pdh modulate virulence through reducing stress tolerance and biofilm formation of Streptococcus suis serotype 2

References

• Silva LM, Baums CG, Rehm T, et al. Virulence-associated gene profiling of Streptococcus suis isolates by PCR. Vet Microbiol. 2006;115:117–127.
   PubMed Web of Science ®Google Scholar
• Wang Y, Yi L, Sun LY, et al. Identification and characterization of a Streptococcus suis immunogenic ornithine carbamoytransferase involved in bacterial adherence. J Microbiol Immunol Infect. 2018;S1684118218301567.
   Google Scholar
• Yang W, Yuxin W, Liyun S, et al. The LuxS/AI-2 system of Streptococcus suis. Appl Microbiol Biotechnol. 2018.102:7231–7238
   Web of Science ®Google Scholar
• Chen C, Tang J, Dong W, et al. A Glimpse of Streptococcal Toxic Shock Syndrome from Comparative Genomics of S. suis 2 Chinese Isolates. Plos One. 2007;2:e315.
   PubMed Web of Science ®Google Scholar
• Tang J, Wang C, Feng Y, et al. Streptococcal toxic shock syndrome caused by Streptococcus suis serotype 2. PLoS Med. 2006;3:e151.
   PubMed Web of Science ®Google Scholar
• Cairns RA, Ioanna P, Sutphin PD, et al. Metabolic targeting of hypoxia and HIF1 in solid tumors can enhance cytotoxic chemotherapy. Proc Natl Acad Sci U S A. 2007;104:9445–9450.
   PubMed Web of Science ®Google Scholar
• Yang W, Li Y, Zongfu W, et al. Comparative proteomic analysis of Streptococcus suis biofilms and planktonic cells that identified biofilm infection-related immunogenic proteins. Plos One. 2012;7:e33371.
   PubMed Web of Science ®Google Scholar
• Korithoski B, Levesque C, Cvitkovitch D. The involvement of the pyruvate dehydrogenase E1 alpha subunit, in Streptococcus mutans acid tolerance. FEMS Microbiol Lett. 2010;289:13–19.
   Web of Science ®Google Scholar
• Welin J, Wilkins JC, Beighton D, et al. Effect of acid shock on protein expression by biofilm cells of Streptococcus mutans. FEMS Microbiol Lett. 2010;227:287–293.
   Web of Science ®Google Scholar
• Dallo SF, Kannan TR, Blaylock MW, et al. Elongation factor Tu and E1 beta subunit of pyruvate dehydrogenase complex act as fibronectin binding proteins in Mycoplasma pneumoniae. Mol Microbiol. 2010;46:1041–1051.
   Web of Science ®Google Scholar
• Layhschmitt G, Podtelejnikov A, Mann M. Proteins complexed to the P1 adhesin of Mycoplasma pneumoniae. Microbiology. 2000;146(Pt 3):741–747.
   PubMed Web of Science ®Google Scholar
• Hezaveh S, Zeng AP, Jandt U. Full Enyzme Complex Simulation: interactions in Human Pyruvate Dehydrogenase Complex. J Chem Inf Model. 2018;58.
   PubMed Web of Science ®Google Scholar
• Kok AD, Hengeveld AF, Martin A, et al. The pyruvate dehydrogenase multi-enzyme complex from Gram-negative bacteria. Biochim Biophys Acta. 1998;1385:353–366.
   PubMed Web of Science ®Google Scholar
• Wang C, Ming L, Feng Y, et al. The involvement of sortase A in high virulence of STSS-causing Streptococcus suis serotype 2. Arch Microbiol. 2009;191:23.
   PubMed Web of Science ®Google Scholar
• Yonashiro R, Eguchi K, Wake M, et al. Pyruvate dehydrogenase PDH-E1Î2 controls tumor progression by altering the metabolic status of cancer cells. Cancer Res. 2018;78(canres.1751.2017).
   PubMed Web of Science ®Google Scholar
• Youngnyun K, Ingram LO, Shanmugam KT. Dihydrolipoamide dehydrogenase mutation alters the NADH sensitivity of pyruvate dehydrogenase complex of Escherichia coli K-12. J Bacteriol. 2008;190:3851.
   PubMed Web of Science ®Google Scholar
• Charland N, Nizet V, Rubens CE, et al. Streptococcus suis serotype 2 interactions with human brain microvascular endothelial cells. Infect Immun. 2000;68:637–643.
   PubMed Web of Science ®Google Scholar
• Feng L, Zhu J, Chang H, et al. The CodY regulator is essential for virulence in Streptococcus suis serotype 2. Sci Rep. 2016;6:21241.
   PubMed Web of Science ®Google Scholar
• Calhoun LN, Kwon YM. The effect of long-term propionate adaptation on the stress resistance of Salmonella Enteritidis. J Appl Microbiol. 2010;109:1294–1300.
   PubMed Web of Science ®Google Scholar
• Wang Y, Zhang W, Wu Z, et al. Functional analysis of luxS in Streptococcus suis reveals a key role in biofilm formation and virulence. Vet Microbiol. 2011;152:151–160.
   PubMed Web of Science ®Google Scholar
• Yang W, Wei Z, Zongfu W, et al. Reduced virulence is an important characteristic of biofilm infection of Streptococcus suis. FEMS Microbiol Lett. 2011;316:36–43.
   PubMed Web of Science ®Google Scholar
• Hanning I, Donoghue DJ, Jarquin R, et al. Campylobacter biofilm phenotype exhibits reduced colonization potential in young chickens and altered in vitro virulence. Poult Sci. 2009;88:1102–1107.
   PubMed Web of Science ®Google Scholar
• Wang Y, Wang Y, Sun L, et al. Streptococcus suis biofilm: regulation, drug-resistance mechanisms, and disinfection strategies. Appl Microbiol Biotechnol. 2018;102:9121–9129.
   Web of Science ®Google Scholar
• Salzillo M, Vastano V, Capri U, et al. Pyruvate dehydrogenase subunit β of Lactobacillus plantarum is a collagen adhesin involved in biofilm formation. J Basic Microbiol. 2016;57:353–357.
   PubMed Web of Science ®Google Scholar
• Li Q, Fu Y, He Y, et al. Fibronectin-/fibrinogen-binding protein (FBPS) is not a critical virulence factor for the Streptococcus suis serotype 2 strain ZY05719. Vet Microbiol. 2017;208:38–46.
   PubMed Web of Science ®Google Scholar
• Nakano T, Goto S, Takaoka Y, et al. A novel moonlight function of glyceraldehyde-3-phosphate dehydrogenase (GAPDH) for immunomodulation. Biofactors. 201844:597–608.
   PubMed Web of Science ®Google Scholar
• Peng G, Pinkston KL, Agathe B, et al. Library screen identifies Enterococcus faecalis CcpA, the catabolite control protein A, as an effector of Ace, a collagen adhesion protein linked to virulence. J Bacteriol. 2013;195:4761–4768.
   PubMed Web of Science ®Google Scholar
• Fiedler T, Kreikemeyer B, Sugareva V, et al. Impact of the Streptococcus pyogenes Mga regulator on human matrix protein binding and interaction with eukaryotic cells. Int J Med Microbiol. 2010;300:248–258.
   PubMed Web of Science ®Google Scholar
• Kim JR, Oh DR, Cha MH, et al. Protective effect of polygoni cuspidati radix and emodin on Vibrio vulnificus cytotoxicity and infection. J Microbiol. 2008;46:737–743.
   PubMed Web of Science ®Google Scholar
• Yang X, Shi G, Guo J, et al. Exosome-encapsulated antibiotic against intracellular infections of methicillin-resistant Staphylococcus aureus. Int J Nanomedicine. 2018;13:8095–8104.
   PubMed Web of Science ®Google Scholar
• Yanyan Z, Bingbing Z, Xiangru W, et al. Fisetin lowersstreptococcus suisserotype 2 pathogenicity in mice by inhibiting the hemolytic activity of suilysin. Front Microbiol. 2018;9:1723.
   PubMed Web of Science ®Google Scholar
• Wei Z, Ping LC. Immunoproteomics of extracellular proteins of Chinese virulent strains of Streptococcus suis type 2. Proteomics. 2010;7:4468–4476.
   Google Scholar
• Xu J, Zheng C, Cao M, et al. The manganese efflux system MntE contributes to the virulence of Streptococcus suis serotype 2. Microb Pathog. 2017;110:S088240101730390X.
   Web of Science ®Google Scholar
• Shippy DC, Eakley NM, Mikheil DM, et al. Role of the flagellar basal-body protein, FlgC, in the binding of Salmonella enterica serovar Enteritidis to host cells. Curr Microbiol. 2014;68:621–628.
   PubMed Web of Science ®Google Scholar
• Gao T, Tan M, Liu W, et al. GidA, a tRNA modification enzyme, contributes to the growth, and Virulence of Streptococcus suis Serotype 2. Front Cell Infect Microbiol. 2016;6:44.
   Web of Science ®Google Scholar
• Tan MF, Liu WQ, Zhang CY, et al. The involvement of MsmK in pathogenesis of the Streptococcus suis serotype 2. Microbiologyopen. 2017;6:e00433.
   Web of Science ®Google Scholar
• Yasser Musa I, Kerr AR, Silva NA, et al. Contribution of the ATP-dependent protease ClpCP to the autolysis and virulence of Streptococcus pneumoniae. Infect Immun. 2005;73:730–740.
   PubMed Web of Science ®Google Scholar
• Diaz-Torres ML, Russell RRB. HtrA protease and processing of extracellular proteins of Streptococcus mutans. FEMS Microbiol Lett. 2001;204:23–28.
   PubMed Web of Science ®Google Scholar
• Wu T, Zhao Z, Zhang L, et al. Trigger factor of Streptococcus suis is involved in stress tolerance and virulence. Microb Pathog. 2011;51:69–76.
   PubMed Web of Science ®Google Scholar
• Grenier D, Grignon L, Gottschalk M. Characterisation of biofilm formation by a Streptococcus suis meningitis isolate. Vet J. 2009;179:292–295.
   PubMed Web of Science ®Google Scholar
• Vanier G, Fittipaldi N, Slater JD, et al. New putative virulence factors of Streptococcus suis involved in invasion of porcine brain microvascular endothelial cells. Microb Pathog. 2009;46:13–20.
   PubMed Web of Science ®Google Scholar
• Huang D, Zhu H, Lin H, et al. First insights into the protective effects of a recombinant swinepox virus expressing truncated MRP of Streptococcus suis type 2 in mice. Berl Munch Tierarztl Wochenschr. 2012;125:144–152.
   PubMed Web of Science ®Google Scholar
• Lalonde M, Segura M, Lacouture S, et al. Interactions between Streptococcus suis serotype 2 and different epithelial cell lines. Microbiology. 2000;146(Pt 8):1913–1921.
   PubMed Web of Science ®Google Scholar
• Li L, Sun L, Song Y, et al. Screening of Actinobacillus pleuropneumoniae LuxS inhibitors. Curr Microbiol. 2013;67:564–571.
   PubMed Web of Science ®Google Scholar
• Yi L, Wang Y, Ma Z, et al. Contribution of fibronectin-binding protein to pathogenesis of Streptococcus equi ssp. zooepidemicus. Pathog Dis. 2013;67:174–183.
   PubMed Web of Science ®Google Scholar
• Zhe M, Hong-Jie F, Cheng-Ping L. Molecular cloning and analysis of the UDP-glucose pyrophosphorylase in Streptococcus equi subsp. zooepidemicus. Mol Biol Rep. 2011;38:2751–2760.
   PubMed Web of Science ®Google Scholar