1,346
Views
6
CrossRef citations to date
0
Altmetric
Brief Report - Commissioned

Normal epithelial cells trigger EphA2-dependent RasV12 cell repulsion at the single cell level

&
Pages 305-310 | Received 04 Apr 2017, Accepted 26 Apr 2017, Published online: 21 Jun 2017

References

  • Di Gregorio A, Bowling S, Rodriguez TA. Cell competition and its role in the regulation of cell fitness from development to cancer. Dev Cell 2016; 38(6):621-34; PMID:27676435; https://doi.org/10.1016/j.devcel.2016.08.012
  • Merino MM, Levayer R, Moreno E. Survival of the fittest: Essential roles of cell competition in development, aging, and cancer. Trends Cell Biol 2016; 26(10):776-88; PMID:27319281; https://doi.org/10.1016/j.tcb.2016.05.009
  • Hogan C, Dupre-Crochet S, Norman M, Kajita M, Zimmermann C, Pelling AE, Piddini E, Baena-López LA, Vincent JP, Itoh Y, et al. Characterization of the interface between normal and transformed epithelial cells. Nat Cell Biol 2009; 11(4):460-7; PMID:19287376; https://doi.org/10.1038/ncb1853
  • Kajita M, Hogan C, Harris AR, Dupre-Crochet S, Itasaki N, Kawakami K, Charras G, Tada M, Fujita Y. Interaction with surrounding normal epithelial cells influences signalling pathways and behaviour of Src-transformed cells. J Cell Sci 2010; 123(Pt 2):171-80; PMID:20026643; https://doi.org/10.1242/jcs.057976
  • Kajita M, Fujita Y. EDAC: Epithelial defence against cancer-cell competition between normal and transformed epithelial cells in mammals. J Biochem 2015; 158(1):15-23; PMID:25991731; https://doi.org/10.1093/jb/mvv050
  • Anton KA, Sinclair J, Ohoka A, Kajita M, Ishikawa S, Benz PM, Renne T, Balda M, Jorgensen C, Matter K, et al. PKA-regulated VASP phosphorylation promotes extrusion of transformed cells from the epithelium. J Cell Sci 2014; 127(Pt 16):3425-33; PMID:24963131; https://doi.org/10.1242/jcs.149674
  • Kadeer A, Maruyama T, Kajita M, Morita T, Sasaki A, Ohoka A, Ishikawa S, Ikegawa M, Shimada T, Fujita Y. Plectin is a novel regulator for apical extrusion of RasV12-transformed cells. Sci Rep 2017; 7:44328; PMID:28281696; https://doi.org/10.1038/srep44328
  • Kajita M, Sugimura K, Ohoka A, Burden J, Suganuma H, Ikegawa M, Shimada T, Kitamura T, Shindoh M, Ishikawa S, et al. Filamin acts as a key regulator in epithelial defence against transformed cells. Nat Commun 2014; 5:4428; PMID:25079702; https://doi.org/10.1038/ncomms5428
  • Hogan C, Serpente N, Cogram P, Hosking CR, Bialucha CU, Feller SM, Braga VM, Birchmeier W, Fujita Y. Rap1 regulates the formation of E-cadherin-based cell-cell contacts. Mol Cell Biol 2004; 24(15):6690-700; PMID:15254236; https://doi.org/10.1128/MCB.24.15.6690-6700.2004
  • Saitoh S, Maruyama T, Yako Y, Kajita M, Fujioka Y, Ohba Y, Kasai N, Sugama N, Kon S, Ishikawa S, et al. Rab5-regulated endocytosis plays a crucial role in apical extrusion of transformed cells. Proc Natl Acad Sci U S A 2017; 114(12):E2327-36; PMID:28270608; https://doi.org/10.1073/pnas.1602349114
  • Porazinski S, de Navascues J, Yako Y, Hill W, Jones MR, Maddison R, Fujita Y, Hogan C. EphA2 drives the segregation of Ras-Transformed epithelial cells from normal neighbors. Curr Biol 2016; 26(23):3220-9; PMID:27839970; https://doi.org/10.1016/j.cub.2016.09.037
  • Macrae M, Neve RM, Rodriguez-Viciana P, Haqq C, Yeh J, Chen C, Gray JW, McCormick F. A conditional feedback loop regulates Ras activity through EphA2. Cancer Cell 2005; 8(2):111-8; PMID:16098464; https://doi.org/10.1016/j.ccr.2005.07.005
  • Fang WB, Brantley-Sieders DM, Hwang Y, Ham AJ, Chen J. Identification and functional analysis of phosphorylated tyrosine residues within EphA2 receptor tyrosine kinase. J Biol Chem 2008; 283(23):16017-26; PMID:18387945; https://doi.org/10.1074/jbc.M709934200
  • Salaita K, Nair PM, Petit RS, Neve RM, Das D, Gray JW, Groves JT. Restriction of receptor movement alters cellular response: physical force sensing by EphA2. Science 2010; 327(5971):1380-5; PMID:20223987; https://doi.org/10.1126/science.1181729
  • Wimmer-Kleikamp SH, Janes PW, Squire A, Bastiaens PI, Lackmann M. Recruitment of Eph receptors into signaling clusters does not require ephrin contact. J Cell Biol 2004; 164(5):661-6; PMID:14993233; https://doi.org/10.1083/jcb.200312001
  • Falivelli G, Lisabeth EM, Rubio de la Torre E, Perez-Tenorio G, Tosato G, Salvucci O, Pasquale EB. Attenuation of eph receptor kinase activation in cancer cells by coexpressed ephrin ligands. PloS One 2013; 8(11):e81445; PMID:24348920; https://doi.org/10.1371/journal.pone.0081445