Does cell polarity matter during spermatogenesis?

References

• Assemat E, Bazellieres E, Pallesi-Pocachard E, Le Bivic A, Massey-Harroche D. Polarity complex proteins. Biochim Biophys Acta 2008; 1778:614-30; PMID:18005931
   PubMed Web of Science ®Google Scholar
• Iden S, Collard JG. Crosstalk between small GTPases and polarity proteins in cell polarization. Nature Rev Mol Cell Biol 2008; 9:846-59; PMID:18946474; http://dx.doi.org/10.1038/nrm2521
   PubMed Web of Science ®Google Scholar
• Wong EWP, Cheng CY. Polarity proteins and cell-cell interactions in the testis. Int Rev Cell Mol Biol 2009; 278:309-53; PMID:19815182; http://dx.doi.org/10.1016/S1937-6448(09)78007-4
   PubMed Web of Science ®Google Scholar
• Yeaman C, Grindstaf K, Nelson W. New perspectives on mechanisms involved in generating epithelial cell polarity. Physiol Rev 1999; 79:73-98; PMID:9922368
   PubMed Web of Science ®Google Scholar
• Ashraf A, Pervaiz S. Hippo circuitry and the redox modulation of hippo components in cancer cell fate decisions. Int J Biochem Cell Biol 2015; 69:20-8; PMID:26456518; http://dx.doi.org/10.1016/j.biocel.2015.10.001
   PubMed Web of Science ®Google Scholar
• Copp AJ, Stanier P, Greene NDE. Neural tube defects: recent advances, unsolved questions, and controversies. The Lancet Neurology 2013; 12:799-810; PMID:23790957; http://dx.doi.org/10.1016/S1474-4422(13)70110-8
   PubMed Web of Science ®Google Scholar
• Gissen P, Arias IM. Structural and functional hepatocyte polarity and liver disease. J Hepatol 2015; 63:1023-37; PMID:26116792; http://dx.doi.org/10.1016/j.jhep.2015.06.015
   PubMed Web of Science ®Google Scholar
• Lin WH, Asmann YW, Anastasiadis PZ. Expression of polarity genes in human cancer. Cancer Informatics 2015; 14(Suppl 3):15-28; PMID:25991909
   PubMedGoogle Scholar
• Su WH, Mruk DD, Wong EWP, Lui WY, Cheng CY. Polarity protein complex Scribble/Lgl/Dlg and epithelial cell barriers. Adv Exp Med Biol 2012; 763:149-70
   PubMed Web of Science ®Google Scholar
• Wong EWP, Mruk DD, Lee WM, Cheng CY. Par3/Par6 polarity complex coordinates apical ectoplasmic specialization and blood-testis barrier restructuring during spermatogenesis. Proc Natl Acad Sci USA 2008; 105:9657-62; PMID:18621709; http://dx.doi.org/10.1073/pnas.0801527105
   PubMed Web of Science ®Google Scholar
• Wong EWP, Sun S, Li MWM, Lee WM, Cheng CY. 14-3-3 protein regulates cell adhesion in the seminiferous epithelium of rat testes. Endocrinology 2009; 150:4713-23; PMID:19608648; http://dx.doi.org/10.1210/en.2009-0427
   PubMed Web of Science ®Google Scholar
• Wong EWP, Mruk DD, Lee WM, Cheng CY. Regulation of blood-testis barrier dynamics by TGF-b3 is a Cdc42-dependent protein trafficking event. Proc Natl Acad Sci USA 2010; 107:11399-404; PMID:20534521; http://dx.doi.org/10.1073/pnas.1001077107
   PubMed Web of Science ®Google Scholar
• Su WH, Wong EWP, Mruk DD, Cheng CY. The Scribble/Lgl/Dlg polarity protein complex is a regulator of blood-testis barrier dynamics and spermatid polarity during spermatogenesis. Endocrinology 2012; 153:6041-53; http://dx.doi.org/10.1210/en.2012-1670
   PubMed Web of Science ®Google Scholar
• Gao Y, Lui WY, Lee WM, Cheng CY. Polarity protein Crumbs homolog-3 (CRB3) regulates ectoplasmic specialization dynamics through its action on F-actin organization in Sertoli cells. Sci Rep 2016; 6:28589 (DOI:10.1038/srep28589); PMID:27358069; http://dx.doi.org/10.1038/srep28589
   PubMed Web of Science ®Google Scholar
• Montcouguiol M, Rachel RA, Lanford PJ, Copeland NG, Jenkins NA, Kelley MW. Identification of Vangl2 and Scrb1 as planar polarity genes in mammals. Nature 2003; 423:173-7; PMID:12724779; http://dx.doi.org/10.1038/nature01618
   PubMed Web of Science ®Google Scholar
• Kallay LM, McNickle A, Brennwald PJ, Hubbard AL, Bralteman LT. Scribble associates with two polarity proteins, Lgl2 and Vangl2, via distinct molecular domains. J Cell Biochem 2006; 99:647-64; PMID:16791850; http://dx.doi.org/10.1002/jcb.20992
   PubMed Web of Science ®Google Scholar
• Goodrich LV, Strutt D. Principles of planara polarity in animal development. Development 2011; 138:1877-92; PMID:21521735; http://dx.doi.org/10.1242/dev.054080
   PubMed Web of Science ®Google Scholar
• Davenport D. The cell biology of planar cell polarity. J Cell Biol 2014; 207:171-9; PMID:25349257; http://dx.doi.org/10.1083/jcb.201408039
   PubMed Web of Science ®Google Scholar
• Tissir F, Goffinet AM. Shaping the nervous system: role of the core planar cell polarity genes. Nat Rev Nruosci 2013; 14:525-35; http://dx.doi.org/10.1038/nrn3525
   PubMed Web of Science ®Google Scholar
• Seo JH, Ziber Y, Babayeva S, Liu J, Kyriakopoulos P, De Marco P, Merello EC, V Gros P, Torban E. Mutations in the planar cell polarity gene, Fuzzy, are associated with neural tube defects in humans. Hum Mol Genet 2011; 20:4324-33; PMID:21840926; http://dx.doi.org/10.1093/hmg/ddr359
   PubMed Web of Science ®Google Scholar
• Carroll TJ, Yu J. The kidney and planar cell polaroity. Curr Top Dev Biol 2012; 101:185-212; PMID:23140630; http://dx.doi.org/10.1016/B978-0-12-394592-1.00011-9
   PubMed Web of Science ®Google Scholar
• Ezan J, Montcouquiol M. Revisiting planar cell polarity in the inner ear. Semin Cell Dev Biol 2013; 24:499-506; PMID:23562830; http://dx.doi.org/10.1016/j.semcdb.2013.03.012
   PubMed Web of Science ®Google Scholar
• May-Simera H, Kelley MW. Planar cell polarity in the inner ear. Curr Top Dev Biol 2012; 101:111-40; PMID:23140627; http://dx.doi.org/10.1016/B978-0-12-394592-1.00006-5
   PubMed Web of Science ®Google Scholar
• Tellkamp F, Vorhagen S, Niessen CM. Epidermal polarity genes in health and disease. Cold Spring Harb Perspect Biol 2014; 4:a015255; http://dx.doi.org/10.1101/cshperspect.a015255
   Google Scholar
• Vandenberg LN, Chauhoud IJJH, Padmanabhan V, Paumgartten FJ, Schoenfelder G. Urinary, circulating and tissue biomonitoring studies indicate widespread exposure to bisphenol A. Cien Saude Colet 2012; 17:407-34; PMID:22267036; http://dx.doi.org/10.1590/S1413-81232012000200015
   PubMed Web of Science ®Google Scholar
• Henderson DJ, Chaudhry B. Getting to the heart of planar cell polarity signaling. Birth Defects Res A Clin Mol Teratol 2011; 91:460-67; PMID:21538810; http://dx.doi.org/10.1002/bdra.20792
   PubMed Web of Science ®Google Scholar
• Eaton S, Martrin-Belmonte F. Cargo sorting in the endocytic pathway: a key regulator of cell polarity and tissue dynamics. Cold Spring Harb Perspect Biol 2014; 6:a016899; PMID:25125399; http://dx.doi.org/10.1101/cshperspect.a016899
   PubMedGoogle Scholar
• Luga V, Wrana JL. Tumor-stroma interaction: Revealing fibroblast-secreted exosomes as potent regulators of Wnt-planar cell polarity signaling in cancer metastasis. Cancer Res 2013; 73:6843-7
   PubMed Web of Science ®Google Scholar
• Adler PN. The frizxzled/stan pathway wand planar cell polarity in the Drosophila wing. Curr Top Dev Biol 2012; 101:1-31; PMID:23140623; http://dx.doi.org/10.1016/B978-0-12-394592-1.00001-6
   PubMed Web of Science ®Google Scholar
• Davenport D, Fuchs E. Planar polarization in embryonic epidermis orchestrates global asymmeteric mophogenesis of hair folicles. Nat Cell Biol 2008; 10:1257-68; PMID:18849982; http://dx.doi.org/10.1038/ncb1784
   PubMed Web of Science ®Google Scholar
• De Marco P, Merello E, Piatelli G, Cama A, Kibar Z, Capra V. Planar cell polarity gene mutations contribute to the etiology of human neural tube defects in our population. Birth Defects Res A Clin Mol Teratol 2014; 100:633-41; PMID:24838524; http://dx.doi.org/10.1002/bdra.23255
   PubMed Web of Science ®Google Scholar
• Hatakeyama J, Wald JH, Printsev I, Ho HY, Carraway KL, 3rd. Vangl1 and Vangl2: planar cell polarity components with a developing role in cancer. Endocr Relat Cancer 2014; 21:R345-56; PMID:24981109; http://dx.doi.org/10.1530/ERC-14-0141
   PubMed Web of Science ®Google Scholar
• Luga V, Wrana JL. Tumor-stroma interaction: Revealing fibroblast-secreted exosomes as potent regulators of Wnt-planar cell polarity signaling in cancer metastasis. Cancer Res 2013; 73:6843-7; PMID:24265274; http://dx.doi.org/10.1158/0008-5472.CAN-13-1791
   PubMed Web of Science ®Google Scholar
• Auharek SA, Avelar GF, Lara NLM, Sharpe RM, Franca LR. Sertoli cell numbers and spermatogenic efficency are increased in inducible nitric oxide synthase (iNOS) mutant-mice. Int J Androl 2011; 34:e621-9; PMID:21831234; http://dx.doi.org/10.1111/j.1365-2605.2011.01209.x
   PubMedGoogle Scholar
• Johnson L, Petty CS, Neaves WB. A comparative study of daily sperm production and testicular composition in humans and rats. Biol Reprod 1980; 22:1233-43; PMID:7417656
   PubMed Web of Science ®Google Scholar
• Amann RP, Howards SS. Daily spermatozoal production and epididymal spermatozoal reserves of the human male. J Urol 1980; 124:211-5; PMID:6772801
   PubMed Web of Science ®Google Scholar
• Xiao X, Mruk DD, Wong CKC, Cheng CY. Germ cell transport across the seminiferous epithelium during spermatogenesis. Physiology 2014; 29:286-98; PMID:24985332; http://dx.doi.org/10.1152/physiol.00001.2014
   PubMed Web of Science ®Google Scholar
• de Kretser DM, Kerr JB. The cytology of the testis. In The Physiology of Reproduction. Vol. 1, 1988; eds. Knobil E, et al. New York: Raven Press pp 837-932.
   Google Scholar
• Berndtson WE, Thompson TL. Changing relationships between testis size, Sertoli cell number and spermatogenesis in Sprague-Dawley rats. J Androl 1990; 11:429-35; PMID:2254176
   PubMed Web of Science ®Google Scholar
• Wing TY, Christensen AK. Morphometric studies on rat seminiferous tubules. Am J Anat 1982; 165:13-25; PMID:7137056; http://dx.doi.org/10.1002/aja.1001650103
   PubMedGoogle Scholar
• Wang ZX, Wreford NG, de Kretser DM. Determination of Sertoli cell numbers in the developing rat testis by sterological methods. Int J Androl 1989; 12:58-64; PMID:2714873; http://dx.doi.org/10.1111/j.1365-2605.1989.tb01285.x
   PubMedGoogle Scholar
• Johnson L, Zane RS, Petty CS, Neaves WB. Quantification of the human Sertoli cell population: its distribution, relation to germ cell numbers, and age-related decline. Biol Reprod 1984; 31:785-95; PMID:6509142; http://dx.doi.org/10.1095/biolreprod31.4.785
   PubMed Web of Science ®Google Scholar
• Ahmed EA, Barten-van Rijbroek AD, Kal HB, Sadri-Ardekani H, Mizrak SC, van Pelt AM, de Rooij DG. Proliferative activity in vitro and DNA repair indicate that adult mouse and human Sertoli cells are not terminally differentiated, quiescent cells. Biol Reprod 2009; 80:1084-91; PMID:19164176; http://dx.doi.org/10.1095/biolreprod.108.071662
   PubMed Web of Science ®Google Scholar
• Chui K, Trivedi A, Cheng CY, Cherbavaz DB, Dazin PF, Huynh ALT, Mitchell JB, Rabinovich GA, Noble-Haeusslein LJ, John CM. Characterization and functionality of proliferative human Sertoli cells. Cell Transplant 2011; 20:619-35; PMID:21054948; http://dx.doi.org/10.3727/096368910X536563
   PubMed Web of Science ®Google Scholar
• Xiao X, Mruk DD, Tang EI, Wong CKC, Lee WM, John CM, Turek PJ, Silvestrini B, Cheng CY. Environmental toxicants perturb human Serotli cell adhesive function via changes in F-actin organization medicated by actin regulatory proteins. Hum Reprod 2014; 29:1279-91; PMID:24532171; http://dx.doi.org/10.1093/humrep/deu011
   PubMed Web of Science ®Google Scholar
• Weber JE, Russell LD, Wong V, Peterson RN. Three dimensional reconstruction of a rat stage V Sertoli cell: II. Morphometry of Sertoli-Sertoli and Sertoli-germ cell relationships. Am J Anat 1983; 167:163-79; PMID:6613902; http://dx.doi.org/10.1002/aja.1001670203
   PubMedGoogle Scholar
• Boussouar F, Benahmed M. Lactate and energy metabolism in male germ cells. Trends Endocrinol Metab 2004; 15:345-50; PMID:15350607; http://dx.doi.org/10.1016/j.tem.2004.07.003
   PubMed Web of Science ®Google Scholar
• Pointis G, Gilleron J, Carette D, Segretain D. Physiological and physiopathological aspects of connexins and communicating gap junctions in spermatogenesis. Philos Trans R Soc Lond B Biol Sci 2010; 365:1607-20; PMID:20403873; http://dx.doi.org/10.1098/rstb.2009.0114
   PubMed Web of Science ®Google Scholar
• Li MWM, Mruk DD, Cheng CY. Gap junctions and blood-tissue barriers. Adv Exp Med Biol 2012; 763:260-80; PMID:23397629
   PubMed Web of Science ®Google Scholar
• Weber JE, Russell LD. A study of intercellular bridges during spermatogenesis in the rat. Am J Anat 1987; 180:1-24; PMID:3661461; http://dx.doi.org/10.1002/aja.1001800102
   PubMedGoogle Scholar
• Tarakanov AO, Goncharova LB. Cell-cell nanotubes: Tunneling through several types of synapses. Commun Integr Biol 2009; 2:359-61; PMID:19721891; http://dx.doi.org/10.4161/cib.2.4.8289
   PubMedGoogle Scholar
• Gerdes HH, Bukoreshtliev NV, Barroso JFV. Tunneling nanotubes: A new route for the exchange of components between animal cells. FEBS Letts 2007; 581:2194-201; PMID:17433307; http://dx.doi.org/10.1016/j.febslet.2007.03.071
   PubMed Web of Science ®Google Scholar
• Vogl AW, Vaid KS, Guttman JA. The Sertoli cell cytoskeleton. Adv Exp Med Biol 2008; 636:186-211; PMID:19856169; http://dx.doi.org/10.1007/978-0-387-09597-4_11
   PubMed Web of Science ®Google Scholar
• Wong EWP, Mruk DD, Cheng CY. Biology and regulation of ectoplasmic specialization, an atypical adherens junction type, in the testis. Biochem Biophys Acta 2008; 1778:692-708; PMID:18068662; http://dx.doi.org/10.1016/j.bbamem.2007.11.006
   PubMed Web of Science ®Google Scholar
• Mruk DD, Cheng CY. Sertoli-Sertoli and Sertoli-germ cell interactions and their significance in germ cell movement in the seminiferous epithelium during spermatogenesis. Endocr Rev 2004; 25:747-806; PMID:15466940; http://dx.doi.org/10.1210/er.2003-0022
   PubMed Web of Science ®Google Scholar
• Cheng CY, Mruk DD. A local autocrine axis in the testes that regulates spermatogenesis. Nature Rev Endocrinol 2010; 6:380-95; PMID:20571538; http://dx.doi.org/10.1038/nrendo.2010.71
   PubMed Web of Science ®Google Scholar
• O'Donnell L, Nicholls PK, O'Bryan MK, McLachlan RI, Stanton PG. Spermiation: the process of sperm release. Spermatogenesis 2011; 1:14-35; PMID:21866274; http://dx.doi.org/10.4161/spmg.1.1.14525
   PubMedGoogle Scholar
• Cheng CY, Mruk DD. Biochemistry of Sertoli cell/germ cell junctions, germ cell transport, and spermiation in the seminiferous epithelium. In Sertoli Cell Biology, 2nd Edition. 2015; Ed. Griswold MD; Amsterdam: Elsevier pp. 333-83; DOI: http://dx.doi.org/10.1016/B978-0-12-417047-6.00012.0.
   Google Scholar
• Clermont Y, Morales C, Hermo L. Endocytic activities of Sertoli cells in the rat. Ann NY Acad Sci 1987; 513:1-15; PMID:3328532; http://dx.doi.org/10.1111/j.1749-6632.1987.tb24994.x
   PubMed Web of Science ®Google Scholar
• Russell LD, Peterson RN. Sertoli cell junctions: morphological and functional correlates. Int Rev Cytol 1985; 94:177-211; PMID:3894273; http://dx.doi.org/10.1016/S0074-7696(08)60397-6
   PubMed Web of Science ®Google Scholar
• Cheng CY, Mruk DD. Cell junction dynamics in the testis: Sertoli-germ cell interactions and male contraceptive development. Physiol Rev 2002; 82:825-74; PMID:12270945; http://dx.doi.org/10.1152/physrev.00009.2002
   PubMed Web of Science ®Google Scholar
• Cheng CY, Mruk DD. The blood-testis barrier and its implication in male contraception. Pharmacol Rev 2012; 64:16-64; PMID:22039149; http://dx.doi.org/10.1124/pr.110.002790
   PubMed Web of Science ®Google Scholar
• Siu MKY, Cheng CY. Dynamic cross-talk between cells and the extracellular matrix in the testis. BioEssays 2004; 26:978-92; PMID:15351968; http://dx.doi.org/10.1002/bies.20082
   PubMed Web of Science ®Google Scholar
• Tang EI, Mruk DD, Cheng CY. MAP/microtubule affinity-regulating kinases, microtubule dynamics, and spermatogenesis. J Endocrinol 2013; 217:R13-R23; PMID:23449618; http://dx.doi.org/10.1530/JOE-12-0586
   PubMedGoogle Scholar
• Tang EI, Mruk DD, Lee WM, Cheng CY. Cell-cell interactions, cell polarity, and the blood-testis barrier. In Cell Polarity 1. 2015; Ed. Ebnet K.; Geneva: Springer International Publishing pp. 303-26; DOI: 10.1007/978-3-319-14463-4_13.
   Google Scholar
• O'Donnell L, O'Bryan MK. Microtubules and spermatogenesis. Semin Cell Dev Biol 2014; 30:45-54; PMID:24440897; http://dx.doi.org/10.1016/j.semcdb.2014.01.003
   PubMed Web of Science ®Google Scholar
• O'Donnell L. Mechanisms of spermiogenesis and spermiation and how they are disturbed. Spermatogenesis 2014; 4:e979623; PMID:26413397; http://dx.doi.org/10.4161/21565562.2014.979623
   PubMedGoogle Scholar
• Qian X, Mruk DD, Cheng YH, Tang EI, Han D, Lee WM, Wong EW, Cheng CY. Actin binding proteins, spermatid transport and spermiation. Semin Cell Dev Biol 2014; 30:75-85; PMID:24735648; http://dx.doi.org/10.1016/j.semcdb.2014.04.018
   PubMed Web of Science ®Google Scholar
• Lee NPY, Cheng CY. Ectoplasmic specialization, a testis-specific cell-cell actin-based adherens junction type: is this a potential target for male contraceptive development. Human Reprod Update 2004; 10:349-69; PMID:15192055; http://dx.doi.org/10.1093/humupd/dmh026
   PubMed Web of Science ®Google Scholar
• Lie PPY, Chan AYN, Mruk DD, Lee WM, Cheng CY. Restricted Arp3 expression in the testis prevents blood-testis barrier disruption during junction restructuring at spermatogenesis. Proc Natl Acad Sci USA 2010; 107:11411-6; PMID:20534520; http://dx.doi.org/10.1073/pnas.1001823107
   PubMed Web of Science ®Google Scholar
• Lie PPY, Mruk DD, Lee WM, Cheng CY. Epidermal growth factor receptor pathway substrate 8 (Eps8) is a novel regulator of cell adhesion and the blood-testis barrier integrity in the seminiferous epithelium. FASEB J 2009; 23:2555-67; PMID:19293393; http://dx.doi.org/10.1096/fj.06-070573
   PubMed Web of Science ®Google Scholar
• Parvinen M. Regulation of the seminiferous epithelium. Endocr Rev 1982; 3:404-17; PMID:6295753; http://dx.doi.org/10.1210/edrv-3-4-404
   PubMed Web of Science ®Google Scholar
• Siu MKY, Mruk DD, Lee WM, Cheng CY. Adhering junction dynamics in the testis are regulated by an interplay of b1-integrin and focal adhesion complex (FAC)-associated proteins. Endocrinology 2003; 144:2141-63; PMID:12697723; http://dx.doi.org/10.1210/en.2002-221035
   PubMed Web of Science ®Google Scholar
• Lie PPY, Mruk DD, Mok KW, Su L, Lee WM, Cheng CY. Focal adhesion kinase-Tyr407 and -Tyr397 exhibit antagonistic effects on blood-testis barrier dynamics in the rat. Proc Natl Acad Sci USA 2012; 109:12562-7; PMID:22797892; http://dx.doi.org/10.1073/pnas.1207606109
   PubMed Web of Science ®Google Scholar
• Wan HT, Mruk DD, Li SYT, Mok KW, Lee WM, Wong CKC, Cheng CY. p-FAK-Tyr397 regulates spermatid adhesion in the rat testis via its effects on F-actin organization at the ectoplasmic specialization. Am J Physiol Endocrinol Metab 2013; 305:E687-99; PMID:23880313; http://dx.doi.org/10.1152/ajpendo.00254.2013
   PubMed Web of Science ®Google Scholar
• Mok KW, Mruk DD, Silvestrini B, Cheng CY. rpS6 regulates blood-testis barrier dynamics by affecting F-actin organization and protein recruitment. Endocrinology 2012; 153:5036-48; PMID:22948214; http://dx.doi.org/10.1210/en.2012-1665
   PubMed Web of Science ®Google Scholar
• Mok KW, Mruk DD, Cheng CY. rpS6 regulates blood-testis barrier dynamics through Akt-mediated effects on MMP-9. J Cell Sci 2014; 127:4870-82; PMID:25217631; http://dx.doi.org/10.1242/jcs.152231
   PubMed Web of Science ®Google Scholar
• Mok KW, Mruk DD, Lee WM, Cheng CY. Rictor/mTORC2 regulates blood-testis barrier dynamics via its effects on gap junction communications and actin filament network. FASEB J 2013; 27:1137-52; PMID:23288930; http://dx.doi.org/10.1096/fj.12-212977
   PubMed Web of Science ®Google Scholar