BabA-mediated adherence of pediatric ulcerogenic H. pylori strains to gastric mucins at neutral and acidic pH

References

• Lai LH, Sung JJ. Helicobacter pylori and benign upper digestive disease. Best Pract Res Clin Gastroenterol. 2007;21(2):261–279. PubMed PMID: 17382276.
   PubMed Web of Science ®Google Scholar
• Atherton JC. The pathogenesis of Helicobacter pylori-induced gastro-duodenal diseases. Annu Rev Pathol. 2006;1:63–96. PubMed PMID: 18039108.
   PubMed Web of Science ®Google Scholar
• Konturek PC, Konturek SJ, Brzozowski T. Helicobacter pylori infection in gastric cancerogenesis. J Physiol Pharmacol. 2009 Sep;60(3):3–21. PubMed PMID: 19826177.
   PubMed Web of Science ®Google Scholar
• Oleastro M, Cordeiro R, Ferrand J, et al. Evaluation of the clinical significance of homB, a novel candidate marker of Helicobacter pylori strains associated with peptic ulcer disease. J Infect Dis. 2008 Nov 1;198(9):1379–1387. PubMed PMID: 18811585.
   PubMed Web of Science ®Google Scholar
• Gerhard M, Lehn N, Neumayer N, et al. Clinical relevance of the Helicobacter pylori gene for blood-group antigen-binding adhesin. Proc Natl Acad Sci U S A. 1999;96(22):12778–12783.
   PubMed Web of Science ®Google Scholar
• Oleastro M, Cordeiro R, Yamaoka Y, et al. Disease association with two Helicobacter pylori duplicate outer membrane protein genes, homB and homA. Gut Pathog. 2009 Jun 22;1(1):12. PubMed PMID: 19545429; PubMed Central PMCID: PMCPMC2706848.
   PubMed Web of Science ®Google Scholar
• Buisine MP, Devisme L, Degand P, et al. Developmental mucin gene expression in the gastroduodenal tract and accessory digestive glands. II. Duodenum and liver, gallbladder, and pancreas. J Histochem Cytochem. 2000 Dec;48(12):1667–1676. PubMed PMID: 11101635.
   PubMed Web of Science ®Google Scholar
• Linden SK, Sutton P, Karlsson NG, et al. Mucins in the mucosal barrier to infection. Mucosal Immunol. 2008 May;13:183–197. PubMed PMID: 19079178; eng.
   PubMed Web of Science ®Google Scholar
• Aspholm-Hurtig M, Dailide G, Lahmann M, et al. Functional adaptation of BabA, the H. pylori ABO blood group antigen binding adhesin. Science. 2004 Jul 23;305(5683):519–522. PubMed PMID: 15273394.
   PubMed Web of Science ®Google Scholar
• Lindén S, Nordman H, Hedenbro J, et al. Strain- and blood group-dependent binding of Helicobacter pylori to human gastric MUC5AC glycoforms. Gastroenterology. 2002;123(6):1923–1930.
   PubMed Web of Science ®Google Scholar
• Linden SK, Wickstrom C, Lindell G, et al. Four modes of adhesion are used during Helicobacter pylori binding to human mucins in the oral and gastric niches. Helicobacter. 2008 Apr;13(2):81–93. PubMed PMID: 18321298; eng.
   PubMed Web of Science ®Google Scholar
• Rossez Y, Gosset P, Boneca IG, et al. The LacdiNAc-Specific Adhesin LabA Mediates Adhesion of Helicobacter pylori to Human Gastric Mucosa. J Infect Dis. 2014 Oct 15;210(8):1286–1295. PubMed PMID: 24755437.
   PubMed Web of Science ®Google Scholar
• Padra M, Adamczyk B, Benktander J, et al. Helicobacter suis binding to carbohydrates on human and porcine gastric mucins and glycolipids occurs via two modes. Virulence. 2018;1–48. DOI:10.1080/21505594.2018.1460979.
   PubMed Web of Science ®Google Scholar
• Ho SB, Shekels LL, Toribara NW, et al. Mucin gene expression in normal, preneoplastic, and neoplastic human gastric epithelium. Cancer Res. 1995 Jun 15;55(12):2681–2690. PubMed PMID: 7780985.
   PubMed Web of Science ®Google Scholar
• Byrd JC, Yan P, Sternberg L, et al. Aberrant expression of gland-type gastric mucin in the surface epithelium of Helicobacter pylori-infected patients. Gastroenterology. 1997;113(2):455–464.
   PubMed Web of Science ®Google Scholar
• Tsai CJ, Herrera-Goepfert R, Tibshirani RJ, et al. Changes of gene expression in gastric preneoplasia following Helicobacter pylori eradication therapy. Cancer Epidemiol Biomarkers Prev. 2006 Feb;15(2):272–280. PubMed PMID: 16492915.
   PubMed Web of Science ®Google Scholar
• Sakamoto S, Watanabe T, Tokumaru T, et al. Expression of Lewisa, Lewisb, Lewisx, Lewisy, siayl-Lewisa, and sialyl-Lewisx blood group antigens in human gastric carcinoma and in normal gastric tissue. Cancer Res. 1989 Feb 1;49(3):745–752. PubMed PMID: 2910493.
   PubMed Web of Science ®Google Scholar
• Cooke CL, An HJ, Kim J, et al. Modification of gastric mucin oligosaccharide expression in rhesus macaques after infection with Helicobacter pylori. Gastroenterology. 2009 Sep;137(3):1061-71, 1071 e1-8. PubMed PMID: 19375420.
   PubMed Web of Science ®Google Scholar
• Linden S, Mahdavi J, Semino-Mora C, et al. Role of ABO secretor status in mucosal innate immunity and H. pylori infection. PLoS Pathog. 2008 Jan;41:e2. PubMed PMID: 18179282; PubMed Central PMCID: PMC2174967. eng.
   PubMed Web of Science ®Google Scholar
• Liu H, Fero JB, Mendez M, et al. Analysis of a single Helicobacter pylori strain over a 10-year period in a primate model. Int J Med Microbiol. 2015 May;305(3):392–403. PubMed PMID: 25804332; PubMed Central PMCID: PMCPMC4376324.
   PubMed Web of Science ®Google Scholar
• Linden SK, Sheng YH, Every AL, et al. MUC1 limits Helicobacter pylori infection both by steric hindrance and by acting as a releasable decoy. PLoS Pathog. 2009 Oct;5(10):e1000617. PubMed PMID: 19816567; PubMed Central PMCID: PMC2752161. eng.
   PubMed Web of Science ®Google Scholar
• Benktander J, Angstrom J, Breimer ME, et al. Redefinition of the carbohydrate binding specificity of Helicobacter pylori BabA adhesin. J Biol Chem. 2012 Sep 14;287(38):31712–31724. PubMed PMID: 22822069; PubMed Central PMCID: PMC3442506.
   PubMed Web of Science ®Google Scholar
• Linden S, Semino-Mora C, Liu H, et al. Role of mucin Lewis status in resistance to Helicobacter pylori infection in pediatric patients. Helicobacter. 2010 Aug;15(4):251–258. PubMed PMID: 20633185; eng.
   PubMed Web of Science ®Google Scholar
• Navabi N, Johansson ME, Raghavan S, et al. Helicobacter pylori Infection Impairs the Mucin Production Rate and Turnover in the Murine Gastric Mucosa. Infect Immun. 2013 Mar;81(3):829–837. PubMed PMID: 23275091; PubMed Central PMCID: PMC3584886.
   PubMed Web of Science ®Google Scholar
• Vitoriano I, Saraiva-Pava KD, Rocha-Goncalves A, et al. Ulcerogenic Helicobacter pylori strains isolated from children: a contribution to get insight into the virulence of the bacteria. PLoS One. 2011;6(10):e26265. PubMed PMID: 22039453; PubMed Central PMCID: PMCPMC3198394.
   PubMed Web of Science ®Google Scholar
• Jin C, Kenny DT, Skoog EC, et al. Structural Diversity of Human Gastric Mucin Glycans. Mol Cell Proteomics. 2017 May;16(5):743–758. PubMed PMID: 28461410; PubMed Central PMCID: PMCPMC5417818.
   PubMed Web of Science ®Google Scholar
• Linden S, Mahdavi J, Hedenbro J, et al. Effects of pH on Helicobacter pylori binding to human gastric mucins: identification of binding to non-MUC5AC mucins. Biochem J. 2004 Dec 1;384(Pt 2):263–270. PubMed PMID: 15260802.
   PubMed Web of Science ®Google Scholar
• Skoog EC, Padra M, Aberg A, et al. BabA dependent binding of Helicobacter pylori to human gastric mucins cause aggregation that inhibits proliferation and is regulated via ArsS. Sci Rep. 2017 Jan;20(7):40656. PubMed PMID: 28106125; PubMed Central PMCID: PMCPMC5247751.
   PubMed Web of Science ®Google Scholar
• Skoog EC, Sjoling A, Navabi N, et al. Human Gastric Mucins Differently Regulate Helicobacter pylori Proliferation, Gene Expression and Interactions with Host Cells. PLoS One. 2012;7(5):e36378. 10.1371/journal.pone.0036378 PONE-D-11-18652 PubMed PMID: 22563496; PubMed Central PMCID: PMC3341350. eng.
   PubMed Web of Science ®Google Scholar
• Kawakubo M, Ito Y, Okimura Y, et al. Natural antibiotic function of a human gastric mucin against Helicobacter pylori infection. Science. 2004 Aug 13;305(5686):1003–1006. PubMed PMID: 15310903.
   PubMed Web of Science ®Google Scholar
• Kivi M, Tindberg Y, Sorberg M, et al. Concordance of Helicobacter pylori strains within families. J Clin Microbiol. 2003 Dec;41(12):5604–5608. PubMed PMID: 14662948; PubMed Central PMCID: PMCPMC309035.
   PubMed Web of Science ®Google Scholar
• Oleastro M, Monteiro L, Lehours P, et al. Identification of markers for Helicobacter pylori strains isolated from children with peptic ulcer disease by suppressive subtractive hybridization. Infect Immun. 2006 Jul;74(7):4064–4074. PubMed PMID: 16790780; PubMed Central PMCID: PMCPMC1489719.
   PubMed Web of Science ®Google Scholar
• Oleastro M, Santos A, Cordeiro R, et al. Clinical relevance and diversity of two homologous genes encoding glycosyltransferases in Helicobacter pylori. J Clin Microbiol. 2010 Aug;48(8):2885–2891. PubMed PMID: 20554820; PubMed Central PMCID: PMCPMC2916562.
   PubMed Web of Science ®Google Scholar
• Park JS, Yeom JS, Seo JH, et al. Immunohistochemical Expressions of MUC2, MUC5AC, and MUC6 in Normal, Helicobacter pylori Infected and Metaplastic Gastric Mucosa of Children and Adolescents. Helicobacter. 2015 Aug;20(4):260–268. PubMed PMID: 25704078.
   PubMed Web of Science ®Google Scholar
• Bugaytsova JA, Bjornham O, Chernov YA, et al. Helicobacter pylori Adapts to Chronic Infection and Gastric Disease via pH-Responsive BabA-Mediated Adherence. Cell Host Microbe. 2017 Mar 8;21(3):376–389. PubMed PMID: 28279347; PubMed Central PMCID: PMCPMC5392239.
   PubMed Web of Science ®Google Scholar
• Hunt RH, Camilleri M, Crowe SE, et al. The stomach in health and disease. Gut. 2015 Oct;64(10):1650–1668. PubMed PMID: 26342014; PubMed Central PMCID: PMCPMC4835810.
   PubMed Web of Science ®Google Scholar
• McAuley JL, Linden SK, Png CW, et al. MUC1 cell surface mucin is a critical element of the mucosal barrier to infection. J Clin Invest. 2007 Aug;117(8):2313–2324. PubMed PMID: 17641781; PubMed Central PMCID: PMC1913485. eng.
   PubMed Web of Science ®Google Scholar
• McGuckin MA, Every A, Skene C, et al. Muc1 mucin limits both Helicobacter pylori colonization of the murine gastric mucosa and the associated gastritis. Gastroenterology. 2007;133(4):1210–1218.
   PubMed Web of Science ®Google Scholar
• Linden S, Boren T, Dubois A, et al. Rhesus monkey gastric mucins: oligomeric structure, glycoforms and Helicobacter pylori binding. Biochem J. 2004 May 1;379(Pt 3):765–775. 10.1042/BJ20031557 BJ20031557. PubMed PMID: 14736333; PubMed Central PMCID: PMC1224112. eng.
   PubMed Web of Science ®Google Scholar
• Nordman H, Davies JR, Lindell G, et al. Gastric MUC5AC and MUC6 are large oligomeric mucins that differ in size, glycosylation and tissue distribution. Biochem J. 2002 May 15;364(Pt 1):191–200. PubMed PMID: 11988092.
   PubMed Web of Science ®Google Scholar
• Herrmann A, Davies JR, Lindell G, et al. Studies on the “insoluble” glycoprotein complex from human colon. Identification of reduction-insensitive MUC2 oligomers and C-terminal cleavage. J Biol Chem. 1999;274(22):15828–15836.
   PubMed Web of Science ®Google Scholar
• Wickstrom C, Davies JR, Eriksen GV, et al. MUC5B is a major gel-forming, oligomeric mucin from human salivary gland, respiratory tract and endocervix: identification of glycoforms and C-terminal cleavage. Biochem J. 1998 Sep 15;334(Pt 3):685–693. PubMed PMID: 9729478; PubMed Central PMCID: PMCPMC1219739.
   PubMed Web of Science ®Google Scholar
• Everest-Dass AV, Abrahams JL, Kolarich D, et al. Structural feature ions for distinguishing N- and O-linked glycan isomers by LC-ESI-IT MS/MS. J Am Soc Mass Spectrom. 2013 Jun;24(6):895–906. PubMed PMID: 23605685.
   PubMed Web of Science ®Google Scholar
• Silva B, Nunes A, Vale FF, et al. The expression of Helicobacter pylori tfs plasticity zone cluster is regulated by pH and adherence, and its composition is associated with differential gastric IL-8 secretion. Helicobacter. 2017 Aug;22(4):e12390. PubMed PMID: 28436598.
   PubMed Web of Science ®Google Scholar
• Nunes A, Rocha R, Vale FF, et al. Genome Sequencing of 10 Helicobacter pylori Pediatric Strains from Patients with Nonulcer Dyspepsia and Peptic Ulcer Disease. Genome Announc. 2015 Feb 05;3(1). e01488–14. PubMed PMID: 25657274; PubMed Central PMCID: PMCPMC4319599.
   PubMedGoogle Scholar
• Aziz RK, Bartels D, Best AA, et al. The RAST Server: rapid annotations using subsystems technology. BMC Genomics. 2008 Feb;8(9):75. PubMed PMID: 18261238; PubMed Central PMCID: PMCPMC2265698.
   PubMed Web of Science ®Google Scholar