Adipose tissue aging partially accounts for fat alterations in HIV lipodystrophy

References

• Domingo P, Estrada V, López-Aldeguer J, et al. Fat redistribution syndromes associated with HIV-1 infection and combination antiretroviral therapy. AIDS Rev. 2012;14(2):112–123.
   PubMed Web of Science ®Google Scholar
• Koethe JR, Lagathu C, Lake JE, et al. HIV and antiretroviral therapy-related fat alterations. Nat Rev Dis Prim. 2020;6(1):48.
   PubMed Web of Science ®Google Scholar
• Grunfeld C, Saag M, Cofrancesco JJ, et al. Study of fat redistribution and metabolic change in HIV infection (FRAM). Regional adipose tissue measured by MRI over 5 years in HIV-infected and control participants indicates persistence of HIV-associated lipoatrophy. AIDS. 2012;24(11):1717–1726.
   Web of Science ®Google Scholar
• Arrive E, Viard JP, Salanave B, et al. ANRS CO19 COVERTE and ENNS study groups. Metabolic risk factors in young adults infected with HIV since childhood compared with the general population. PLoS One. 2018;13(11):e0206745.
   PubMed Web of Science ®Google Scholar
• AGEhIV Cohort Study Group, Schouten J, Wit FW, Stolte IG, et al. Cross-sectional comparison of the prevalence of age-associated comorbidities and their risk factors between HIV-infected and uninfected individuals: the age HIV cohort study. Clin Infect Dis. 2014;59(12):1787–1797.
   PubMed Web of Science ®Google Scholar
• Wing EJ. HIV and aging. Int J Infect Dis. 2016;53:61–68.
   PubMed Web of Science ®Google Scholar
• Stout MB, Justice JN, Nicklas BJ, et al. Physiological aging: links among adipose tissue dysfunction, diabetes, and frailty. Physiology. 2017;32(1):: 09–19.
   PubMed Web of Science ®Google Scholar
• Mancuso P, Bouchard B. The impact of aging on adipose function and adipokine synthesis. Front Endocrinol (Lausanne). 2019;10(137): eCollection 2019. 10.3389/fendo.2019.00137.
   Google Scholar
• Kuk JL, Saunders TJ, Davidson LE, et al. Age-related changes in total and regional fat distribution. Ageing Res Rev. 2009;8(4):339–348.
   PubMed Web of Science ®Google Scholar
• Wollina U, Wetzker R, Abdel-Naser MB, et al. Role of adipose tissue in facial aging. Clin Interv Aging. 2017;12:2069–2076.
   PubMed Web of Science ®Google Scholar
• Livshits G, Kalinkovich A. Inflammaging as a common ground for the development and maintenance of sarcopenia, obesity, cardiomyopathy and dysbiosis. Ageing Res Rev. 2019;56:100980.
   PubMed Web of Science ®Google Scholar
• Tchkonia T, Morbeck DE, Von Zglinicki T, et al. Fat tissue, aging, and cellular senescence. Aging Cell. 2010;9(5):667–684.
   PubMed Web of Science ®Google Scholar
• Ghosh AK, Mau T, O’Brien M, et al. Impaired autophagy activity is linked to elevated ER-stress and inflammation in aging adipose tissue. Aging (Albany. NY). 2016;8(10):2525–2537.
   Google Scholar
• Caron-Debarle M, Lagathu C, Boccara F, et al. HIV-associated lipodystrophy: from fat injury to premature agin. Trends Mol Med. 2010;16(5):218–229.
   PubMed Web of Science ®Google Scholar
• Lichtenstein KA, Ward DJ, Moorman AC, et al. HIV Outpatient Study Investigators, Clinical assessment of HIV-associated lipodystrophy in an ambulatory population. AIDS. 2001;15(11):1389–1398.
   PubMedGoogle Scholar
• Cereijo R, Gallego-Escuredo JM, Moure R, et al. The molecular signature of HIV-1-associated lipomatosis reveals differential involvement of brown and beige/brite adipocyte cell lineages. PLoS One. 2015;10(8):e0136571.
   PubMed Web of Science ®Google Scholar
• Hondares E, Gallego-Escuredo JM, Flachs P, et al. Fibroblast growth factor-21 is expressed in neonatal and pheochromocytoma-induced adult human brown adipose tissue. Metabolism. 2014;63(3):312–317.
   PubMed Web of Science ®Google Scholar
• O’Callaghan NJ, Fenech M. A quantitative PCR method for measuring absolute telomere length. Biol Proced Online. 2011;13(1):3.
   PubMed Web of Science ®Google Scholar
• Frühbeck G, Catalán V, Rodríguez A, et al. Adiponectin-leptin ratio is a functional biomarker of adipose tissue inflammation. Nutrients. 2019;11(2):454.
   PubMed Web of Science ®Google Scholar
• Frühbeck G, Catalán V, Rodríguez A, et al. Adiponectin-leptin ratio: a promising index to estimate adipose tissue dysfunction. Relation with obesity-associated cardiometabolic risk. Adipocyte. 2018;7(1):57–62.
   PubMed Web of Science ®Google Scholar
• Kitada M, Koya D. Autophagy in metabolic disease and ageing. Nat Rev Endocrinol. 2021;17(11):647–661.
   PubMed Web of Science ®Google Scholar
• Domingo P, Cabeza MC, Pruvost A, et al. Relationship between HIV/highly active antiretroviral therapy (HAART)-associated lipodystrophy syndrome and stavudine-triphosphate intracellular levels in patients with stavudine-based antiretroviral regimens. Clin Infect Dis. 2010;50(7):1033–1040.
   PubMed Web of Science ®Google Scholar
• Villarroya J, Gallego-Escuredo JM, Delgado-Anglés A, et al. Aging is associated with increased FGF21 levels but unaltered FGF21 responsiveness in adipose tissue. Aging Cell. 2018;17(5):e12822.
   PubMed Web of Science ®Google Scholar
• Giralt M, Domingo P, Guallar JP, et al. HIV-1 infection alters gene expression in adipose tissue, which contributes to HIV-1/HAART-associated lipodystrophy. Antivir Ther. 2006;11(6):729–740.
   PubMed Web of Science ®Google Scholar
• Michaud M, Balardy L, Moulis G, et al. Proinflammatory cytokines, aging, and age-related diseases. J Am Med Dir Assoc. 2013;14(12):877–882.
   PubMed Web of Science ®Google Scholar
• Johnson JA, Albu JB, Engelson ES, et al. Increased systemic and adipose tissue cytokines in patients with HIV-associated lipodystrophy. Am J Physiol Endocrinol Metab. 2004;286(2):49–52.
   Web of Science ®Google Scholar
• Lagathu C, Kim M, Maachi M, et al. HIV antiretroviral treatment alters adipokine expression and insulin sensitivity of adipose tissue in vitro and in vivo. Biochimie. 2005;87(1):65–71. SPEC. ISS.
   PubMed Web of Science ®Google Scholar
• Villarroya F, Domingo P, Giralt M. Lipodystrophy in HIV 1-infected patients: lessons for obesity research. Int J Obes (London). 2007;31(12):1763–1776
   PubMed Web of Science ®Google Scholar
• Villarroya F, Domingo P, Giralt M. Lipodystrophy associated with highly active anti-retroviral therapy for HIV infection: the adipocyte as a target of anti-retroviral-induced mitochondrial toxicity. Trends Pharmacol Sci. 2005;26(2):88–93.
   PubMed Web of Science ®Google Scholar
• Roszkowska-Gancarz M, Jonas M, Owczarz M, et al. Age-related changes of leptin and leptin receptor variants in healthy elderly and long-lived adults. Geriatr Gerontol Int. 2015;15(3):365–371.
   PubMed Web of Science ®Google Scholar
• Lakowa N, Trieu N, Flehmig G, et al. Telomere length differences between subcutaneous and visceral adipose tissue in humans. Biochem Biophys Res Commun. 2015;457(3):426–432.
   PubMed Web of Science ®Google Scholar
• Liu Z, Jin L, Yang JK, et al. The dysfunctional MDM2-p53 axis in adipocytes contributes to aging-related metabolic complications by induction of lipodystrophy. Diabetes. 2018;67(11):2397–2409.
   PubMed Web of Science ®Google Scholar
• Caron M, Auclair M, Donadille B, et al. Human lipodystrophies linked to mutations in A-type lamins and to HIV protease inhibitor therapy are both associated with prelamin A accumulation, oxidative stress and premature cellular senescence. Cell Death Differ. 2007;14(10):1759–1767.
   PubMed Web of Science ®Google Scholar
• Vernochet C, Azoulay S, Duva D, et al. Differential effect of HIV protease inhibitors on adipogenesis: intracellular ritonavir is not sufficient to inhibit differentiation. AIDS. 2003;17(15):2177–2180.
   PubMed Web of Science ®Google Scholar
• Zhang B, MacNaul K, Szalkowski D, et al. Inhibition of adipocyte differentiation by HIV protease inhibitors. J Clin Endocrinol Metab. 1999;84(11):4274–4277.
   PubMed Web of Science ®Google Scholar
• Gallego-Escuredo JM, Gutierrez MM, Diaz-Delfin J, et al. Differential effects of efavirenz and lopinavir/ritonavir on human adipocyte differentiation, gene expression and release of adipokines and pro-inflammatory cytokines. Curr HIV Res. 2010;8(7):545–553.
   PubMed Web of Science ®Google Scholar
• Giralt M, Domingo P, Villarroya F. Adipose tissue biology and HIV-infection. Best Pract Res Clin Endocrinol Metab. 2011;25(3):487–499.
   PubMed Web of Science ®Google Scholar
• Hudgins AD, Tazearslan C, Tare A, et al. Age- and tissue-specific expression of senescence biomarkers in mice. Front Genet. 2018 eCollection 2018; 91: 10.3389/fgene.2018.00059
   PubMedGoogle Scholar
• Rubinsztein DC, Mariño G, Kroemer G. Autophagy and aging. Cell. 2011;146(5):682–695. Cell.
   PubMed Web of Science ®Google Scholar
• Stankov MV, Panayotova-Dimitrova D, Leverkus M, et al. Thymidine analogues suppress autophagy and adipogenesis in cultured adipocytes. Antimicrob Agents Chemother. 2013;57(1):543–551.
   PubMed Web of Science ®Google Scholar