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Virulence Volume 11, 2020 - Issue 1
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Research paper

Characteristics of asymptomatic COVID-19 infection and progression: A multicenter, retrospective study

Chao Yua Department of Respiratory and Critical Care Medicine, Naval Hospital of Eastern Theater of PLA,Zhoushan, Zhejiang, P. R. China;b No.5 Department of Infectious Diseases, Guanggu District, The Maternal and Child Health Hospital of Hubei Province, Wuhan, Hubei, P. R. ChinaView further author information
,
Miao Zhouc Department of Anesthesiology and SICU, Xinhua Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai, P. R. ChinaView further author information
,
Yang Liud Department of Anesthesiology, Changzheng Hospital, Second Military Medical University, Shanghai, P. R. ChinaView further author information
,
Tinglin Guoa Department of Respiratory and Critical Care Medicine, Naval Hospital of Eastern Theater of PLA,Zhoushan, Zhejiang, P. R. China;b No.5 Department of Infectious Diseases, Guanggu District, The Maternal and Child Health Hospital of Hubei Province, Wuhan, Hubei, P. R. ChinaView further author information
,
Chongyang Oua Department of Respiratory and Critical Care Medicine, Naval Hospital of Eastern Theater of PLA,Zhoushan, Zhejiang, P. R. China;b No.5 Department of Infectious Diseases, Guanggu District, The Maternal and Child Health Hospital of Hubei Province, Wuhan, Hubei, P. R. ChinaView further author information
,
Liye Yangd Department of Anesthesiology, Changzheng Hospital, Second Military Medical University, Shanghai, P. R. China;e No.2 Department of Infectious Diseases, Wuhan Huoshenshan Hospital, Wuhan, Hubei, P. R. ChinaView further author information
,
Yan Lif Department of Orthopedics, Ningxiang People’s Hospital, Changsha City, Hunan, P. R. China;g Department of Tuberculosis, North Ward 5, Wuhan Jinyintan Hospital, Wuhan, Hubei, P. R. ChinaView further author information
,
Dongliang Lih Department of Hepatobiliary Medicine, The 900th Hospital of the People’s Liberation Army Joint Service Force, Fuzhou, Fujian, P. R. China;i No.8 Department of Infectious Diseases, Taikang Tongji (Wuhan) Hospital of Hubei Province, Wuhan, Hubei, P. R. ChinaView further author information
,
Xinyu Huj Graduate School, Hebei North University, Zhangjiakou, Hebei, P. R. ChinaView further author information
,
Li Shuaia Department of Respiratory and Critical Care Medicine, Naval Hospital of Eastern Theater of PLA,Zhoushan, Zhejiang, P. R. ChinaCorrespondence[email protected]
View further author information
,
Bin Wangk Department of Oncology, Changhai Hospital, Second Military Medical University, Shanghai, P. R. ChinaCorrespondence[email protected]
View further author information
&
Zui Zoud Department of Anesthesiology, Changzheng Hospital, Second Military Medical University, Shanghai, P. R. China;l No.3 Department of Infectious Diseases, Guanggu District, The Maternal and Child Health Hospital of Hubei Province, Wuhan, Hubei, P. R. ChinaCorrespondence[email protected]
View further author information
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Pages 1006-1014 | Received 24 May 2020, Accepted 19 Jul 2020, Published online: 12 Aug 2020

References

  • WHO. Coronavirus disease 2019 (COVID-19) Situation Report – 101; 2020. Epub April 30.
  • Del Rio C, Malani PN. COVID-19-new insights on a rapidly changing epidemic. Jama. 2020 Feb 28;323(14):1339–1340. PubMed PMID: 32108857.
  • Bai Y, Yao L, Wei T, et al. Presumed asymptomatic carrier transmission of COVID-19. Jama. 2020 Feb 21;323(14):1406–1407. PubMed PMID: 32083643. Pubmed Central PMCID: 7042844.
  • Rothe C, Schunk M, Sothmann P, et al. Transmission of 2019-nCoV infection from an asymptomatic contact in Germany. N Engl J Med. 2020 Mar 5;382(10):970–971. PubMed PMID: 32003551. Pubmed Central PMCID: 7120970.
  • Novel Coronavirus Pneumonia Emergency Response Epidemiology T. [The epidemiological characteristics of an outbreak of 2019 novel coronavirus diseases (COVID-19) in China]. Zhonghua Liu Xing Bing Xue Za Zhi. 2020 Feb 17;41(2):145–151. PubMed PMID: 32064853. .
  • Zhou X, Li Y, Li T, et al. Follow-up of asymptomatic patients with SARS-CoV-2 infection. Clin Microbiol Infect. 2020 Mar;28:S1198-743X(20)30169–5. PubMed PMID: 32234453.
  • WHO. Clinical management of severe acute respiratory infection when novel coronavirus (2019-nCoV) infection is suspected: interim guidance, 28 January 2020. World Health Organization. 28 Jan 2020.
  • Li G, Li W, He X, et al. Asymptomatic and presymptomatic infectors: hidden sources of COVID-19 disease. Clin Infect Dis. 2020 Apr 9:ciaa418. PubMed PMID: 32271372. Pubmed Central PMCID: 7184467. doi:https://doi.org/10.1093/cid/ciaa418
  • Jacob B, Aguilar JSF, Lauren M, et al. Gutierrez investigating the impact of asymptomatic carriers on COVID-19 transmission. medRxiv. 2020. Available from: https://www.medrxiv.org/content/https://doi.org/10.1101/2020.03.18.20037994v3
  • Long QX, Tang XJ, Shi QL, et al. Clinical and immunological assessment of asymptomatic SARS-CoV-2 infections. Nat Med. 2020 Jun 18. PubMed PMID: 32555424. DOI:https://doi.org/10.1038/s41591-020-0965-6.
  • Lauer SA, Grantz KH, Bi Q, et al. The incubation period of coronavirus disease 2019 (COVID-19) from publicly reported confirmed cases: estimation and application. Ann Intern Med. 2020 May 5;172(9):577–582. PubMed PMID: 32150748. Pubmed Central PMCID: 7081172.
  • Han H. Estimate the incubation period of coronavirus 2019 (COVID-19). medRxiv. 2020.
  • Wang D, Hu B, Hu C, et al. Clinical characteristics of 138 hospitalized patients with 2019 novel coronavirus-infected Pneumonia in Wuhan, China. Jama. 2020 Feb 7;323(11):1061–1069. PubMed PMID: 32031570. Pubmed Central PMCID: 7042881.
  • Zhou F, Yu T, Du R, et al. Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China: a retrospective cohort study. Lancet. 2020 Mar 28;395(10229):1054–1062. PubMed PMID: 32171076.
  • Zhang P, Zhu L, Cai J, et al. Association of inpatient use of angiotensin converting enzyme inhibitors and angiotensin ii receptor blockers with mortality among patients with hypertension hospitalized with COVID-19. Circ Res. 2020 Apr 17. PubMed PMID: 32302265. DOI:https://doi.org/10.1161/CIRCRESAHA.120.317134.
  • Xu DZH, Gong H, Chen J, et al. Identification of a potential mechanism of acute kidney injury during the covid-19 outbreak: a study based on single-cell transcriptome analysis. Preprints. 2020;2020020331.
  • Zhang C, Shi L, Wang FS. Liver injury in COVID-19: management and challenges. Lancet Gastroenterol Hepatol. 2020 5;May(5):428–430. PubMed PMID: 32145190. Pubmed Central PMCID: 7129165.
  • Caibin Fan KL, Ding Y, Lu Lu W, et al. ACE2 expression in kidney and testis may cause kidney and testis damage after 2019-nCoV infection. medRxiv. 2020.
  • He X, Lau EHY, Wu P, et al. Temporal dynamics in viral shedding and transmissibility of COVID-19. Nat Med. 2020 May;26(5):672–675. PubMed PMID: 32296168.
  • Zou L, Ruan F, Huang M, et al. sars-cov-2 viral load in upper respiratory specimens of infected patients. N Engl J Med. 2020 Mar 19;382(12):1177–1179. PubMed PMID: 32074444. Pubmed Central PMCID: 7121626.
  • Li N, Wang X, Lv T. Prolonged SARS-CoV-2 RNA shedding: not a rare phenomenon. J Med Virol. 2020 Apr 29. PubMed PMID: 32347980. DOI:https://doi.org/10.1002/jmv.25952.
  • Xu K, Chen Y, Yuan J, et al. Factors associated with prolonged viral RNA shedding in patients with COVID-19. Clin Infect Dis. 2020 Apr 9 PubMed PMID: 32271376. Pubmed Central PMCID: 7184421. DOI:https://doi.org/10.1093/cid/ciaa351.
  • Lan L, Xu D, Ye G, et al. Positive RT-PCR Test Results in Patients Recovered From COVID-19. Jama. 2020 Feb 27;323(15):1502–1503. PubMed PMID: 32105304. Pubmed Central PMCID: 7047852.
  • Jianghong AXL, Xiao T, Qian S, et al. Clinical characteristics of the recovered COVID-19 patients with re-detectable positive RNA test. medRxiv. 2020.
  • Yuhan Xing WN, Wu Q, Li W, et al. Prolonged presence of SARS-CoV-2 in feces of pediatric patients during the convalescent phase. medRxiv. 2020.
  • Xiao AT, Tong YX, Zhang S. False-negative of RT-PCR and prolonged nucleic acid conversion in COVID-19: rather than recurrence. J Med Virol. 2020 Apr 9. PubMed PMID: 32270882. DOI:https://doi.org/10.1002/jmv.25855.
  • Yao XH, He ZC, Li TY, et al. Pathological evidence for residual SARS-CoV-2 in pulmonary tissues of a ready-for-discharge patient. Cell Res. 2020 Apr 28;30:541–543. PubMed PMID: 32346074. .

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