CRM197-conjugated peptides vaccine of HCMV pp65 and gH induce maturation of DC and effective viral-specific T cell responses

References

• Griffiths P, Reeves M. Pathogenesis of human cytomegalovirus in the immunocompromised host. Nat Rev Microbiol. 2021;19:759–14.
   PubMed Web of Science ®Google Scholar
• Griffiths P, Baraniak I. The pathogenesis of human cytomegalovirus. J Pathol. 2015;235(2):288–297.
   PubMed Web of Science ®Google Scholar
• Ye L, Qian Y. Functional profile of human cytomegalovirus genes and their associated diseases: a review. Front Microbiol. 2020;11:2104.
   PubMed Web of Science ®Google Scholar
• Sezgin E, An P. Host genetics of cytomegalovirus pathogenesis. Front Genet. 2019;10:616.
   PubMed Web of Science ®Google Scholar
• Mercorelli B, Sinigalia E. Human cytomegalovirus DNA replication: antiviral targets and drugs. Rev Med Virol. 2008;18(3):177–210.
   PubMed Web of Science ®Google Scholar
• Wang D, Fu TM. Progress on human cytomegalovirus vaccines for prevention of congenital infection and disease. Curr Opin Virol. 2014;6:13–23.
   PubMed Web of Science ®Google Scholar
• Inoue N, Abe M. Vaccine development for cytomegalovirus. Adv Exp Med Biol. 2018;1045:271–296.
   PubMed Web of Science ®Google Scholar
• Long X, Qiu Y. Insight for immunotherapy of HCMV infection. Int J Biol Sci. 2021;17(11):2899–2911.
   PubMed Web of Science ®Google Scholar
• Tomtishen JP. Human cytomegalovirus tegument proteins (pp65, pp71, pp150, pp28). Virol J. 2012;9(1):22. 3rd
   PubMedGoogle Scholar
• Chevillotte M, Landwehr S. Major tegument protein pp65 of human cytomegalovirus is required for the incorporation of pUL69 and pUL97 into the virus particle and for viral growth in macrophages. J Virol. 2009;83(6):2480–2490.
   PubMed Web of Science ®Google Scholar
• Lim JB, Kim HO. Identification of HLA-A*2402-restricted HCMV immediate early-1 (IE-1) epitopes as targets for CD8+ HCMV-specific cytotoxic T lymphocytes. J Transl Med. 2009;7(1):72.
   PubMedGoogle Scholar
• Caló S, Cortese M. The human cytomegalovirus UL116 gene encodes an envelope glycoprotein forming a complex with gH independently from gL. J Virol. 2016;90(10):4926–4938.
   PubMed Web of Science ®Google Scholar
• McWatters BJ, Stenberg RM. Characterization of the human cytomegalovirus UL75 (glycoprotein H) late gene promoter. Virology. 2002;303(2):309–316.
   PubMed Web of Science ®Google Scholar
• Théry C, Amigorena S. The cell biology of antigen presentation in dendritic cells. Curr Opin Immunol. 2001;13(1):45–51.
   PubMed Web of Science ®Google Scholar
• Qian C, Cao X. Dendritic cells in the regulation of immunity and inflammation. Semin Immunol. 2018;35:3–11.
   PubMed Web of Science ®Google Scholar
• Berges C, Naujokat C. A cell line model for the differentiation of human dendritic cells. Biochem Biophys Res Commun. 2005;333(3):896–907.
   PubMed Web of Science ®Google Scholar
• Reis e Sousa C. Dendritic cells in a mature age. Nat Rev Immunol. 2006;6(6):476–483.
   PubMed Web of Science ®Google Scholar
• Gaudino SJ, Kumar P. Cross-Talk between antigen presenting cells and T cells impacts intestinal homeostasis, bacterial infections, and tumorigenesis. Front Immunol. 2019;10:360.
   PubMed Web of Science ®Google Scholar
• Nicoli F, Paul S. Harnessing the induction of CD8(+) T-cell responses through metabolic regulation by pathogen-recognition-receptor triggering in antigen presenting cells. Front Immunol. 2018;9:2372.
   PubMed Web of Science ®Google Scholar
• Wang K, Zhou L, Zhang X. Hepatitis E vaccine candidate harboring a non-particulate immunogen of E2 fused with CRM197 fragment a. Antiviral Res. 2019;164:154–161.
   PubMed Web of Science ®Google Scholar
• Wang C, Wang L, Chen B-C. CRM197-coupled der p 2 peptides suppress allergic airway inflammation in a der p 2-induced asthma mouse model. Int Arch Allergy Immunol. 2019;180(3):173–181.
   PubMed Web of Science ®Google Scholar
• Tobias J, Jasinska J, Baier K. Enhanced and long term immunogenicity of a her-2/neu multi-epitope vaccine conjugated to the carrier CRM197 in conjunction with the adjuvant montanide. BMC Cancer. 2017;17(1):118.
   PubMedGoogle Scholar
• Chauhan V, Singh MP. Immuno-informatics approach to design a multi-epitope vaccine to combat cytomegalovirus infection. Eur J Pharm Sci. 2020;147:105279.
   PubMed Web of Science ®Google Scholar
• Li Z, Zhang F, Zhang C. Immunoinformatics prediction of OMP2b and BCSP31 for designing multi-epitope vaccine against Brucella. Mol Immunol. 2019;114:651–660.
   PubMed Web of Science ®Google Scholar
• Sun P, Ju H, Liu Z. Bioinformatics resources and tools for conformational B-cell epitope prediction. Comput Math Methods Med. 2013;2013:943636.
   PubMed Web of Science ®Google Scholar
• Chauhan V, Goyal K, Singh MP. Identification of broadly reactive epitopes targeting major glycoproteins of herpes simplex virus (HSV) 1 and 2 - an immunoinformatics analysis. Infect Genet Evol. 2018;61:24–35.
   PubMed Web of Science ®Google Scholar
• Chauhan V, Singh MP, Ratho RK. Identification of T cell and B cell epitopes against Indian HCV-genotype-3a for vaccine development- an in silico analysis. Biologicals. 2018;53:63–71.
   PubMed Web of Science ®Google Scholar
• Alam A, Ali S, Ahamad S. From ZikV genome to vaccine: in silico approach for the epitope-based peptide vaccine against Zika virus envelope glycoprotein. Immunology. 2016;149(4):386–399.
   PubMed Web of Science ®Google Scholar
• Ahmad HI, Afzal G, Jamal A. In silico structural, functional, and phylogenetic analysis of cytochrome (CYPD) protein family. BioMed Res Int. 2021;2021:5574789.
   PubMed Web of Science ®Google Scholar
• Akya A, Farasat A, Ghadiri K. Identification of HLA-I restricted epitopes in six vaccine candidates of Leishmania tropica using immunoinformatics and molecular dynamics simulation approaches. Infect Genet Evol. 2019;75:103953.
   PubMed Web of Science ®Google Scholar
• Jiang S, Nan F, Zhang S. CRM197-conjugated multi antigen dominant epitope for effective human cytomegalovirus vaccine development. Int j biol macromol. 2022;224:79–93.
   PubMed Web of Science ®Google Scholar
• Longhi MS, Hussain MJ, Bogdanos DP. Cytochrome P450IID6-specific CD8 T cell immune responses mirror disease activity in autoimmune hepatitis type 2. Hepatology. 2007;46(2):472–484.
   PubMed Web of Science ®Google Scholar
• Araf Y, Moin AT, Timofeev VI. Immunoinformatic design of a multivalent peptide vaccine against mucormycosis: targeting ftr1 protein of major causative fungi. Front Immunol. 2022;13:863234.
   PubMed Web of Science ®Google Scholar
• Gupta A, Narayan B, Kumar S. Vaccine potential of a recombinant bivalent fusion protein LcrV-HSP70 against plague and yersiniosis. Front Immunol. 2020;11:988.
   PubMed Web of Science ®Google Scholar
• Vingtdeux V, Zhao H, Chandakkar P. A modification-specific peptide-based immunization approach using CRM197 carrier protein: development of a selective vaccine against pyroglutamate Aβ peptides. Mol Med. 2017;22(1):841–849.
   PubMedGoogle Scholar
• Bai Y, Xuan B, Liu H. Tuberous sclerosis complex protein 2-independent activation of mTORC1 by human cytomegalovirus pUL38. J Virol. 2015;89(15):7625–7635.
   PubMed Web of Science ®Google Scholar
• Hosogai M, Shima N, Nakatani Y. Analysis of human cytomegalovirus replication in primary cultured human corneal endothelial cells. Br J Ophthalmol. 2015;99(11):1583–1590.
   PubMed Web of Science ®Google Scholar
• Krishna BA, Wills MR, Sinclair JH. Advances in the treatment of cytomegalovirus. Br Med Bull. 2019;131(1):5–17.
   PubMed Web of Science ®Google Scholar
• Pandey RK, Ojha R, Dipti K. Immunoselective algorithm to devise multi-epitope subunit vaccine fighting against human cytomegalovirus infection. Infect Genet Evol. 2020;82:104282.
   PubMed Web of Science ®Google Scholar
• Fadaka AO, Sibuyi NRS, Martin DR. Immunoinformatics design of a novel epitope-based vaccine candidate against dengue virus. Sci Rep. 2021;11(1):19707.
   PubMed Web of Science ®Google Scholar
• Chen HZ, Tang LL, Yu X-L. Bioinformatics analysis of epitope-based vaccine design against the novel SARS-CoV-2. Infect Dis Poverty. 2020;9(1):88.
   PubMed Web of Science ®Google Scholar
• He Y, Yu W, Xiao L. Conjugation of Zika virus EDIII with CRM(197), 8-arm PEG and mannan for development of an effective Zika virus vaccine. Int j biol macromol. 2021;190:713–721.
   PubMed Web of Science ®Google Scholar
• Han JC, Li QX, Fang JB. GII.P16-GII.2 recombinant norovirus VLPs polarize macrophages into the M1 phenotype for Th1 immune responses. Front Immunol. 2021;12:781718.
   PubMed Web of Science ®Google Scholar
• Barhoumi M, Koutsoni OS, Dotsika E. Leishmania infantum LeIF and its recombinant polypeptides induce the maturation of dendritic cells in vitro: an insight for dendritic cells based vaccine. Immunol Lett. 2019;210:20–28.
   PubMed Web of Science ®Google Scholar
• Liu X, Chen N, Lin S. Synthesized peptides 705–734 from hepatitis C virus E2 glycoprotein induce dendritic cell maturation by activating p38 MAPK signaling. Int Immunopharmacol. 2016;30:194–201.
   PubMed Web of Science ®Google Scholar
• Cao S, Li Y, Ye J. Japanese encephalitis Virus wild strain infection suppresses dendritic cells maturation and function, and causes the expansion of regulatory T cells. Virol J. 2011;8(1):39.
   PubMedGoogle Scholar
• Lee JY, Kim H, Cha MY. Clostridium difficile toxin a promotes dendritic cell maturation and chemokine CXCL2 expression through p38, IKK, and the NF-κB signaling pathway. J Mol Med (Berl). 2009;87(2):169–180.
   PubMed Web of Science ®Google Scholar
• Mogensen TH, Paludan SR. Reading the viral signature by toll-like receptors and other pattern recognition receptors. J Mol Med (Berl). 2005;83(3):180–192.
   PubMed Web of Science ®Google Scholar
• Lysakova-Devine T, Keogh B, Harrington B. Viral inhibitory peptide of TLR4, a peptide derived from vaccinia protein A46, specifically inhibits TLR4 by directly targeting MyD88 adaptor-like and TRIF-related adaptor molecule. J Immunol. 2010;185(7):4261–4271.
   PubMed Web of Science ®Google Scholar
• Krstanović F, Britt WJ, Jonjić S. Cytomegalovirus infection and inflammation in developing brain. Viruses. 2021;13(6):13.
   Web of Science ®Google Scholar
• Vieira Braga FA, Hertoghs KM, van Lier RAW. Molecular characterization of HCMV-specific immune responses: parallels between CD8 + T cells, CD4 + T cells, and NK cells. Eur J Immunol. 2015;45(9):2433–2445.
   PubMed Web of Science ®Google Scholar
• van Lier RA, ten Berge IJ, Gamadia LE. Human CD8(+) T-cell differentiation in response to viruses. Nat Rev Immunol. 2003;3(12):931–939.
   PubMed Web of Science ®Google Scholar
• Wherry EJ, Ahmed R. Memory CD8 T-cell differentiation during viral infection. J Virol. 2004;78(11):5535–5545.
   PubMed Web of Science ®Google Scholar
• Dhital R, Anand S, Graber B. Murine cytomegalovirus promotes renal allograft inflammation via Th1/17 cells and IL-17A. Am J Transplant. 2022;22(10):2306–2322.
   PubMed Web of Science ®Google Scholar
• Wunsch M, Zhang W, Hanson J. Characterization of the HCMV-specific CD4 T cell responses that are associated with protective immunity. Viruses. 2015;7(8):4414–4437.
   PubMed Web of Science ®Google Scholar
• Ohkura N, Sakaguchi S. Transcriptional and epigenetic basis of treg cell development and function: its genetic anomalies or variations in autoimmune diseases. Cell Res. 2020;30(6):465–474.
   PubMed Web of Science ®Google Scholar