Communication between natural killer T cells and adipocytes in obesity

References

• Caspar-Bauguil S, Cousin B, Galinier A, Segafredo C, Nibbelink M, André M, Casteilla L, Pénicaud L. Adipose tissues as an ancestral immune organ: site-specific change in obesity. FEBS Lett 2005; 579:3487-92; PMID:15953605; http://dx.doi.org/10.1016/j.febslet.2005.05.031
   PubMed Web of Science ®Google Scholar
• Cao H. Adipocytokines in obesity and metabolic disease. J Endocrinol 2014; 220:T47-59; PMID:24403378; http://dx.doi.org/10.1530/JOE-13-0339
   PubMed Web of Science ®Google Scholar
• Waki H and Tontonoz P. Endocrine functions of adipose tissue. Annu Rev Pathol 2007; 2:31-56; PMID:18039092; http://dx.doi.org/10.1146/annurev.pathol.2.010506.091859
   PubMed Web of Science ®Google Scholar
• Spiegelman BM, Flier JS. Obesity and the regulation of energy balance. Cell 2001; 104:531-43; PMID:11239410; http://dx.doi.org/10.1016/S0092-8674(01)00240-9
   PubMed Web of Science ®Google Scholar
• Lumeng CN, Saltiel AR. Inflammatory links between obesity and metabolic disease. J Clin Invest 2011; 121:2111-7; PMID:21633179; http://dx.doi.org/10.1172/JCI57132
   PubMed Web of Science ®Google Scholar
• Hotamisligil GS. Inflammation and metabolic disorders. Nature 2006; 444:860-7; PMID:17167474; http://dx.doi.org/10.1038/nature05485
   PubMed Web of Science ®Google Scholar
• Greenberg AS, Coleman RA, Kraemer FB, McManaman JL, Obin MS, Puri V, Yan QW, Miyoshi H, Mashek DG. The role of lipid droplets in metabolic disease in rodents and humans. J Clin Invest 2011; 121:2102-10; PMID:21633178; http://dx.doi.org/10.1172/JCI46069
   PubMed Web of Science ®Google Scholar
• Hegde V, Dhurandhar NV. Microbes and obesity–interrelationship between infection, adipose tissue and the immune system. Clin Microbiol Infect 2013; 19:314-20; PMID:23506525; http://dx.doi.org/10.1111/1469-0691.12157
   PubMed Web of Science ®Google Scholar
• Knights AJ, Funnell AP, Pearson RC, Crossley M, Bell-Anderson KS. Adipokines and insulin action: A sensitive issue. Adipocyte 2014; 3:88-96; PMID:24719781; http://dx.doi.org/10.4161/adip.27552
   PubMedGoogle Scholar
• Rosen ED, Spiegelman BM. Adipocytes as regulators of energy balance and glucose homeostasis. Nature 2006; 444:847-53; PMID:17167472; http://dx.doi.org/10.1038/nature05483
   PubMed Web of Science ®Google Scholar
• Brestoff JR, Artis D. Immune regulation of metabolic homeostasis in health and disease. Cell 2015; 161:146-60; PMID:25815992; http://dx.doi.org/10.1016/j.cell.2015.02.022
   PubMed Web of Science ®Google Scholar
• Shoelson SE, Lee J, Goldfine AB. Inflammation and insulin resistance. J Clin Invest 2006; 116:1793-801; PMID:16823477; http://dx.doi.org/10.1172/JCI29069
   PubMed Web of Science ®Google Scholar
• Mraz M, Haluzik M. The role of adipose tissue immune cells in obesity and low-grade inflammation. J Endocrinol 2014; 222:R113-27; PMID:25006217; http://dx.doi.org/10.1530/JOE-14-0283
   PubMed Web of Science ®Google Scholar
• Weisberg SP, McCann D, Desai M, Rosenbaum M, Leibel RL, Ferrante AW Jr. Obesity is associated with macrophage accumulation in adipose tissue. J Clin Invest 2003; 112:1796-808; PMID:25006217; http://dx.doi.org/10.1172/JCI200319246
   PubMed Web of Science ®Google Scholar
• Nishimura S, Manabe I, Nagasaki M, Eto K, Yamashita H, Ohsugi M, Otsu M, Hara K, Ueki K, Sugiura S, et al. CD8+ effector T cells contribute to macrophage recruitment and adipose tissue inflammation in obesity. Nat Med 2009; 15:914-20; PMID:19633658; http://dx.doi.org/10.1038/nm.1964
   PubMed Web of Science ®Google Scholar
• Wensveen FM, Jelenčić V, Valentić S, Šestan M, Wensveen TT, Theurich S, Glasner A, Mendrila D, Štimac D, Wunderlich FT, et al. NK cells link obesity-induced adipose stress to inflammation and insulin resistance. Nat Immunol 2015; 16:376-85; PMID:25729921; http://dx.doi.org/10.1038/ni.3120
   PubMed Web of Science ®Google Scholar
• Feuerer M, Herrero L, Cipolletta D, Naaz A, Wong J, Nayer A, Lee J, Goldfine AB, Benoist C, Shoelson S, et al. Lean, but not obese, fat is enriched for a unique population of regulatory T cells that affect metabolic parameters. Nat Med 2009; 15:930-9; PMID:19633656; http://dx.doi.org/10.1038/nm.2002
   PubMed Web of Science ®Google Scholar
• Lee MW, Odegaard JI, Mukundan L, Qiu Y, Molofsky AB, Nussbaum JC, Yun K, Locksley RM, Chawla A. Activated type 2 innate lymphoid cells regulate beige fat biogenesis. Cell 2015; 160:74-87; PMID:25543153; http://dx.doi.org/10.1016/j.cell.2014.12.011
   PubMed Web of Science ®Google Scholar
• Van Kaer L. NKT cells: T lymphocytes with innate effector functions. Curr Opin Immunol 2007; 19:354-64; PMID:17428648; http://dx.doi.org/10.1016/j.coi.2007.03.001
   PubMed Web of Science ®Google Scholar
• Bendelac A, Savage PB, Teyton L. The biology of NKT cells. Annu Rev Immunol 2007; 25:297-336; PMID:17150027; http://dx.doi.org/10.1146/annurev.immunol.25.022106.141711
   PubMed Web of Science ®Google Scholar
• Kawano T, Cui J, Koezuka Y, Toura I, Kaneko Y, Motoki K, Ueno H, Nakagawa R, Sato H, Kondo E, et al. CD1d-restricted and TCR-mediated activation of Va14 NKT cells by glycosylceramides. Science 1997; 278:1626-9; PMID:9374463; http://dx.doi.org/10.1126/science.278.5343.1626
   PubMed Web of Science ®Google Scholar
• Halder RC, Aguilera C, Maricic I, Kumar V. Type II NKT cell-mediated anergy induction in type I NKT cells prevents inflammatory liver disease. J Clin Invest 2007; 117:2302-12; PMID:17641782; http://dx.doi.org/10.1172/JCI31602
   PubMed Web of Science ®Google Scholar
• Wu L, Van Kaer L. Contribution of lipid-reactive natural killer T cells to obesity-associated inflammation and insulin resistance. Adipocyte 2013; 2:12-16; PMID:23700548; http://dx.doi.org/10.4161/adip.22296
   PubMedGoogle Scholar
• Rakhshandehroo M, Kalkhoven E, Boes M. Invariant natural killer T cells in adipose tissue: novel regulators of immune-mediated metabolic disease. Cell Mol Life Sci 2013; 70:4711-27; PMID:23835837; http://dx.doi.org/10.1007/s00018-013-1414-1
   PubMed Web of Science ®Google Scholar
• Lynch L, Nowak M, Varghese B, Clark J, Hogan AE, Toxavidis V, Balk SP, O'Shea D, O'Farrelly C, Exley MA. Adipose tissue invariant NKT cells protect against diet-induced obesity and metabolic disorder through regulatory cytokine production. Immunity 2012; 37:574-87; PMID:22981538; http://dx.doi.org/10.1016/j.immuni.2012.06.016
   PubMed Web of Science ®Google Scholar
• Schipper HS, Rakhshandehroo M, van de Graaf SF, Venken K, Koppen A, Stienstra R, Prop S, Meerding J, Hamers N, Besra G, et al. Natural killer T cells in adipose tissue prevent insulin resistance. J Clin Invest 2012; 122:3343-54; PMID:22863618; http://dx.doi.org/10.1172/JCI62739
   PubMed Web of Science ®Google Scholar
• Sag D, Krause P, Hedrick CC, Kronenberg M, Wingender G. IL-10-producing NKT10 cells are a distinct regulatory invariant NKT cell subset. J Clin Invest 2014; 124:3725-40; PMID:25061873; http://dx.doi.org/10.1172/JCI72308
   PubMed Web of Science ®Google Scholar
• Lynch L, Michelet X, Zhang S, Brennan PJ, Moseman A, Lester C, Besra G, Vomhof-Dekrey EE, Tighe M, Koay HF, et al. Regulatory iNKT cells lack expression of the transcription factor PLZF and control the homeostasis of T(reg) cells and macrophages in adipose tissue. Nat Immunol 2015; 16:85-95; PMID:25436972; http://dx.doi.org/10.1038/ni.3047
   PubMed Web of Science ®Google Scholar
• Wu L, Parekh VV, Gabriel CL, Bracy DP, Marks-Shulman PA, Tamboli RA, Kim S, Mendez-Fernandez YV, Besra GS, Lomenick JP, et al. Activation of invariant natural killer T cells by lipid excess promotes tissue inflammation, insulin resistance, and hepatic steatosis in obese mice. Proc Natl Acad Sci U S A 2012; 109:E1143-52; PMID:22493234; http://dx.doi.org/10.1073/pnas.1200498109
   PubMed Web of Science ®Google Scholar
• Ohmura K, Ishimori N, Ohmura Y, Tokuhara S, Nozawa A, Horii S, Andoh Y, Fujii S, Iwabuchi K, Onoé K, et al. Natural killer T cells are involved in adipose tissues inflammation and glucose intolerance in diet-induced obese mice. Arterioscler Thromb Vasc Biol 2010; 30:193-9; PMID:19910631; http://dx.doi.org/10.1161/ATVBAHA.109.198614
   PubMed Web of Science ®Google Scholar
• Satoh M, Andoh Y, Clingan CS, Ogura H, Fujii S, Eshima K, Nakayama T, Taniguchi M, Hirata N, Ishimori N, et al. Type II NKT cells stimulate diet-induced obesity by mediating adipose tissue inflammation, steatohepatitis and insulin resistance. PLoS One 2012; 7:e30568; PMID:22383967
   PubMedGoogle Scholar
• Mantell BS, Stefanovic-Racic M, Yang X, Dedousis N, Sipula IJ, O'Doherty RM. Mice lacking NKT cells but with a complete complement of CD8+ T-cells are not protected against the metabolic abnormalities of diet-induced obesity. PLoS One 2011; 6:e19831; PMID:21674035
   PubMedGoogle Scholar
• Kotas ME, Medzhitov R. Homeostasis, inflammation, and disease susceptibility. Cell 2015; 160:816-27; PMID:25723161; http://dx.doi.org/10.1016/j.cell.2015.02.010
   PubMed Web of Science ®Google Scholar
• Kotas ME, Lee H-Y, Gillum MP, Annicelli C, Guigni BA, Shulman GI, Medzhitov R. Impact of CD1d deficiency on metabolism. PLoS One 2011; 6:e25478; PMID:21980475
   PubMed Web of Science ®Google Scholar
• Huh JY, Kim JI, Park YJ, Hwang IJ, Lee YS, Sohn JH, Lee SK, Alfadda AA, Kim SS, Choi SH, et al. A novel function of adipocytes in lipid antigen presentation to iNKT cells. Mol Cell Biol 2013; 33:328-39; PMID:23149942; http://dx.doi.org/10.1128/MCB.00552-12
   PubMed Web of Science ®Google Scholar
• Rakhshandehroo M, Gijzel SM, Siersbæk R, Broekema MF, de Haar C, Schipper HS, Boes M, Mandrup S, Kalkhoven E. CD1d-mediated presentation of endogenous lipid antigens by adipocytes requires microsomal triglyceride transfer protein. J Biol Chem 2014; 289:22128-39; PMID:24966328; http://dx.doi.org/10.1074/jbc.M114.551242
   PubMed Web of Science ®Google Scholar
• Bai L, Constantinides MG, Thomas SY, Reboulet R, Meng F, Koentgen F, Teyton L, Savage PB, Bendelac A. Distinct APCs explain the cytokine bias of α-galactosylceramide variants in vivo. J Immunol 2012; 188:3053-61; PMID:22393151; http://dx.doi.org/10.4049/jimmunol.1102414
   PubMed Web of Science ®Google Scholar
• Wang ZV, Deng Y, Wang QA, Sun K, Scherer PE. Identification and characterization of a promoter cassette conferring adipocyte-specific gene expression. Endocrinology 2010; 151:2933-9; PMID:20363877; http://dx.doi.org/10.1210/en.2010-0136
   PubMed Web of Science ®Google Scholar
• Satoh M, Hoshino M, Fujita K, Iizuka M, Fujii S, Clingan CS, Van Kaer L, Iwabuchi K. Adipocyte-specific CD1d-deficiency mitigates diet-induced obesity and insulin resistance in mice. Sci Rep 2016; 6:28473; PMID:27329323; http://dx.doi.org/10.1038/srep28473
   PubMed Web of Science ®Google Scholar
• Holzapfel KL, Tyznik AJ, Kronenberg M, Hogquist KA. Antigen-dependent versus-independent activation of invariant NKT cells during infection. J Immunol 2014; 192:5490-8; PMID:24813205; http://dx.doi.org/10.4049/jimmunol.1400722
   PubMed Web of Science ®Google Scholar