Barriers and facilitators of adherence to antiretroviral treatment at a public health facility in Ghana: a mixed method study

References

• Gona PN, Gona CM, Ballout S, et al. Burden and changes in HIV/AIDS morbidity and mortality in Southern Africa Development Community Countries, 1990–2017. BMC Public Health. 2020;20(1):867.
   PubMed Web of Science ®Google Scholar
• Global HIV and AIDS statistics Fact Sheet. Accessed on the 19th of 2022 Jan 19th via https://www.unaids.org/en/resources/fact-sheetonhttps://www.unAIDS.org/sites/default/files/media_asset/Global_AIDS_update_2017_en.pdf
   Google Scholar
• Mbuagbaw L, Mertz D, Lawson DO, et al. Strategies to improve adherence to antiretroviral therapy and retention in care for people living with HIV in high-income countries: a protocol for an overview of systematic reviews. BMJ open. 2018;8(9):e022982.
   PubMed Web of Science ®Google Scholar
• UNAIDS. Understanding fast‐track: accelerating action to end the AIDS epidemic by 2030. 2015. [cited 11th December, 2020]. Available at URL: https://www.unAIDS.org/sites/default/files/media_asset/201506_JC2743_Understanding_FastTrack_en.pdf.
   Google Scholar
• UNAIDS. The aids epidemic can be ended by 2030 With your help. 2016. [cited 11th December, 2020]. Available at URL: https://www.unAIDS.org/sites/default/files/media_asset/UNAIDS_with-your-help_en.pdf.
   Google Scholar
• Kim SH, Gerver SM, Fidler S, et al. Adherence to antiretroviral therapy in adolescents living with HIV: systematic review and meta-analysis. AIDS. 2014;28(13):1945–1956.
   PubMed Web of Science ®Google Scholar
• UNAIDS. UNAIDS Data 2020. 2020.[cited 11th December, 2020]. https://www.unAIDS.org/sites/default/files/media_asset/2020_AIDS-data-book_en.pdf.
   Google Scholar
• Ankrah DN, Koster ES, Mantel-Teeuwisse AK, et al. Facilitators and barriers to antiretroviral therapy adherence among adolescents in Ghana. Patient Prefer Adherence. 2016;10:329–337.
   PubMed Web of Science ®Google Scholar
• Chaiyachati KH, Ogbuoji O, Price M, et al. Interventions to improve adherence to antiretroviral therapy: a rapid systematic review. AIDS. 2014;28 Suppl 2:S187–204.
   PubMed Web of Science ®Google Scholar
• Spaan P, van Luenen S, Garnefski N, et al. Psychosocial interventions enhance HIV medication adherence: a systematic review and meta-analysis. J Health Psychol. 2020;25(10–11):1326–1340.
   PubMed Web of Science ®Google Scholar
• Azia IN, Mukumbang FC, van Wyk B. Barriers to adherence to antiretroviral treatment in a regional hospital in Vredenburg, Western Cape, South Africa. South Afr J HIV Med. 2016;17(1):476.
   PubMed Web of Science ®Google Scholar
• Scanlon ML, and Vreeman RC. Current strategies for improving access and adherence to antiretroviral therapies in resource-limited settings. HIV/AIDS. Vol. 5. (Auckland NZ), Dove Medical Press, 2013.1–17
   Google Scholar
• Mai HT, Le GM, Tran BX, et al. Adherence to antiretroviral therapy among HIV/ AIDS patients in the context of early treatment initiation in Vietnam. Patient Prefer Adherence. 2018;12:2131–2137.
   PubMed Web of Science ®Google Scholar
• Poku RA, Owusu AY, Mullen PD, et al. Antiretroviral therapy maintenance among HIV-positive women in Ghana: the influence of poverty. AIDS Care. 2020;32(6):779–784.
   PubMed Web of Science ®Google Scholar
• Merten S, Kenter E, McKenzie O, et al. Patient-reported barriers and drivers of adherence to antiretrovirals in sub-Saharan Africa: a meta-ethnography. Trop Med Int Health. 2010;15 Suppl 1:16–33.
   PubMed Web of Science ®Google Scholar
• Dzansi G, Tornu E, Chipps J. Promoters and inhibitors of treatment adherence among HIV/AIDS patients receiving antiretroviral therapy in Ghana: narratives from an underserved population. PloS one. 2020;15(3):e0230159.
   PubMed Web of Science ®Google Scholar
• Campbell JI, Eyal N, Musiimenta A, et al. Ugandan study participants experience electronic monitoring of antiretroviral therapy adherence as welcomed pressure to adhere. AIDS Behav. 2018;22(10):3363–3372.
   PubMed Web of Science ®Google Scholar
• Ayisi Addo S, Abdulai M, Yawson A, et al. Availability of HIV services along the continuum of HIV testing, care and treatment in Ghana. BMC Health Serv Res. 2018;18(1):739.
   PubMedGoogle Scholar
• Biritwum RB. HIV in Ghana. Postgraduate Medical Journal of Ghana. 2014;3(2):71–72.
   Google Scholar
• Baisley K, Baeten JM, Hughes JP, et al. Summary measures of adherence using pill counts in two HIV prevention trials: the need for standardisation in reporting. AIDS Behav. 2013;17(9):3108–3119.
   PubMed Web of Science ®Google Scholar
• Achieng L, Musangi H, Billingsley K, et al. The use of pill counts as a facilitator of adherence with antiretroviral therapy in resource limited settings. PloS one. 2013;8(12):e67259.
   PubMed Web of Science ®Google Scholar
• Ghana Health Service. Differentiated Service Delivery for HIV in Ghana - An Operational Manual NACP. 2017. [cited 11th December, 2020]. Available at URL: https://www.differentiatedservicedelivery.org/Portals/0/adam/Content/nD4Qpp8C6Ei7R-TPPAKeLw/File/DSD%20for%20HIV%20in%20Ghana_FINAL.pdf.
   Google Scholar
• Adjetey V, Obiri-Yeboah D, Dornoo B. Differentiated service delivery: a qualitative study of people living with HIV and accessing care in a tertiary facility in Ghana. BMC Health Serv Res. 2019;19(1):95.
   PubMedGoogle Scholar
• Adam A, Fusheini A, Ayanore MA, et al. HIV stigma and status disclosure in three municipalities in Ghana. Ann Glob Health. 2021;87(1):49.
   PubMed Web of Science ®Google Scholar
• Obirikorang C, Selleh PK, Abledu JK, et al. Predictors of adherence to antiretroviral therapy among HIV/AIDS Patients in the Upper West Region of Ghana. Isrn AIDS. 2013;2013:873939.
   PubMedGoogle Scholar
• Ghana AIDS Commission - Ghana HIV Fact Sheet. 2019. [cited 13th December, 2020]. Available at URL: https://www.ghanAIDS.gov.gh/mcadmin/Uploads/2019%20FACT%20SHEET%2022%2006%202020%20revised(1).pdf
   Google Scholar
• Ghana Statistical Service. 2010 Population and housing census: summary report of final results. [cited 13th December, 2020]. Available at URL: https://www2.statsghana.gov.gh/pop_stats.html.
   Google Scholar
• Neupane S, Dhungana GP, Ghimire HC. Adherence to antiretroviral treatment and associated factors among people living with HIV and AIDS in CHITWAN, Nepal. BMC Public Health. 2019;19(1):720.
   PubMedGoogle Scholar
• Ndubuka NO, Ehlers VJ. Adult patients’ adherence to anti-retroviral treatment: a survey correlating pharmacy refill records and pill counts with immunological and virological indices. Int J Nurs Stud. 2011;48(11):1323–1329.
   PubMed Web of Science ®Google Scholar
• Adeoti AO, Dada M, Elebiyo T, et al. Survey of antiretroviral therapy adherence and predictors of poor adherence among HIV patients in a tertiary institution in Nigeria. Pan Afr Med J. 2019;33:277.
   PubMed Web of Science ®Google Scholar
• Moomba K, Van Wyk B. Social and economic barriers to adherence among patients at Livingstone General Hospital in Zambia. Afr J Prim Health Care Fam Med. 2019;11(1):e1–e6.
   PubMed Web of Science ®Google Scholar
• Zakumumpa H, Rujumba J, Kwiringira J, et al. Understanding implementation barriers in the national scale-up of differentiated ART delivery in Uganda. BMC Health Serv Res. 2020;20(1):222.
   PubMed Web of Science ®Google Scholar
• Engler K, Lènàrt A, Lessard D, et al. Barriers to antiretroviral therapy adherence in developed countries: a qualitative synthesis to develop a conceptual framework for a new patient-reported outcome measure. AIDS Care. 2018;30(sup1):17–28.
   PubMed Web of Science ®Google Scholar
• Bezabhe WM, Chalmers L, Bereznicki LR, et al. Adherence to antiretroviral therapy and virologic failure: a meta-analysis. Medicine (Baltimore). 2016;95(15):e3361.
   PubMed Web of Science ®Google Scholar
• Heestermans T, Browne JL, Aitken SC, et al. Determinants of adherence to antiretroviral therapy among HIV-positive adults in sub-Saharan Africa: a systematic review. BMJ Glob Health. 2016;1(4):e000125.
   PubMed Web of Science ®Google Scholar
• Okotah AN, Korbuvi J. adherence to antiretroviral therapy (Art) among adult HIV positive patients in volta Regional Hospital, Ghana. Value Health. 2014;17(7):A329.
   PubMed Web of Science ®Google Scholar
• Prah J, Hayfron-Benjamin A, and Abdulai M, et al., Factors affecting adherence to antiretroviral therapy among HIV/AIDS patients in cape coast metropolis. Ghana J HIV AIDS. 2018. 4(1). doi: https://doi.org/10.16966/2380-5536.149
   Google Scholar
• van den Boogaard J, Lyimo RA, Boeree MJ, et al. Electronic monitoring of treatment adherence and validation of alternative adherence measures in tuberculosis patients: a pilot study. Bull World Health Organ. 2011;89(9):632–640.
   PubMed Web of Science ®Google Scholar
• El Alili M, Vrijens B, Demonceau J, et al. A scoping review of studies comparing the medication event monitoring system (MEMS) with alternative methods for measuring medication adherence. Br J Clin Pharmacol. 2016;82(1):268–279.
   PubMed Web of Science ®Google Scholar
• Boateng MA, Danso-Appiah A, Turkson BK, et al. Integrating biomedical and herbal medicine in Ghana - experiences from the Kumasi South Hospital: a qualitative study. BMC Complement Altern Med. 2016;16:189.
   PubMed Web of Science ®Google Scholar
• van Andel T, Myren B, van Onselen S. Ghana’s herbal market. J Ethnopharmacol. 2012;140(2):368–378.
   PubMed Web of Science ®Google Scholar
• Ameade EP, Amalba A, Helegbe GK, et al. Medical students’ knowledge and attitude towards complementary and alternative medicine - A survey in Ghana. J Tradit Complement Med. 2016;6(3):230–236.
   PubMedGoogle Scholar
• Aziato L, Antwi HO. Facilitators and barriers of herbal medicine use in Accra, Ghana: an inductive exploratory study. BMC Complement Altern Med. 2016;16:142.
   PubMed Web of Science ®Google Scholar
• Laar A, Amoah Ampah E, Fernandez Y, et al. ‘What the herbal medicine can do for me in a week, the orthodox does in a year’: perceived efficacy of local alternative therapies influences medication adherence in patients with atherosclerotic cardiovascular disease. Health Expect. 2021;24(2):444–455.
   PubMed Web of Science ®Google Scholar
• Atinga RA, Yarney L, Gavu NM. Factors influencing long-term medication non-adherence among diabetes and hypertensive patients in Ghana: a qualitative investigation. PloS one. 2018;13(3):e0193995.
   PubMed Web of Science ®Google Scholar
• Dhar L, Dantas J, and Ali M, A systematic review of factors influencing medication adherence to hypertension treatment in developing countries. Open Journal of Epidemiology. 2017;7(3):211–250.
   Google Scholar
• Sefah I, Essah D, Haque M, et al. COVID-19, health care and self-medication issues in resource-limited settings: findings and implications based on experiences in Ghana. Adv Hum Biol. 2021;11(3):224–233.
   Web of Science ®Google Scholar
• Sefah I, Ogunleye O, Essah D, et al. Rapid assessment of the potential paucity and price increases for suggested medicines and protection equipment for COVID-19 across developing countries with a particular focus on Africa and the implications. Front Pharmacol. 2021; 11. 2055 https://doi.org/10.3389/fphar.2020.588106
   Google Scholar
• Yang Y. Use of herbal drugs to treat COVID-19 should be with caution. Lancet. 2020;395(10238):1689–1690. London, England.
   PubMed Web of Science ®Google Scholar
• Nkeck JR, Tsafack EE, Ndoadoumgue AL, et al. An alert on the incautious use of herbal medicines by sub-Saharan African populations to fight against the COVID-19. Pamj. 2020;35(2):26.
   Google Scholar
• Becker N, Cordeiro LS, Poudel KC, et al. Individual, household, and community level barriers to ART adherence among women in rural Eswatini. PloS one. 2020;15(4):e0231952.
   PubMed Web of Science ®Google Scholar
• Vagiri RV, Meyer JC, Godman B, et al. Relationship between adherence and health-related quality of life among HIV-patients in South Africa: findings and implications. J AIDS HIV Res. 2018;10(8):121–132.
   Google Scholar
• Shubber Z, Mills EJ, Nachega JB, et al. Patient-reported barriers to adherence to antiretroviral therapy: a systematic review and meta-Analysis. PLoS Med. 2016;13(11):e1002183–e.
   PubMed Web of Science ®Google Scholar