Harnessing adipogenesis to prevent obesity

References

• Rosen ED, Spiegelman BM. Adipocytes as regulators of energy balance and glucose homeostasis. Nature. 2006 Dec 14;444(7121):847–853. PubMed PMID: 17167472; PubMed Central PMCID: PMCPMC3212857.
   PubMed Web of Science ®Google Scholar
• WHO. Obesity and overweight 2018; [ cited 2018 Feb 16]. Available from: https://www.who.int/news-room/fact-sheets/detail/obesity-and-overweight
   Google Scholar
• Farrell G. Insulin resistance, obesity, and liver cancer. Clin Gastroenterol Hepatol. 2014 Jan;12(1):117–119. PubMed PMID: 23954644.
   PubMed Web of Science ®Google Scholar
• Segula D. Complications of obesity in adults: a short review of the literature. Malawi Med J. 2014 Mar;26(1):20–24. PubMed PMID: 24959321; PubMed Central PMCID: PMCPMC4062780.
   PubMed Web of Science ®Google Scholar
• Haczeyni F, Bell-Anderson KS, Farrell GC. Causes and mechanisms of adipocyte enlargement and adipose expansion. Obes Rev. 2018 Mar;19(3):406–420. PubMed PMID: 29243339.
   PubMed Web of Science ®Google Scholar
• Sun K, Kusminski CM, Scherer PE. Adipose tissue remodeling and obesity. J Clin Invest. 2011 Jun;121(6):2094–2101. PubMed PMID: 21633177; PubMed Central PMCID: PMCPMC3104761.
   PubMed Web of Science ®Google Scholar
• Rosen ED, Spiegelman BM. What we talk about when we talk about fat. Cell. 2014 Jan 16;156(1–2):20–44. PubMed PMID: 24439368; PubMed Central PMCID: PMCPMC3934003.
   PubMed Web of Science ®Google Scholar
• Lefterova MI, Lazar MA. New developments in adipogenesis. Trends Endocrinol Metab. 2009 Apr;20(3):107–114. PubMed PMID: 19269847.
   PubMed Web of Science ®Google Scholar
• Rosen ED, MacDougald OA. Adipocyte differentiation from the inside out. Nat Rev Mol Cell Biol. 2006 Dec;7(12):885–896. PubMed PMID: 17139329.
   PubMed Web of Science ®Google Scholar
• Tang QQ, Lane MD. Adipogenesis: from stem cell to adipocyte. Annu Rev Biochem. 2012;81:715–736. PubMed PMID: 22463691.
   PubMed Web of Science ®Google Scholar
• Schwalie PC, Dong H, Zachara M, et al. A stromal cell population that inhibits adipogenesis in mammalian fat depots. Nature. 2018 Jul;559(7712):103–108. 10.1038/s41586-018-0226-8. PubMed PMID: 29925944.
   PubMed Web of Science ®Google Scholar
• Buckner JH. Mechanisms of impaired regulation by CD4(+)CD25(+)FOXP3(+) regulatory T cells in human autoimmune diseases. Nat Rev Immunol. 2010 Dec;10(12):849–859. PubMed PMID: 21107346; PubMed Central PMCID: PMCPMC3046807.
   PubMed Web of Science ®Google Scholar
• Cvetanovich GL, Hafler DA. Human regulatory T cells in autoimmune diseases. Curr Opin Immunol. 2010 Dec;22(6):753–760. PubMed PMID: 20869862; PubMed Central PMCID: PMCPMC2997859.
   PubMed Web of Science ®Google Scholar
• Kasper IR, Apostolidis SA, Sharabi A, et al. Empowering regulatory T cells in autoimmunity. Trends Mol Med. 2016 Sep;22(9):784–797. PubMed PMID: 27461103; PubMed Central PMCID: PMCPMC5003773.
   PubMed Web of Science ®Google Scholar
• Wang QA, Tao C, Gupta RK, et al. Tracking adipogenesis during white adipose tissue development, expansion and regeneration. Nat Med. 2013 Oct;19(10):1338–1344. PubMed PMID: 23995282; PubMed Central PMCID: PMCPMC4075943.
   PubMed Web of Science ®Google Scholar
• Baglioni S, Cantini G, Poli G, et al. Functional differences in visceral and subcutaneous fat pads originate from differences in the adipose stem cell. PLoS One. 2012;7(5):e36569. PubMed PMID: 22574183; PubMed Central PMCID: PMCPMC3344924.
   PubMed Web of Science ®Google Scholar
• Church CD, Berry R, Rodeheffer MS. Isolation and study of adipocyte precursors. Methods Enzymol. 2014;537:31–46. PubMed PMID: 24480340; PubMed Central PMCID: PMCPMC4276307.
   PubMed Web of Science ®Google Scholar
• Haider N, Dusseault J, Larose L. Nck1 deficiency impairs adipogenesis by activation of PDGFRalpha in preadipocytes. iScience. 2018 Aug 31;6:22–37. PubMed PMID: 30240612; PubMed Central PMCID: PMCPMC6137712.
   PubMed Web of Science ®Google Scholar
• Macotela Y, Emanuelli B, Mori MA, et al. Intrinsic differences in adipocyte precursor cells from different white fat depots. Diabetes. 2012 Jul;61(7):1691–1699. PubMed PMID: 22596050; PubMed Central PMCID: PMCPMC3379665.
   PubMed Web of Science ®Google Scholar
• Miwa H, Era T. Tracing the destiny of mesenchymal stem cells from embryo to adult bone marrow and white adipose tissue via Pdgfralpha expression. Development. 2018 Jan 29;145(2):1-9. 10.1242/dev.155879. PubMed PMID: 29378823.
   PubMedGoogle Scholar
• Lee YH, Petkova AP, Mottillo EP, et al. In vivo identification of bipotential adipocyte progenitors recruited by beta3-adrenoceptor activation and high-fat feeding. Cell Metab. 2012 Apr 4;15(4):480–491. PubMed PMID: 22482730; PubMed Central PMCID: PMCPMC3322390.
   PubMed Web of Science ®Google Scholar
• Iwayama T, Steele C, Yao L, et al. PDGFRalpha signaling drives adipose tissue fibrosis by targeting progenitor cell plasticity. Genes Dev. 2015 Jun 01;29(11):1106–1119. PubMed PMID: 26019175; PubMed Central PMCID: PMCPMC4470280.
   PubMed Web of Science ®Google Scholar
• Sun C, Berry WL, Olson LE. PDGFRalpha controls the balance of stromal and adipogenic cells during adipose tissue organogenesis. Development. 2017 Jan 01 1;144:83–94. PubMed PMID: 28049691; PubMed Central PMCID: PMCPMC5278626.
   PubMed Web of Science ®Google Scholar
• Lagos-Quintana M, Rauhut R, Lendeckel W, et al. Identification of novel genes coding for small expressed RNAs. Science. 2001 Oct 26;294(5543):853–858. PubMed PMID: 11679670.
   PubMed Web of Science ®Google Scholar
• Lau NC, Lim LP, Weinstein EG, et al. An abundant class of tiny RNAs with probable regulatory roles in Caenorhabditis elegans. Science. 2001 Oct 26;294(5543):858–862. PubMed PMID: 11679671.
   PubMed Web of Science ®Google Scholar
• Lee RC, Ambros V. An extensive class of small RNAs in Caenorhabditis elegans. Science. 2001 Oct 26;294(5543):862–864. PubMed PMID: 11679672.
   PubMed Web of Science ®Google Scholar
• Chatterjee S, Grosshans H. Active turnover modulates mature microRNA activity in Caenorhabditis elegans. Nature. 2009 Sep 24;461(7263):546–549. PubMed PMID: 19734881.
   PubMed Web of Science ®Google Scholar
• Djuranovic S, Nahvi A, Green R. miRNA-mediated gene silencing by translational repression followed by mRNA deadenylation and decay. Science. 2012 Apr 13;336(6078):237–240. PubMed PMID: 22499947; PubMed Central PMCID: PMCPMC3971879.
   PubMed Web of Science ®Google Scholar
• Jiang Q, Wang Y, Hao Y, et al. miR2Disease: a manually curated database for microRNA deregulation in human disease. Nucleic Acids Res. 2009 Jan;37(Database issue):D98–104. PubMed PMID: 18927107; PubMed Central PMCID: PMCPMC2686559.
   PubMed Web of Science ®Google Scholar
• Krichevsky AM, King KS, Donahue CP, et al. A microRNA array reveals extensive regulation of microRNAs during brain development. RNA. 2003 Oct;9(10):1274–1281. PubMed PMID: 13130141; PubMed Central PMCID: PMCPMC1370491.
   PubMed Web of Science ®Google Scholar
• Londin E, Loher P, Telonis AG, et al. Analysis of 13 cell types reveals evidence for the expression of numerous novel primate- and tissue-specific microRNAs. Proc Natl Acad Sci U S A. 2015 Mar 10;112(10):E1106–15. PubMed PMID: 25713380; PubMed Central PMCID: PMCPMC4364231.
   PubMed Web of Science ®Google Scholar
• Lorente-Cebrian S, Gonzalez-Muniesa P, Milagro FI, et al. MicroRNAs and other non-coding RNAs in adipose tissue and obesity: emerging roles as biomarkers and therapeutic targets. Clin Sci (Lond). 2019 Jan 15;133(1):23–40. PubMed PMID: 30606812.
   PubMed Web of Science ®Google Scholar
• Sadie-Van Gijsen H. Adipocyte biology: it is time to upgrade to a new model. J Cell Physiol. 2018. DOI:10.1002/jcp.27266
   PubMed Web of Science ®Google Scholar
• Son YH, Ka S, Kim AY, et al. Regulation of adipocyte differentiation via MicroRNAs. Endocrinol Metab (Seoul). 2014 Jun;29(2):122–135. PubMed PMID: 25031884; PubMed Central PMCID: PMCPMC4091493.
   PubMedGoogle Scholar
• Kim YJ, Hwang SJ, Bae YC, et al. MiR-21 regulates adipogenic differentiation through the modulation of TGF-beta signaling in mesenchymal stem cells derived from human adipose tissue. Stem Cells. 2009 Dec;27(12):3093–3102. PubMed PMID: 19816956.
   PubMed Web of Science ®Google Scholar
• Shi C, Zhang M, Tong M, et al. miR-148a is associated with obesity and modulates adipocyte differentiation of mesenchymal stem cells through Wnt signaling. Sci Rep. 2015 May 22;5:9930. PubMed PMID: 26001136; PubMed Central PMCID: PMCPMC4441322.
   PubMed Web of Science ®Google Scholar
• Zhang XM, Wang LH, Su DJ, et al. MicroRNA-29b promotes the adipogenic differentiation of human adipose tissue-derived stromal cells. Obesity (Silver Spring). 2016 May;24(5):1097–1105. PubMed PMID: 27030318.
   PubMed Web of Science ®Google Scholar
• Qin LC, Niu Y, Chen W, et al. A deep investigation into the adipogenesis mechanism: profile of microRNAs regulating adipogenesis by modulating the canonical Wnt/β-catenin signaling pathway. BMC Genomics. 2010;11(320):1-10.
   Web of Science ®Google Scholar
• He H, Chen K, Wang F, et al. miR-204-5p promotes the adipogenic differentiation of human adipose-derived mesenchymal stem cells by modulating DVL3 expression and suppressing Wnt/beta-catenin signaling. Int J Mol Med. 2015 Jun;35(6):1587–1595. PubMed PMID: 25847080; PubMed Central PMCID: PMCPMC4432921.
   PubMed Web of Science ®Google Scholar
• Shen L, Li Q, Wang J, et al. miR-144-3p promotes adipogenesis through releasing C/EBPalpha from Klf3 and CtBP2. Front Genet. 2018;9:677. PubMed PMID: 30619490; PubMed Central PMCID: PMCPMC6305703.
   PubMed Web of Science ®Google Scholar
• Chen L, Chen Y, Zhang S, et al. MiR-540 as a novel adipogenic inhibitor impairs adipogenesis via suppression of PPARγ. J Cell Biochem. 2015 Jun;116(6):969–976. PubMed PMID: 25560764.
   PubMed Web of Science ®Google Scholar
• Karbiener M, Fischer C, Nowitsch S, et al. microRNA miR-27b impairs human adipocyte differentiation and targets PPARγ. Biochem Biophys Res Commun. 2009 Dec 11;390(2):247–251. PubMed PMID: 19800867.
   PubMed Web of Science ®Google Scholar
• Kim SY, Kim AY, Lee HW, et al. miR-27a is a negative regulator of adipocyte differentiation via suppressing PPARγ expression. Biochem Biophys Res Commun. 2010 Feb 12;392(3):323–328. PubMed PMID: 20060380.
   PubMed Web of Science ®Google Scholar
• Lee EK, Lee MJ, Abdelmohsen K, et al. miR-130 suppresses adipogenesis by inhibiting peroxisome proliferator-activated receptor gamma expression. Mol Cell Biol. 2011 Feb;31(4):626–638. PubMed PMID: 21135128; PubMed Central PMCID: PMCPMC3028659.
   PubMed Web of Science ®Google Scholar
• Lin Q, Gao Z, Alarcon RM, et al. A role of miR-27 in the regulation of adipogenesis. FEBS J. 2009 Apr;276(8):2348–2358. PubMed PMID: 19348006; PubMed Central PMCID: PMCPMC5330386.
   PubMed Web of Science ®Google Scholar
• Wu D, Xi QY, Cheng X, et al. miR-146a-5p inhibits TNF-alpha-induced adipogenesis via targeting insulin receptor in primary porcine adipocytes. J Lipid Res. 2016 Aug;57(8):1360–1372. PubMed PMID: 27324794; PubMed Central PMCID: PMCPMC4959853.
   PubMed Web of Science ®Google Scholar
• Chen C, Deng Y, Hu X, et al. miR-128-3p regulates 3T3-L1 adipogenesis and lipolysis by targeting Pparg and Sertad2. J Physiol Biochem. 2018 Aug;74(3):381–393. 10.1007/s13105-018-0625-1. PubMed PMID: 29654510.
   PubMed Web of Science ®Google Scholar
• Liu S, Yang Y, Wu J. TNFalpha-induced up-regulation of miR-155 inhibits adipogenesis by down-regulating early adipogenic transcription factors. Biochem Biophys Res Commun. 2011 Oct 28;414(3):618–624. PubMed PMID: 21986534.
   PubMed Web of Science ®Google Scholar
• Sun F, Wang J, Pan Q, et al. Characterization of function and regulation of miR-24-1 and miR-31. Biochem Biophys Res Commun. 2009 Mar 13;380(3):660–665. PubMed PMID: 19285018.
   PubMed Web of Science ®Google Scholar
• Tang YF, Zhang Y, Li XY, et al. Expression of miR-31, miR-125b-5p, and miR-326 in the adipogenic differentiation process of adipose-derived stem cells. OMICS. 2009 Aug;13(4):331–336. PubMed PMID: 19422302.
   PubMed Web of Science ®Google Scholar
• Koh EH, Chernis N, Saha PK, et al. miR-30a remodels subcutaneous adipose tissue inflammation to improve insulin sensitivity in obesity. Diabetes. 2018 Jul 12;67:2541–2553. PubMed PMID: 30002134.
   PubMed Web of Science ®Google Scholar
• Zhang Z, Wu S, Muhammad S, et al. miR-103/107 promote ER stress-mediated apoptosis via targeting the Wnt3a/beta-catenin/ATF6 pathway in preadipocytes. J Lipid Res. 2018 May;59(5):843–853. PubMed PMID: 29483204; PubMed Central PMCID: PMCPMC5928437.
   PubMed Web of Science ®Google Scholar
• Al-Rawaf HA. Circulating microRNAs and adipokines as markers of metabolic syndrome in adolescents with obesity. Clin Nutr. 2018 Sep 25. DOI:10.1016/j.clnu.2018.09.024. PubMed PMID: 30309709.
   PubMed Web of Science ®Google Scholar
• Manning P, Munasinghe PE, Bellae Papannarao J, et al. Acute weight loss restores dysregulated circulating microRNAs in obese individuals. J Clin Endocrinol Metab. 2018 Oct 31. DOI:10.1210/jc.2018-00684. PubMed PMID: 30383229.
   Web of Science ®Google Scholar
• Derrien T, Johnson R, Bussotti G, et al. The GENCODE v7 catalog of human long noncoding RNAs: analysis of their gene structure, evolution, and expression. Genome Res. 2012 Sep;22(9):1775–1789. PubMed PMID: 22955988; PubMed Central PMCID: PMCPMC3431493.
   PubMed Web of Science ®Google Scholar
• Washietl S, Kellis M, Garber M. Evolutionary dynamics and tissue specificity of human long noncoding RNAs in six mammals. Genome Res. 2014 Apr;24(4):616–628. PubMed PMID: 24429298; PubMed Central PMCID: PMCPMC3975061.
   PubMed Web of Science ®Google Scholar
• Sun L, Goff LA, Trapnell C, et al. Long noncoding RNAs regulate adipogenesis. Proc Natl Acad Sci U S A. 2013 Feb 26;110(9):3387–3392. PubMed PMID: 23401553; PubMed Central PMCID: PMCPMC3587215.
   PubMed Web of Science ®Google Scholar
• Yang Q, Wan Q, Zhang L, et al. Analysis of LncRNA expression in cell differentiation. RNA Biol. 2018 Mar 4;15(3):413–422. PubMed PMID: 29508657; PubMed Central PMCID: PMCPMC5927722.
   PubMed Web of Science ®Google Scholar
• Xu B, Gerin I, Miao H, et al. Multiple roles for the non-coding RNA SRA in regulation of adipogenesis and insulin sensitivity. PLoS One. 2010 Dec 2;5(12):e14199. PubMed PMID: 21152033; PubMed Central PMCID: PMCPMC2996286.
   PubMed Web of Science ®Google Scholar
• Chen J, Liu Y, Lu S, et al. The role and possible mechanism of lncRNA U90926 in modulating 3T3-L1 preadipocyte differentiation. Int J Obes (Lond). 2017 Feb;41(2):299–308. PubMed PMID: 27780975; PubMed Central PMCID: PMCPMC5309343.
   PubMed Web of Science ®Google Scholar
• Cooper DR, Carter G, Li P, et al. Long non-coding RNA NEAT1 associates with SRp40 to temporally regulate PPARγ2 splicing during adipogenesis in 3T3-L1 cells. Genes (Basel). 2014 Nov 27;5(4):1050–1063. PubMed PMID: 25437750; PubMed Central PMCID: PMCPMC4276926.
   PubMed Web of Science ®Google Scholar
• Huang Y, Jin C, Zheng Y, et al. Knockdown of lncRNA MIR31HG inhibits adipocyte differentiation of human adipose-derived stem cells via histone modification of FABP4. Sci Rep. 2017 Aug 14;7(1):8080. PubMed PMID: 28808264; PubMed Central PMCID: PMCPMC5556051.
   PubMedGoogle Scholar
• Huang Y, Zheng Y, Jin C, et al. Long non-coding RNA H19 inhibits adipocyte differentiation of bone marrow mesenchymal stem cells through epigenetic modulation of histone deacetylases. Sci Rep. 2016 Jun 28;6:28897. PubMed PMID: 27349231; PubMed Central PMCID: PMCPMC4924093.
   PubMed Web of Science ®Google Scholar
• Li M, Sun X, Cai H, et al. Long non-coding RNA ADNCR suppresses adipogenic differentiation by targeting miR-204. Biochim Biophys Acta. 2016 Jul;1859(7):871–882. PubMed PMID: 27156885.
   PubMed Web of Science ®Google Scholar
• Li Z, Jin C, Chen S, et al. Long non-coding RNA MEG3 inhibits adipogenesis and promotes osteogenesis of human adipose-derived mesenchymal stem cells via miR-140-5p. Mol Cell Biochem. 2017 Sep;433(1–2):51–60. PubMed PMID: 28382492.
   PubMed Web of Science ®Google Scholar
• Pang WJ, Lin LG, Xiong Y, et al. Knockdown of PU.1 AS lncRNA inhibits adipogenesis through enhancing PU.1 mRNA translation. J Cell Biochem. 2013 Nov;114(11):2500–2512. PubMed PMID: 23749759.
   PubMed Web of Science ®Google Scholar
• Xiao T, Liu L, Li H, et al. Long noncoding RNA ADINR regulates adipogenesis by transcriptionally activating C/EBPα. Stem Cell Rep. 2015 Nov 10;5(5):856–865. PubMed PMID: 26489893; PubMed Central PMCID: PMCPMC4649137.
   PubMed Web of Science ®Google Scholar
• Gao H, Kerr A, Jiao H, et al. Long non-coding RNAs associated with metabolic traits in human white adipose tissue. EBioMedicine. 2018 Apr;30:248–260. PubMed PMID: 29580841; PubMed Central PMCID: PMCPMC5952343.
   PubMed Web of Science ®Google Scholar
• Zhu E, Zhang J, Li Y, et al. Long noncoding RNA Plnc1 controls adipocyte differentiation by regulating peroxisome proliferator-activated receptor gamma. FASEB J. 2018 Oct2:fj201800739RRR. DOI:10.1096/fj.201800739RRR. PubMed PMID: 30277818.
   Web of Science ®Google Scholar