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Original Articles

Molecular Approaches to Antithrombotic Therapy

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Pages 77-86 | Published online: 17 May 2016

Selected Reading

  • Fenton JW et al: Human thrombin: Preparative evaluation, structural properties, and enzymatic specificity. In The Chemistry and Physiology of the Human Plasma Proteins, Bing DH (Ed), Pergamon Press, New York, 1978, pp 151–183
  • Johnson PH et al: Biochemistry and genetic engineering of hirudin. Semin Thromb Hemost 15:302, 1989
  • Vu T-K et al: Molecular cloning of a functional thrombin receptor reveals a novel proteolytic mechanism of receptor activation. Cell 64:1057, 1991
  • Maraganore JM et al: Design and characterization of hirulogs: A novel class of bivalent peptide inhibitors of thrombin. Biochem 29:7095, 1990
  • Yasuda T et al: Comparative effects of aspirin, a synthetic thrombin inhibitor and a monoclonal antiplatelet glycoprotein Ilb/IIIa antibody on coronary artery reperfusion, reocclusion and bleeding with recombinant tissue-type plasminogen activator in a canine preparation. J Am Coll Cardiol 16:714, 1990
  • Rosenberg RD: Heparin, antithrombin, and abnormal clotting. Ann Rev Med 29:367, 1978
  • Tollefsen DM, Sugimori T, Maimone MM: Effect of low molecular weight heparin preparations on the inhibition of thrombin by heparin cofactor II. Semin Thromb Hemost 16(Suppl): 66. 1990
  • Hsia JH et al: A comparison between heparin and low-dose aspirin as adjunctive therapy with tissue plasminogen activator for acute myocardial infarction. N Engl J Med 323:1433, 1990
  • SCATI Group: Randomized controlled trial of subcutaneous calcium- heparin in acute myocardial infarction. Lancet II: 182, 1989
  • De Agostini AI, Rosenberg RD: New approaches for defining the molecular basis of anticoagulantly active heparan sulfate production. Ann NY Acad Sci 614:279, 1991
  • Pratt CW, Church FC: Antithrombin: Structure and function. Semin Hematol 28:3, 1991
  • Pratt CW et al: Physiochemical aspects of heparin cofactor II. Ann NY Acad Sci 556:104, 1989
  • Waxman L et al: Tick anticoagulant peptide (TAP) is a novel inhibitor of blood coagulation factor Xa. Science 248:593, 1990
  • Gruber A et al: Inhibition of thrombus formation by activated recombinant protein C in a primate model of arterial thrombosis. Circulation 82: 578, 1990

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