Lysosomal acid lipase promotes endothelial proliferation in cold-activated adipose tissue

References

• Bartelt A, Heeren J. Adipose tissue browning and metabolic health. Nat Rev Endocrinol. 2014;10(1):24–36.
   PubMed Web of Science ®Google Scholar
• Heine M, Fischer AW, Schlein C, et al. Lipolysis triggers a systemic insulin response essential for efficient energy replenishment of activated brown adipose tissue in mice. Cell Metab. 2018;28(4):644–655 e4.
   PubMed Web of Science ®Google Scholar
• Han J, Lee JE, Jin J, et al. The spatiotemporal development of adipose tissue. Development. 2011;138(22):5027–5037.
   PubMed Web of Science ®Google Scholar
• Luo X, Jia R, Luo XQ, et al. Cold exposure differentially stimulates angiogenesis in BAT and WAT of mice: implication in adrenergic activation. Cell Physiol Biochem. 2017;42(3):974–986.
   PubMedGoogle Scholar
• Tran KV, Gealekman O, Frontini A, et al. The vascular endothelium of the adipose tissue gives rise to both white and brown fat cells. Cell Metab. 2012;15(2):222–229.
   PubMed Web of Science ®Google Scholar
• Xue Y, Petrovic N, Cao R, et al. Hypoxia-independent angiogenesis in adipose tissues during cold acclimation. Cell Metab. 2009;9(1):99–109.
   PubMed Web of Science ®Google Scholar
• Abumrad N, Coburn C, Ibrahimi A. Membrane proteins implicated in long-chain fatty acid uptake by mammalian cells: CD36, FATP and FABPm. Biochim Biophys Acta. 1999;1441(1):4–13.
   PubMed Web of Science ®Google Scholar
• Fischer AW, Cannon B, Nedergaard J. Leptin: is it thermogenic? Endocr Rev. 2020;41(2): 232–260.
   PubMed Web of Science ®Google Scholar
• Hoeke G, Kooijman S, Boon MR, et al. Role of brown fat in lipoprotein metabolism and atherosclerosis. Circ Res. 2016;118(1):173–182.
   PubMed Web of Science ®Google Scholar
• Heeren J, Scheja L. Metabolic-associated fatty liver disease and lipoprotein metabolism. Mol Metab. 2021;50:101238.
   PubMed Web of Science ®Google Scholar
• Bartelt A, Bruns OT, Reimer R, et al. Brown adipose tissue activity controls triglyceride clearance. Nat Med. 2011;17(2):200–205.
   PubMed Web of Science ®Google Scholar
• Khedoe PP, Hoeke G, Kooijman S, et al. Brown adipose tissue takes up plasma triglycerides mostly after lipolysis. J Lipid Res. 2015;56(1):51–59.
   PubMed Web of Science ®Google Scholar
• Schlein C, Talukdar S, Heine M, et al. FGF21 lowers plasma triglycerides by accelerating lipoprotein catabolism in white and brown adipose tissues. Cell Metab. 2016;23(3):441–453.
   PubMed Web of Science ®Google Scholar
• Zechner R, Zimmermann R, Eichmann TO, et al. FAT SIGNALS–lipases and lipolysis in lipid metabolism and signaling. Cell Metab. 2012;15(3):279–291.
   PubMed Web of Science ®Google Scholar
• Ahmadian M, Abbott MJ, Tang T, et al. Desnutrin/ATGL is regulated by AMPK and is required for a brown adipose phenotype. Cell Metab. 2011;13(6):739–748.
   PubMed Web of Science ®Google Scholar
• Haemmerle G, Lass A, Zimmermann R, et al. Defective lipolysis and altered energy metabolism in mice lacking adipose triglyceride lipase. Science. 2006;312(5774):734–737.
   PubMed Web of Science ®Google Scholar
• Schreiber R, Diwoky C, Schoiswohl G, et al. Cold-induced thermogenesis depends on ATGL-mediated lipolysis in cardiac muscle, but not brown adipose tissue. Cell Metab. 2017;26(5):753–763 e7.
   PubMed Web of Science ®Google Scholar
• Shin H, Ma Y, Chanturiya T, et al. Lipolysis in brown adipocytes is not essential for cold-induced thermogenesis in mice. Cell Metab. 2017;26(5):764–777 e5.
   PubMed Web of Science ®Google Scholar
• Osuga J, Ishibashi S, Oka T, et al. Targeted disruption of hormone-sensitive lipase results in male sterility and adipocyte hypertrophy, but not in obesity. Proc Natl Acad Sci U S A. 2000;97(2):787–792.
   PubMed Web of Science ®Google Scholar
• Wang SP, Laurin N, Himms-Hagen J, et al. The adipose tissue phenotype of hormone-sensitive lipase deficiency in mice. Obesity Res. 2001;9(2):119–128.
   PubMedGoogle Scholar
• Chitraju C, Fischer AW, Farese RV Jr., et al. Lipid droplets in brown adipose tissue are dispensable for cold-induced thermogenesis. Cell Rep. 2020;33(5):108348.
   PubMed Web of Science ®Google Scholar
• Fischer AW, Jaeckstein MY, Gottschling K, et al. Lysosomal lipoprotein processing in endothelial cells stimulates adipose tissue thermogenic adaptation. Cell Metab. 2021;33(3):547–564 e7.
   PubMed Web of Science ®Google Scholar
• Sheriff S, Du H, Grabowski GA. Characterization of lysosomal acid lipase by site-directed mutagenesis and heterologous expression. J Biol Chem. 1995;270(46):27766–27772.
   PubMed Web of Science ®Google Scholar
• Cabodevilla AG, Tang S, Lee S, et al. Eruptive xanthoma model reveals endothelial cells internalize and metabolize chylomicrons, leading to extravascular triglyceride accumulation. J Clin Invest. 2021;131(12): e145800.
   PubMed Web of Science ®Google Scholar
• Brundert M, Ewert A, Heeren J, et al. Scavenger receptor class B type I mediates the selective uptake of high-density lipoprotein-associated cholesteryl ester by the liver in mice. Arterioscler Thromb Vasc Biol. 2005;25(1):143–148.
   PubMed Web of Science ®Google Scholar
• Jang E, Robert J, Rohrer L, et al. Transendothelial transport of lipoproteins. Atherosclerosis. 2020;315:111–125.
   PubMed Web of Science ®Google Scholar
• Robert J, Osto E, Von Eckardstein A. The endothelium is both a target and a barrier of HDL’s protective functions. Cells. 2021;10(5):1041.
   PubMed Web of Science ®Google Scholar
• Rohrer L, Ohnsorg PM, Lehner M, et al. High-density lipoprotein transport through aortic endothelial cells involves scavenger receptor BI and ATP-binding cassette transporter G1. Circ Res. 2009;104(10):1142–1150.
   PubMed Web of Science ®Google Scholar
• Kalluri AS, Vellarikkal SK, Edelman ER, et al. Single-Cell analysis of the normal mouse aorta reveals functionally distinct endothelial cell populations. Circulation. 2019;140(2):147–163.
   PubMed Web of Science ®Google Scholar
• Nolan DJ, Ginsberg M, Israely E, et al. Molecular signatures of tissue-specific microvascular endothelial cell heterogeneity in organ maintenance and regeneration. Dev Cell. 2013;26(2):204–219.
   PubMed Web of Science ®Google Scholar
• Beigneux AP, Davies BS, Gin P, et al. Glycosylphosphatidylinositol-anchored high-density lipoprotein-binding protein 1 plays a critical role in the lipolytic processing of chylomicrons. Cell Metab. 2007;5(4):279–291.
   PubMed Web of Science ®Google Scholar
• Davies BS, Beigneux AP, Barnes RH 2nd, et al. GPIHBP1 is responsible for the entry of lipoprotein lipase into capillaries. Cell Metab. 2010;12(1):42–52.
   PubMed Web of Science ®Google Scholar
• Gupta RK, Mepani RJ, Kleiner S, et al. Zfp423 expression identifies committed preadipocytes and localizes to adipose endothelial and perivascular cells. Cell Metab. 2012;15(2):230–239.
   PubMed Web of Science ®Google Scholar
• Tang W, Zeve D, Suh JM, et al. White fat progenitor cells reside in the adipose vasculature. Science. 2008;322(5901):583–586.
   PubMed Web of Science ®Google Scholar
• Min SY, Kady J, Nam M, et al. Human ‘brite/beige’ adipocytes develop from capillary networks, and their implantation improves metabolic homeostasis in mice. Nat Med. 2016;22(3):312–318.
   PubMed Web of Science ®Google Scholar
• Kalucka J, de Rooij L, Goveia J, et al. Single-Cell transcriptome atlas of murine endothelial cells. Cell. 2020;180(4):764–779 e20.
   PubMed Web of Science ®Google Scholar
• Lother A, Bergemann S, Deng L, et al. Cardiac endothelial cell transcriptome. Arterioscler Thromb Vasc Biol. 2018;38(3):566–574.
   PubMed Web of Science ®Google Scholar
• Pericleous M, Kelly C, Wang T, et al. Wolman’s disease and cholesteryl ester storage disorder: the phenotypic spectrum of lysosomal acid lipase deficiency. Lancet Gastroenterol Hepatol. 2017;2(9):670–679.
   PubMed Web of Science ®Google Scholar
• Fischer AW, Schlein C, Cannon B, et al. Intact innervation is essential for diet-induced recruitment of brown adipose tissue. Am J Physiol Endocrinol Metab. 2019;316(3):E487–E503.
   PubMed Web of Science ®Google Scholar
• Fischer AW, Shabalina IG, Mattsson CL, et al. UCP1 inhibition in Cidea-overexpressing mice is physiologically counteracted by brown adipose tissue hyperrecruitment. Am J Physiol Endocrinol Metab. 2017;312(1):E72–E87.
   PubMed Web of Science ®Google Scholar