Review of human pegivirus: Prevalence, transmission, pathogenesis, and clinical implication

References

• Marano G, Franchini M, Farina B, et al. The human pegivirus: a new name for an “ancient” virus. can transfusion medicine come up with something new? Acta Virol. 2017;61:401–412.
   PubMed Web of Science ®Google Scholar
• Chivero ET, Stapleton JT. Tropism of human pegivirus (formerly known as GB virus C/hepatitis G virus) and host immunomodulation: insights into a highly successful viral infection. J Gen Virol. 2015;96:1521–1532.
   PubMed Web of Science ®Google Scholar
• Stapleton JT, Foung S, Muerhoff AS, et al. The GB viruses: a review and proposed classification of GBV-A, GBV-C (HGV), and GBV-D in genus pegivirus within the family Flaviviridae. J Gen Virol. 2011;92:233–246.
   PubMed Web of Science ®Google Scholar
• Schwarze-Zander C, Blackard JT, Rockstroh JK. Role of GB virus C in modulating HIV disease. Expert Rev Anti Infect Ther. 2012;10:563–572.
   PubMed Web of Science ®Google Scholar
• Giret MTM, Kallas EG. GBV-C: state of the art and future prospects. Curr HIV/AIDS Rep. 2012;9:26–33.
   PubMed Web of Science ®Google Scholar
• Bhattarai N, Stapleton JT. GB virus C: the good boy virus? Trends Microbiol. 2012;20:124–130.
   PubMed Web of Science ®Google Scholar
• Mohr EL, Stapleton JT. GB virus type C interactions with HIV: the role of envelope glycoproteins. J Viral Hepat. 2009;16:757–768.
   PubMed Web of Science ®Google Scholar
• Deinhardt F, Holmes AW, Capps RB, et al. Studies on the transmission of human viral hepatitis to marmoset monkeys. I. transmission of disease, serial passages, and description of liver lesions. J Exp Med. 1967;125:673–688.
   PubMed Web of Science ®Google Scholar
• Simons JN, Pilot-Matias TJ, Leary TP, et al. Identification of two flavivirus-like genomes in the GB hepatitis agent. Proc Natl Acad Sci U S A. 1995;92:3401–3405.
   PubMed Web of Science ®Google Scholar
• Simons JN, Leary TP, Dawson GJ, et al. Isolation of novel virus-like sequences associated with human hepatitis. Nat Med. 1995;1:564–569.
   PubMed Web of Science ®Google Scholar
• Leary TP, Muerhoff AS, Simons JN, et al. Sequence and genomic organization of GBV-C: a novel member of the flaviviridae associated with human non-A-E hepatitis. J Med Virol. 1996;48:60–67.
   PubMed Web of Science ®Google Scholar
• Linnen J, Wages J, Zhang-Keck ZY, et al. Molecular cloning and disease association of hepatitis G virus: a transfusion-transmissible agent. Science. 1996;271:505–508.
   PubMed Web of Science ®Google Scholar
• Epstein JH, Quan P-L, Briese T, et al. Identification of GBV-D, a novel GB-like flavivirus from old world frugivorous bats (pteropus giganteus) in Bangladesh. PLoS Pathog. 2010;6:e1000972.
   PubMed Web of Science ®Google Scholar
• Bukh J, Apgar CL, Yanagi M. Toward a surrogate model for hepatitis C virus: an infectious molecular clone of the GB virus-B hepatitis agent. Virology. 1999;262:470–478.
   PubMed Web of Science ®Google Scholar
• Martin A, Bodola F, Sangar DV, et al. Chronic hepatitis associated with GB virus B persistence in a tamarin after intrahepatic inoculation of synthetic viral RNA. Proc Natl Acad Sci U S A. 2003;100:9962–9967.
   PubMed Web of Science ®Google Scholar
• Adams NJ, Prescott LE, Jarvis LM, et al. Detection in chimpanzees of a novel flavivirus related to GB virus-C/hepatitis G virus. J Gen Virol. 1998;79((Pt 8)):1871–1877.
   PubMedGoogle Scholar
• Birkenmeyer LG, Desai SM, Muerhoff AS, et al. Isolation of a GB virus-related genome from a chimpanzee. J Med Virol. 1998;56:44–51.
   PubMed Web of Science ®Google Scholar
• Bukh J, Apgar CL. Five new or recently discovered (GBV-A) virus species are indigenous to new world monkeys and may constitute a separate genus of the Flaviviridae. Virology. 1997;229:429–436.
   PubMed Web of Science ®Google Scholar
• Charrel RN, De Micco P, de Lamballerie X. Phylogenetic analysis of GB viruses A and C: evidence for cospeciation between virus isolates and their primate hosts. J Gen Virol. 1999;80((Pt 9)):2329–2335.
   PubMedGoogle Scholar
• Mohr EL, Murthy KK, McLinden JH, et al. The natural history of non-human GB virus C in captive chimpanzees. J Gen Virol. 2011 92 :91–100.
   PubMed Web of Science ®Google Scholar
• Sibley SD, Lauck M, Bailey AL, et al. Discovery and characterization of distinct simian pegiviruses in three wild African old world monkey species. PLoS One. 2014;9(6):e98569.
   PubMed Web of Science ®Google Scholar
• Kapoor A, Simmonds P, Cullen JM, et al. Identification of a pegivirus (GB virus-like virus) that infects horses. J Virol. 2013;87:7185–7190.
   PubMed Web of Science ®Google Scholar
• de Souza AJS, Malheiros AP, de Sousa ERP, et al. First report of equine pegivirus in South America, Brazil. Acta Trop. 2015;152:56–59.
   PubMed Web of Science ®Google Scholar
• Tang W, Zhu N, Wang H, et al. Identification and genetic characterization of equine pegivirus in China. J Gen Virol. 2018;99:768–776.
   PubMed Web of Science ®Google Scholar
• Tomlinson JE, Wolfisberg R, Fahnøe U, et al. Equine pegiviruses cause persistent infection of bone marrow and are not associated with hepatitis. PLoS Pathog. 2020;16:e1008677.
   PubMed Web of Science ®Google Scholar
• Kapoor A, Simmonds P, Scheel TKH, et al. Identification of rodent homologs of hepatitis C virus and pegiviruses. mBio. 2013;4:e00216–e00213.
   PubMed Web of Science ®Google Scholar
• Quan P-L, Firth C, Conte JM, et al. Bats are a major natural reservoir for hepaciviruses and pegiviruses. Proc Natl Acad Sci U S A. 2013;110:8194–8199.
   PubMed Web of Science ®Google Scholar
• Van Nguyen D, Van Nguyen C, Bonsall D, et al. Detection and characterization of homologues of human hepatitis viruses and pegiviruses in rodents and bats in Vietnam. Viruses. 2018;10 102.
   PubMed Web of Science ®Google Scholar
• Wu Z, Wu Y, Zhang W, et al. The first nonmammalian pegivirus demonstrates efficient replication and high lymphotropism. J Virol. 2020 94 :e01150–20.
   PubMed Web of Science ®Google Scholar
• Zhen W, Wu Y, Zhang W, et al. Emergence of a novel pegivirus species in southwest China showing a high rate of coinfection with parvovirus and circovirus in geese. Poult Sci. 2021;100:101251.
   PubMed Web of Science ®Google Scholar
• Kapoor A, Kumar A, Simmonds P, et al. Virome analysis of transfusion recipients reveals a novel human virus that shares genomic features with hepaciviruses and pegiviruses. mBio. 2015;6:e01466–e01415.
   PubMed Web of Science ®Google Scholar
• Berg MG, Lee D, Coller K, et al. Discovery of a novel human pegivirus in blood associated with hepatitis C virus co-infection. PLoS Pathog. 2015;11:e1005325. DOI:10.1371/journal.ppat.1005325.
   PubMed Web of Science ®Google Scholar
• Liang Y, Hu F, Fan H, et al. Difference of intrahost dynamics of the second human pegivirus and hepatitis C virus in HPgV-2/HCV-Coinfected patients. Front Cell Infect Microbiol. 2021;11:728415.
   PubMed Web of Science ®Google Scholar
• Wang H, Wan Z, Sun Q, et al. Second human pegivirus in hepatitis c virus-infected and hepatitis c virus/HIV-1-Co-infected persons who inject drugs, China. Emerg Infect Dis. 2018;24:908–911.
   PubMed Web of Science ®Google Scholar
• Anh NT, Hong NTT, Nhu LNT, et al. Detection and characterization of human pegivirus 2, Vietnam. Emerg Infect Dis. 2018;24:2063–2067.
   PubMed Web of Science ®Google Scholar
• Rodgers MA, Holzmayer V, Vallari A, et al. Hepatitis C virus surveillance and identification of human pegivirus 2 in a large Cameroonian cohort. J Viral Hepat. 2019;26:30–37.
   PubMed Web of Science ®Google Scholar
• Simons JN, Desai SM, Schultz DE, et al. Translation initiation in GB viruses A and C: evidence for internal ribosome entry and implications for genome organization. J Virol. 1996;70:6126–6135.
   PubMed Web of Science ®Google Scholar
• Kim CW, Chang K-M. Hepatitis C virus: virology and life cycle. Clin Mol Hepatol. 2013;19:17–25.
   PubMedGoogle Scholar
• Kim JP, Fry KE. Molecular characterization of the hepatitis G virus. J Viral Hepat. 1997;4:77–79.
   PubMed Web of Science ®Google Scholar
• Agnello V, Abel G, Elfahal M, et al. Hepatitis C virus and other flaviviridae viruses enter cells via low density lipoprotein receptor. Proc Natl Acad Sci U S A. 1999;96:12766–12771.
   PubMed Web of Science ®Google Scholar
• Moradpour D, Penin F, Rice CM. Replication of hepatitis C virus. Nat Rev Microbiol. 2007;5:453–463.
   PubMed Web of Science ®Google Scholar
• Xiang J, Klinzman D, McLinden J, et al. Characterization of hepatitis G virus (GB-C virus) particles: evidence for a nucleocapsid and expression of sequences upstream of the E1 protein. J Virol. 1998;72:2738–2744.
   PubMed Web of Science ®Google Scholar
• Dubuisson J. Hepatitis C virus proteins. World J Gastroenterol. 2007;13:2406–2415.
   PubMed Web of Science ®Google Scholar
• Tacke M, Schmolke S, Schlueter V, et al. Humoral immune response to the E2 protein of hepatitis G virus is associated with long-term recovery from infection and reveals a high frequency of hepatitis G virus exposure among healthy blood donors. Hepatology. 1997;26:1626–1633.
   PubMed Web of Science ®Google Scholar
• Tillmann HL, Heringlake S, Trautwein C, et al. Antibodies against the GB virus C envelope 2 protein before liver transplantation protect against GB virus C de novo infection. Hepatology. 1998;28:379–384.
   PubMed Web of Science ®Google Scholar
• Eissmann K, Mueller S, Sticht H, et al. HIV-1 fusion is blocked through binding of GB Virus C E2-derived peptides to the HIV-1 gp41 disulfide loop [corrected]. PLoS One. 2013;8:e54452.
   PubMed Web of Science ®Google Scholar
• Mohr EL, Xiang J, McLinden JH, et al. GB virus type C envelope protein E2 elicits antibodies that react with a cellular antigen on HIV-1 particles and neutralize diverse HIV-1 isolates. J Immunol. 2010;185:4496–4505.
   PubMed Web of Science ®Google Scholar
• Chivero ET, Bhattarai N, McLinden JH, et al. Human pegivirus (HPgV; formerly known as GBV-C) inhibits IL-12 dependent natural killer cell function. Virology. 2015;485:116–127.
   PubMed Web of Science ®Google Scholar
• Bhattarai N, McLinden JH, Xiang J, et al. GB virus C envelope protein E2 inhibits TCR-induced IL-2 production and alters IL-2-signaling pathways. J Immunol. 2012;189:2211–2216.
   PubMed Web of Science ®Google Scholar
• Penin F, Dubuisson J, Rey FA, et al. Structural biology of hepatitis C virus. Hepatology. 2004 39 :5–19.
   PubMed Web of Science ®Google Scholar
• Neddermann P, Tomei L, Steinkühler C, et al. The nonstructural proteins of the hepatitis C virus: structure and functions. Biol Chem. 1997;378:469–476.
   PubMed Web of Science ®Google Scholar
• Belyaev AS, Chong S, Novikov A, et al. Hepatitis G virus encodes protease activities which can effect processing of the virus putative nonstructural proteins. J Virol. 1998;72:868–872.
   PubMed Web of Science ®Google Scholar
• Yang N, Dai R, Zhang X. Global prevalence of human pegivirus-1 in healthy volunteer blood donors: a systematic review and meta-analysis. Vox Sang. 2020;115:107–119.
   PubMed Web of Science ®Google Scholar
• Zimmerman J, Blackard JT. Human pegivirus type 1 infection in Asia-A review of the literature. Rev Med Virol. 2021:e2257.
   PubMed Web of Science ®Google Scholar
• El-Zayadi AR, Abe K, Selim O, et al. Prevalence of GBV-C/hepatitis G virus viraemia among blood donors, health care personnel, chronic non-B non-C hepatitis, chronic hepatitis C and hemodialysis patients in Egypt. J Virol Methods. 1999;80:53–58.
   PubMed Web of Science ®Google Scholar
• Ben Dhifallah I, Ayouni K, Chouiha A, et al. Genotype distribution and prevalence of human pegivirus among high-risk populations in Tunisia. Intervirology. 2016;59:170–178.
   PubMed Web of Science ®Google Scholar
• de Pina-araujo IIM, Horta MA, Do Amaral Mello FC, et al. Human pegivirus 1 in Cabo Verde: prevalence and genotypic distribution among HIV-infected individuals. Arch Virol. 2021;166:1345–1353.
   PubMed Web of Science ®Google Scholar
• Sathar MA, Soni PN, Naicker S, et al. GB virus C/hepatitis G virus infection in KwaZulu Natal, South Africa. J Med Virol. 1999;59:38–44.
   PubMed Web of Science ®Google Scholar
• Casteling A, Song E, Sim J, et al. GB virus C prevalence in blood donors and high risk groups for parenterally transmitted agents from Gauteng, South Africa. J Med Virol. 1998;55:103–108.
   PubMed Web of Science ®Google Scholar
• Shaker EK, Al-Jebouri MM, Al-Mayah QS, et al. Phylogenetic analysis of human pegivirus from anti-hepatitis C virus IgG- positive patients. Infect Genet Evol. 2021;96:105099.
   PubMed Web of Science ®Google Scholar
• Ghanbari R, Ravanshad M, Hosseini SY, et al. Genotyping and infection rate of GBV-C among Iranian HCV- infected patients. Hepat Mon. 2010;10:80–87.
   PubMed Web of Science ®Google Scholar
• Abu Odeh RO, Al-Moslih MI, Al-Jokhdar MW, et al. Detection and genotyping of GBV-C virus in the United Arab Emirates. J Med Virol. 2005;76:534–540.
   PubMed Web of Science ®Google Scholar
• Yan J, Chen LL, Luo YH, et al. High frequencies of HGV and TTV infections in blood donors in Hangzhou. World J Gastroenterol. 2001;7:637–641.
   PubMed Web of Science ®Google Scholar
• Nakatsuji Y, Shih JW, Tanaka E, et al. Prevalence and disease association of hepatitis G virus infection in Japan. J Viral Hepat. 1996;3:307–316.
   PubMed Web of Science ®Google Scholar
• Brown KE, Wong S, Buu M, et al. High prevalence of GB virus C/hepatitis G virus in healthy persons in Ho Chi Minh City, Vietnam. J Infect Dis. 1997;175:450–453.
   PubMed Web of Science ®Google Scholar
• Nakai K, Win KM, Oo SS, et al. Molecular characteristic-based epidemiology of hepatitis B, C, and E viruses and GB virus C/hepatitis G virus in Myanmar. J Clin Microbiol. 2001;39:1536–1539.
   PubMed Web of Science ®Google Scholar
• Jeon MJ, Shin JH, Suh SP, et al. TT virus and hepatitis G virus infections in Korean blood donors and patients with chronic liver disease. World J Gastroenterol. 2003;9:741–744.
   PubMed Web of Science ®Google Scholar
• Kondo Y, Mizokami M, Nakano T, et al. Prevalence and molecular epidemiology of GB virus C/hepatitis G virus infection in Mongolia. J Med Virol. 1997;52:143–148.
   PubMed Web of Science ®Google Scholar
• Moaven LD, Hyland CA, Young IF, et al. Prevalence of hepatitis G virus in Queensland blood donors. Med J Aust. 1996;165:369–371.
   PubMed Web of Science ®Google Scholar
• Hitzler WE, Runkel S. Prevalence, persistence and liver enzyme levels of HGV RNA-positive blood donors determined by large-scale screening and transmission by blood components. Clin Lab. 2004;50:25–31.
   PubMedGoogle Scholar
• Mercier B, Barclais A, Botte C, et al. Prevalence of GBV C/HGV RNA and GBV C/HGV antibodies in French volunteer blood donors: results of a collaborative study. Vox Sang. 1999;76:166–169.
   PubMed Web of Science ®Google Scholar
• Blair CS, Davidson F, Lycett C, et al. Prevalence, incidence, and clinical characteristics of hepatitis G virus/GB virus C infection in Scottish blood donors. J Infect Dis. 1998;178:1779–1782.
   PubMed Web of Science ®Google Scholar
• Césaire R, Martial J, Maier H, et al. Infection with GB virus C/hepatitis G virus among blood donors and hemophiliacs in Martinique, a Caribbean island. J Med Virol. 1999;59:160–163.
   PubMed Web of Science ®Google Scholar
• Alter HJ, Nakatsuji Y, Melpolder J, et al. The incidence of transfusion-associated hepatitis G virus infection and its relation to liver disease. N Engl J Med. 1997;336:747–754.
   PubMed Web of Science ®Google Scholar
• Giulivi A, Slinger R, Tepper M, et al. Prevalence of GBV-C/hepatitis G virus viremia and anti-E2 in Canadian blood donors. Vox Sang. 2000;79:201–205.
   PubMed Web of Science ®Google Scholar
• Alvarado-Mora MV, Botelho L, Nishiya A, et al. Frequency and genotypic distribution of GB virus C (GBV-C) among Colombian population with hepatitis B (HBV) or hepatitis C (HCV) infection. Virol J. 2011;8:345.
   PubMed Web of Science ®Google Scholar
• Silva ADSN, Silva CP, Barata RR, et al. Human pegivirus (HPgV, GBV-C) RNA in volunteer blood donors from a public hemotherapy service in Northern Brazil. Virol J. 2020;17:153.
   PubMed Web of Science ®Google Scholar
• Slavov SN, Maraninchi Silveira R, Hespanhol MR, et al. Human pegivirus-1 (HPgV-1) RNA prevalence and genotypes in volunteer blood donors from the Brazilian Amazon. Transfus Clin Biol. 2019;26:234–239.
   PubMed Web of Science ®Google Scholar
• Konomi N, Miyoshi C, La Fuente Zerain C, et al. Epidemiology of hepatitis B, C, E, and G virus infections and molecular analysis of hepatitis G virus isolates in Bolivia. J Clin Microbiol. 1999;37:3291–3295.
   PubMed Web of Science ®Google Scholar
• N’Guessan KF, Boyce C, Kwara A, et al. Human pegivirus (HPgV) infection in Ghanaians co-infected with human immunodeficiency virus (HIV) and hepatitis B virus (HBV). Virus Genes. 2018;54:361–367.
   PubMed Web of Science ®Google Scholar
• Jõgeda E-L, Huik K, Pauskar M, et al. Prevalence and genotypes of GBV-C and its associations with HIV infection among persons who inject drugs in Eastern Europe. J Med Virol. 2017;89:632–638.
   PubMed Web of Science ®Google Scholar
• Neibecker M, Schwarze-Zander C, Rockstroh JK, et al. Evidence for extensive genotypic diversity and recombination of GB virus C (GBV-C) in Germany. J Med Virol. 2011;83:685–694.
   PubMed Web of Science ®Google Scholar
• Li Z, Li Y, Liang Y, et al. Prevalence and risk factors of human pegivirus type 1 infection in hematopoietic stem cell transplantation patients. Int J Infect Dis. 2019;85:111–113.
   PubMed Web of Science ®Google Scholar
• Yu ML, Chuang WL, Wang LY, et al. Status and natural course of GB virus C/hepatitis G virus infection among high-risk groups and volunteer blood donors in Taiwan. J Gastroenterol Hepatol. 2000;15:1404–1410.
   PubMed Web of Science ®Google Scholar
• Loureiro CL, Alonso R, Pacheco BA, et al. High prevalence of GB virus C/hepatitis G virus genotype 3 among autochthonous Venezuelan populations. J Med Virol. 2002;68:357–362.
   PubMed Web of Science ®Google Scholar
• Lee CK, Tang JW-T, Chiu L, et al. Epidemiology of GB virus type C among patients infected with HIV in Singapore. J Med Virol. 2014;86:737–744.
   PubMed Web of Science ®Google Scholar
• Handajani R, Soetjipto L, Suryohudoyo MI, et al. Prevalence of GB virus C/hepatitis G virus infection among various populations in Surabaya, Indonesia, and identification of novel groups of sequence variants. J Clin Microbiol. 2000;38:662–668.
   PubMed Web of Science ®Google Scholar
• Naito H, Abe K. Genotyping system of GBV-C/HGV type 1 to type 4 by the polymerase chain reaction using type-specific primers and geographical distribution of viral genotypes. J Virol Methods. 2001;91:3–9.
   PubMed Web of Science ®Google Scholar
• Anggorowati N, Yano Y, Subronto YW, et al. GB virus C infection in Indonesian HIV-positive patients. Microbiol Immunol. 2013;57:298–308.
   PubMed Web of Science ®Google Scholar
• AbuOdeh RO, Al-Absi E, Ali NH, et al. Detection and phylogenetic analysis of human pegivirus (GBV-C) among blood donors and patients infected with hepatitis B virus (HBV) in Qatar. J Med Virol. 2015;87:2074–2081.
   PubMed Web of Science ®Google Scholar
• Miao Z, Gao L, Song Y, et al. Prevalence and clinical impact of human pegivirus-1 infection in HIV-1-infected individuals in Yunnan, China. Viruses. 2017;9 28.
   PubMed Web of Science ®Google Scholar
• Deuffic-Burban S, Delarocque-Astagneau E, Abiteboul D, et al. Blood-borne viruses in health care workers: prevention and management. J Clin Virol. 2011 52 :4–10.
   PubMed Web of Science ®Google Scholar
• Nordbø SA, Krokstad S, Winge P, et al. Prevalence of GB virus C (also called hepatitis G virus) markers in Norwegian blood donors. J Clin Microbiol. 2000;38:2584–2590.
   PubMed Web of Science ®Google Scholar
• Nerurkar VR, Chua PK, Hoffmann PR, et al. High prevalence of GB virus C/hepatitis G virus infection among homosexual men infected with human immunodeficiency virus type 1: evidence for sexual transmission. J Med Virol. 1998;56:123–127.
   PubMed Web of Science ®Google Scholar
• Scallan MF, Clutterbuck D, Jarvis LM, et al. Sexual transmission of GB virus C/hepatitis G virus. J Med Virol. 1998;55:203–208.
   PubMed Web of Science ®Google Scholar
• Bourlet T, Guglielminotti C, Evrard M, et al. Prevalence of GBV-C/hepatitis G virus RNA and E2 antibody among subjects infected with human immunodeficiency virus type 1 after parenteral or sexual exposure. J Med Virol. 1999;58:373–377.
   PubMed Web of Science ®Google Scholar
• Chakraborty R, Rees G, Bourboulia D, et al. Viral coinfections among African children infected with human immunodeficiency virus type 1. Clin Infect Dis. 2003;36:922–924.
   PubMed Web of Science ®Google Scholar
• Compston LI, Li C, Sarkodie F, et al. Prevalence of persistent and latent viruses in untreated patients infected with HIV-1 from Ghana, West Africa. J Med Virol. 2009;81:1860–1868.
   PubMed Web of Science ®Google Scholar
• Rodríguez AK, Garzaro DJ, Loureiro CL, et al. HIV-1 and GBV-C co-infection in Venezuela. J Infect Dev Ctries. 2014;8:863–868.
   PubMed Web of Science ®Google Scholar
• Alcalde R, Nishiya A, Casseb J, et al. Prevalence and distribution of the GBV-C/HGV among HIV-1-infected patients under anti-retroviral therapy. Virus Res. 2010;151:148–152.
   PubMed Web of Science ®Google Scholar
• Bhanich Supapol W, Remis RS, Raboud J, et al. Prevalence and correlates of GB virus C infection in HIV-infected and HIV-uninfected pregnant women in Bangkok, Thailand. J Med Virol. 2011;83:33–44.
   PubMed Web of Science ®Google Scholar
• Keyvani H, Mohammadi A, Haji-Abdolbaghi M. Prevalence of GBV-C RNA in HIV infected individuals in Tehran, Iran. Iran J Public Health. 2010;39:22–27.
   PubMed Web of Science ®Google Scholar
• Feng Y, Liu L, Feng Y-M, et al. GB virus C infection in patients with HIV/Hepatitis C virus coinfection: improvement of the liver function in chronic hepatitis C. Hepat Mon. 2014;14:e14169.
   PubMed Web of Science ®Google Scholar
• Shahid M, Idrees M, Butt AM, et al. Short article: hepatitis C and G virus coinfection in Punjab, Pakistan: incidence and its correlation analysis with clinical data. Eur J Gastroenterol Hepatol. 2019;31:389–392.
   PubMed Web of Science ®Google Scholar
• Hofer H, Aydin I, Neumueller-Guber S, et al. Prevalence and clinical significance of GB virus type C/hepatitis G virus coinfection in patients with chronic hepatitis C undergoing antiviral therapy. J Viral Hepat. 2011;18:513–517.
   PubMed Web of Science ®Google Scholar
• Alhetheel A, El-Hazmi MM. Hepatitis G virus in Saudi blood donors and chronic hepatitis B and C patients. J Infect Dev Ctries. 2014;8:110–115.
   PubMed Web of Science ®Google Scholar
• Kar P, Bedi P, Berry N, et al. Hepatitis G virus (HGV) infection in voluntary and commercial blood donors in India. Diagn Microbiol Infect Dis. 2000 38 :7–10.
   PubMed Web of Science ®Google Scholar
• Arankalle VA, Deshmukh TM, Chobe LP, et al. Hepatitis G virus infection in India: prevalence and phylogenetic analysis based on 5’ non-coding region. Indian J Gastroenterol. 2001;20:13–17.
   PubMedGoogle Scholar
• Wang X, Sun D, Zhuang H. Follow-up studies on hepatitis G infection in plasma donors with positive antibody against hepatitis C (in Chinese). Zhonghua Yu Fang Yi Xue Za Zhi. 1997;31:269–271.
   PubMedGoogle Scholar
• Odeh RA, Yasin S, Nasrallah G, et al. Rates of infection and phylogenetic analysis of GB virus-C among Kuwaiti and Jordanian blood donors. Intervirology. 2010;53:402–407.
   PubMed Web of Science ®Google Scholar
• Wang HL, Jin DY. Prevalence and genotype of hepatitis G virus in Chinese professional blood donors and hepatitis patients. J Infect Dis. 1997;175:1229–1233.
   PubMed Web of Science ®Google Scholar
• Wang T, Chen J, Zhang Q, et al. Prevalence of hepatitis G virus infection among 67,348 blood donors in mainland China. BMC Public Health. 2019;19:685.
   PubMed Web of Science ®Google Scholar
• Feng Y, Zhao W, Feng Y, et al. A novel genotype of GB virus C: its identification and predominance among injecting drug users in Yunnan, China. PLoS One. 2011;6:e21151.
   PubMed Web of Science ®Google Scholar
• Wu RR, Mizokami M, Cao K, et al. GB virus C/hepatitis G virus infection in southern China. J Infect Dis. 1997;175:168–171.
   PubMed Web of Science ®Google Scholar
• Hyland CA, Mison L, Solomon N, et al. Exposure to GB virus type C or hepatitis G virus in selected Australian adult and children populations. Transfusion. 1998;38:821–827.
   PubMed Web of Science ®Google Scholar
• Löve A, Stanzeit B, Gudmundsson S, et al. Hepatitis G virus infections in Iceland. J Viral Hepat. 1999;6:255–260.
   PubMed Web of Science ®Google Scholar
• Christensen PB, Fisker N, Mygind LH, et al. GB virus C epidemiology in Denmark: different routes of transmission in children and low- and high-risk adults. J Med Virol. 2003;70:156–162.
   PubMed Web of Science ®Google Scholar
• Jongerius J, Boland G, van der Poel C, et al. GB virus type C viremia and envelope antibodies among population subsets in The Netherlands. Vox Sang. 1999;76:81–84.
   PubMed Web of Science ®Google Scholar
• Gutierrez RA, Dawson GJ, Knigge MF, et al. Seroprevalence of GB virus C and persistence of RNA and antibody. J Med Virol. 1997;53:167–173.
   PubMed Web of Science ®Google Scholar
• Dawson GJ, Schlauder GG, Pilot-Matias TJ, et al. Prevalence studies of GB virus-C infection using reverse transcriptase-polymerase chain reaction. J Med Virol. 1996 50 :97–103.
   PubMed Web of Science ®Google Scholar
• Oubiña JR, Mathet V, Feld M, et al. Genetic diversity of GBV-C/HGV strains among HIV infected-IVDU and blood donors from Buenos Aires, Argentina. Virus Res. 1999;65:121–129.
   PubMed Web of Science ®Google Scholar
• Tian D-Y, Yang D-F, Xia N-S, et al. The serological prevalence and risk factor analysis of hepatitis G virus infection in Hubei Province of China. World J Gastroenterol. 2000;6:585–587.
   PubMed Web of Science ®Google Scholar
• Berzsenyi MD, Bowden DS, Bailey MJ, et al. Male to male sex is associated with a high prevalence of exposure to GB virus C. J Clin Virol. 2005;33:243–246.
   PubMed Web of Science ®Google Scholar
• Asim M, Potukuchi SK, Arora A, et al. Hepatitis-G virus infection in multi-transfused patients and intravenous drug abusers: new Delhi experience. Dig Dis Sci. 2008;53:1383–1389.
   PubMed Web of Science ®Google Scholar
• Katayama Y, Apichartpiyakul C, Handajani R, et al. GB virus C/hepatitis G virus (GBV-C/HGV) infection in Chiang Mai, Thailand, and identification of variants on the basis of 5’-untranslated region sequences. Arch Virol. 1997;142:2433–2445.
   PubMed Web of Science ®Google Scholar
• Shrestha SM, Shrestha S, Tsuda F, et al. Infection with GB virus C and hepatitis C virus in drug addicts, patients on maintenance hemodialysis, or with chronic liver disease in Nepal. J Med Virol. 1997;53:157–161.
   PubMed Web of Science ®Google Scholar
• Ru H, Wen X, Liang W. [Investigation of HGV infection in various populations in Guangxi]. Zhonghua Shi Yan He Lin Chuang Bing Du Xue Za Zhi. 1998;12:336–339.
   PubMedGoogle Scholar
• Hwang SJ, Chu CW, Lu RH, et al. Seroprevalence of GB virus C/hepatitis G virus-RNA and anti-envelope antibody in high-risk populations in Taiwan. J Gastroenterol Hepatol. 2000;15:1171–1175.
   PubMed Web of Science ®Google Scholar
• Li G, Ma -H-H, Lau GKK, et al. Prevalence of hepatitis G virus infection and homology of different viral strains in Southern China. World J Gastroenterol. 2002;8:1081–1087.
   PubMed Web of Science ®Google Scholar
• Poovorawan Y, Theamboonlers A, Chongsrisawat V, et al. Prevalence of infection with hepatitis G virus among various groups in Thailand. Ann Trop Med Parasitol. 1998;92:89–95.
   PubMed Web of Science ®Google Scholar
• Lu L, Ng MH, Zhou B, et al. Detection and genotyping of GBV-C/HGV variants in China. Virus Res. 2001;73:131–144.
   PubMed Web of Science ®Google Scholar
• Noguchi S, Sata M, Suzuki H, et al. GB virus C (GBV-C)/hepatitis G virus (HGV) infection among intravenous drug users in Japan. Virus Res. 1997;49:155–162.
   PubMed Web of Science ®Google Scholar
• Suganuma N, Ikeda S, Taketa K, et al. Risk analysis of the exposure to GB virus C/hepatitis G virus among populations of intravenous drug users, commercial sex workers and male outpatients at STD clinic in Chiang Mai, Thailand: a cross-sectional case-control study. Acta Med Okayama. 1998;52:161–167.
   PubMed Web of Science ®Google Scholar
• Taklual W, Tang S, Yue W. Effect of human pegivirus route of transmission on the genetic distribution of the virus: an institution based cross-sectional study. Virol J. 2019;16:50.
   PubMed Web of Science ®Google Scholar
• Ramezani A, Mohraz M, Vahabpour R, et al. Frequency of hepatitis G virus infection among HIV positive subjects with parenteral and sexual exposure. J Gastrointestin Liver Dis. 2008;17:269–272.
   PubMed Web of Science ®Google Scholar
• Zhou B, Ma W, Wang H, et al. Investigation on hepatitis G virus (HGV) infection among different populations in Shenzhen. Zhonghua Shi Yan He Lin Chuang Bing Du Xue Za Zhi. 1997;11:348–351.
   PubMedGoogle Scholar
• Schwarze-Zander C, Blackard JT, Zheng H, et al. GB virus C (GBV-C) infection in hepatitis C virus (HCV)/HIV-coinfected patients receiving HCV treatment: importance of the GBV-C genotype. J Infect Dis. 2006;194:410–419.
   PubMed Web of Science ®Google Scholar
• Ramia S, Mokhbat J, Sibai A, et al. Exposure rates to hepatitis C and G virus infections among HIV-infected patients: evidence of efficient transmission of HGV by the sexual route. Int J STD AIDS. 2004;15:463–466.
   PubMed Web of Science ®Google Scholar
• Baklan Z, Gorisek JR, Poljak M, et al. Prevalence of HIV, hepatitis B, C and G virus infections among injecting drug users on methadone maintenance treatment in Maribor. Wien Klin Wochenschr. 2004;116(Suppl 2):5–7.
   PubMedGoogle Scholar
• Ibáñez A, Giménez-Barcons M, Tajahuerce A, et al. Prevalence and genotypes of GB virus C/hepatitis G virus (GBV-C/HGV) and hepatitis C virus among patients infected with human immunodeficiency virus: evidence of GBV-C/HGV sexual transmission. J Med Virol. 1998;55:293–299.
   PubMed Web of Science ®Google Scholar
• Kojima M, Kanazawa K, Hakamada T, et al. Infection with hepatitis GB virus C in intravenous drug abusers with type C chronic liver diseases. Nihon Rinsho. 1997;55:549–553.
   PubMedGoogle Scholar
• Nübling CM, Bialleck H, Fürsch AJ, et al. Frequencies of GB virus C/hepatitis G virus genomes and of specific antibodies in German risk and non-risk populations. J Med Virol. 1997;53:218–224.
   PubMed Web of Science ®Google Scholar
• Kotaki T, Khairunisa SQ, Sukartiningrum SD, et al. High prevalence of HIV-1 CRF01_AE viruses among female commercial sex workers residing in Surabaya, Indonesia. PLoS One. 2013;8:e82645.
   PubMed Web of Science ®Google Scholar
• Hattori J, Ibe S, Nagai H, et al. Prevalence of infection and genotypes of GBV-C/HGV among homosexual men. Microbiol Immunol. 2003;47:759–763.
   PubMed Web of Science ®Google Scholar
• Liu Z, Li L, Chen Z, et al. Prevalence of GB virus type C viraemia in MSM with or without HIV-1 infection in Beijing, China. Epidemiol Infect. 2012;140:2199–2209.
   PubMed Web of Science ®Google Scholar
• Seemayer CA, Viazov S, Philipp T, et al. Detection of GBV-C/HGV RNA in saliva and serum, but not in urine of infected patients. Infection. 1998;26:39–41.
   PubMed Web of Science ®Google Scholar
• Stapleton JT. GB virus type C/Hepatitis G virus. Semin Liver Dis. 2003;23:137–148.
   PubMed Web of Science ®Google Scholar
• Tanaka E, Kiyosawa K, Shimoda K, et al. Evolution of hepatitis G virus infection and antibody response to envelope protein in patients with transfusion-associated non-A, non-B hepatitis. J Viral Hepat. 1998;5:153–159.
   PubMed Web of Science ®Google Scholar
• Stapleton JT, Xiang J, McLinden JH, et al. A novel T cell evasion mechanism in persistent RNA virus infection. Trans Am Clin Climatol Assoc. 2014 125 :14–24.
   PubMedGoogle Scholar
• Elkayam O, Hassoba HM, Ferrell LD, et al. GB virus C (GBV-C/HGV) and E2 antibodies in children preliver and postliver transplant. Pediatr Res. 1999;45:795–798.
   PubMed Web of Science ®Google Scholar
• Heringlake S, Ockenga J, Tillmann HL, et al. GB virus C/hepatitis G virus infection: a favorable prognostic factor in human immunodeficiency virus-infected patients? J Infect Dis. 1998;177:1723–1726.
   PubMed Web of Science ®Google Scholar
• Nunnari G, Nigro L, Palermo F, et al. Slower progression of HIV-1 infection in persons with GB virus C co-infection correlates with an intact T-helper 1 cytokine profile. Ann Intern Med. 2003;139:26–30.
   PubMed Web of Science ®Google Scholar
• Tillmann HL, Heiken H, Knapik-Botor A, et al. Infection with GB virus C and reduced mortality among HIV-infected patients. N Engl J Med. 2001;345:715–724.
   PubMed Web of Science ®Google Scholar
• Toyoda H, Fukuda Y, Hayakawa T, et al. Effect of GB virus C/hepatitis G virus coinfection on the course of HIV infection in hemophilia patients in Japan. J Acquir Immune Defic Syndr Hum Retrovirol. 1998;17:209–213.
   PubMedGoogle Scholar
• Williams CF, Klinzman D, Yamashita TE, et al. Persistent GB virus C infection and survival in HIV-infected men. N Engl J Med. 2004;350:981–990.
   PubMed Web of Science ®Google Scholar
• Xiang J, Wünschmann S, Diekema DJ, et al. Effect of coinfection with GB virus C on survival among patients with HIV infection. N Engl J Med. 2001;345:707–714.
   PubMed Web of Science ®Google Scholar
• Zhang W, Chaloner K, Tillmann HL, et al. Effect of early and late GB virus C viraemia on survival of HIV-infected individuals: a meta-analysis. HIV Med. 2006;7:173–180.
   PubMed Web of Science ®Google Scholar
• Vahidnia F, Petersen M, Stapleton JT, et al. Acquisition of GB virus type C and lower mortality in patients with advanced HIV disease. Clin Infect Dis. 2012;55(7):1012–1019.
   PubMed Web of Science ®Google Scholar
• Chang CM, Stapleton JT, Klinzman D, et al. GBV-C infection and risk of NHL among U.S. adults. Cancer Res. 2014;74:5553–5560.
   PubMed Web of Science ®Google Scholar
• Civardi G, Tanzi E, Ferrari B, et al. High prevalence of anti-HGV/E2 antibodies in HCV-positive patients with non Hodgkin’s lymphoma. Haematologica. 1998;83:957–958.
   PubMed Web of Science ®Google Scholar
• De Renzo A, Persico E, de Marino F, et al. High prevalence of hepatitis G virus infection in Hodgkin’s disease and B-cell lymphoproliferative disorders: absence of correlation with hepatitis C virus infection. Haematologica 2002 . 87:714–718.
   PubMed Web of Science ®Google Scholar
• Ellenrieder V, Weidenbach H, Frickhofen N, et al. HCV and HGV in B-cell non-Hodgkin’s lymphoma. J Hepatol. 1998;28:34–39.
   PubMed Web of Science ®Google Scholar
• Nakamura S, Takagi T, Matsuda T. Hepatitis G virus RNA in patients with B-cell non-Hodgkin’s lymphoma. Br J Haematol. 1997;98:1051–1052.
   PubMed Web of Science ®Google Scholar
• Krajden M, Yu A, Braybrook H, et al. GBV-C/hepatitis G virus infection and non-Hodgkin lymphoma: a case control study. Int J Cancer. 2010;126(12):2885–2892.
   PubMed Web of Science ®Google Scholar
• Fama A, Xiang J, Link BK, et al. Human pegivirus infection and lymphoma risk and prognosis: a North American study. Br J Haematol. 2018;182:644–653.
   PubMed Web of Science ®Google Scholar
• Fama A, Larson MC, Link BK, et al. Human pegivirus infection and lymphoma risk: a systematic review and meta-analysis. Clin Infect Dis. 2020;71:1221–1228.
   PubMed Web of Science ®Google Scholar
• Chivero ET, Bhattarai N, Rydze RT, et al. Human pegivirus RNA is found in multiple blood mononuclear cells in vivo and serum-derived viral RNA-containing particles are infectious in vitro. J Gen Virol. 2014;95:1307–1319.
   PubMed Web of Science ®Google Scholar
• Balcom EF, Doan MAL, Branton WG, et al. Human pegivirus-1 associated leukoencephalitis: clinical and molecular features. Ann Neurol. 2018;84:781–787.
   PubMed Web of Science ®Google Scholar
• Doan MAL, Roczkowsky A, Smith M, et al. Infection of glia by human pegivirus suppresses peroxisomal and antiviral signaling pathways. J Virol. 2021;95:e0107421.
   PubMed Web of Science ®Google Scholar
• Cheinquer H, Sette H, Wolff FH, et al. Treatment of chronic HCV infection with the new Direct Acting Antivirals (DAA): first report of a real world experience in Southern Brazil. Ann Hepatol. 2017;16:727–733.
   PubMed Web of Science ®Google Scholar
• Feeney ER, Chung RT. Antiviral treatment of hepatitis C. Bmj. 2014;348:g3308.
   PubMedGoogle Scholar
• Pawlotsky J-M. New hepatitis C therapies: the toolbox, strategies, and challenges. Gastroenterology. 2014;146:1176–1192.
   PubMed Web of Science ®Google Scholar
• Sievert W, Razavi H, Estes C, et al. Enhanced antiviral treatment efficacy and uptake in preventing the rising burden of hepatitis C-related liver disease and costs in Australia. J Gastroenterol Hepatol. 2014;29(Suppl 1):1–9.
   PubMedGoogle Scholar
• Wan Z, Liu J, Hu F, et al. Evidence that the second human pegivirus (HPgV-2) is primarily a lymphotropic virus and can replicate independent of HCV replication. Emerg Microbes Infect. 2020;9(1):485–495.
   PubMed Web of Science ®Google Scholar
• N’Guessan KF, Anderson M, Phinius B, et al. The impact of human pegivirus on CD4 cell count in HIV-positive persons in Botswana. Open Forum Infect Dis. 2017;4(4):ofx222.
   PubMed Web of Science ®Google Scholar
• Yirrell DL, Wright E, Shafer LA, et al. Association between active GB virus-C (hepatitis G) infection and HIV-1 disease in Uganda. Int J STD AIDS. 2007;18(4):244–249.
   PubMed Web of Science ®Google Scholar
• Weintrob AC, Hamilton JD, Hahn C, et al. Active or prior GB virus C infection does not protect against vertical transmission of HIV in coinfected women from Tanzania. Clin Infect Dis. 2004;38:e46–e48.
   PubMed Web of Science ®Google Scholar
• Mosam A, Sathar MA, Dawood H, et al. Effect of GB virus C co-infection on response to generic HAART in African patients with HIV-1 clade C infection. AIDS. 2007;21:1377–1379.
   PubMed Web of Science ®Google Scholar
• Horemheb-Rubio G, Ramos-Cervantes P, Arroyo-Figueroa H, et al. High HPgV replication is associated with improved surrogate markers of HIV progression. PLoS One. 2017;12:e0184494.
   PubMed Web of Science ®Google Scholar
• de Miranda BKB, de Sá KSG, Da Silva ANR, et al. GBV-C/HIV-1 coinfection is associated with low HIV-1 viral load and high CD4 T lymphocyte count. Arch Virol. 2017;162:3431–3438.
   PubMed Web of Science ®Google Scholar
• Sahni H, Kirkwood K, Kyriakides TC, et al. GBV-C viremia and clinical events in advanced HIV infection. J Med Virol. 2014;86(3):426–432.
   PubMed Web of Science ®Google Scholar
• Li C, Collini P, Danso K, et al. GB virus C and HIV-1 RNA load in single virus and co-infected West African individuals. AIDS. 2006;20(3):379–386.
   PubMed Web of Science ®Google Scholar
• Schwarze-Zander C, Neibecker M, Othman S, et al. GB virus C coinfection in advanced HIV type-1 disease is associated with low CCR5 and CXCR4 surface expression on CD4+ T-cells. Antivir Ther. 2010;15(5):745–752.
   PubMed Web of Science ®Google Scholar
• Maidana-Giret MT, Silva TM, Sauer MM, et al. GB virus type C infection modulates T-cell activation independently of HIV-1 viral load. AIDS. 2009;23:2277–2287.
   PubMed Web of Science ®Google Scholar
• Björkman P, Flamholc L, Nauclér A, et al. GB virus C during the natural course of HIV-1 infection: viremia at diagnosis does not predict mortality. AIDS. 2004;18(6):877–886.
   PubMed Web of Science ®Google Scholar
• Gill CJ, Griffith JL, Jacobson D, et al. Relationship of HIV viral loads, CD4 counts, and HAART use to health-related quality of life. J Acquir Immune Defic Syndr. 2002;30:485–492.
   PubMed Web of Science ®Google Scholar
• van Leth F, Andrews S, Grinsztejn B, et al. The effect of baseline CD4 cell count and HIV-1 viral load on the efficacy and safety of nevirapine or efavirenz-based first-line HAART. AIDS. 2005;19(5):463–471.
   PubMed Web of Science ®Google Scholar
• Liu K, Li Y, Xu R, et al. HIV-1 infection alters the viral composition of plasma in men who have sex with men. mSphere. 2021;6 e00081–21.
   PubMed Web of Science ®Google Scholar
• Xiang J, Sathar MA, McLinden JH, et al. South African GB virus C isolates: interactions between genotypes 1 and 5 isolates and HIV. J Infect Dis. 2005;192:2147–2151.
   PubMed Web of Science ®Google Scholar
• Lanteri MC, Vahidnia F, Tan S, et al. Downregulation of cytokines and chemokines by GB virus C after transmission via blood transfusion in HIV-positive blood recipients. J Infect Dis. 2015;211:1585–1596.
   PubMed Web of Science ®Google Scholar
• Tenckhoff S, Kaiser T, Bredeek F, et al. Role of GB virus C in HIV-1-infected and hepatitis C virus-infected hemophiliac children and adolescents. J Acquir Immune Defic Syndr. 2012;61:243–248.
   PubMed Web of Science ®Google Scholar
• Xiang J, George SL, Wünschmann S, et al. Inhibition of HIV-1 replication by GB virus C infection through increases in RANTES, MIP-1alpha, MIP-1beta, and SDF-1. Lancet. 2004;363:2040–2046.
   PubMed Web of Science ®Google Scholar
• Nattermann J, Nischalke H-D, Kupfer B, et al. Regulation of CC chemokine receptor 5 in hepatitis G virus infection. AIDS. 2003;17:1457–1462.
   PubMed Web of Science ®Google Scholar
• Lederman MM, Penn-Nicholson A, Cho M, et al. Biology of CCR5 and its role in HIV infection and treatment. Jama. 2006;296:815–826.
   PubMed Web of Science ®Google Scholar
• Lalle E, Sacchi A, Abbate I, et al. Activation of interferon response genes and of plasmacytoid dendritic cells in HIV-1 positive subjects with GB virus C co-infection. Int J Immunopathol Pharmacol. 2008;21:161–171.
   PubMed Web of Science ®Google Scholar
• Moore JP, Kitchen SG, Pugach P, et al. The CCR5 and CXCR4 coreceptors–central to understanding the transmission and pathogenesis of human immunodeficiency virus type 1 infection. AIDS Res Hum Retroviruses. 2004;20:111–126.
   PubMed Web of Science ®Google Scholar
• Herrera E, Gomara MJ, Mazzini S, et al. Synthetic peptides of hepatitis G virus (GBV-C/HGV) in the selection of putative peptide inhibitors of the HIV-1 fusion peptide. J Phys Chem B. 2009;113:7383–7391.
   PubMed Web of Science ®Google Scholar
• Koedel Y, Eissmann K, Wend H, et al. Peptides derived from a distinct region of GB virus C glycoprotein E2 mediate strain-specific HIV-1 entry inhibition. J Virol. 2011;85:7037–7047.
   PubMed Web of Science ®Google Scholar
• Spellberg B, Edwards JE. Type 1/Type 2 immunity in infectious diseases. Clin Infect Dis. 2001 32 :76–102.
   PubMed Web of Science ®Google Scholar
• Johann-Liang R, Cervia J, Noel GJ. Endogenous interleukin-2 serum levels in children infected with human immunodeficiency virus. Clin Infect Dis. 1997;25:1233–1236.
   PubMed Web of Science ®Google Scholar
• Clerici M, Balotta C, Salvaggio A, et al. Human immunodeficiency virus (HIV) phenotype and interleukin-2/ interleukin-10 ratio are associated markers of protection and progression in HIV infection. Blood. 1996;88:574–579.
   PubMed Web of Science ®Google Scholar
• Barcellini W, Rizzardi GP, Borghi MO, et al. TH1 and TH2 cytokine production by peripheral blood mononuclear cells from HIV-infected patients. AIDS. 1994;8:757–762.
   PubMed Web of Science ®Google Scholar
• Nel AE. T-cell activation through the antigen receptor. Part 1: signaling components, signaling pathways, and signal integration at the T-cell antigen receptor synapse. J Allergy Clin Immunol. 2002;109:758–770.
   PubMed Web of Science ®Google Scholar
• Paredes R, López Benaldo de Quirós JC, Fernández-Cruz E, et al. The potential role of interleukin-2 in patients with HIV infection. AIDS Rev. 2002;4:36–40.
   PubMedGoogle Scholar
• Bhattarai N, McLinden JH, Xiang J, et al. GB virus C particles inhibit T cell activation via envelope E2 protein-mediated inhibition of TCR signaling. J Immunol. 2013;190:6351–6359.
   PubMed Web of Science ®Google Scholar
• Hunt PW, Martin JN, Sinclair E, et al. T cell activation is associated with lower CD4+ T cell gains in human immunodeficiency virus-infected patients with sustained viral suppression during antiretroviral therapy. J Infect Dis. 2003;187:1534–1543.
   PubMed Web of Science ®Google Scholar
• Moenkemeyer M, Schmidt RE, Wedemeyer H, et al. GBV-C coinfection is negatively correlated to fas expression and fas-mediated apoptosis in HIV-1 infected patients. J Med Virol. 2008;80:1933–1940.
   PubMed Web of Science ®Google Scholar
• Björkman P, Flamholc L, Molnegren V, et al. Enhanced and resumed GB virus C replication in HIV-1-infected individuals receiving HAART. AIDS. 2007;21:1641–1643.
   PubMed Web of Science ®Google Scholar
• Berzsenyi MD, Bowden DS, Kelly HA, et al. Reduction in hepatitis C-related liver disease associated with GB virus C in human immunodeficiency virus coinfection. Gastroenterology. 2007;133:1821–1830.
   PubMed Web of Science ®Google Scholar
• Berzsenyi MD, Woollard DJ, McLean CA, et al. Down-regulation of intra-hepatic T-cell signaling associated with GB virus C in a HCV/HIV co-infected group with reduced liver disease. J Hepatol. 2011;55(3):536–544.
   PubMed Web of Science ®Google Scholar
• Pawlotsky JM, Roudot-Thoraval F, Muerhoff AS, et al. GB virus C (GBV-C) infection in patients with chronic hepatitis C. influence on liver disease and on hepatitis virus behaviour: effect of interferon alfa therapy. J Med Virol. 1998;54:26–37.
   PubMed Web of Science ®Google Scholar
• Goeser T, Seipp S, Wahl R, et al. Clinical presentation of GB-C virus infection in drug abusers with chronic hepatitis C. J Hepatol. 1997;26:498–502.
   PubMed Web of Science ®Google Scholar
• Li T, Tang S, Su Y, et al. High prevalence and viremia of human pegivirus 2 in the HIV-infected population in honghe prefecture, Yunnan province. Arch Virol. 2020;165:619–626.
   PubMed Web of Science ®Google Scholar
• Sridhar S, Yip CCY, Chew NFS, et al. Epidemiological and clinical characteristics of human hepegivirus 1 infection in patients with hepatitis C. Open Forum Infect Dis. 2019;6:ofz329.
   PubMed Web of Science ®Google Scholar
• Lauck M, Bailey AL, Andersen KG, et al. GB virus C coinfections in West African Ebola patients. J Virol. 2015;89:2425–2429.
   PubMed Web of Science ®Google Scholar
• Fan X, Xu Y, Solomon H, et al. Is hepatitis G/GB virus-C virus hepatotropic? Detection of hepatitis G/GB virus-C viral RNA in liver and serum. J Med Virol. 1999;58:160–164.
   PubMed Web of Science ®Google Scholar
• Pessoa MG, Terrault NA, Detmer J, et al. Quantitation of hepatitis G and C viruses in the liver: evidence that hepatitis G virus is not hepatotropic. Hepatology. 1998;27:877–880.
   PubMed Web of Science ®Google Scholar
• Tucker TJ, Smuts HE, Eedes C, et al. Evidence that the GBV-C/hepatitis G virus is primarily a lymphotropic virus. J Med Virol. 2000;61:52–58.
   PubMed Web of Science ®Google Scholar
• Berg T, Müller AR, Platz KP, et al. Dynamics of GB virus C viremia early after orthotopic liver transplantation indicates extrahepatic tissues as the predominant site of GB virus C replication. Hepatology. 1999;29(1):245–249.
   PubMed Web of Science ®Google Scholar
• George SL, Varmaz D, Stapleton JT. GB virus C replicates in primary T and B lymphocytes. J Infect Dis. 2006;193:451–454.
   PubMed Web of Science ®Google Scholar
• Kisiel E, Cortez KC, Pawełczyk A, et al. Hepatitis G virus/GBV-C in serum, peripheral blood mononuclear cells and bone marrow in patients with hematological malignancies. Infect Genet Evol. 2013;19:195–199.
   PubMed Web of Science ®Google Scholar
• Mellor J, Haydon G, Blair C, et al. Low level or absent in vivo replication of hepatitis C virus and hepatitis G virus/GB virus C in peripheral blood mononuclear cells. J Gen Virol. 1998;79((Pt 4)):705–714.
   PubMedGoogle Scholar
• George SL, Xiang J, Stapleton JT. Clinical isolates of GB virus type C vary in their ability to persist and replicate in peripheral blood mononuclear cell cultures. Virology. 2003;316:191–201.
   PubMed Web of Science ®Google Scholar
• Radkowski M, Kubicka J, Kisiel E, et al. Detection of active hepatitis C virus and hepatitis G virus/GB virus C replication in bone marrow in human subjects. Blood. 2000;95:3986–3989.
   PubMed Web of Science ®Google Scholar
• Bailey AL, Lauck M, Mohns M, et al. Durable sequence stability and bone marrow tropism in a macaque model of human pegivirus infection. Sci Transl Med. 2015;7:305ra144.
   PubMed Web of Science ®Google Scholar
• Bukh J, Kim JP, Govindarajan S, et al. Experimental infection of chimpanzees with hepatitis G virus and genetic analysis of the virus. J Infect Dis. 1998;177:855–862.
   PubMed Web of Science ®Google Scholar
• Wolf D, Goff SP. Host restriction factors blocking retroviral replication. Annu Rev Genet. 2008;42(1):143–163.
   PubMedGoogle Scholar
• Neumann G, Kawaoka Y. Reverse genetics systems for the generation of segmented negative-sense RNA viruses entirely from cloned cDNA. Curr Top Microbiol Immunol. 2004;283:43–60.
   PubMed Web of Science ®Google Scholar
• Zhong J, Gastaminza P, Cheng G, et al. Robust hepatitis C virus infection in vitro. Proc Natl Acad Sci U S A. 2005;102:9294–9299.
   PubMed Web of Science ®Google Scholar
• Blight KJ, Kolykhalov AA, Rice CM. Efficient initiation of HCV RNA replication in cell culture. Science. 2000;290:1972–1974.
   PubMed Web of Science ®Google Scholar
• Shan C, Xie X, Muruato AE, et al. An infectious cdna clone of zika virus to study viral virulence, mosquito transmission, and antiviral inhibitors. Cell Host Microbe. 2016;19(6):891–900.
   PubMed Web of Science ®Google Scholar
• Tsetsarkin KA, Kenney H, Chen R, et al. A full-length infectious cDNA clone of zika virus from the 2015 epidemic in Brazil as a genetic platform for studies of virus-host interactions and vaccine development. mBio. 2016;7 e01114–16.
   PubMed Web of Science ®Google Scholar
• Puri B, Polo S, Hayes CG, et al. Construction of a full length infectious clone for dengue-1 virus Western Pacific,74 strain. Virus Genes. 2000;20:57–63.
   PubMed Web of Science ®Google Scholar
• Kinney RM, Butrapet S, Chang GJ, et al. Construction of infectious cDNA clones for dengue 2 virus: strain 16681 and its attenuated vaccine derivative, strain PDK-53. Virology. 1997;230:300–308.
   PubMed Web of Science ®Google Scholar
• Xie X, Muruato A, Lokugamage KG, et al. An Infectious cDNA Clone of SARS-CoV-2. Cell Host Microbe. 2020 27 :841–848.e3.
   PubMed Web of Science ®Google Scholar
• Thi Nhu Thao T, Labroussaa F, Ebert N, et al. Rapid reconstruction of SARS-CoV-2 using a synthetic genomics platform. Nature. 2020;582:561–565.
   PubMed Web of Science ®Google Scholar
• Hou YJ, Okuda K, Edwards CE, et al. SARS-CoV-2 reverse genetics reveals a variable infection gradient in the respiratory Tract. Cell. 2020 182 :429–446.e14.
   PubMed Web of Science ®Google Scholar
• Xiang J, Wünschmann S, Schmidt W, et al. Full-length GB virus C (hepatitis G virus) RNA transcripts are infectious in primary CD4-positive T cells. J Virol. 2000;74:9125–9133.
   PubMed Web of Science ®Google Scholar
• Ren H, Zhu F-L, Cao -M-M, et al. Hepatitis G virus genomic RNA is pathogenic to Macaca mulatta. World J Gastroenterol. 2005;11:970–975.
   PubMed Web of Science ®Google Scholar
• Cheng Y, Zhang W, Li J, et al. Serological and histological findings in infection and transmission of GBV-C/HGV to macaques. J Med Virol. 2000;60:28–33.
   PubMed Web of Science ®Google Scholar
• Evans DT, Silvestri G. Nonhuman primate models in AIDS research. Curr Opin HIV AIDS. 2013;8:255–261.
   PubMed Web of Science ®Google Scholar
• Shultz LD, Ishikawa F, Greiner DL. Humanized mice in translational biomedical research. Nat Rev Immunol. 2007;7:118–130.
   PubMed Web of Science ®Google Scholar
• Bagasra O, Bagasra AU, Sheraz M, et al. Potential utility of GB virus type C as a preventive vaccine for HIV-1. Expert Rev Vaccines. 2012;11:335–347.
   PubMed Web of Science ®Google Scholar
• Bailey AL, Buechler CR, Matson DR, et al. Pegivirus avoids immune recognition but does not attenuate acute-phase disease in a macaque model of HIV infection. PLoS Pathog. 2017;13:e1006692.
   PubMed Web of Science ®Google Scholar
• Greenhalgh S, Schmidt R, Day T. Fighting the public health burden of AIDS with the human pegivirus. Am J Epidemiol. 2019;188:1586–1594.
   PubMed Web of Science ®Google Scholar
• Thézé J, Lowes S, Parker J, et al. Evolutionary and phylogenetic analysis of the hepaciviruses and pegiviruses. Genome Biol Evol. 2015;7:2996–3008.
   PubMed Web of Science ®Google Scholar
• Ghai RR, Sibley SD, Lauck M, et al. Deep sequencing identifies two genotypes and high viral genetic diversity of human pegivirus (GB virus C) in rural Ugandan patients. J Gen Virol. 2013;94:2670–2678.
   PubMed Web of Science ®Google Scholar
• Nakao H, Okamoto H, Fukuda M, et al. Mutation rate of GB virus C/hepatitis G virus over the entire genome and in subgenomic regions. Virology. 1997;233:43–50.
   PubMed Web of Science ®Google Scholar
• Tumbo A-M, Schindler T, Dangy J-P, et al. Role of human pegivirus infections in whole plasmodium falciparum sporozoite vaccination and controlled human malaria infection in African volunteers. Virol J. 2021;18:28.
   PubMed Web of Science ®Google Scholar