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Research Paper

Novel regulation of the transcription factor ZHX2 by N-terminal methylation

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Pages 1-15 | Received 23 Feb 2022, Accepted 13 May 2022, Published online: 25 May 2022

References

  • Faughn JD, Dean WL, Schaner Tooley CE. The N-terminal methyltransferase homologs NRMT1 and NRMT2 exhibit novel regulation of activity through heterotrimer formation. Protein Sci. 2018;27(9):1585–1599.
  • Chen T, Muratore TL, Schaner-Tooley CE, et al. N-terminal alpha-methylation of RCC1 is necessary for stable chromatin association and normal mitosis. Nat Cell Biol. 2007;9(5):596–603.
  • Stock A, Clarke S, Clarke C, et al. N-terminal methylation of proteins: structure, function and specificity. FEBS Lett. 1987;220(1):8–14.
  • Tooley CE, Petkowski JJ, Muratore-Schroeder TL, et al. NRMT is an alpha-N-methyltransferase that methylates RCC1 and retinoblastoma protein. Nature. 2010;466(7310):1125–1128.
  • Petkowski JJ, Schaner Tooley CE, Anderson LC, et al. Substrate specificity of mammalian N-terminal alpha-amino methyltransferase NRMT. Biochemistry. 2012;51(30):5942–5950.
  • Dai X, Otake K, You C, et al. Identification of novel alpha-n-methylation of CENP-B that regulates its binding to the centromeric DNA. J Proteome Res. 2013;12(9):4167–4175.
  • Dai X, Rulten SL, You C, et al. Identification and functional characterizations of N-terminal alpha-N-methylation and phosphorylation of serine 461 in human poly(ADP-ribose) polymerase 3. J Proteome Res. 2015;14(6):2575–2582.
  • Cai Q, Fu L, Wang Z, et al. alpha-N-methylation of damaged DNA-binding protein 2 (DDB2) and its function in nucleotide excision repair. J Biol Chem. 2014;289(23):16046–16056.
  • Sathyan KM, Fachinetti D, Foltz DR. alpha-amino trimethylation of CENP-A by NRMT is required for full recruitment of the centromere. Nat Commun. 2017;8:14678.
  • Nevitt C, Tooley JG, Schaner Tooley CE. N-terminal acetylation and methylation differentially affect the function of MYL9. Biochem J. 2018;475(20):3201–3219.
  • Jia K, Huang G, Wu W, et al. In vivo methylation of OLA1 revealed by activity-based target profiling of NTMT1. Chem Sci. 2019;10(35):8094–8099.
  • Bonsignore LA, Tooley JG, Van Hoose PM, et al. NRMT1 knockout mice exhibit phenotypes associated with impaired DNA repair and premature aging. Mech Ageing Dev. 2015;146–148:42–52.
  • Jiang J, Creasy KT, Purnell J, et al. Zhx2 (zinc fingers and homeoboxes 2) regulates major urinary protein gene expression in the mouse liver. J Biol Chem. 2017;292(16):6765–6774.
  • Creasy KT, Jiang J, Ren H, et al. Zinc fingers and homeoboxes 2 (Zhx2) regulates sexually dimorphic cyp gene expression in the adult mouse liver. Gene Expr. 2016;17(1):7–17.
  • Kawata H, Yamada K, Shou Z, et al. The mouse zinc-fingers and homeoboxes (ZHX) family; ZHX2 forms a heterodimer with ZHX3. Gene. 2003;323:133–140.
  • Kawata H, Yamada K, Shou Z, et al. Zinc-fingers and homeoboxes (ZHX) 2, a novel member of the ZHX family, functions as a transcriptional repressor. Biochem J. 2003;373(Pt 3):747–757.
  • Bird LE, Ren J, Nettleship JE, et al. Novel structural features in two ZHX homeodomains derived from a systematic study of single and multiple domains. BMC Struct Biol. 2010;10:13.
  • Wienk H, Lammers I, Hotze A, et al. The tandem zinc-finger region of human ZHX adopts a novel C2H2 zinc finger structure with a C-terminal extension. Biochemistry. 2009;48(21):4431–4439.
  • Perincheri S, Dingle RW, Peterson ML, et al. Hereditary persistence of alpha-fetoprotein and H19 expression in liver of BALB/cJ mice is due to a retrovirus insertion in the Zhx2 gene. PNAS. 2005;102( 2):396–401.
  • Morford LA, Davis C, Jin L, et al. The oncofetal gene glypican 3 is regulated in the postnatal liver by zinc fingers and homeoboxes 2 and in the regenerating liver by alpha-fetoprotein regulator 2. Hepatology. 2007;46(5):1541–1547.
  • Spear BT, Jin L, Ramasamy S, et al. Transcriptional control in the mammalian liver: liver development, perinatal repression, and zonal gene regulation. Cell Mol Life Sci. 2006;63(24):2922–2938.
  • Yue X, Zhang Z, Liang X, et al. Zinc fingers and homeoboxes 2 inhibits hepatocellular carcinoma cell proliferation and represses expression of cyclins A and E. Gastroenterology. 2012;142(7):1559–70.e2.
  • Liu Y, Ma D, Ji C. Zinc fingers and homeoboxes family in human diseases. Cancer Gene Ther. 2015;22(5):223–226.
  • Zhang J, Wu T, Simon J, et al. VHL substrate transcription factor ZHX2 as an oncogenic driver in clear cell renal cell carcinoma. Science (New York, NY). 2018;361(6399):290–295.
  • Robinson MD, Oshlack A. A scaling normalization method for differential expression analysis of RNA-seq data. Genome Biol. 2010;11(3):R25.
  • McCarthy DJ, Chen Y, Smyth GK. Differential expression analysis of multifactor RNA-Seq experiments with respect to biological variation. Nucleic Acids Res. 2012;40(10):4288–4297.
  • Petkowski Janusz J, Bonsignore Lindsay A, Tooley John G, et al. NRMT2 is an N-terminal monomethylase that primes for its homologue NRMT1. Biochem J. 2013;456(3):453–462.
  • Shields KM, Tooley JG, Petkowski JJ, et al. Select human cancer mutants of NRMT1 alter its catalytic activity and decrease N-terminal trimethylation. Protein Sci. 2017;26(8):1639–1652.
  • Chen X, Yamamoto M, Fujii K, et al. Differential reactivation of fetal/neonatal genes in mouse liver tumors induced in cirrhotic and non-cirrhotic conditions. Cancer Sci. 2015;106(8):972–981.
  • Chen T, Brownawell AM, Macara IG. Nucleocytoplasmic shuttling of JAZ, a new cargo protein for exportin-5. Mol Cell Biol. 2004;24(15):6608–6619.
  • Zhou Y, Rui L. Major urinary protein regulation of chemical communication and nutrient metabolism. Vitam Horm. 2010;83:151–163.
  • McDonnell AM, Dang CH. Basic review of the cytochrome p450 system. J Adv Pract Oncol. 2013;4(4):263–268.
  • Spector AA. Arachidonic acid cytochrome P450 epoxygenase pathway. J Lipid Res. 2009;50(Suppl):S52–6.
  • Sowers MR, Wilson AL, Kardia SR, et al. Aromatase gene (CYP 19) polymorphisms and endogenous androgen concentrations in a multiracial/multiethnic, multisite study of women at midlife. Am J Med. 2006;119(9 Suppl 1):S23–30.
  • Niwa T, Murayama N, Imagawa Y, et al. Regioselective hydroxylation of steroid hormones by human cytochromes P450. Drug Metab Rev. 2015;47(2):89–110.
  • Zhou Y, Jiang L, Rui L. Identification of MUP1 as a regulator for glucose and lipid metabolism in mice. J Biol Chem. 2009;284(17):11152–11159.
  • Gao H, Cao Y, Xia H, et al. CYP4A11 is involved in the development of nonalcoholic fatty liver disease via ROS‑induced lipid peroxidation and inflammation. Int J Mol Med. 2020;45(4):1121–1129.
  • Abdelmegeed MA, Choi Y, Godlewski G, et al. Cytochrome P450-2E1 promotes fast food-mediated hepatic fibrosis. Sci Rep. 2017;7:39764.
  • Grozdanov PN, Yovchev MI, Dabeva MD. The oncofetal protein glypican-3 is a novel marker of hepatic progenitor/oval cells. Lab Invest. 2006;86(12):1272–1284.
  • Song Y, Liu C, Liu X, et al. H19 promotes cholestatic liver fibrosis by preventing ZEB1-mediated inhibition of epithelial cell adhesion molecule. Hepatology. 2017;66(4):1183–1196.
  • Zhu J, Luo Z, Pan Y, et al. H19/miR-148a/USP4 axis facilitates liver fibrosis by enhancing TGF-β signaling in both hepatic stellate cells and hepatocytes. J Cell Physiol. 2019;234(6):9698–9710.
  • Kuhlmann WD, Peschke P. Hepatic progenitor cells, stem cells, and AFP expression in models of liver injury. Int J Exp Pathol. 2006;87(5):343–359.
  • Clinkenbeard EL, Turpin C, Jiang J, et al. Liver size and lipid content differences between BALB/c and BALB/cJ mice on a high-fat diet are due, in part, to Zhx2. Mamm Genome. 2019;30(7–8):226–236.
  • Catlin JP, Marziali LN, Rein B, et al. Age-related neurodegeneration and cognitive impairments of NRMT1 knockout mice are preceded by misregulation of RB and abnormal neural stem cell development. Cell Death Dis. 2021;12(11):1014.
  • Wu C, Qiu R, Wang J, et al. ZHX2 interacts with ephrin-B and regulates neural progenitor maintenance in the developing cerebral cortex. J Neurosci. 2009;29(23):7404–7412.
  • Nail AN, Smith JJ, Peterson ML, et al. Evolutionary analysis of the zinc finger and homeoboxes family of proteins identifies multiple conserved domains and a common early chordate ancestor. Genome Biol Evol. 2020;12(3):174–184.

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