Advanced search
Publication Cover
Small GTPases Volume 11, 2020 - Issue 3
Submit an article Journal homepage
710
Views
9
CrossRef citations to date
0
Altmetric
Brief Report

A novel prenyl-polybasic domain code determines lipid-binding specificity of the K-Ras membrane anchor

Yong ZhouDepartment of Integrative Biology and Pharmacology McGovern Medical School, University of Texas Health Science Center at Houston, Houston, Texas, U.S.A.
&
John F. HancockDepartment of Integrative Biology and Pharmacology McGovern Medical School, University of Texas Health Science Center at Houston, Houston, Texas, U.S.A.Correspondence[email protected]
Pages 220-224 | Received 06 Aug 2017, Accepted 11 Sep 2017, Published online: 15 Jan 2018

References

  • Prior, IA., Hancock, JF. Ras trafficking, localization and compartmentalized signalling. Semin Cell Dev Biol. 2012;23(2):p. 145–53. https://doi.org/10.1016/j.semcdb.2011.09.002
  • Downward, J. Targeting RAS signalling pathways in cancer therapy. Nat Rev Cancer. 2003;3(1):p. 11–22. https://doi.org/10.1038/nrc969
  • Prior, IA., Lewis, PD., Mattos, C. A comprehensive survey of ras mutations in cancer. Cancer Res. 2012;72(10):p. 2457–67. https://doi.org/10.1158/0008-5472.CAN-11-2612
  • Prior, IA., Hancock, JF. Compartmentalization of Ras proteins. J Cell Sci. 2001;114(Pt 9):p. 1603–8.
  • Hancock, JF., et al., All ras proteins are polyisoprenylated but only some are palmitoylated. Cell. 1989;57(7):p. 1167–77. https://doi.org/10.1016/0092-8674(89)90054-8
  • Hancock, JF., et al., A CAAX or a CAAL motif and a second signal are sufficient for plasma membrane targeting of ras proteins. EMBO J. 1991;10(13):p. 4033–9.
  • Hancock, JF., Paterson, H., Marshall, CJ. A polybasic domain or palmitoylation is required in addition to the CAAX motif to localize p21ras to the plasma membrane. Cell. 1990;63(1):p. 133–9. https://doi.org/10.1016/0092-8674(90)90294-O
  • Tsai, FD., et al., K-Ras4A splice variant is widely expressed in cancer and uses a hybrid membrane-targeting motif. Proc Natl Acad Sci U S A. 2015;112(3):p. 779–84. https://doi.org/10.1073/pnas.1412811112
  • Prior, IA., et al., Direct visualization of Ras proteins in spatially distinct cell surface microdomains. J Cell Biol, 2003. 160: p. 165–170. https://doi.org/10.1083/jcb.200209091
  • Hancock, JF., Ras proteins: different signals from different locations. Nat Rev Mol Cell Biol. 2003;4(5):p. 373–84. https://doi.org/10.1038/nrm1105
  • Plowman, SJ., et al., H-ras, K-ras, and inner plasma membrane raft proteins operate in nanoclusters with differential dependence on the actin cytoskeleton. Proc Natl Acad Sci U S A. 2005;102(43):p. 15500–5. https://doi.org/10.1073/pnas.0504114102
  • Zhou, Y., Hancock, JF., Ras nanoclusters: Versatile lipid-based signaling platforms. Biochim Biophys Acta. 2015;1853(4):p. 841–849. https://doi.org/10.1016/j.bbamcr.2014.09.008
  • Zhou, Y., et al., Signal Integration by Lipid-Mediated Spatial Cross Talk between Ras Nanoclusters. Mol Cell Biol. 2014;34(5):p. 862–76. https://doi.org/10.1128/MCB.01227-13
  • Zhou, Y., et al., SIGNAL TRANSDUCTION. Membrane potential modulates plasma membrane phospholipid dynamics and K-Ras signaling. Science. 2015;349(6250):p. 873–6. https://doi.org/10.1126/science.aaa5619
  • Zhou, Y., et al., Lipid-Sorting Specificity Encoded in K-Ras Membrane Anchor Regulates Signal Output. Cell. 2017;168(1-2):p. 239–251. e16. https://doi.org/10.1016/j.cell.2016.11.059
  • Gambhir, A., et al., Electrostatic sequestration of PIP2 on phospholipid membranes by basic/aromatic regions of proteins. Biophys J. 2004;86(4):p. 2188–207. https://doi.org/10.1016/S0006-3495(04)74278-2
  • McLaughlin, S., et al., PIP(2) and proteins: interactions, organization, and information flow. Annu Rev Biophys Biomol Struct. 2002;31:p. 151–75. https://doi.org/10.1146/annurev.biophys.31.082901.134259
  • Cho, KJ., et al., Staurosporines disrupt phosphatidylserine trafficking and mislocalize Ras proteins. J Biol Chem, 2012;287(52):p. 43573–84. https://doi.org/10.1074/jbc.M112.424457
  • Cho, KJ., et al., Inhibition of Acid Sphingomyelinase Depletes Cellular Phosphatidylserine and Mislocalizes K-Ras from the Plasma Membrane. Mol Cell Biol, 2015. 36(2):p. 363–74.
  • van der Hoeven, D., et al., Fendiline inhibits K-Ras plasma membrane localization and blocks K-Ras signal transmission. Mol Cell Biol, 2013. 33(2): p. 237–51. https://doi.org/10.1128/MCB.00884-12

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.