–2665.
   PubMed Web of Science ®Google Scholar
• Jankovic D, Kullberg MC, Feng CG, et al. Conventional T -bet+Foxp3– Th1 cells are the major source of host-protective regulatory IL-10 during intracellular protozoan infection. J Exp Med. 2007;204:273–283.
   PubMed Web of Science ®Google Scholar
• Anderson CF, Oukka M, Kuchroo VJ, et al. CD4+CD25–Foxp3– Th1 cells are the source of IL-10-mediated immune suppression in chronic cutaneous leishmaniasis. J Exp Med. 2007;204:285–297.
   PubMed Web of Science ®Google Scholar
• Bergmann C, Strauss L, Zeidler R, et al. Expansion and characteristics of human T regulatory type 1 cells in co-cultures simulating tumor microenvironment. Cancer Immunol Immunother. 2007;56:1429–1442.
   PubMed Web of Science ®Google Scholar
• Li MO, Wan YY, Flavell RA. T cell-produced transforming growth factor-β1 controls T cell tolerance and regulates Th1- and Th17-cell differentiation. Immunity. 2007;26:579–591.
   PubMed Web of Science ®Google Scholar
• Collison LW, Workman CJ, Kuo TT, et al. The inhibitory cytokine IL-35 contributes to regulatory T -cell function. Nature. 2007;450:566–569.
   PubMed Web of Science ®Google Scholar
• Hawrylowicz CM, O’Garra A. Potential role of interleukin-10-secreting regulatory T cells in allergy and asthma. Nature Rev Immunol. 2005;5:271–283.
   PubMed Web of Science ®Google Scholar
• Annacker O, Asseman C, Read S, et al. F. Interleukin-10 in the regulation of T cell-induced colitis. J Autoimmun. 2003;20:277–279.
   PubMed Web of Science ®Google Scholar
• Joetham A, Takeda K, Taube C, et al. Naturally occurring lung CD4+CD25+ T cell regulation of airway allergic responses depends on IL-10 induction of TGF-β. J Immunol. 2007;178:1433–1442.
   PubMed Web of Science ®Google Scholar
• Nakamura K, Kitani A, Strober W. Cell contact-dependent immunosuppression by CD4(+)CD25(+) regulatory T cells is mediated by cell surface-bound transforming growth factor beta. J Exp Med. 2001;194(5):629–644.
   PubMed Web of Science ®Google Scholar
• Piccirillo CA, Letterio JJ, Thornton AM, et al. CD4+CD25+ regulatory T cells can mediate suppressor function in the absence of transforming growth factor β1 production and responsiveness. J Exp Med. 2002;196:237–246.
   PubMed Web of Science ®Google Scholar
• de la Rosa M, Rutz S, Dorninger H, et al. A. Interleukin-2 is essential for CD4+CD25+ regulatory T cell function. Eur J Immunol. 2004;34:2480–2488.
   PubMed Web of Science ®Google Scholar
• Grossman WJ, Verbsky JW, Tollefsen BL, et al. Differential expression of granzymes A and B in human cytotoxic lymphocyte subsets and T regulatory cells. Blood. 2004;104(9):2840–2848.
   PubMed Web of Science ®Google Scholar
• Fallarino F, Grohmann U, Hwang KW, et al. Modulation of tryptophan catabolism by regulatory T cells. Nat Immunol. 2003;4(12):1206–1212.
   PubMed Web of Science ®Google Scholar
• Mellor AL, Munn DH. IDO expression by dendritic cells: tolerance and tryptophan catabolism. Nat Rev Immunol. 2004;4:762–774.
   PubMed Web of Science ®Google Scholar
• Workman CJ, Vignali DA. Negative regulation of T cell homeostasis by lymphocyte activation gene-3 (CD223). J Immunol. 2005;174(2):688–695.
   PubMed Web of Science ®Google Scholar
• Kroetz DN, Deepe GS Jr. CCR5 dictates the equilibrium of proinflammatory IL-17+ and regulatory Foxp3+ T cells in fungal infection. J Immunol. 2010;184:5224–5231.
   PubMed Web of Science ®Google Scholar
• Netea MG, Sutmuller R, Hermann C, et al. Toll-like receptor 2 suppresses immunity against Candida albicans through induction of IL-10 and regulatory T cells. J Immunol. 2004;172:3712–3718.
   PubMed Web of Science ®Google Scholar
• Sutmuller RP, Den Brok MH, Kramer M, et al. Toll-like receptor 2 controls expansion and function of regulatory T cells. J Clin Invest. 2006;116:485–494.
   PubMed Web of Science ®Google Scholar
• Felonato M, Pina A, Araujo EF, et al. Anti-CD25 Treatment depletes Treg cells and decreases disease severity in susceptible and resistant mice infected with Paracoccidioides brasiliensis. PLoS One. 2012;7(11):e51071.
   PubMed Web of Science ®Google Scholar
• Bazan SB, Costa TA, de Araújo EF, et al. Loss- and Gain-of-Function approaches indicate a dual role exerted by regulatory T cells in pulmonary Paracoccidioidomycosis. PLoS Negl Trop Dis. 2015;9(10):e0004189.
   PubMed Web of Science ®Google Scholar
• Cavassani KA, Campanelli AP, Moreira AP, et al. Systemic and local characterization of regulatory T cells in a chronic fungal infection in humans. J Immunol. 2006;177(9):5811–5818.
   PubMed Web of Science ®Google Scholar
• Montagnoli C, Fallarino F, Gaziano R, et al. Immunity and tolerance to Aspergillus involve functionally distinct regulatory T cells and tryptophan catabolism. J Immunol. 2006;176:1712–1723.
   PubMed Web of Science ®Google Scholar
• Schulze B, Piehler D, Eschke M, et al. Therapeutic expansion of CD4+Foxp3+ regulatory T cells limits allergic airway inflammation during pulmonary fungal infection. Pathog Dis. 2016;74(4):ftw020.
   PubMed Web of Science ®Google Scholar
• Schulze B, Piehler D, Eschke M, et al. CD4(+) Foxp3(+) regulatory T cells suppress fatal T helper 2 cell immunity during pulmonary fungal infection. Eur J Immunol. 2014;44(12):3596–3604.
   PubMed Web of Science ®Google Scholar
• Whibley N, Gaffen SL. Brithers in arms: Th17 and Treg responses in Candida albicans immunity. PLoS Pathog. 2014;10(12):e1004456.
   PubMed Web of Science ®Google Scholar
• Wiesner DL, Smith KD, Kotov DI, et al. Regulatory T cell induction and retention in the lungs drives suppression of detrimental type 2 Th cells during pulmonary cryptococcal infection. J Immunol. 2016;196(1):365–374.
   PubMed Web of Science ®Google Scholar
• Regulatory BY. T cells and infection: a dangerous necessity. Nat Rev Immunol. 2007;7(11):875–888.
   PubMed Web of Science ®Google Scholar
• Medzhitov R, Schneider DS, Soares MP. Disease tolerance as a defense strategy. Science. 2012;335(6071):936–941.
   PubMed Web of Science ®Google Scholar
• Belkaid Y, Piccirillo CA, Mendez S, et al. CD4+CD25+ regulatory T cells control Leishmania major persistence and immunity. Nature. 2002;420:502–507.
   PubMed Web of Science ®Google Scholar
• Hisaeda H, Maekawa Y, Iwakawa D, et al. Escape of malaria parasites from host immunity requires CD4+ CD25+ regulatory T cells. Nat Med. 2004;10(1):29–30.
   PubMed Web of Science ®Google Scholar
• Scott-Browne JP, Shafiani S, Tucker-Heard G, et al. Expansion and function of Foxp3-expressing T regulatory cells during tuberculosis. J Exp Med. 2007;204:2159–2169.
   PubMed Web of Science ®Google Scholar
• Veiga-Parga T, Sehrawat S, Rouse BT. Role of regulatory T cells during virus infection. Immunol Rev. 2013;255(1):182–196.
   PubMed Web of Science ®Google Scholar
• Betts RJ, Ho AW, Kemeny DM. Partial depletion of natural CD4(+)CD25(+) regulatory T cells with anti-CD25 antibody does not alter the course of acute influenza A virus infection. PLoS One. 2011;6(11):e27849.
   PubMed Web of Science ®Google Scholar
• Brincks EL, Roberts AD, Cookenham T, et al. Antigen-specific memory regulatory CD4+Foxp3+ T cells control memory responses to influenza virus infection. J Immunol. 2013;190(7):3438–46.61.
   PubMed Web of Science ®Google Scholar
• Pandiyan P, Conti HR, Zheng L, et al. CD4+CD25+Foxp3+ regulatory T cells promote Th17 cells in vitro and enhance host resistance in mouse Candida albicans Th17 cell infection model. Immunity. 2011;34:422–434.
   PubMed Web of Science ®Google Scholar
• Montagnoli C, Bacci A, Bozza S, et al. B7/CD28-dependent CD4+CD25+regulatory T cells are essential components of the memory-protective immunity to Candida albicans. J Immunol. 2002;169:6298–6308.
   PubMed Web of Science ®Google Scholar
• De Luca A, Montagnoli C, Zelante T, et al. Functional yet balanced reactivity to Candida albicans requires TRIF, MyD88, and IDO-dependent inhibition of Rorc. J Immunol. 2007;179:5999–6008.
   PubMed Web of Science ®Google Scholar
• Martinez R. Epidemiology of paracoccidioidomycosis. Rev Inst Med Trop Sao Paulo. 2015;57(Suppl 19):11–20.
   PubMed Web of Science ®Google Scholar
• Marques SA. Paracoccidioidomycosis: epidemiological, clinical, diagnostic and treatment up-dating. An Bras Dermatol. 2013;88(5):700–711.
   PubMed Web of Science ®Google Scholar
• Bocca AL, Amaral AC, Teixeira MM, et al. Paracoccidioidomycosis: eco-epidemiology, taxonomy and clinical and therapeutic issues. Future Microbiol. 2013;8(9):1177–1191.
   PubMed Web of Science ®Google Scholar
• Bellissimo-Rodrigues F, Machado AA, Martinez R. Paracoccidioidomycosis epidemiological features of a 1,000-cases series from a hyperendemic area on the southeast of Brazil. Am J Trop Med Hyg. 2011;85(3):546–550.
   PubMed Web of Science ®Google Scholar
• Ramos ESM, Saraiva LE. Paracoccidioidomycosis. Dermatol Clin. 2008;26(2):257–269.
   PubMed Web of Science ®Google Scholar
• Bagagli E, Theodoro RC, Bosco SM, et al. Paracoccidioides brasiliensis: phylogenetic and ecological aspects. Mycopathologia. 2008;165(4–5):197–207.
   PubMed Web of Science ®Google Scholar
• Benard G. An overview of the immunopathology of human paracoccidioidomycosis. Mycopathologia. 2008;165(4–5):209–221.
   PubMed Web of Science ®Google Scholar
• Queiroz-Telles F, Fahal AH, Falci DR, et al. Neglected endemic mycoses. Lancet Infect Dis. 2017;17(11):e367–e377.
   PubMed Web of Science ®Google Scholar
• Marques SA. Paracoccidioidomycosis. Clin Dermatol. 2012;30(6):610–615.
   PubMed Web of Science ®Google Scholar
• Shikanai-Yasuda MA, Telles Filho FQ, Mendes RP, et al. Guidelines in paracoccidioidomycosis. Rev Soc Bras Med Trop. 2006;39(3):297–310.
   PubMedGoogle Scholar
• Pereira RM, Bucaretchi F, Barison EM, et al. Paracoccidioidomycosis in children: clinical presentation, follow-up and outcome. Rev Inst Med Trop Sao Paulo. 2004;46(3):127–131.
   PubMedGoogle Scholar
• Blotta MH, Mamoni RL, Oliveira SJ, et al. Endemic regions of paracoccidioidomycosis in Brazil: a clinical and epidemiologic study of 584 cases in the southeast region. Am J Trop Med Hyg. 1999;61(3):390–394.
   PubMed Web of Science ®Google Scholar
• Fava Netto C. Epidemiologic surveys of histoplasmin and paracoccidioidin sensitivity in Brazil. Rev Inst Med Trop Sao Paulo. 1998;40(3):155–164.
   PubMedGoogle Scholar
• de Castro LF, Ferreira MC, da Silva RM, et al. Characterization of the immune response in human paracoccidioidomycosis. J Infect. 2013;67(5):470–485.
   PubMed Web of Science ®Google Scholar
• Mamoni RL, Blotta MH. Flow-cytometric analysis of cytokine production in human paracoccidioidomycosis. Cytokine. 2006;35(3–4):207–216.
   PubMed Web of Science ®Google Scholar
• Oliveira SJ, Mamoni RL, Musatti CC, et al. Cytokines and lymphocyte proliferation in juvenile and adult forms of paracoccidioidomycosis: comparison with infected and non-infected controls. Microbes Infect. 2002;4(2):139–144.
   PubMed Web of Science ®Google Scholar
• Chequer-Bou-Habib D, Daniel-Ribeiro C, Banic DM, et al. Polyclonal B cell activation in paracoccidioidomycosis. Polyclonal activation in paracoccidioidomycosis. Mycopathologia. 1989;108(2):89–93.
   PubMed Web of Science ®Google Scholar
• Mamoni RL, Nouer SA, Oliveira SJ, et al. Enhanced production of specific IgG4, IgE, IgA and TGF-beta in sera from patients with the juvenile form of paracoccidioidomycosis. Med Mycol. 2002;40(2):153–159.
   PubMed Web of Science ®Google Scholar
• Juvenale M, Del Negro GM, Duarte AJ, et al. Antibody isotypes to a Paracoccidioides brasiliensis somatic antigen in sub-acute and chronic form paracoccidioidomycosis. J Med Microbiol. 2001;50(2):127–134.
   PubMed Web of Science ®Google Scholar
• Baida H, Biselli PJ, Juvenale M, et al. Differential antibody isotype expression to the major Paracoccidioides brasiliensis antigen in juvenile and adult form paracoccidioidomycosis. Microbes Infect. 1999;1(4):273–278.
   PubMed Web of Science ®Google Scholar
• Kashino SS, Fazioli RA, Cafalli-Favati C, et al. Resistance to Paracoccidioides brasiliensis infection is linked to a preferential Th1 immune response, whereas susceptibility is associated with absence of IFN-gamma production. J Interferon Cytokine Res. 2000;20(1):89–97.
   PubMed Web of Science ®Google Scholar
• Xidieh CF, Lenzi HL, Calich VL, et al. Influence of the genetic background on the pattern of lesions developed by resistant and susceptible mice infected with Paracoccidioides brasiliensis. Med Microbiol Immunol. 1999;188(1):41–49.
   PubMed Web of Science ®Google Scholar
• Calich VL, Vaz CA, Burger E. Immunity to Paracoccidioides brasiliensis infection. Res Immunol. 1998;149(4–5):407–417.
   PubMedGoogle Scholar
• Calich VL, Kashino SS. Cytokines produced by susceptible and resistant mice in the course of Paracoccidioides brasiliensis infection. Braz J Med Biol Res. 1998;31(5):615–623.
   PubMed Web of Science ®Google Scholar
• Musatti CC, Rezkallah MT, Mendes E, et al. In vivo and in vitro evaluation of cell-mediated immunity in patients with paracoccidiodomycosis. Cell Immunol. 1976;24(2):365–378.
   PubMed Web of Science ®Google Scholar
• Restrepo A, Restrepo M, de Restrepo F, et al. Immune responses in paracoccidioidomycosis. A controlled study of 16 patients before and after treatment. Sabouraudia. 1978;16(2):151–163.
   PubMedGoogle Scholar
• Mota NG, Rezkallah-Iwasso MT, Peracoli MT, et al. Correlation between cell-mediated immunity and clinical forms of paracoccidioidomycosis. Trans R Soc Trop Med Hyg. 1985;79(6):765–772.
   PubMed Web of Science ®Google Scholar
• Campanelli AP, Martins GA, Souto JT, et al. Fas-Fas ligand (CD95-CD95L) and cytotoxic T lymphocyte antigen-4 engagement mediate T cell unresponsiveness in patients with paracoccidioidomycosis. J Infect Dis. 2003;187(9):1496–1505.
   PubMed Web of Science ®Google Scholar
• Ferreira MC, de Oliveira RT, da Silva RM, et al. Involvement of regulatory T cells in the immunosuppression characteristic of patients with paracoccidioidomycosis. Infect Immun. 2010;78(10):4392–4401.
   PubMed Web of Science ®Google Scholar
• Cardoso RM, Jham BC, do Carmo GM, et al. The relation between Foxp3(+) regulatory T cells and fungal density in oral paracoccidioidomycosis: a preliminary study. Mycoses. 2014;57(12):771–774.
   PubMed Web of Science ®Google Scholar
• Vignali DA, Collison LW, Workman CJ. How regulatory T cells work. Nat Rev Immunol. 2008;8(7):523–532.
   PubMed Web of Science ®Google Scholar
• Munn DH, Sharma MD, Mellor AL. Ligation of B7-1/B7-2 by human CD4+ T cells triggers indoleamine 2,3-dioxygenase activity in dendritic cells. J Immunol. 2004;172(7):4100–4110.
   PubMed Web of Science ®Google Scholar
• Mayer E, Hölzl M, Ahmadi S, et al. CTLA4-Ig immunosuppressive activity at the level of dendritic cell/T cell crosstalk. Int Immunopharmacol. 2013;15(3):638–645.
   PubMed Web of Science ®Google Scholar
• Oida T, Xu L, Weiner HL, et al. TGF-beta-mediated suppression by CD4+CD25+ T cells is facilitated by CTLA-4 signaling. J Immunol. 2006;177(4):2331.
   PubMed Web of Science ®Google Scholar
• Ju ST, Matsui K, Ozdemirli M. Molecular and cellular mechanisms regulating T and B cell apoptosis through Fas/FasL interaction. Int Rev Immunol. 1999;18(5–6):485–513.
   PubMedGoogle Scholar
• Xu G, Shi Y. Apoptosis signaling pathways and lymphocyte homeostasis. Cell Res. 2007;17(9):759–771.
   PubMed Web of Science ®Google Scholar
• Schmidt A, Oberle N, Krammer PH. Molecular mechanisms of Treg-mediated T cell suppression. Front Immunol. 2012;3:51.
   PubMed Web of Science ®Google Scholar
• Esebanmen GE, Langridge WHR. The role of TGF-beta signaling in dendritic cell tolerance. Immunol Res. 2017;65(5):987–994.
   PubMed Web of Science ®Google Scholar
• Fujio K, Komai T, Inoue M, et al. Revisiting the regulatory roles of the TGF-beta family of cytokines. Autoimmun Rev. 2016;15(9):917–922.
   PubMed Web of Science ®Google Scholar
• Fantini MC, Becker C, Monteleone G, et al. Cutting edge: TGF-beta induces a regulatory phenotype in CD4+CD25- T cells through Foxp3 induction and down-regulation of Smad7. J Immunol. 2004;172(9):5149–5153.
   PubMed Web of Science ®Google Scholar
• Shikanai-Yasuda MA, Mendes RP, Colombo AL, et al. Brazilian guidelines for the clinical management of paracoccidioidomycosis. Rev Soc Bras Med Trop. 2017;50(5):715–740.
   PubMed Web of Science ®Google Scholar
• Felonato M, Pina A, Bernardino S, et al. CD28 exerts protective and detrimental effects in a pulmonary model of paracoccidioidomycosis. Infect Immun. 2010;78:4922–4935.
   PubMed Web of Science ®Google Scholar
• Moreira AP, Cavassani KA, Massafera Tristão FS, et al. CCR5-dependent regulatory T cell migration mediates fungal survival and severe immunosuppression. J Immunol. 2008;180(5):3049–3056.
   PubMed Web of Science ®Google Scholar
• Puerta-Arias JD, Pino-Tamayo PA, Arango JC, et al. Depletion of neutrophils promotes the resolution of pulmonary inflammation and fibrosis in mice infected with Paracoccidioides brasiliensis. PLoS One. 2016;11(9):e0163985.
   PubMed Web of Science ®Google Scholar
• Tristão FS, Rocha FA, Moreira AP, et al. 5-Lipoxygenase activity increases susceptibility to experimental Paracoccidioides brasiliensis infection. Infect Immun. 2013;81(4):1256–1266.
   PubMed Web of Science ®Google Scholar
• Noal V, Santos S, Ferreira K, et al. Infection with Paracoccidioides brasiliensis induces B-1 cell migration and activation of regulatory T cells. Microbes Infect. 2016;18(12):798–803.
   PubMed Web of Science ®Google Scholar
• de Amorim J, Magalhães A, Muñoz JE, et al. DNA vaccine encoding peptide P10 against experimental paracoccidioidomycosis induces long-term protection in presence of regulatory T cells. Microbes Infect. 2013;15(3):181–191.
   PubMed Web of Science ®Google Scholar
• Loures FV, Pina A, Felonato M, et al. TLR2 is a negative regulator of Th17 cells and tissue pathology in a pulmonary model of fungal infection. J Immunol. 2009;183(2):1279–1290.
   PubMed Web of Science ®Google Scholar
• Loures FV, Pina A, Felonato M, et al. TLR4 signaling leads to a more severe fungal infection associated with enhanced proinflammatory immunity and impaired expansion of regulatory T cells. Infec Immun. 2010;78:1078–1088.
   PubMed Web of Science ®Google Scholar
• Loures FV, Pina A, Felonato M, et al. MyD88 signaling is required for efficient innate and adaptive immune responses to Paracoccidioides brasiliensis infection. Infect Immun. 2011;79(6):2470–2480.
   PubMed Web of Science ®Google Scholar
• Loures FV, Araújo EF, Feriotti C, et al. Dectin-1 induces M1 macrophages and prominent expansion of CD8+IL-17+ cells in pulmonary paracoccidioidomycosis. J Infect Dis. 2014;210(5):762–773.
   PubMed Web of Science ®Google Scholar
• Tavares AH, Magalhães KG, Almeida RD, et al. NLRP3 inflammasome activation by Paracoccidioides brasiliensis. PLoS Negl Trop Dis. 2013;7(12):e2595.
   PubMed Web of Science ®Google Scholar
• Ketelut-Carneiro N, Silva GK, Rocha FA, et al. IL-18 triggered by the Nlrp3 inflammasome induces host innate resistance in a pulmonary model of fungal infection. J Immunol. 2015;194(9):4507–4517.
   PubMed Web of Science ®Google Scholar
• Feriotti C, de Araújo EF, Loures FV, et al. NOD-Like Receptor P3 Inflammasome controls protective Th1/Th17 immunity against pulmonary paracoccidioidomycosis. Front Immunol. 2017;8:e786.
   PubMed Web of Science ®Google Scholar
• Baban B, Chandler PR, Sharma MD, et al. IDO activates regulatory T cells and blocks their conversion into Th17-like T cells. J Immunol. 2009;183(4):2475–2483.
   PubMed Web of Science ®Google Scholar
• Romani L. Immunity to fungal infections. Nat Rev Immunol. 2011;11(4):275–288.
   PubMed Web of Science ®Google Scholar
• Romani L, Zelante T, De Luca A, et al. Indoleamine 2,3-dioxygenase (IDO) in inflammation and allergy to Aspergillus. Med Mycol. 2009;47(Suppl 1):S154–61.
   PubMedGoogle Scholar
• Bonifazi P, Zelante T, D’Angelo C, et al. Balancing inflammation and tolerance in vivo through dendritic cells by the commensal Candida albicans. Mucosal Immunol. 2009;2(4):362–374.
   PubMed Web of Science ®Google Scholar
• Araújo EF, Loures FV, Bazan SB, et al. Indoleamine 2,3-Dioxygenase controls fungal loads and immunity in paracoccidioidomicosis but is more important to susceptible than resistant hosts. PLoS Negl Trop Dis. 2014;8(11):e3330.
   PubMed Web of Science ®Google Scholar
• Araújo EF, Medeiros DH, Galdino NA, et al. Tolerogenic Plasmacytoid dendritic cells control Paracoccidioides brasiliensis infection by inducting regulatory T cells in an IDO-dependent manner. PLoS Pathog. 2016;12(12):e1006115.
   PubMed Web of Science ®Google Scholar
• de Araújo EF, Feriotti C, Galdino NAL, et al. The IDO-AhR axis controls Th17/Treg immunity in a pulmonary model of fungal infection. Front Immunol. 2017;8:e880.
   PubMed Web of Science ®Google Scholar
• de Araújo EF, Loures FV, Feriotti C, et al. Disease tolerance mediated by phosphorylated indoleamine-2,3 dioxygenase confers resistance to a primary fungal pathogen. Front Immunol. 2017;8:e1522.
   PubMed Web of Science ®Google Scholar