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Original Research

Phenotypic analysis of T cells infiltrating colon cancers: Correlations with oncogenetic status

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Article: e1016698 | Received 13 Oct 2014, Accepted 03 Feb 2015, Published online: 15 Jul 2015

References

  • Dunn GP, Old LJ, Schreiber RD. The three Es of cancer immunoediting. Annu Rev Immunol 2004; 22: 329-60; PMID:15032581; http://dx.doi.org/10.1146/annurev.immunol.22.012703.104803
  • Pages F, Berger A, Camus M, Sanchez-Cabo F, Costes A, Molidor R, Mlecnik B, Kirilovsky A, Nilsson M, Damotte D, et al. Effector memory T cells, early metastasis, and survival in colorectal cancer. N Engl J Med 2005; 353: 2654-66; PMID:16371631; http://dx.doi.org/10.1056/NEJMoa051424
  • Brenner H, Kloor M, Pox CP. Colorectal cancer. Lancet 2014; 383: 1490-502; PMID:24225001; http://dx.doi.org/10.1016/S0140-6736(13)61649-9
  • Pino MS, Chung DC. The chromosomal instability pathway in colon cancer. Gastroenterology 2010; 138: 2059-72; PMID:20420946; http://dx.doi.org/10.1053/j.gastro.2009.12.065
  • Manne U, Shanmugam C, Katkoori VR, Bumpers HL, Grizzle WE. Development and progression of colorectal neoplasia. Cancer Biomark 2010; 9: 235-65; PMID:22112479
  • Markowitz SD, Bertagnolli MM. Molecular origins of cancer: Molecular basis of colorectal cancer. N Engl J Med 2009; 361: 2449-60; PMID:20018966; http://dx.doi.org/10.1056/NEJMra0804588
  • Al-Sohaily S, Biankin A, Leong R, Kohonen-Corish M, Warusavitarne J. Molecular pathways in colorectal cancer. J Gastroenterol Hepatol 2012; 27: 1423-31; PMID:22694276; http://dx.doi.org/10.1111/j.1440-1746.2012.07200.x
  • Boland CR, Goel A. Microsatellite instability in colorectal cancer. Gastroenterology 2010; 138: 2073-87 e3; PMID:20420947; http://dx.doi.org/10.1053/j.gastro.2009.12.064
  • Tol J, Nagtegaal ID, Punt CJ. BRAF mutation in metastatic colorectal cancer. N Engl J Med 2009; 361: 98-9; PMID:19571295; http://dx.doi.org/10.1056/NEJMc0904160
  • Douillard JY, Oliner KS, Siena S, Tabernero J, Burkes R, Barugel M, Humblet Y, Bodoky G, Cunningham D, Jassem J, et al. Panitumumab-FOLFOX4 treatment and RAS mutations in colorectal cancer. N Engl J Med 2013; 369: 1023-34; PMID:24024839; http://dx.doi.org/10.1056/NEJMoa1305275
  • Tejpar S, Bertagnolli M, Bosman F, Lenz HJ, Garraway L, Waldman F, Warren R, Bild A, Collins-Brennan D, Hahn H, et al. Prognostic and predictive biomarkers in resected colon cancer: current status and future perspectives for integrating genomics into biomarker discovery. Oncologist 2010; 15: 390-404; PMID:20350999; http://dx.doi.org/10.1634/theoncologist.2009-0233
  • Tougeron D, Fauquembergue E, Latouche JB. [Immune response and colorectal cancer]. Bull Cancer 2013; 100: 283-94; PMID:23501583
  • Allez M, Tieng V, Nakazawa A, Treton X, Pacault V, Dulphy N, Caillat-Zucman S, Paul P, Gornet JM, Douay C, et al. CD4+NKG2D+ T cells in Crohn's disease mediate inflammatory and cytotoxic responses through MICA interactions. Gastroenterology 2007; 132: 2346-58; PMID:17570210; http://dx.doi.org/10.1053/j.gastro.2007.03.025
  • Pariente B, Mocan I, Camus M, Dutertre CA, Ettersperger J, Cattan P, Gornet JM, Dulphy N, Charron D, Lémann M, et al. Activation of the receptor NKG2D leads to production of Th17 cytokines in CD4+ T cells of patients with Crohn's disease. Gastroenterology 2011; 141: 217-26, 26 e1-2; PMID:21600899; http://dx.doi.org/10.1053/j.gastro.2011.03.061
  • Groh V, Smythe K, Dai Z, Spies T. Fas-ligand-mediated paracrine T cell regulation by the receptor NKG2D in tumor immunity. Nat Immunol 2006; 7: 755-62; PMID:16732291; http://dx.doi.org/10.1038/ni1350
  • Nausch N, Cerwenka A. NKG2D ligands in tumor immunity. Oncogene 2008; 27: 5944-58; PMID:18836475; http://dx.doi.org/10.1038/onc.2008.272
  • Fridman WH, Pages F, Sautes-Fridman C, Galon J. The immune contexture in human tumours: impact on clinical outcome. Nat Rev Cancer 2012; 12: 298-306; PMID:22419253; http://dx.doi.org/10.1038/nrc3245
  • Pernot S, Terme M, Voron T, Colussi O, Marcheteau E, Tartour E, Taieb J. Colorectal cancer and immunity: what we know and perspectives. World J Gastroenterol 2014; 20: 3738-50; PMID:24833840; http://dx.doi.org/10.3748/wjg.v20.i14.3738
  • Galon J, Costes A, Sanchez-Cabo F, Kirilovsky A, Mlecnik B, Lagorce-Pagès C, Tosolini M, Camus M, Berger A, Wind P, et al. Type, density, and location of immune cells within human colorectal tumors predict clinical outcome. Science 2006; 313: 1960-4; PMID:17008531; http://dx.doi.org/10.1126/science.1129139
  • Mlecnik B, Tosolini M, Kirilovsky A, Berger A, Bindea G, Meatchi T, Bruneval P, Trajanoski Z, Fridman WH, Pagès F, et al. Histopathologic-based prognostic factors of colorectal cancers are associated with the state of the local immune reaction. J Clin Oncol 2011; 29: 610-8; PMID:21245428; http://dx.doi.org/10.1200/JCO.2010.30.5425
  • Maccalli C, Pende D, Castelli C, Mingari MC, Robbins PF, Parmiani G. NKG2D engagement of colorectal cancer-specific T cells strengthens TCR-mediated antigen stimulation and elicits TCR independent anti-tumor activity. Eur J Immunol 2003; 33: 2033-43; PMID:12884870; http://dx.doi.org/10.1002/eji.200323909
  • McGilvray RW, Eagle RA, Watson NF, Al-Attar A, Ball G, Jafferji I, Trowsdale J, Durrant LG. NKG2D ligand expression in human colorectal cancer reveals associations with prognosis and evidence for immunoediting. Clin Cancer Res 2009; 15: 6993-7002; PMID:19861434; http://dx.doi.org/10.1158/1078-0432.CCR-09-0991
  • Salama P, Phillips M, Grieu F, Morris M, Zeps N, Joseph D, Platell C, Iacopetta B. Tumor-infiltrating FOXP3+ T regulatory cells show strong prognostic significance in colorectal cancer. J Clin Oncol 2009; 27: 186-92; PMID:19064967; http://dx.doi.org/10.1200/JCO.2008.18.7229
  • Whiteside TL. Regulatory T cell subsets in human cancer: are they regulating for or against tumor progression? Cancer Immunol Immunother 2014; 63: 67-72; PMID:24213679; http://dx.doi.org/10.1007/s00262-013-1490-y
  • Hanahan D, Weinberg RA. The hallmarks of cancer. Cell 2000; 100: 57-70; PMID:10647931; http://dx.doi.org/10.1016/S0092-8674(00)81683-9
  • Hanahan D, Weinberg RA. Hallmarks of cancer: the next generation. Cell 2011; 144: 646-74; PMID:21376230; http://dx.doi.org/10.1016/j.cell.2011.02.013
  • Van Cutsem E, Kohne CH, Hitre E, Zaluski J, Chang Chien CR, Makhson A, D'Haens G, Pintér T, Lim R, Bodoky G, et al. Cetuximab and chemotherapy as initial treatment for metastatic colorectal cancer. N Engl J Med 2009; 360: 1408-17; PMID:19339720; http://dx.doi.org/10.1056/NEJMoa0805019
  • Liao X, Lochhead P, Nishihara R, Morikawa T, Kuchiba A, Yamauchi M, Imamura Y, Qian ZR, Baba Y, Shima K, et al. Aspirin use, tumor PIK3CA mutation, and colorectal-cancer survival. N Engl J Med 2012; 367: 1596-606; PMID:23094721; http://dx.doi.org/10.1056/NEJMoa1207756
  • Lievre A, Bachet JB, Boige V, Cayre A, Le Corre D, Buc E, Ychou M, Bouché O, Landi B, Louvet C, André T, et al. KRAS mutations as an independent prognostic factor in patients with advanced colorectal cancer treated with cetuximab. J Clin Oncol 2008; 26: 374-9; PMID:18202412; http://dx.doi.org/10.1200/JCO.2007.12.5906
  • Benlloch S, Paya A, Alenda C, Bessa X, Andreu M, Jover R, Castells A, Llor X, Aranda FI, Massutí B. Detection of BRAF V600E mutation in colorectal cancer: comparison of automatic sequencing and real-time chemistry methodology. J Mol Diagn 2006; 8: 540-3; PMID:17065421; http://dx.doi.org/10.2353/jmoldx.2006.060070
  • Pawlik TM, Raut CP, Rodriguez-Bigas MA. Colorectal carcinogenesis: MSI-H versus MSI-L. Dis Markers 2004; 20: 199-206; PMID:15528785; http://dx.doi.org/10.1155/2004/368680
  • Flaman JM, Frebourg T, Moreau V, Charbonnier F, Martin C, Chappuis P, Sappino AP, Limacher IM, Bron L, Benhattar J, et al. A simple p53 functional assay for screening cell lines, blood, and tumors. Proc Natl Acad Sci U S A 1995; 92: 3963-7; PMID:7732013; http://dx.doi.org/10.1073/pnas.92.9.3963

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