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Original Research

Phase Ib study of poly-epitope peptide vaccination to thymidylate synthase (TSPP) and GOLFIG chemo-immunotherapy for treatment of metastatic colorectal cancer patients

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Article: e1101205 | Received 05 Aug 2015, Accepted 23 Sep 2015, Published online: 08 Apr 2016

References

  • Franks HA, Wang Q, Patel PM. New anticancer immunotherapies. Anticancer Res 2012 Jul; 32(7):2439-53; PMID:22753700
  • Mellstedt H, Vansteenkiste J, Thatcher N. Vaccines for the treatment of non-small cell lung cancer: investigational approaches and clinical experience. Lung Cancer 2011 Jul; 73(1):11-7 Epub 2011 Apr 6. Review; PMID:21474197; http://dx.doi.org/10.1016/j.lungcan.2011.02.023
  • Buonaguro L, Petrizzo A, Tornesello ML, Buonaguro FM. Translating tumor antigens into cancer vaccines. Clin Vaccine Immunol 2011 Jan; 18(1):23-34 Epub 2010 Nov 3. Review; PMID:21048000; PMID:24316553; http://dx.doi.org/10.1128/CVI.00286-10
  • Baxevanis CN, Perez SA, Papamichail M. Cancer immunotherapy. Crit Rev Clin Lab Sci 2009; 46(4):167-89 Review; PMID:19650714; http://dx.doi.org/10.1080/10408360902937809
  • Mocellin S, Pilati P, Nitti D. Peptide-based anticancer vaccines: recent advances and future perspectives. Curr Med Chem 2009; 16(36):4779-96 Review; PMID:19929787; http://dx.doi.org/10.2174/092986709789909648
  • Scardino A, Alimandi M, Correale P, Smith SG, Bei R, Firat H, Faure O, Graf-Dubois S, Marrocco J, Chouaib S et al. A polyepitope DNA vaccine targeted to HER2/ErbB-2 elicits a broad range of human and murine CTL effectors to protect against tumor challenge. Cancer Res 2007 Jul 15; 67(14):7028-36; PMID:17638916; http://dx.doi.org/10.1158/0008-5472.CAN-06-3998
  • Francini G, Scardino A, Kosmatopoulos K, Lemonnier FA, Campoccia G, Sabatino M, Pozzessere D, Petrioli R, Lozzi L, Neri P et al. High-affinity HLA-A(*)02.01 peptides from parathyroid hormone-related protein generate in vitro and in vivo antitumor CTL response without autoimmune side effects. J Immunol 2002 Nov 1; 169(9):4840-9; PMID:12391194; http://dx.doi.org/10.4049/jimmunol.169.9.4840
  • Correale P, Sabatino M, Cusi MG, Micheli L, Nencini C, Pozzessere D, Petrioli R, Aquino A, De Vecchis L, Turriziani M et al. In vitro generation of cytotoxic T lymphocytes against HLA-A2.1-restricted peptides derived from human thymidylate synthase. J Chemother 2001 Oct; 13(5):519-26; PMID:11760216; http://dx.doi.org/10.1179/joc.2001.13.5.519
  • Correale P, Del Vecchio MT, Di Genova G, Savellini GG, La Placa M, Terrosi C, Vestri M, Urso R, Lemonnier F, Aquino A et al. Five-fluorouracil-based chemotherapy enhances the antitumor activity of a thymidylate synthase-directed polyepitopic peptide vaccine. J Natl Cancer Inst 2005 Oct 5; 97(19):1437-45; PMID:16204693; http://dx.doi.org/10.1093/jnci/dji188
  • Rustum YM. Thymidylate synthase: a critical target in cancer therapy? Front Biosci 2004 Sep 1; 9:2467-73. Review; PMID:15353299; http://dx.doi.org/10.2741/1408
  • Van Der Wilt CL, Peters GJ. New targets for pyrimidine antimetabolites in the treatment of solid tumours. One: Thymidylate synthase. Pharm World Sci 1994 Apr 15; 16(2):84-103; PMID:7518280; http://dx.doi.org/10.1007/BF01880660
  • Ligabue A, Marverti G, Liebl U, Myllykallio H. Transcriptional activation and cell cycle block are the keys for 5-fluorouracil induced up-regulation of human thymidylate synthase expression. PLoS One 2012; 7(10):e47318. Epub 2012 Oct 9; PMID:23056627; http://dx.doi.org/10.1371/journal.pone.0047318
  • Correale P, Del Vecchio MT, La Placa M, Montagnani F, Di Genova G, Gori Savellini G, Terrosi C, Mannucci S, Giorgi G, Francini G et al. Chemotherapeutic drugs may be used to enhance the killing efficacy of human tumor antigen peptide specific CTLs. J Immunother 2008; 31:132-47; PMID:18481383; http://dx.doi.org/10.1097/CJI.0b013e31815b69c8
  • Correale P, Cusi MG, Del Vecchio MT, Aquino A, Prete SP, Tsang KY, Micheli L, Nencini C, La Placa M, Montagnani F et al. Dendritic cell-mediated cross-presentation of antigens derived from colon carcinoma cells exposed to a highly cytotoxic multidrug regimen with gemcitabine, oxaliplatin, 5-fluorouracil, and leucovorin, elicits a powerful human antigen-specific CTL response with antitumor activity in vitro. J Immunol 2005 Jul 15; 175(2):820-8; PMID:16002679; http://dx.doi.org/10.4049/jimmunol.175.2.820
  • Correale P, Cusi MG, Tsang KY, Del Vecchio MT, Marsili S, Placa ML, Intrivici C, Aquino A, Micheli L, Nencini C et al. Chemo-immunotherapy of metastatic colorectal carcinoma with gemcitabine plus FOLFOX 4 followed by subcutaneous granulocyte macrophage colony-stimulating factor and interleukin-2 induces strong immunologic and antitumor activity in metastatic colon cancer patients. J Clin Oncol 2005 Dec 10; 23(35):8950-8. Epub 2005 Aug 1; PMID:16061910; http://dx.doi.org/10.1200/JCO.2005.12.147
  • Correale P, Aquino A, Giuliani A, Pellegrini M, Micheli L, Cusi MG, Nencini C, Petrioli R, Prete SP, De Vecchis L et al. Treatment of colon and breast carcinoma cells with 5-Fluorouracil enhances expression of carcinoembryonic antigen and to HLA-A(*)02.01 restricted, CEA-peptide-specific cytotoxic T cells in vitro. Int J Cancer 2003 Apr 10; 104(4):437-45; PMID:12584740; http://dx.doi.org/10.1002/ijc.10969
  • Correale P, Marra M, Remondo C, Migali C, Arcuri FP, Carducci A, Loiacono L, Abruzzese A, Tagliaferri P, Caraglia M. Cytotoxic drugs up-regulate Epidermal Growth Factor Receptor (EGFR) expression in colon cancer cells and enhance their susceptibility to EGFR-targeted Antibody-Dependent-Cell-mediated-Cytotoxicity (ADCC). Eur J Cancer Jun 2010; 46(9):1703-11, IF= 4.454; PMID:20399639; http://dx.doi.org/10.1016/j.ejca.2010.03.005
  • Correale P, Botta C, Cusi MG, Del Vecchio MT, De Santi M, Gori Savellini G, Bestoso E, Apollinari S, Ginanneschi C, Mannucci S et al. Cetuximab −/− chemotherapy enhances dendritic cell-mediated phagocytosis of colon cancer cells and ignites a highly efficient colon cancer antigen-specific cytotoxic T-cell response in vitro. Int J Cancer 2012 Apr 1; 130(7):1577-89 Epub 2011 Aug 16; PMID:21618510; http://dx.doi.org/10.1002/ijc.26181
  • Botta C, Correale P. Cetuximab-based immune-chemotherapy enhances antigen presentation and cytotoxic T cell activity in colorectal cancer patients. J Immunotherapy 2012 Jun; 35(5):440-7; PMID:22576349; http://dx.doi.org/10.1097/CJI.0b013e31825943aa
  • Correale P, TagliaferriP, Fioravanti A, Del VecchioMT, RemondoC, Montagnani F, RotundoMS, Ginanneschi C, Martellucci I, Francini E et al. Immunity feedback and clinical outcome in colon cancer patients undergoing chemo-immunotherapy with Gemcitabine + FOLFOX followed by subcutaneous Granulocyte Macrophage-Colony Stimulating Factor and Aldesleukine (GOLFIG-1 trial). Clin Cancer Res 2008; 14(13):4192-9; PMID:18593999; http://dx.doi.org/10.1158/1078-0432.CCR-07-5278
  • Correale P, Botta C, Rotundo MS, Guglielmo A, Conca R, Licchetta A, Pastina P, Bestoso E, Ciliberto D, Cusi MG et al. Immune-boost with gemcitabine, oxaliplatin, levofolinate, 5-flurouracil, granulocyte/macrophage colony-stimulating-factor (GM-CSF) and aldesleukine (GOLFIG) enhances progression-free and overall-survival over FOLFOX chemotherapy in metastatic colorectal cancer patients: GOLFIG-2 multi-centric open label randomized phase III trial. J Immunother 2014 Jan; 37(1):26-35; PMID:24316553; http://dx.doi.org/10.1097/CJI.0000000000000004
  • Cusi MG, Botta C, Pastina P, Rossetti MG, Dreassi E, Guidelli GM, Fioravanti A, Martino EC, Gandolfo C, Pagliuchi M, Basile A, Carbone SF, Ricci V, Micheli L, Tassone P, Tagliaferri P, Pirtoli L, Correale P. Phase I trial of thymidylate synthase poly-epitope peptide (TSPP) vaccine in advanced cancer patients. Cancer Immunol Immunother. 2015 Sep; 64(9):1159-73; PMID:26031574; http://dx.doi.org/10.1007/s00262-015-1711-7.
  • CorrealeP, Campoccia G, Tsang KY, Micheli L, CusiG, Sabatino M, BruniG, SestiniS, PetrioliR, Pozzessere D et al. Recruitment of dendritic cells and enhanced antigen specific immune-reactivity in cancer patients treated with hrGM-CSF (molgramostim) and hr IL-2: results from a Phase Ib Clinical Trial. Eur J Cancer 2001; 37 (7):892-902; PMID:11313178; http://dx.doi.org/10.1016/S0959-8049(01)00063-6
  • Czerkinsky CC, Nilsson LA, Nygren H, Ouchterlony O, Tarkowski A. A solid-phase enzyme-linked immunospot (ELISPOT) assay for enumeration of specific antibody-secreting cells. J Immunol Met 1983; 65 (1-2):109-21; PMID:6361139; http://dx.doi.org/10.1016/0022-1759(83)90308-3
  • Moodie Z, Price L, Gouttefangeas C, Mander A, Janetzki S, Lower M, Welters MJ, Ottensmeier C, van der Burg SH, Britten CM. Response definition criteria for ELISPOT assays revisited. Cancer Immunol Immunother 2010; 59 (10):1489-501; PMID:20549207; http://dx.doi.org/10.1007/s00262-010-0875-4
  • Correale P, Bertoldi I, Miracco C, FioravantiA, Francini G. Occurrence of discoid lupus erythematousus in a good responder colon carcinoma patient receiving chemo-immunotherapy. J Chemother. 2008 Apr; 20(2):278-81. IF= 0.922; PMID:18467257; http://dx.doi.org/10.1179/joc.2008.20.2.278
  • Mantovani A, Allavena P, Sica A, Balkwill F. Cancer-related inflammation. Nature 2008; 454 (7203):436-44; PMID:18650914; http://dx.doi.org/10.1038/nature07205
  • Predina J, Eruslanov E, Judy B, Kapoor V, Cheng G, Wang LC, Sun J, Moon EK, Fridlender ZG, Albelda S et al. Changes in the local tumor microenvironment in recurrent cancers may explain the failure of vaccines after surgery. Proc Natl Acad Sci USA 2013; 110 (5):E415-424; PMID:23271806; http://dx.doi.org/10.1073/pnas.1211850110
  • Botta C, Barbieri V, Ciliberto D, Rossi A, Rocco D, Addeo R, Staropoli N, Pastina P, Marvaso G, Martellucci I et al. Systemic inflammatory status at baseline predicts bevacizumab benefit in advanced non-small cell lung cancer patients. Cancer Biol therapy 2013; 14 (6):469-75; PMID:23760488; http://dx.doi.org/10.4161/cbt.24425
  • Jafri SH, Shi R, Mills G. Advance lung cancer inflammation index (ALI) at diagnosis is a prognostic marker in patients with metastatic non-small cell lung cancer (NSCLC): a retrospective review. BMC cancer 2013; 13:158; PMID:23530866; http://dx.doi.org/10.1186/1471-2407-13-158
  • Templeton AJ, McNamara MG, Seruga B, Vera-Badillo FE, Aneja P, Ocana A, Leibowitz-Amit R, Sonpavde G, Knox JJ, Tran B et al. Prognostic role of neutrophil-to-lymphocyte ratio in solid tumors: a systematic review and meta-analysis. J Natl Cancer Inst 2014; 106 (6):dju124; PMID:24875653; http://dx.doi.org/10.1093/jnci/dju124
  • Sakaguchi S, Yamaguchi T, Nomura T, Ono M. Regulatory T cells and immune tolerance. Cell 2008; 133 (5):775-87; PMID:18510923; http://dx.doi.org/10.1016/j.cell.2008.05.009
  • Sallusto F, Lanzavecchia A. Heterogeneity of CD4+ memory T cells: functional modules for tailored immunity. Eur J Immunol 2009; 39 (8):2076-82; PMID:19672903; http://dx.doi.org/10.1002/eji.200939722
  • Forster R, Schubel A, Breitfeld D, Kremmer E, Renner-Muller I, Wolf E, Lipp M. CCR7 coordinates the primary immune response by establishing functional microenvironments in secondary lymphoid organs. Cell 1999; 99 (1):23-33; PMID:10520991; http://dx.doi.org/10.1016/S0092-8674(00)80059-8
  • Sallusto F, Geginat J, Lanzavecchia A. Central memory and effector memory T cell subsets: function, generation, and maintenance. Annu Rev Immunol 2004; 22:745-63; PMID:15032595; http://dx.doi.org/10.1146/annurev.immunol.22.012703.104702
  • Correale P, Rotundo MS, Botta C, Del Vecchio MT, Ginanneschi C, Licchetta A, Conca R, Apollinari S, De Luca F, Tassone P et al. Tumor infiltration by T lymphocytes expressing chemokine receptor 7 (CCR7) is predictive of favorable outcome in patients with advanced colorectal carcinoma. Clin Cancer Res 2012; 18 (3):850-7; PMID:22142823; http://dx.doi.org/10.1158/1078-0432.CCR-10-3186
  • Correale P, Rotundo MS, Botta C, Del Vecchio MT, Tassone P, Tagliaferri P. Tumor infiltration by chemokine receptor 7 (CCR7)(+) T-lymphocytes is a favorable prognostic factor in metastatic colorectal cancer. Oncoimmunol 2012; 1 (4):531-2; PMID:22754775; http://dx.doi.org/10.4161/onci.19404
  • Terrazzano G, Carbone E. NK cells blur the frontier between innate and acquired immunity. Front Immunol 2012; 3:400; PMID:23293641; http://dx.doi.org/10.3389/fimmu.2012.00400

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