Transplantation of brown adipose tissue up-regulates miR-99a to ameliorate liver metabolic disorders in diabetic mice by targeting NOX4

References

• Gao X, Fan J-G. Diagnosis and management of non-alcoholic fatty liver disease and related metabolic disorders: consensus statement from the Study Group of Liver and Metabolism, Chinese Society of Endocrinology. J Diabetes. 2013;5(4):406–415.
   PubMed Web of Science ®Google Scholar
• Golabi P, Paik J, Hwang JP, et al. Prevalence and outcomes of non-alcoholic fatty liver disease (NAFLD) among Asian American adults in the United States. Liver Int. 2019;39(4):748–757.
   PubMed Web of Science ®Google Scholar
• Machado MV, Michelotti GA, Jewell ML, et al. Caspase-2 promotes obesity, the metabolic syndrome and nonalcoholic fatty liver disease. Cell Death Dis. 2016;7(2):e2096–e2096.
   PubMedGoogle Scholar
• Chang Y, Jung H, Cho J, et al. Metabolically healthy obesity and the development of nonalcoholic fatty liver disease. Am J Gastroenterol. 2016;111(8):1133–1140.
   PubMed Web of Science ®Google Scholar
• Fang Y, Chen H, Wang C, et al. Pathogenesis of non-alcoholic fatty liver disease in children and adolescence: from “two hit theory” to “multiple hit model”. World J Gastroenterol. 2018;24(27):2974–2983.
   PubMed Web of Science ®Google Scholar
• Li Y, Zhu S, Li B, et al. Association between non-alcoholic fatty liver disease and chronic kidney disease in population with prediabetes or diabetes. Int Urol Nephrol. 2014;46(9):1785–1791.
   PubMed Web of Science ®Google Scholar
• Bhala N, Angulo P, van der Poorten D, et al. The natural history of nonalcoholic fatty liver disease with advanced fibrosis or cirrhosis: an international collaborative study. Hepatology. 2011;54(4):1208–1216.
   PubMed Web of Science ®Google Scholar
• Peirce V, Carobbio S, Vidal-Puig A. The different shades of fat. Nature. 2014;510(7503):76–83.
   PubMed Web of Science ®Google Scholar
• Townsend K, Tseng YH. Brown adipose tissue: recent insights into development, metabolic function and therapeutic potential. Adipocyte. 2012;1(1):13–24.
   PubMedGoogle Scholar
• Cypess AM, Doyle AN, Sass CA, et al. Quantification of human and rodent brown adipose tissue function using 99mTc-methoxyisobutylisonitrile SPECT/CT and 18F-FDG PET/CT. J Nucl Med. 2013;54(11):1896–1901.
   PubMed Web of Science ®Google Scholar
• Cypess AM, Haft CR, Laughlin MR, et al. Brown fat in humans: consensus points and experimental guidelines. Cell Metab. 2014;20(3):408–415.
   PubMed Web of Science ®Google Scholar
• Villarroya F, Cereijo R, Villarroya J, et al. Brown adipose tissue as a secretory organ. Nat Rev Endocrinol. 2017;13(1):26–35.
   PubMed Web of Science ®Google Scholar
• Thomou T, Mori MA, Dreyfuss JM, et al. Adipose-derived circulating miRNAs regulate gene expression in other tissues. Nature. 2017;542(7642):450–455.
   PubMed Web of Science ®Google Scholar
• Seki A, Sakai Y, Komura T, et al. Adipose tissue-derived stem cells as a regenerative therapy for a mouse steatohepatitis-induced cirrhosis model. Hepatology. 2013;58(3):1133–1142.
   PubMed Web of Science ®Google Scholar
• Liao N, Pan F, Wang Y, et al. Adipose tissue-derived stem cells promote the reversion of non-alcoholic fatty liver disease: an in vivo study. Int J Mol Med. 2016;37(5):1389–1396.
   PubMed Web of Science ®Google Scholar
• Pan F, Liao N, Zheng Y, et al. Intrahepatic transplantation of adipose-derived stem cells attenuates the progression of non-alcoholic fatty liver disease in rats. Mol Med Rep. 2015;12(3):3725–3733.
   PubMed Web of Science ®Google Scholar
• Liao N, Zheng Y, Xie H, et al. Adipose tissue-derived stem cells ameliorate hyperglycemia, insulin resistance and liver fibrosis in the type 2 diabetic rats. Stem Cell Res Ther. 2017;8(1):286.
   PubMedGoogle Scholar
• Stanford KI, Middelbeek RJW, Townsend KL, et al. Brown adipose tissue regulates glucose homeostasis and insulin sensitivity. J Clin Invest. 2013;123(1):215–223.
   PubMed Web of Science ®Google Scholar
• Kusakabe T, Tanioka H, Ebihara K, et al. Beneficial effects of leptin on glycaemic and lipid control in a mouse model of type 2 diabetes with increased adiposity induced by streptozotocin and a high-fat diet. Diabetologia. 2009;52(4):675–683.
   PubMed Web of Science ®Google Scholar
• Zeng W, Huang Y, Shao C, et al. [Biochemical and pathological analysis of mice with type 2 diabetes mellitus induced by high-fat diet and low-dose streptozotocin injections]. Nan Fang Yi Ke Da Xue Xue Bao. 2014;34(8):1115–1120.
   PubMedGoogle Scholar
• Bugianesi E, McCullough AJ, Marchesini G. Insulin resistance: A metabolic pathway to chronic liver disease. Hepatology. 2005;42(5):987–1000.
   PubMed Web of Science ®Google Scholar
• Campbell PT, Newton CC, Patel AV, et al. Diabetes and cause-specific mortality in a prospective cohort of one million U.S. adults. Diabetes Care. 2012;35(9):1835–1844.
   PubMed Web of Science ®Google Scholar
• Day CP, James OF. Steatohepatitis: a tale of two “hits”? Gastroenterology. 1998;114(4):842–845.
   PubMed Web of Science ®Google Scholar
• Abenavoli L, Milic N, Di Renzo L, et al. Metabolic aspects of adult patients with nonalcoholic fatty liver disease. World J Gastroenterol. 2016;22(31):7006.
   PubMed Web of Science ®Google Scholar
• Paik Y, Kim J, Aoyama T, et al. Role of NADPH Oxidases in Liver Fibrosis. Antioxid Redox Sign. 2014;20(17):2854–2872.
   PubMed Web of Science ®Google Scholar
• Sancho P, Mainez J, Crosas-Molist E, et al. NADPH oxidase NOX4 mediates stellate cell activation and hepatocyte cell death during liver fibrosis development. Plos One. 2012;7(9):e45285.
   PubMed Web of Science ®Google Scholar
• Lan T, Kisseleva T, Brenner DA. Deficiency of NOX1 or NOX4 prevents liver inflammation and fibrosis in mice through inhibition of hepatic stellate cell activation. Plos One. 2015;10(7):e0129743.
   PubMed Web of Science ®Google Scholar
• Chan EC, Peshavariya HM, Liu GS, et al. Nox4 modulates collagen production stimulated by transforming growth factor beta1 in vivo and in vitro. Biochem Biophys Res Commun. 2013;430(3):918–925.
   PubMed Web of Science ®Google Scholar
• Sugimoto R, Enjoji M, Kohjima M, et al. High glucose stimulates hepatic stellate cells to proliferate and to produce collagen through free radical production and activation of mitogen-activated protein kinase. Liver Int. 2005;25(5):1018–1026.
   PubMed Web of Science ®Google Scholar
• Mu J, Woods J, Zhou YP, et al. Chronic inhibition of dipeptidyl peptidase-4 with a sitagliptin analog preserves pancreatic -cell mass and function in a rodent model of type 2 diabetes. Diabetes. 2006;55(6):1695–1704.
   PubMed Web of Science ®Google Scholar
• Kim T, Kim M, Cheong Y, et al. Hepatic role in an early glucose-lowering effect by a novel dipeptidyl peptidase 4 inhibitor, evogliptin, in a rodent model of type 2 diabetes. Eur J Pharmacol. 2016;771:65–76.
   PubMed Web of Science ®Google Scholar
• Zhang X, Wang Z, Huang Y. Effects of chronic administration of alogliptin on the development of diabetes and β-cell function in high fat diet/streptozotocin diabetic mice. Diabetes Obes Metab. 2011;13(4):337–347.
   PubMed Web of Science ®Google Scholar
• Nedergaard J, Bengtsson T, Cannon B. Unexpected evidence for active brown adipose tissue in adult humans. Am J Physiol-Endoc M. 2007;293(2):E444–E452.
   PubMed Web of Science ®Google Scholar
• Cohade C, Osman M, Pannu HK, et al. Uptake in supraclavicular area fat (“USA-Fat”): description on 18F-FDG PET/CT. J Nucl Med. 2003;44(2):170–176.
   PubMed Web of Science ®Google Scholar
• Gunawardana SC, Piston DW. Reversal of type 1 diabetes in mice by brown adipose tissue transplant. Diabetes. 2012;61(3):674–682.
   PubMed Web of Science ®Google Scholar
• Liu X, Wang S, You Y, et al. Brown adipose tissue transplantation reverses obesity in Ob/Ob Mice. Endocrinology. 2015;156(7):2461–2469.
   PubMed Web of Science ®Google Scholar
• Chang E, Kim D, Yang H, et al. CB1 receptor blockade ameliorates hepatic fat infiltration and inflammation and increases Nrf2-AMPK pathway in a rat model of severely uncontrolled diabetes. Plos One. 2018;13(10):e0206152.
   Web of Science ®Google Scholar
• Nigi L, Grieco G, Ventriglia G, et al. MicroRNAs as regulators of insulin signaling: research updates and potential therapeutic perspectives in type 2 diabetes. Int J Mol Sci. 2018;19(12):3705.
   Web of Science ®Google Scholar
• Huang Y, Yan Y, Xv W, et al. A new insight into the roles of miRNAs in metabolic syndrome. Biomed Res Int. 2018;2018:7372636.
   PubMed Web of Science ®Google Scholar
• Jin X, Ye YF, Chen SH, et al. MicroRNA expression pattern in different stages of nonalcoholic fatty liver disease. Digest Liver Dis. 2009;41(4):289–297.
   Web of Science ®Google Scholar
• Cheung O, Puri P, Eicken C, et al. Nonalcoholic steatohepatitis is associated with altered hepatic MicroRNA expression. Hepatology. 2008;48(6):1810–1820.
   PubMed Web of Science ®Google Scholar
• He Z, Yang JJ, Zhang R, et al. Circulating miR-29b positively correlates with non-alcoholic fatty liver disease in a Chinese population. J Dig Dis. 2019;20(4):189–195.
   PubMed Web of Science ®Google Scholar
• Cai YY, Zhang HB, Fan CX, et al. Renoprotective effects of brown adipose tissue activation in diabetic mice. J Diabetes. 2019;11(12):958–970.
   Web of Science ®Google Scholar
• Zhu M, Wang Q, Zhou W, et al. Integrated analysis of hepatic mRNA and miRNA profiles identified molecular networks and potential biomarkers of NAFLD. Sci Rep. 2018;8(1):7628.
   PubMedGoogle Scholar
• SUN M, HONG S, LI W, et al. miR-99a regulates ROS-mediated invasion and migration of lung adenocarcinoma cells by targeting NOX4. Oncol Rep. 2016;35(5):2755–2766.
   PubMed Web of Science ®Google Scholar
• Zhang P, Wang P, Zhao L, et al. The deubiquitinating enzyme TNFAIP3 mediates inactivation of hepatic ASK1 and ameliorates nonalcoholic steatohepatitis. Nat Med. 2017;24(1):84–94.
   PubMed Web of Science ®Google Scholar
• Wang PX, Ji YX, Zhang XJ, et al. Targeting CASP8 and FADD-like apoptosis regulator ameliorates nonalcoholic steatohepatitis in mice and nonhuman primates. Nat Med. 2017;23(4):439–449.
   PubMed Web of Science ®Google Scholar
• Chen X, Tan X, Li S, et al. LncRNA NEAT1 promotes hepatic lipid accumulation via regulating miR-146a-5p/ROCK1 in nonalcoholic fatty liver disease. Life Sci. 2019;235:116829.
   PubMed Web of Science ®Google Scholar
• Xu L, Li Y, Yin L, et al. miR-125a-5p ameliorates hepatic glycolipid metabolism disorder in type 2 diabetes mellitus through targeting of STAT3. Theranostics. 2018;8(20):5593–5609.
   PubMed Web of Science ®Google Scholar