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Original Articles

Modeling AIDS in a Mouse

Pages 41-60 | Published online: 24 Jun 2015

Selected Reading

  • Alkhatib G et al: CC CKR5: A RANTES, MIP-la, MIP-lb receptor as a fusion cofactor for macrophage-tropic HIV-1. Science 272: 1955, 1996
  • Levy JA: Pathogenesis of human immunodeficiency virus infection. Microbiol Rev 57: 183, 1993
  • Liu R et al: Homozygous defect in HIV-1 coreceptor accounts for resistance of some multiply-exposed individuals to HIV-1 infection. Cell 86: 367, 1996
  • McCune J et al: The SCID-hu mouse: A small animal model for HIV infection and pathogenesis. Annu Rev Immunol 9: 399, 1991
  • Mosier DE et al: Human immunodeficiency virus infection of human- PBL-SCID mice. Science 251: 791, 1991
  • Mosier DE et al: Resistance to human immunodeficiency virus 1 infection of SCID mice reconstituted with peripheral blood leukocytes from donors vaccinated with vaccinated gpl60 and recombinant gp 160. Proc Natl Acad Sci USA 90: 2443, 1993
  • Mosier DE et al: Rapid loss of CD4+ T cells in human-PBL-SCID mice by noncytopathic HIV isolates. Science 260: 689, 1993
  • Mosier DE: Human immunodeficiency virus infection of human cells transplanted to severe combined immunodeficient mice. Adv Immunol (in press)
  • Parren PW et al: Protection against HIV-1 infection in hu-PBL-SCID mice by passive immunization with a neutralizing human monoclonal antibody against the gpl20 CD4-binding site. AIDS 9:F1, 1995
  • van Kuyk R et al: Cloned human CD8+ cytotoxic T lymphocytes protect human peripheral blood leukocyte-severe combined immunodeficient mice from HIV-1 infection by an HLA-unrestricted mechanism. J Immunol 153: 4826, 1994

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