References
- Betz MJ, Enerback S. Targeting thermogenesis in brown fat and muscle to treat obesity and metabolic disease. Nat Rev Endocrinol. 2018;14:77–87.
- Harms M, Seale P. Brown and beige fat: development, function and therapeutic potential. Nat Med. 2013;19:1252–1263.
- Kajimura S, Spiegelman BM, Brown SP. Beige fat: physiological roles beyond heat generation. Cell Metab. 2015;22:546–559.
- Lucchini FC, Wueest S, Challa TD, et al. ASK1 inhibits browning of white adipose tissue in obesity. Nat Commun. 2020;11:1642.
- Rogers NH, Landa A, Park S, et al. Aging leads to a programmed loss of brown adipocytes in murine subcutaneous white adipose tissue. Aging Cell. 2012;11:1074–1083.
- Berry DC, Jiang Y, Arpke RW, et al. Cellular aging contributes to failure of cold-induced beige adipocyte formation in old mice and humans. Cell Metab. 2017;25(1):166–181.
- Tchkonia T, Morbeck DE, Von Zglinicki T, et al. Fat tissue, aging, and cellular senescence. Aging Cell. 2010;9:667–684.
- Ghosh AK, O’Brien M, Mau T, et al. Adipose tissue senescence and inflammation in aging is reversed by the young milieu. J Gerontol A Biol Sci Med Sci. 2019;74:1709–1715.
- Hattori K, Naguro I, Runchel C, et al. The roles of ASK family proteins in stress responses and diseases. Cell Commun Signal. 2009;7:9.
- Hayakawa R, Hayakawa T, Takeda K, et al. Therapeutic targets in the ASK1-dependent stress signaling pathways. Proc Jpn Acad Ser B Phys Biol Sci. 2012;88:434–453.
- Cani PD, Amar J, Iglesias MA, et al. Metabolic endotoxemia initiates obesity and insulin resistance. Diabetes. 2007;56:1761–1772.
- Hotamisligil GS, Shargill NS, Spiegelman BM. Adipose expression of tumor necrosis factor-alpha: direct role in obesity-linked insulin resistance. Science. 1993;259:87–91.
- Matsuzawa A, Saegusa K, Noguchi T, et al. ROS-dependent activation of the TRAF6-ASK1-p38 pathway is selectively required for TLR4-mediated innate immunity. Nat Immunol. 2005;6(6):587–592.
- Challa TD, Wueest S, Lucchini FC, et al. Liver ASK1 protects from non-alcoholic fatty liver disease and fibrosis. EMBO Mol Med. 2019;11(10):e10124.
- Haim Y, Blüher M, Konrad D, et al. ASK1 (MAP3K5) is transcriptionally upregulated by E2F1 in adipose tissue in obesity, molecularly defining a human dysmetabolic obese phenotype. Mol Metab. 2017;6(7):725–736.
- Kovsan J, Osnis A, Maissel A, et al. Depot-specific adipocyte cell lines reveal differential drug-induced responses of white adipocytes–relevance for partial lipodystrophy. Am J Physiol Endocrinol Metab. 2009;296:E315–322.
- Ortiz-Montero P, Londono-Vallejo A, Vernot JP, et al. and IL-8 cytokines induce a self- and cross-reinforced senescence/inflammatory milieu strengthening tumorigenic capabilities in the MCF-7 breast cancer cell line. Cell Commun Signal. 2017;15:17.
- Kang W, Shang L, Wang T, et al. Rho-kinase inhibitor Y-27632 downregulates LPS-induced IL-6 and IL-8 production via blocking p38 MAPK and NF-kappaB pathways in human gingival fibroblasts. J Periodontol. 2018;89:883–893.
- Zhao M, Chen X. Effect of lipopolysaccharides on adipogenic potential and premature senescence of adipocyte progenitors. Am J Physiol Endocrinol Metab. 2015;309:E334–344.
- Newsholme P, de Bittencourt PI Jr. The fat cell senescence hypothesis: a mechanism responsible for abrogating the resolution of inflammation in chronic disease. Curr Opin Clin Nutr Metab Care. 2014;17:295–305.
- Chen YW, Harris RA, Hatahet Z, et al. Ablation of XP-V gene causes adipose tissue senescence and metabolic abnormalities. Proc Natl Acad Sci U S A. 2015;112:E4556–4564.
- Minamino T, Orimo M, Shimizu I, et al. A crucial role for adipose tissue p53 in the regulation of insulin resistance. Nat Med. 2009;15(9):1082–1087.
- Cao W, Daniel KW, Robidoux J, et al. p38 mitogen-activated protein kinase is the central regulator of cyclic AMP-dependent transcription of the brown fat uncoupling protein 1 gene. Mol Cell Biol. 2004;24(7):3057–3067.
- Bordicchia M, Liu D, Amri EZ, et al. Cardiac natriuretic peptides act via p38 MAPK to induce the brown fat thermogenic program in mouse and human adipocytes. J Clin Invest. 2012;122:1022–1036.
- Zhang Y, Li R, Meng Y, et al. Irisin stimulates browning of white adipocytes through mitogen-activated protein kinase p38 MAP kinase and ERK MAP kinase signaling. Diabetes. 2014;63(2):514–525.
- Zhang Y, Xie C, Wang H, et al. Irisin exerts dual effects on browning and adipogenesis of human white adipocytes. Am J Physiol Endocrinol Metab. 2016;311:E530–541.
- Matesanz N, Bernardo E, Acín-Pérez R, et al. MKK6 controls T3-mediated browning of white adipose tissue. Nat Commun. 2017;8(1):856.
- Matesanz N, Nikolic I, Leiva M, et al. p38alpha blocks brown adipose tissue thermogenesis through p38delta inhibition. PLoS Biol. 2018;16:e2004455.
- Niu J, Chen T, Han L, et al. Transcriptional activation of the senescence regulator Lsh by E2F1. Mech Ageing Dev. 2011;132(4):180–186.