Investigating increased hematopoietic stem cell fitness in a novel mouse model

References

• Orkin SH, Zon LI. Hematopoiesis: an evolving paradigm for stem cell biology. Cell. 2008;132(4):631–644.
   PubMed Web of Science ®Google Scholar
• Paik EJ, Zon LI. Hematopoietic development in the zebrafish. Int J Dev Biol. 2010;54(6–7):1127–1137.
   PubMed Web of Science ®Google Scholar
• McGrath KE, Frame JM, Fromm GJ, et al. A transient definitive erythroid lineage with unique regulation of the beta-globin locus in the mammalian embryo. Blood. 2011;117(17):4600–4608.
   PubMed Web of Science ®Google Scholar
• Bertrand JY, Kim AD, Violette EP, et al. Definitive hematopoiesis initiates through a committed erythromyeloid progenitor in the zebrafish embryo. Development. 2007;134(23):4147–4156.
   PubMed Web of Science ®Google Scholar
• Cumano A, Godin I. Ontogeny of the hematopoietic system. Annu Rev Immunol. 2007;25(1):745–785.
   PubMed Web of Science ®Google Scholar
• Pietras EM, Warr MR, Passegue E. Cell cycle regulation in hematopoietic stem cells. J Cell Biol. 2011;195(5):709–720.
   PubMed Web of Science ®Google Scholar
• Schofield R. The relationship between the spleen colony-forming cell and the haemopoietic stem cell. Blood Cells. 1978;4(1–2):7–25.
   PubMedGoogle Scholar
• Mendez-Ferrer S, Bonnet D, Steensma DP, et al. Bone marrow niches in haematological malignancies. Nat Rev Cancer. 2020;20:285–298.
   PubMed Web of Science ®Google Scholar
• Jacobson LO, Simmons EL, Marks EK, et al. Recovery from radiation injury. Science. 1951;113(2940):510–511.
   PubMed Web of Science ®Google Scholar
• Lorenz E, Uphoff D, Reid TR, et al. Modification of irradiation injury in mice and guinea pigs by bone marrow injections. J Natl Cancer Inst. 1951;12(1):197–201.
   PubMedGoogle Scholar
• Urso P, Congdon CC. The effect of the amount of isologous bone marrow injected on the recovery of hematopoietic organs, survival and body weight after lethal irradiation injury in mice. Blood. 1957;12(3):251–260.
   PubMed Web of Science ®Google Scholar
• Becker AJ, Mc CE, Till JE. Cytological demonstration of the clonal nature of spleen colonies derived from transplanted mouse marrow cells. Nature. 1963;197(4866):452–454.
   PubMedGoogle Scholar
• Gong B, Oest ME, Mann KA, et al. Raman spectroscopy demonstrates prolonged alteration of bone chemical composition following extremity localized irradiation. Bone. 2013;57(1):252–258.
   PubMed Web of Science ®Google Scholar
• Hooper AT, Butler JM, Nolan DJ, et al. Engraftment and reconstitution of hematopoiesis is dependent on VEGFR2-mediated regeneration of sinusoidal endothelial cells. Cell Stem Cell. 2009;4(3):263–274. .
   PubMed Web of Science ®Google Scholar
• Poulos MG, Guo P, Kofler NM, et al. Endothelial Jagged-1 is necessary for homeostatic and regenerative hematopoiesis. Cell Rep. 2013;4(5):1022–1034. .
   PubMed Web of Science ®Google Scholar
• Sun J, Ramos A, Chapman B, et al. Clonal dynamics of native Hematopoiesis. Nature. 2014;514(7522):322–327.
   PubMed Web of Science ®Google Scholar
• Baker WH, Limanni A, Chang CM, et al. Comparison of interleukin-1 alpha gene expression and protein levels in the murine spleen after lethal and sublethal total-body irradiation. Radiat Res. 1995;143(3):320–326.
   PubMed Web of Science ®Google Scholar
• Tan W, Huang W, Zhong Q, et al. IL-17 receptor knockout mice have enhanced myelotoxicity and impaired hemopoietic recovery following gamma irradiation. J Immunol. 2006;176(10):6186–6193.
   PubMed Web of Science ®Google Scholar
• Zhou BO, Yu H, Yue R, et al. Bone marrow adipocytes promote the regeneration of stem cells and Hematopoiesis by secreting SCF. Nat Cell Biol. 2017;19(8):891–903.
   PubMed Web of Science ®Google Scholar
• Ksionda O, Limnander A, Roose JP. RasGRP Ras guanine nucleotide exchange factors in cancer. Front Biol (Beijing). 2013;8(5):508–532.
   PubMedGoogle Scholar
• Hartzell C, Ksionda O, Lemmens E, et al. Dysregulated RasGRP1 responds to cytokine receptor input in T cell leukemogenesis. Sci Signal. 2013;6(268):ra21. .
   PubMed Web of Science ®Google Scholar
• Karra L, Romero-Moya D, Ksionda O, et al. Increased baseline RASGRP1 signals enhance stem cell fitness during native hematopoiesis. Oncogene. 2020 Nov;39(45):6920-6934. doi: 10.1038/s41388-020-01469-8. Epub 2020 Sep 28.PMID: 32989257.
   Google Scholar
• Stine RR, Matunis EL. Stem cell competition: finding balance in the niche. Trends Cell Biol. 2013;23(8):357–364.
   PubMed Web of Science ®Google Scholar
• Cheung TH, Rando TA. Molecular regulation of stem cell quiescence. Nat Rev Mol Cell Biol. 2013;14(6):329–340.
   PubMed Web of Science ®Google Scholar
• Thomas J, Liu F, Link DC. Mechanisms of mobilization of hematopoietic progenitors with granulocyte colony-stimulating factor. Curr Opin Hematol. 2002;9(3):183–189.
   PubMed Web of Science ®Google Scholar
• Burgess RJ, Agathocleous M, Morrison SJ. Metabolic regulation of stem cell function. J Intern Med. 2014;276(1):12–24.
   PubMed Web of Science ®Google Scholar
• McLeod CJ, Wang L, Wong C, et al. Stem cell dynamics in response to nutrient availability. Curr Biol. 2010;20(23):2100–2105.
   PubMed Web of Science ®Google Scholar
• Yu WM, Liu X, Shen J, et al. Metabolic regulation by the mitochondrial phosphatase PTPMT1 is required for hematopoietic stem cell differentiation. Cell Stem Cell. 2013;12(1):62–74.
   PubMed Web of Science ®Google Scholar
• Yanes O, Clark J, Wong DM, et al. Metabolic oxidation regulates embryonic stem cell differentiation. Nat Chem Biol. 2010;6(6):411–417.
   PubMed Web of Science ®Google Scholar
• Karigane D, Takubo K. Metabolic regulation of hematopoietic and leukemic stem/progenitor cells under homeostatic and stress conditions. Int J Hematol. 2017;106(1):18–26.
   PubMed Web of Science ®Google Scholar
• Suda T, Takubo K, Semenza GL. Metabolic regulation of hematopoietic stem cells in the hypoxic niche. Cell Stem Cell. 2011;9(4):298–310.
   PubMed Web of Science ®Google Scholar
• Takubo K, Nagamatsu G, Kobayashi CI, et al. Regulation of glycolysis by Pdk functions as a metabolic checkpoint for cell cycle quiescence in hematopoietic stem cells. Cell Stem Cell. 2013;12(1):49–61. .
   PubMed Web of Science ®Google Scholar
• Simsek T, Kocabas F, Zheng J, et al. The distinct metabolic profile of hematopoietic stem cells reflects their location in a hypoxic niche. Cell Stem Cell. 2010;7(3):380–390.
   PubMed Web of Science ®Google Scholar
• Takubo K, Goda N, Yamada W, et al. Regulation of the HIF-1alpha level is essential for hematopoietic stem cells. Cell Stem Cell. 2010;7(3):391–402. .
   PubMed Web of Science ®Google Scholar
• Ito K, Carracedo A, Weiss D, et al. A PML-PPAR-delta pathway for fatty acid oxidation regulates hematopoietic stem cell maintenance. Nat Med. 2012;18(9):1350–1358. .
   PubMed Web of Science ®Google Scholar
• Efeyan A, Comb WC, Sabatini DM. Nutrient-sensing mechanisms and pathways. Nature. 2015;517(7534):302–310.
   PubMed Web of Science ®Google Scholar
• Saxton RA, Sabatini DM. mTOR signaling in growth, metabolism, and disease. Cell. 2017;168(6):960–976.
   PubMed Web of Science ®Google Scholar
• Laplante M, Sabatini DM. mTOR signaling in growth control and disease. Cell. 2012;149(2):274–293.
   PubMed Web of Science ®Google Scholar
• Sarbassov DD, Ali SM, Sengupta S, et al. Prolonged rapamycin treatment inhibits mTORC2 assembly and Akt/PKB. Mol Cell. 2006;22(2):159–168.
   PubMed Web of Science ®Google Scholar
• Sampson LL, Davis AK, Grogg MW, et al. mTOR disruption causes intestinal epithelial cell defects and intestinal atrophy postinjury in mice. Faseb J. 2016;30(3):1263–1275.
   PubMed Web of Science ®Google Scholar
• Magri L, Cambiaghi M, Cominelli M, et al. Sustained activation of mTOR pathway in embryonic neural stem cells leads to development of tuberous sclerosis complex-associated lesions. Cell Stem Cell. 2011;9(5):447–462. .
   PubMed Web of Science ®Google Scholar
• Easley CAT, Ben-Yehudah A, Redinger CJ, et al. mTOR-mediated activation of p70 S6K induces differentiation of pluripotent human embryonic stem cells. Cell Reprogram. 2010;12(3):263–273.
   PubMed Web of Science ®Google Scholar
• Chen T, Shen L, Yu J, et al. Rapamycin and other longevity-promoting compounds enhance the generation of mouse induced pluripotent stem cells. Aging Cell. 2011;10(5):908–911.
   PubMed Web of Science ®Google Scholar
• Hoshii T, Tadokoro Y, Naka K, et al. mTORC1 is essential for leukemia propagation but not stem cell self-renewal. J Clin Invest. 2012;122(6):2114–2129.
   PubMed Web of Science ®Google Scholar
• Kalaitzidis D, Sykes SM, Wang Z, et al. mTOR complex 1 plays critical roles in hematopoiesis and Pten-loss-evoked leukemogenesis. Cell Stem Cell. 2012;11:429–439.
   PubMed Web of Science ®Google Scholar
• Ghosh J, Kobayashi M, Ramdas B, et al. S6K1 regulates hematopoietic stem cell self-renewal and leukemia maintenance. J Clin Invest. 2016;126(7):2621–2625. .
   PubMed Web of Science ®Google Scholar
• Zhang Y, Gao S, Xia J, et al. Hematopoietic hierarchy – an updated roadmap. Trends Cell Biol. 2018;28(12):976–986.
   PubMed Web of Science ®Google Scholar
• Sawen P, Eldeeb M, Erlandsson E, et al. Murine HSCs contribute actively to native hematopoiesis but with reduced differentiation capacity upon aging. Elife. 2018;7:7.
   Web of Science ®Google Scholar
• Buitenhuis M, Coffer PJ. The role of the PI3K-PKB signaling module in regulation of hematopoiesis. Cell Cycle. 2009;8(4):560–566.
   PubMed Web of Science ®Google Scholar
• Elich M, Sauer K. Regulation of hematopoietic cell development and function through phosphoinositides. Front Immunol. 2018;9:931.
   PubMed Web of Science ®Google Scholar
• Ksionda O, Mues M, Wandler AM, et al. Comprehensive analysis of T cell leukemia signals reveals heterogeneity in the PI3 kinase-Akt pathway and limitations of PI3 kinase inhibitors as monotherapy. PLoS One. 2018;13(5):e0193849. .
   PubMed Web of Science ®Google Scholar
• Gutierrez A, Sanda T, Grebliunaite R, et al. High frequency of PTEN, PI3K, and AKT abnormalities in T-cell acute lymphoblastic leukemia. Blood. 2009;114(3):647–650. .
   PubMed Web of Science ®Google Scholar
• Subramaniam PS, Whye DW, Efimenko E, et al. Targeting nonclassical oncogenes for therapy in T-ALL. Cancer Cell. 2012;21(4):459–472. .
   PubMed Web of Science ®Google Scholar
• Zhang J, Ding L, Holmfeldt L, et al. The genetic basis of early T-cell precursor acute lymphoblastic leukaemia. Nature. 2012;481(7380):157–163. .
   PubMed Web of Science ®Google Scholar
• Mues M, Karra L, Romero-Moya D, et al. High-complexity shrna libraries and PI3 kinase inhibition in cancer: high-fidelity synthetic lethality predictions. Cell Rep. 2019;27(2):631–647 e635. .
   PubMed Web of Science ®Google Scholar
• Porter SN, Cluster AS, Signer RAJ, et al. Pten cell autonomously modulates the hematopoietic stem cell response to inflammatory cytokines. Stem Cell Reports. 2016;6(6):806–814.
   PubMed Web of Science ®Google Scholar
• Tesio M, Oser GM, Baccelli I, et al. Pten loss in the bone marrow leads to G-CSF-mediated HSC mobilization. J Exp Med. 2013;210(11):2337–2349.
   PubMed Web of Science ®Google Scholar
• Xu Z, Wang M, Wang L, et al. Aberrant expression of TSC2 gene in the newly diagnosed acute leukemia. Leuk Res. 2009;33(7):891–897.
   PubMed Web of Science ®Google Scholar
• Kentsis A, Look AT. Distinct and dynamic requirements for mTOR signaling in hematopoiesis and leukemogenesis. Cell Stem Cell. 2012;11(3):281–282.
   PubMed Web of Science ®Google Scholar
• Magee JA, Ikenoue T, Nakada D, et al. Temporal changes in PTEN and mTORC2 regulation of hematopoietic stem cell self-renewal and leukemia suppression. Cell Stem Cell. 2012;11(3):415–428.
   PubMed Web of Science ®Google Scholar