Seizure clusters

References

• Ngugi AK, Bottomley C, Kleinschmidt I, et al. Estimation of the burden of active and life-time epilepsy: a Meta-analytic approach. Epilepsia. 2010;51(5):883–890.
   PubMed Web of Science ®Google Scholar
• World Health Organization. Neurological disorders: public health challenges. Geneva, Switzerland: World Health Organization; 2006.
   Google Scholar
• Fiest KM, Sauro KM, Wiebe S, et al. Prevalence and incidence of epilepsy: a systematic review and Meta-analysis of international studies. Neurology. 2017;88(3):296–303.
   PubMed Web of Science ®Google Scholar
• England MJ, Liverman CT, Schultz AM, et al. Summary: a reprint from epilepsy across the spectrum: promoting health and understanding. Epilepsy Curr. 2012;12(6):245–253.
   PubMed Web of Science ®Google Scholar
• Detyniecki K, O’Bryan J, Choezom T, et al. Prevalence and predictors of seizure clusters: a prospective observational study of adult patients with epilepsy. Epilepsy Behav. 2018;88:349–356.
   PubMed Web of Science ®Google Scholar
• Mitchell WG. Status epilepticus and acute repetitive seizures in children, adolescents, and young adults: etiology, outcome, and treatment. Epilepsia. 1996;37(Suppl 1):S74–S80.
   PubMedGoogle Scholar
• Penovich PE, Buelow J, Steinberg K, et al. Burden of seizure clusters on patients with epilepsy and caregivers: survey of patient, caregiver, and clinician perspectives. Neurologist. 2017;22(6):207–214.
   PubMed Web of Science ®Google Scholar
• Meletti S, Lucchi C, Monti G, et al. Decreased allopregnanolone levels in cerebrospinal fluid obtained during status epilepticus. Epilepsia. 2017;58(2):e16–e20.
   PubMed Web of Science ®Google Scholar
• Meletti S, Lucchi C, Monti G, et al. Low levels of progesterone and derivatives in cerebrospinal fluid of patients affected by status epilepticus. J Neurochem. 2018;147(2):275–284.
   PubMed Web of Science ®Google Scholar
• Costa A-M, Lucchi C, Malkoç A, et al. Relationship between Delta rhythm, seizure occurrence and allopregnanolone hippocampal levels in epileptic rats exposed to the rebound effect. Pharmaceuticals. 2021;14(2):127.
   Web of Science ®Google Scholar
• Abou-Khalil B, Wheless J, Rogin J, et al. A double-blind, randomized, placebo-controlled trial of a diazepam auto-injector administered by caregivers to patients with epilepsy who require intermittent intervention for acute repetitive seizures. Epilepsia. 2013;54(11):1968–1976.
   PubMed Web of Science ®Google Scholar
• Gujjar AR, Nandhagopal R, Jacob PC, et al. Intravenous levetiracetam vs phenytoin for status epilepticus and cluster seizures: a prospective, randomized study. Seizure. 2017;49:8–12.
   PubMed Web of Science ®Google Scholar
• Haut SR, Seinfeld S, Pellock J. Benzodiazepine use in seizure emergencies: a systematic review. Epilepsy Behav. 2016;63:109–117.
   PubMed Web of Science ®Google Scholar
• Dreifuss FE, Rosman NP, Cloyd JC, et al. A comparison of rectal diazepam gel and placebo for acute repetitive seizures. N Engl J Med. 1998;338(26):1869–1875.
   PubMed Web of Science ®Google Scholar
• Rose AB, McCabe PH, Gilliam FG, et al. Occurrence of seizure clusters and status epilepticus during inpatient video-EEG monitoring. Neurology. 2003;60(6):975–978.
   PubMed Web of Science ®Google Scholar
• Sillanpaa M, Schmidt D. Seizure clustering during drug treatment affects seizure outcome and mortality of childhood-onset epilepsy. Brain. 2008;131(Pt 4):938–944.
   PubMedGoogle Scholar
• Caraballo RH, Cersosimo RO, Fejerman N. Benign focal seizures of adolescence: a prospective study. Epilepsia. 2004;45(12):1600–1603.
   PubMed Web of Science ®Google Scholar
• Haut SR. Seizure clustering. Epilepsy Behav. 2006;8(1):50–55.
   PubMed Web of Science ®Google Scholar
• Jafarpour S, Hirsch LJ, Gaínza-Lein M, et al. Seizure cluster: definition, prevalence, consequences, and management. Seizure. 2019; 68:9–15.
   PubMed Web of Science ®Google Scholar
• Haut SR, Lipton RB, LeValley AJ, et al. Identifying seizure clusters in patients with epilepsy. Neurology. 2005;65(8):1313–1315.
   PubMed Web of Science ®Google Scholar
• Asadi-Pooya AA, Nei M, Sharan A, et al. Seizure clusters in drug-resistant focal epilepsy. Epilepsia. 2016;57(9):e187-90–e190.
   PubMed Web of Science ®Google Scholar
• Haut SR, Shinnar S, Moshé SL. Seizure clustering: risks and outcomes. Epilepsia. 2005;46(1):146–149.
   PubMed Web of Science ®Google Scholar
• Chen B, Choi H, Hirsch LJ, et al. Prevalence and risk factors of seizure clusters in adult patients with epilepsy. Epilepsy Res. 2017; 133:98–102.
   PubMed Web of Science ®Google Scholar
• Bortel A, Lévesque M, Biagini G, et al. Convulsive status epilepticus duration as determinant for epileptogenesis and interictal discharge generation in the rat limbic system. Neurobiol Dis. 2010;40(2):478–489.
   PubMed Web of Science ®Google Scholar
• Costa AM, Lucchi C, Simonini C, et al. Status epilepticus dynamics predicts latency to spontaneous seizures in the kainic acid model. Cell Physiol Biochem. 2020;54(3):493–507.
   PubMedGoogle Scholar
• Haut SR, Swick C, Freeman K, et al. Seizure clustering during epilepsy monitoring. Epilepsia. 2002;43(7):711–715.
   PubMed Web of Science ®Google Scholar
• Martinez C, Sullivan T, Hauser WA. Prevalence of acute repetitive seizures (ARS) in the United Kingdom. Epilepsy Res. 2009;87(2–3):137–143.
   PubMed Web of Science ®Google Scholar
• Gidal B, Klein P, Hirsch LJ. Seizure clusters, rescue treatments, seizure action plans: Unmet needs and emerging formulations. Epilepsy Behav. 2020;112:107391.
   PubMed Web of Science ®Google Scholar
• Renfroe JB, Wheless JW. Earlier use of adjunctive vagus nerve stimulation therapy for refractory epilepsy. Neurology. 2002;59(6, Suppl4):S26–S30.
   PubMed Web of Science ®Google Scholar
• McKee HR, Abou-Khalil B. Outpatient pharmacotherapy and modes of administration for acute repetitive and prolonged seizures. CNS Drugs. 2015;29(1):55–70.
   PubMed Web of Science ®Google Scholar
• Cereghino JJ, Mitchell WG, Murphy J, et al. Treating repetitive seizures with a rectal diazepam formulation: a randomized study. The North american diastat study group. Neurology. 1998;51(5):1274–1282.
   PubMed Web of Science ®Google Scholar
• Scott RC, Besag FM, Boyd SG, et al. Buccal absorption of midazolam: pharmacokinetics and EEG pharmacodynamics. Epilepsia. 1998;39(3):290–294.
   PubMed Web of Science ®Google Scholar
• Scott RC, Besag FM, Neville BG. Buccal midazolam and rectal diazepam for treatment of prolonged seizures in childhood and adolescence: a randomised trial. Lancet. 1999;353(9153):623–626.
   PubMed Web of Science ®Google Scholar
• McIntyre J, Robertson S, Norris E, et al. Safety and efficacy of buccal midazolam versus rectal diazepam for emergency treatment of seizures in children: a randomised controlled trial. Lancet. 2005;366(9481):205–210.
   PubMed Web of Science ®Google Scholar
• Talukdar B, Chakrabarty B. Efficacy of buccal midazolam compared to intravenous diazepam in controlling convulsions in children: a randomized controlled trial. Brain Dev. 2009;31(10):744–749.
   PubMed Web of Science ®Google Scholar
• Bancke LL, Dworak HA, Rodvold KA, et al. Pharmacokinetics, pharmacodynamics, and safety of USL261, a midazolam formulation optimized for intranasal delivery, in a randomized study with healthy volunteers. Epilepsia. 2015;56(11):1723–1731.
   PubMed Web of Science ®Google Scholar
• Detyniecki K, Van Ess PJ, Sequeira DJ, Wheless JW, et al. Safety and efficacy of midazolam nasal spray in the outpatient treatment of patients with seizure clusters-a randomized, double-blind, placebo-controlled trial. Epilepsia. 2019;60(9):1797–1808.
   PubMed Web of Science ®Google Scholar
• Hogan RE, Gidal BE, Koplowitz B, et al. Bioavailability and safety of diazepam intranasal solution compared to oral and rectal diazepam in healthy volunteers. Epilepsia. 2020;61(3):455–464.
   PubMed Web of Science ®Google Scholar
• Hogan RE, Tarquinio D, Sperling MR, et al. Pharmacokinetics and safety of VALTOCO (NRL-1; diazepam nasal spray) in patients with epilepsy during seizure (ictal/peri-ictal) and nonseizure (interictal) conditions: a phase 1, open-label study. Epilepsia. 2020;61(5):935–943.
   PubMed Web of Science ®Google Scholar
• Garnett WR, Barr WH, Edinboro LE, et al. Diazepam autoinjector intramuscular delivery system versus diazepam rectal gel: a pharmacokinetic comparison. Epilepsy Res. 2011;93(1):11–16.
   PubMed Web of Science ®Google Scholar
• Rogin J, Wheless J, Abou-Khalil B, et al. Safety and effectiveness of long-term treatment with diazepam auto-injector administered by caregivers in an outpatient setting for the treatment of acute repetitive seizures. Epilepsia. 2014;55(9):1444–1451.
   PubMed Web of Science ®Google Scholar
• Rogawski MA, Heller AH. Diazepam buccal film for the treatment of acute seizures. Epilepsy Behav. 2019;101(Pt B):106537.
   PubMedGoogle Scholar
• French JA, Wechsler R, Gelfand MA, et al. Inhaled alprazolam rapidly suppresses epileptic activity in photosensitive participants. Epilepsia. 2019;60(8):1602–1609.
   PubMed Web of Science ®Google Scholar
• Maglalang PD, Rautiola D, Siegel RA, et al. Rescue therapies for seizure emergencies: new modes of administration. Epilepsia. 2018;59(Suppl 2):207–215.
   PubMedGoogle Scholar