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Research Paper

Clinical and genomic analysis of virulence-related genes in bloodstream infections caused by Acinetobacter baumannii

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Pages 1920-1927 | Received 24 Jan 2022, Accepted 29 Sep 2022, Published online: 28 Oct 2022

References

  • Vrancianu CO, Gheorghe I, Czobor IB, et al. Antibiotic resistance profiles, molecular mechanisms and innovative treatment strategies of Acinetobacter baumannii. Microorganisms. 2020;8(6):935. DOI:10.3390/microorganisms8060935
  • Monem S, Furmanek-Blaszk B, Lupkowska A, et al. Mechanisms protecting Acinetobacter baumannii against multiple stresses triggered by the host immune response, antibiotics and outside-host environment. Int J Mol Sci. 2020;21(15):5498.
  • Roca I, Espinal P, Vila-Farres X, et al. The Acinetobacter baumannii Oxymoron: commensal hospital dweller turned pan-drug-resistant menace. Front Microbiol. 2012;3:148.
  • McConnell MJ, Actis L, Pachon J. Acinetobacter baumannii: human infections, factors contributing to pathogenesis and animal models. FEMS Microbiol Rev. 2013;37(2):130–155.
  • Antunes LC, Visca P, Towner KJ. Acinetobacter baumannii: evolution of a global pathogen. Pathog Dis. 2014;71(3):292–301.
  • Asim P, Naik NA, Muralidhar V, et al. Clinical and economic outcomes of Acinetobacter vis a vis non-Acinetobacter infections in an Indian teaching hospital. Perspect Clin Res. 2016;7(1):28–31.
  • Ballouz T, Aridi J, Afif C, et al. Risk factors, clinical presentation, and outcome of Acinetobacter baumannii bacteremia. Front Cell Infect Microbiol. 2017;7:156.
  • Gulen TA, Guner R, Celikbilek N, et al. Clinical importance and cost of bacteremia caused by nosocomial multi drug resistant Acinetobacter baumannii. Int J Infect Dis. 2015;38:32–35.
  • Townsend J, Park AN, Gander R, et al. Acinetobacter infections and outcomes at an academic medical center: a disease of long-term care. Open Forum Infect Dis. 2015;2(1):ofv023.
  • Gu Z, Han Y, Meng T, et al. Risk factors and clinical outcomes for patients with Acinetobacter baumannii bacteremia. Medicine (Baltimore). 2016;95(9):e2943. DOI:10.1097/MD.0000000000002943
  • Guo N, Xue W, Tang D, et al. Risk factors and outcomes of hospitalized patients with blood infections caused by multidrug-resistant Acinetobacter baumannii complex in a hospital of Northern China. Am J Infect Control. 2016;44(4):e37–39.
  • Chopra T, Marchaim D, Awali RA, et al. Epidemiology of bloodstream infections caused by Acinetobacter baumannii and impact of drug resistance to both carbapenems and ampicillin-sulbactam on clinical outcomes. Antimicrob Agents Chemother. 2013;57(12):6270–6275.
  • Chopra T, Marchaim D, Johnson PC, et al. Risk factors and outcomes for patients with bloodstream infection due to Acinetobacter baumannii-calcoaceticus complex. Antimicrob Agents Chemother. 2014;58(8):4630–4635.
  • Nutman A, Glick R, Temkin E, et al. A case-control study to identify predictors of 14-day mortality following carbapenem-resistant Acinetobacter baumannii bacteraemia. Clin Microbiol Infect. 2014;20(12):O1028–1034.
  • Freire MP, de Oliveira Garcia D, Garcia CP, et al. Bloodstream infection caused by extensively drug-resistant Acinetobacter baumannii in cancer patients: high mortality associated with delayed treatment rather than with the degree of neutropenia. Clin Microbiol Infect. 2016;22(4):352–358.
  • Du X, Xu X, Yao J, et al. Predictors of mortality in patients infected with carbapenem-resistant Acinetobacter baumannii: a systematic review and meta-analysis. Am J Infect Control. 2019;47(9):1140–1145.
  • Bartual SG, Seifert H, Hippler C, et al. Development of a multilocus sequence typing scheme for characterization of clinical isolates of Acinetobacter baumannii. J Clin Microbiol. 2005;43(9):4382–4390. 43/9/4382 [pii]. DOI:10.1128/JCM.43.9.4382-4390.2005
  • Hayden RT, Clinton LK, Hewitt C, et al. Rapid Antimicrobial susceptibility testing using forward laser light scatter technology. J Clin Microbiol. 2016;54(11):2701–2706.
  • Guo B, Abdelraouf K, Ledesma KR, et al. Predicting bacterial fitness cost associated with drug resistance. J Antimicrob Chemother. 2012;67(4):928–932.
  • Tam VH, Perez C, Ledesma KR, et al. Transcriptional profiles of pulmonary innate immune responses to isogenic antibiotic-susceptible and multidrug-resistant Pseudomonas aeruginosa. Microbiol Immunol. 2018;62(4):291–294.
  • Peleg AY, Jara S, Monga D, et al. Galleria mellonella as a model system to study Acinetobacter baumannii pathogenesis and therapeutics. Antimicrob Agents Chemother. 2009;53(6):2605–2609.
  • Corral J, Perez-Varela M, Barbe J, et al. Direct interaction between RecA and a CheW-like protein is required for surface-associated motility, chemotaxis and the full virulence of Acinetobacter baumannii strain ATCC 17978. Virulence. 2020;11(1):315–326.
  • Abdelraouf K, Kabbara S, Ledesma KR, et al. Effect of multidrug resistance-conferring mutations on the fitness and virulence of Pseudomonas aeruginosa. J Antimicrob Chemother. 2011;66(6):1311–1317.
  • Chen WP, Kuo TT. A simple and rapid method for the preparation of gram-negative bacterial genomic DNA. Nucleic Acids Res. 1993;21(9):2260.
  • Chen S, Zhou Y, Chen Y, et al. Fastp: an ultra-fast all-in-one FASTQ preprocessor. Bioinformatics. 2018;34(17):i884–890.
  • Antipov D, Korobeynikov A, McLean JS, et al. hybridSpades: an algorithm for hybrid assembly of short and long reads. Bioinformatics. 2016;32(7):1009–1015.
  • Tacconelli E, Carrara E, Savoldi A, et al. Discovery, research, and development of new antibiotics: the WHO priority list of antibiotic-resistant bacteria and tuberculosis. Lancet Infect Dis. 2018;18(3):318–327.
  • Dijkshoorn L, Nemec A, Seifert H. An increasing threat in hospitals: multidrug-resistant Acinetobacter baumannii. Nat Rev Microbiol. 2007;5(12):939–951.
  • Lee CR, Lee JH, Park M, et al. Biology of Acinetobacter baumannii: pathogenesis, antibiotic resistance mechanisms, and prospective treatment options. Front Cell Infect Microbiol. 2017;7:55.
  • Gebhardt MJ, Gallagher LA, Jacobson RK, et al. Joint transcriptional control of virulence and resistance to antibiotic and environmental stress in Acinetobacter baumannii. MBio. 2015;6(6). e01660–01615. 10.1128/mBio.01660-15
  • Wang N, Ozer EA, Mandel MJ, et al. Genome-wide identification of Acinetobacter baumannii genes necessary for persistence in the lung. MBio. 2014; 5(3):e01163–01114. doi:10.1128/mBio.01163-14.
  • Bhuiyan MS, Ellett F, Murray GL, et al. Acinetobacter baumannii phenylacetic acid metabolism influences infection outcome through a direct effect on neutrophil chemotaxis. Proc Natl Acad Sci U S A. 2016;113(34):9599–9604.
  • Weber BS, Kinsella RL, Harding CM, et al. The secrets of Acinetobacter secretion. Trends Microbiol. 2017;25(7):532–545.
  • Leclercq SY, Sullivan MJ, Ipe DS, et al. Pathogenesis of Streptococcus urinary tract infection depends on bacterial strain and beta-hemolysin/cytolysin that mediates cytotoxicity, cytokine synthesis, inflammation and virulence. Sci Rep. 2016;6:29000.
  • Batista JH, da Silva Neto JF. Chromobacterium violaceum Pathogenicity: updates and insights from genome sequencing of novel chromobacterium species. Front Microbiol. 2017;8:2213.
  • Stead CM, Omsland A, Beare PA, et al. Sec-mediated secretion by Coxiella burnetii. BMC Microbiol. 2013;13:222.
  • Maurakis S, Keller K, Maxwell CN, et al. The novel interaction between Neisseria gonorrhoeae TdfJ and human S100A7 allows gonococci to subvert host zinc restriction. PLoS Pathog. 2019;15(8):e1007937.