Screening for phagocytosis resistance-related genes via a transposon mutant library of Streptococcus suis serotype 2

References

• Feng Y, Zhang H, Wu Z, et al. Streptococcus suis infection: an emerging/reemerging challenge of bacterial infectious diseases? Virulence. 2014;5(4):477–497.
   PubMed Web of Science ®Google Scholar
• Gottschalk M, Xu J, Calzas C, et al. Streptococcus suis: a new emerging or an old neglected zoonotic pathogen? Future Microbiol. 2010;5(3):371–391.
   PubMed Web of Science ®Google Scholar
• Liu R, Zhang P, Su Y, et al. A novel suicide shuttle plasmid for Streptococcus suis serotype 2 and Streptococcus equi ssp. zooepidemicus gene mutation. Sci Rep. 2016;6:27133.
   PubMed Web of Science ®Google Scholar
• Cameron DE, Urbach JM, Mekalanos JJ. A defined transposon mutant library and its use in identifying motility genes in Vibrio cholerae. Proc Natl Acad Sci U S A. 2008;105(25):8736–8741.
   PubMed Web of Science ®Google Scholar
• Jung H-J, Littmann ER, Seok R, et al. Genome-wide screening for enteric colonization factors in carbapenem-resistant ST258 Klebsiella pneumoniae. mBio. 2019;10(2):e02663–02618.
   PubMed Web of Science ®Google Scholar
• Le Breton Y, Mistry P, Valdes KM, et al. Genome-wide identification of genes required for fitness of group A Streptococcus in human blood. Infect Immun. 2013;81(3):862–875.
   PubMed Web of Science ®Google Scholar
• Pang M, Xie X, Dong Y, et al. Identification of novel virulence-related genes in Aeromonas hydrophila by screening transposon mutants in a Tetrahymena infection model. Vet Microbiol. 2017;199:36–46.
   PubMed Web of Science ®Google Scholar
• Flannagan RS, Heit B, Heinrichs DE. Antimicrobial mechanisms of macrophages and the immune evasion strategies of Staphylococcus aureus. Pathogens. 2015;4(4):826–868.
   PubMed Web of Science ®Google Scholar
• Smith HE, Damman M, van der Velde J, et al. Identification and characterization of the cps locus of Streptococcus suis serotype 2: the capsule protects against phagocytosis and is an important virulence factor. Infect Immun. 1999;67(4):1750–1756.
   PubMed Web of Science ®Google Scholar
• Benga L, Fulde M, Neis C, et al. Polysaccharide capsule and suilysin contribute to extracellular survival of Streptococcus suis co-cultivated with primary porcine phagocytes. Vet Microbiol. 2008;132(1–2):211–219.
   PubMed Web of Science ®Google Scholar
• Lecours MP, Fittipaldi N, Takamatsu D, et al. Sialylation of Streptococcus suis serotype 2 is essential for capsule expression but is not responsible for the main capsular epitope. Microbes Infect. 2012;14:11.
   Web of Science ®Google Scholar
• Yu J, Pian Y, Ge J, et al. Functional and structural characterization of the antiphagocytic properties of a novel transglutaminase from Streptococcus suis. J Biol Chem. 2015;290(31):19081–19092.
   PubMed Web of Science ®Google Scholar
• Pian Y, Gan S, Wang S, et al. Fhb, a novel factor H-binding surface protein, contributes to the antiphagocytic ability and virulence of Streptococcus suis. Infect Immun. 2012;80(7):2402–2413.
   PubMed Web of Science ®Google Scholar
• Lakkitjaroen N, Takamatsu D, Okura M, et al. Capsule loss or death: the position of mutations among capsule genes sways the destiny of Streptococcus suis. FEMS Microbiol Lett. 2014;354(1):46–54.
   PubMed Web of Science ®Google Scholar
• Dubrac S, Msadek T. Identification of genes controlled by the essential YycG/YycF two-component system of Staphylococcus aureus. J Bacteriol. 2004;186(4):1175–1181.
   PubMed Web of Science ®Google Scholar
• Howell A, Dubrac S, Andersen KK, et al. Genes controlled by the essential YycG/YycF two-component system of Bacillus subtilis revealed through a novel hybrid regulator approach. Mol Microbiol. 2003;49(6):1639–1655.
   PubMed Web of Science ®Google Scholar
• Segura M, Gottschalk M, Olivier M. Encapsulated Streptococcus suis inhibits activation of signaling pathways involved in phagocytosis. Infect Immun. 2004;72(9):5322–5330.
   PubMed Web of Science ®Google Scholar
• Tang Y, Zhang X, Wu W, et al. Inactivation of the sodA gene of Streptococcus suis type 2 encoding superoxide dismutase leads to reduced virulence to mice. Vet Microbiol. 2012;158(3–4):360–366.
   PubMed Web of Science ®Google Scholar
• Yamaguchi M, Terao Y, Ogawa T, et al. Role of Streptococcus sanguinis sortase A in bacterial colonization. Microbes Infect. 2006;8(12–13):2791–2796.
   PubMed Web of Science ®Google Scholar
• Hyams C, Yuste J, Bax K, et al. Streptococcus pneumoniae resistance to complement-mediated immunity is dependent on the capsular serotype. Infect Immun. 2010b;78(2):716–725.
   PubMed Web of Science ®Google Scholar
• Wu Z, Wu C, Shao J, et al. The Streptococcus suis transcriptional landscape reveals adaptation mechanisms in pig blood and cerebrospinal fluid. RNA. 2014;20(6):882–898.
   PubMed Web of Science ®Google Scholar
• Takamatsu D, Osaki M, Sekizaki T. Thermosensitive suicide vectors for gene replacement in Streptococcus suis. Plasmid. 2001;46(2):140–148.
   Google Scholar
• Takamatsu D, Osaki M, Sekizaki T. Construction and characterization of streptococcus suis–Escherichia coli shuttle cloning vectors. Plasmid. 2001;45(2):101–113.
   Google Scholar
• Caron E, Hall A. Identifification of two distinct mechanisms of phagocytosis controlled by different Rho GTPases. Science. 1998;282(5394):1717–1721.
   PubMed Web of Science ®Google Scholar
• May RC, Machesky LM. Phagocytosis and the actin cytoskeleton. J Cell Sci. 2001;114(Pt 6):1061–1077.
   PubMed Web of Science ®Google Scholar
• Flannagan RS, Cosío G, Grinstein S. Antimicrobial mechanisms of phagocytes and bacterial evasion strategies. Nat Rev Microbiol. 2009;7(5):355–366.
   PubMed Web of Science ®Google Scholar
• Caron E, Crepin VF, Simpson N, et al. Subversion of actin dynamics by EPEC and EHEC. Curr Opin Microbiol. 2006;9(1):40–45.
   PubMed Web of Science ®Google Scholar
• Shao F, Merritt PM, Bao Z, et al. A Yersinia effector and a Pseudomonas avirulence protein define a family of cysteine proteases functioning in bacterial pathogenesis. Cell. 2002;109(5):575–588.
   PubMed Web of Science ®Google Scholar
• Carlin AF, Chang YC, Areschoug T, et al. Group B Streptococcus suppression of phagocyte functions by protein-mediated engagement of human Siglec-5. J Exp Med. 2009a;206(8):1691–1699.
   PubMed Web of Science ®Google Scholar
• Carlin AF, Uchiyama S, Chang YC, et al. Molecular mimicry of host sialylated glycans allows a bacterial pathogen to engage neutrophil Siglec-9 and dampen the innate immune response. Blood. 2009b;113(14):3333–3336.
   PubMed Web of Science ®Google Scholar
• Pinheiro da Silva F, Aloulou M, Skurnik D, et al. CD16 promotes Escherichia coli sepsis through an FcR gamma inhibitory pathway that prevents phagocytosis and facilitates inflammation. Nat Med. 2007;13(11):1368–1374.
   PubMed Web of Science ®Google Scholar
• Vandal OH, Pierini LM, Schnappinger D, et al. A membrane protein preserves intrabacterial pH in intraphagosomal Mycobacterium tuberculosis. Nat Med. 2008;14(8):849–854.
   PubMed Web of Science ®Google Scholar
• Ng VH, Cox JS, Sousa AO, et al. Role of KatG catalase‐peroxidase in mycobacterial pathogenesis: countering the phagocyte oxidative burst. Mol Microbiol. 2004;52(5):1291–1302.
   PubMed Web of Science ®Google Scholar
• Fischetti VA. Streptococcal M protein: molecular design and biological behavior. Clin Microbiol Rev. 1989;2(3):285–314.
   PubMed Web of Science ®Google Scholar
• Moses A, Wessels E, Zalcman MR, et al. Relative contributions of hyaluronic acid capsule and M protein to virulence in a mucoid strain of the group A Streptococcus. Infect Immun. 1997;65(1):64–71.
   PubMed Web of Science ®Google Scholar
• Seele J, Beineke A, Hillermann L, et al. The immunoglobulin M-degrading enzyme of Streptococcus suis, IdeSsuis, is involved in complement evasion. Vet Res. 2015;46(1):45.
   PubMedGoogle Scholar
• Hyams C, Camberlein E, Cohen JM, et al. The Streptococcus pneumoniae capsule inhibits complement activity and neutrophil phagocytosis by multiple mechanisms. Infect Immun. 2010a;78(2):704–715.
   PubMed Web of Science ®Google Scholar
• Marques MB, Kasper DL, Pangburn MK, et al. Prevention of C3 deposition by capsular polysaccharide is a virulence mechanism of type III group B streptococci. Infect Immun. 1992;60(10):3986–3993.
   PubMed Web of Science ®Google Scholar
• Brazeau C, Gottschalk M, Vincelette S, et al. In vitro phagocytosis and survival of Streptococcus suis capsular type 2 inside murine macrophages. Microbiology. 1996;142(Pt 5):1231–1237.
   PubMedGoogle Scholar
• Sang Y, Ren J, Qin R, et al. Acetylation regulating protein stability and DNA-binding ability of HilD, thus modulating Salmonella typhimurium virulence. J Infect Dis. 2017;216(8):1018–1026.
   PubMed Web of Science ®Google Scholar
• Tikhomirova A, Trappetti C, Standish AJ, et al. Specific growth conditions induce a Streptococcus pneumoniae non-mucoidal, small colony variant and determine the outcome of its co-culture with Haemophilus influenzae. Pathog Dis. 2018;76(7). DOI:https://doi.org/10.1093/femspd/fty074
   Google Scholar
• Sutcliffe IC, Russell R. Lipoproteins of gram-positive bacteria. J Bacteriol. 1995;177(5):1123.
   PubMed Web of Science ®Google Scholar
• Brown JS, Gilliland SM, Holden DW. A Streptococcus pneumoniae pathogenicity island encoding an ABC transporter involved in iron uptake and virulence. Mol Microbiol. 2001;40(3):572–585.
   PubMed Web of Science ®Google Scholar
• Miyaji EN, Dias WO, Gamberini M, et al. PsaA (pneumococcal surface adhesin A) and PspA (pneumococcal surface protein A) DNA vaccines induce humoral and cellular immune responses against Streptococcus pneumoniae. Vaccine. 2001;20(5–6):805–812.
   PubMed Web of Science ®Google Scholar
• Semchenko EA, Day CJ, Seib KL. MetQ of Neisseria gonorrhoeae is a surface-expressed antigen that elicits bactericidal and functional blocking antibodies. Infect Immun. 2017;85(2):e00898–00816.
   PubMed Web of Science ®Google Scholar
• Gu H, Zhu H, Lu C. Use of in vivo-induced antigen technology (IVIAT) for the identification of Streptococcus suis serotype 2 in vivo-induced bacterial protein antigens. BMC Microbiol. 2009;9(1):201.
   PubMedGoogle Scholar
• Basavanna S, Khandavilli S, Yuste J, et al. Screening of streptococcus pneumoniae abc transporter mutants demonstrates that livjhmgf, a branched-chain amino acid ABC transporter, is necessary for disease pathogenesis. Infect Immun. 2009;77(8):3412–3423.
   PubMed Web of Science ®Google Scholar
• Molzen T, Burghout P, Bootsma H, et al. Genome-wide identification of Streptococcus pneumoniae genes essential for bacterial replication during experimental meningitis. Infect Immun. 2011;79(1):288–297.
   PubMed Web of Science ®Google Scholar
• Segura M, Gottschalk M. Streptococcus suis interactions with the murine macrophage cell line j774: adhesion and cytotoxicity. Infect Immun. 2002;70(8):4312–4322.
   PubMed Web of Science ®Google Scholar
• Utsumi R. Bacterial signal transduction: networks and drug targets. Vol. 631. Springer, New York; 2008.
   Google Scholar
• Wagner C, Saizieu A, Schonfeld A, et al. Genetic analysis and functional characterization of the Streptococcus pneumoniae vic operon. Infect Immun. 2002;70(11):6121–6128.
   PubMed Web of Science ®Google Scholar
• Ng WL, Robertson GT, Kazmierczak KM, et al. Constitutive expression of PcsB suppresses the requirement for the essential VicR (YycF) response regulator in Streptococcus pneumoniae R6. Mol Microbiol. 2003;50(5):1647–1663.
   PubMed Web of Science ®Google Scholar
• Mohedano ML, Overweg K, De La Fuente A, et al. Evidence that the essential response regulator YycF in Streptococcus pneumoniae modulates expression of fatty acid biosynthesis genes and alters membrane composition. J Bacteriol. 2005;187(7):2357–2367.
   PubMed Web of Science ®Google Scholar
• Senadheera DB, Cordova M, Ayala EA, et al. Regulation of bacteriocin production and cell death by the VicRK signaling system in Streptococcus mutans. J Bacteriol. 2012;194(6):1307–1316.
   PubMed Web of Science ®Google Scholar
• Ahn S-J, Burne RA. Effects of oxygen on biofilm formation and the AtlA autolysin of Streptococcus mutans. J Bacteriol. 2007;189(17):6293–6302.
   PubMed Web of Science ®Google Scholar
• Ng WL, Tsui H-CT, Winkler ME. Regulation of the pspA virulence factor and essential pcsB murein biosynthetic genes by the phosphorylated VicR (YycF) response regulator in Streptococcus pneumoniae. J Bacteriol. 2005;187(21):7444–7459.
   PubMed Web of Science ®Google Scholar
• Tu AH, Fulgham RL, McCrory MA, et al. Pneumococcal surface protein A inhibits complement activation by Streptococcus pneumoniae. Infect Immun. 1999;67(9):4720–4724.
   PubMed Web of Science ®Google Scholar
• Martinez PJ, Farhan A, Mustafa M, et al. PspA facilitates evasion of pneumococci from bactericidal activity of neutrophil extracellular traps (NETs). Microb Pathog. 2019;136:103653.
   PubMed Web of Science ®Google Scholar
• Xu B, Zhang P, Li W, et al. hsdS, Belonging to the type i restriction-modification system, contributes to the Streptococcus suis serotype 2 survival ability in phagocytes. Front Microbiol. 2017;8:1524.
   PubMed Web of Science ®Google Scholar