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OncoImmunology Volume 4, 2015 - Issue 7
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Splenectomy restores tumoricidal activity to promote elimination of intraocular tumors

Kyle C McKennaDepartment of Biology; Franciscan University of Steubenville; Steubenville, OHUSACorrespondence[email protected]
Article: e1011516 | Received 09 Jan 2015, Accepted 21 Jan 2015, Published online: 17 Jun 2015

References

  • Streilein JW, Niederkorn JY. Induction of anterior chamber-associated immune deviation requires an intact, functional spleen. J Exp Med 1981; 153:1058-1067; PMID:6788883; http://dx.doi.org/10.1084/jem.153.5.1058
  • Miller MR, Mandell JB, Beatty KM, Harvey SAK, Rizzo MJ, Previte DM, Thorne SH, McKenna KC. Splenectomy promotes indirect elimination of intraocular tumors by CD8+ T cells that is associated with IFNγ-and Fas/FasL-dependent activation of intratumoral macrophages. Cancer Immunol Res 2014; 2:1175-1185; PMID:25248763; http://dx.doi.org/10.1158/2326-6066.CIR-14-0093-T
  • McKenna KC, Previte DM. Influence of CD8+ T regulatory cells on intraocular tumor development. Fron Immunol 2012; 3:303; PMID:NOT_FOUND
  • Streilein JW, Niderkorn JY. Characterization of the suppressor cell(s) responsible for anterior chamber-associated immune deviation (ACAID) induced in BALB/c mice by P815 cells. J Immunol 1985; 184:1381-1387; PMID:3155766
  • McKenna KC, Xu Y, Kapp JA. Injection of soluble antigen into the anterior chamber of the eye induces expansion and functional unresponsiveness of antigen-specific CD8+ T cells. J Immunol 2002; 169:5630-5637; PMID:12421942; http://dx.doi.org/10.4049/jimmunol.169.10.5630
  • McKenna KC, Kapp JA. Accumulation of immunosuppressive CD11b+ myeloid cells correlates with the failure to prevent tumor growth in the anterior chamber of the eye. J Immunol 2006; 177:1599-1608; PMID:16849468; http://dx.doi.org/10.4049/jimmunol.177.3.1599
  • Ksander BR, Streilein JW. Analysis of cytotoxic T cell responses to intracameral allogeneic tumors. Invest Ophthalmol Vis Sci 1989; 30:323-329; PMID:2492486
  • Vicetti Miguel RD, Cherpes TL, Watson LJ, McKenna KC. CTL induction of tumoricidal nitric oxide production by intratumoral macrophages is critical for tumor elimination. J Immunol 2010; 185:6706-6718; PMID:21041723; http://dx.doi.org/10.4049/jimmunol.0903411
  • Hollenbaugh JA, Dutton RW. IFN-gamma regulates donor CD8 T cell expansion, migration, and leads to apoptosis of cells of a solid tumor. J Immunol 2006; 177:3004-3011; PMID:16920936; http://dx.doi.org/10.4049/jimmunol.177.5.3004
  • Ugel S, Peranzoni E, Desantis G, Chioda M, Walter S, Weinschenk T, Ochando JC, Cabrelle A, Mandruzzato S, Bronte V. Immune tolerance to tumor antigens occurs in a specialized environment of the spleen. Cell Rep 2012; 2:628-639; PMID:22959433; http://dx.doi.org/10.1016/j.celrep.2012.08.006

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