Tumor cell-derived microparticles polarize M2 tumor-associated macrophages for tumor progression

References

• Pollard JW. Tumour-educated macrophages promote tumour progression and metastasis. Nat Rev Cancer 2004; 4:71-8; PMID:14708027; http://dx.doi.org/10.1038/nrc1256
   PubMed Web of Science ®Google Scholar
• Ruffell B, Coussens LM. Macrophages and therapeutic resistance in cancer. Cancer Cell 2015; 27:462-72; PMID:25858805; http://dx.doi.org/10.1016/j.ccell.2015.02.015
   PubMed Web of Science ®Google Scholar
• De Palma M, Lewis CE. Macrophage regulation of tumor responses to anticancer therapies. Cancer Cell 2013; 23:277-86; PMID:23518347; http://dx.doi.org/10.1016/j.ccr.2013.02.013
   PubMed Web of Science ®Google Scholar
• Jinushi M, Chiba S, Yoshiyama H, Masutomi K, Kinoshita I, Dosaka-Akita H, Yagita H, Takaoka A, Tahara H. Tumor-associated macrophages regulate tumorigenicity and anticancer drug responses of cancer stem/initiating cells. Proc Natl Acad Sci U S A 2011; 108:12425-30; PMID:21746895; http://dx.doi.org/10.1073/pnas.1106645108
   PubMed Web of Science ®Google Scholar
• Okuda H, Kobayashi A, Xia B, Watabe M, Pai SK, Hirota S, Xing F, Liu W, Pandey PR, Fukuda K et al. Hyaluronan synthase HAS2 promotes tumor progression in bone by stimulating the interaction of breast cancer stem-like cells with macrophages and stromal cells. Cancer Res 2012; 72:537-47; PMID:22113945; http://dx.doi.org/10.1158/0008-5472.CAN-11-1678
   PubMed Web of Science ®Google Scholar
• Hagemann T, Lawrence T, McNeish I, Charles KA, Kulbe H, Thompson RG, Robinson SC, Balkwill FR. “Re-educating” tumor-associated macrophages by targeting NF-kappaB. J Exp Med 2008; 205:1261-8; PMID:18490490; http://dx.doi.org/10.1084/jem.20080108
   PubMed Web of Science ®Google Scholar
• Zhang W, Zhu XD, Sun HC, Xiong YQ, Zhuang PY, Xu HX, Kong LQ, Wang L, Wu WZ, Tang ZY. Depletion of tumor-associated macrophages enhances the effect of sorafenib in metastatic liver cancer models by antimetastatic and antiangiogenic effects. Clin Cancer Res 2010; 16:3420-30; PMID:20570927; http://dx.doi.org/10.1158/1078-0432.CCR-09-2904
   PubMed Web of Science ®Google Scholar
• Germano G, Frapolli R, Belgiovine C, Anselmo A, Pesce S, Liguori M, Erba E, Uboldi S, Zucchetti M, Pasqualini F et al. Role of macrophage targeting in the antitumor activity of trabectedin. Cancer Cell 2013; 23:249-62; PMID:23410977; http://dx.doi.org/10.1016/j.ccr.2013.01.008
   PubMed Web of Science ®Google Scholar
• Ong SM, Tan YC, Beretta O, Jiang D, Yeap WH, Tai JJ, Wong WC, Yang H, Schwarz H, Lim KH et al. Macrophages in human colorectal cancer are pro-inflammatory and prime T cells towards an anti-tumour type-1 inflammatory response. Eur J Immunol 2012; 42:89-100; PMID:22009685; http://dx.doi.org/10.1002/eji.201141825
   PubMed Web of Science ®Google Scholar
• Qin Z, Blankenstein T. CD4+ T cell–mediated tumor rejection involves inhibition of angiogenesis that is dependent on IFN gamma receptor expression by nonhematopoietic cells. Immunity 2000; 12:677-86; PMID:10894167; http://dx.doi.org/10.1016/S1074-7613(00)80218-6
   PubMed Web of Science ®Google Scholar
• Sica A, Mantovani A. Macrophage plasticity and polarization: in vivo veritas. J Clin Invest 2012; 122:787-95; PMID:22378047; http://dx.doi.org/10.1172/JCI59643
   PubMed Web of Science ®Google Scholar
• Colegio OR, Chu NQ, Szabo AL, Chu T, Rhebergen AM, Jairam V, Cyrus N, Brokowski CE, Eisenbarth SC, Phillips GM et al. Functional polarization of tumour-associated macrophages by tumour-derived lactic acid. Nature 2014; 513:559-63; PMID:25043024; http://dx.doi.org/10.1038/nature13490
   PubMed Web of Science ®Google Scholar
• Mause SF, Weber C. Microparticles: protagonists of a novel communication network for intercellular information exchange. Circ Res 2010; 107:1047-57; PMID:21030722; http://dx.doi.org/10.1161/CIRCRESAHA.110.226456
   PubMed Web of Science ®Google Scholar
• Tual-Chalot S, Leonetti D, Andriantsitohaina R, Martinez MC. Microvesicles: intercellular vectors of biological messages. Mol Interv 2011; 11:88-94; PMID:21540467; http://dx.doi.org/10.1124/mi.11.2.5
   PubMedGoogle Scholar
• Thery C, Ostrowski M, Segura E. Membrane vesicles as conveyors of immune responses. Nat Rev Immunol 2009; 9:581-93; PMID:19498381; http://dx.doi.org/10.1038/nri2567
   PubMed Web of Science ®Google Scholar
• Li D, Jia H, Zhang H, Lv M, Liu J, Zhang Y, Huang T, Huang B. TLR4 signaling induces the release of microparticles by tumor cells that regulate inflammatory cytokine IL-6 of macrophages via microRNA let-7b. Oncoimmunology 2012; 1:687-93; PMID:22934260; http://dx.doi.org/10.4161/onci.19854
   PubMed Web of Science ®Google Scholar
• Tang K, Zhang Y, Zhang H, Xu P, Liu J, Ma J, Lv M, Li D, Katirai F, Shen GX et al. Delivery of chemotherapeutic drugs in tumour cell-derived microparticles. Nat Commun 2012; 3:1282; PMID:23250412; http://dx.doi.org/10.1038/ncomms2282
   PubMed Web of Science ®Google Scholar
• Hiwatashi K, Tamiya T, Hasegawa E, Fukaya T, Hashimoto M, Kakoi K, Kashiwagi I, Kimura A, Inoue N, Morita R et al. Suppression of SOCS3 in macrophages prevents cancer metastasis by modifying macrophage phase and MCP2/CCL8 induction. Cancer Lett 2011; 308:172-80; PMID:21624767; http://dx.doi.org/10.1016/j.canlet.2011.04.024
   PubMed Web of Science ®Google Scholar
• Jenkins SJ, Ruckerl D, Cook PC, Jones LH, Finkelman FD, van Rooijen N, MacDonald AS, Allen JE. Local macrophage proliferation, rather than recruitment from the blood, is a signature of TH2 inflammation. Science 2011; 332:1284-8; PMID:21566158; http://dx.doi.org/10.1126/science.1204351
   PubMed Web of Science ®Google Scholar
• Sieweke MH, Allen JE. Beyond stem cells: self-renewal of differentiated macrophages. Science 2013; 342:1242974; PMID:24264994; http://dx.doi.org/10.1126/science.1242974
   PubMed Web of Science ®Google Scholar
• Medema JP. Cancer stem cells: the challenges ahead. Nat Cell Biol 2013; 15:338-44; PMID:23548926; http://dx.doi.org/10.1038/ncb2717
   PubMed Web of Science ®Google Scholar
• Liu J, Tan Y, Zhang H, Zhang Y, Xu P, Chen J, Poh YC, Tang K, Wang N, Huang B. Soft fibrin gels promote selection and growth of tumorigenic cells. Nat Mater 2012; 11:734-41; PMID:22751180; http://dx.doi.org/10.1038/nmat3361
   PubMed Web of Science ®Google Scholar
• Tan Y, Tajik A, Chen J, Jia Q, Chowdhury F, Wang L, Chen J, Zhang S, Hong Y, Yi H et al. Matrix softness regulates plasticity of tumour-repopulating cells via H3K9 demethylation and Sox2 expression. Nat Commun 2014; 5:4619; PMID:25099074; http://dx.doi.org/10.1038/ncomms5619
   PubMed Web of Science ®Google Scholar
• Santini R, Pietrobono S, Pandolfi S, Montagnani V, D'Amico M, Penachioni JY, Vinci MC, Borgognoni L, Stecca B. SOX2 regulates self-renewal and tumorigenicity of human melanoma-initiating cells. Oncogene 2014; 33:4697-708; PMID:24681955; http://dx.doi.org/10.1038/onc.2014.71
   PubMed Web of Science ®Google Scholar
• Fan QM, Jing YY, Yu GF, Kou XR, Ye F, Gao L, Li R, Zhao QD, Yang Y, Lu ZH et al. Tumor-associated macrophages promote cancer stem cell-like properties via transforming growth factor-beta1-induced epithelial-mesenchymal transition in hepatocellular carcinoma. Cancer Lett 2014; 352:160-8; PMID:24892648; http://dx.doi.org/10.1016/j.canlet.2014.05.008
   PubMed Web of Science ®Google Scholar
• Sica A, Bronte V. Altered macrophage differentiation and immune dysfunction in tumor development. J Clin Invest 2007; 117:1155-66; PMID:17476345; http://dx.doi.org/10.1172/JCI31422
   PubMed Web of Science ®Google Scholar
• Zhang H, Tang K, Zhang Y, Ma R, Ma J, Li Y, Luo S, Liang X, Ji T, Gu Z et al. Cell-free tumor microparticle vaccines stimulate dendritic cells via cGAS/STING signaling. Cancer Immunol Res 2015; 3:196-205; PMID:25477253; http://dx.doi.org/10.1158/2326-6066.CIR-14-0177
   PubMed Web of Science ®Google Scholar
• Chen H, Sun H, You F, Sun W, Zhou X, Chen L, Yang J, Wang Y, Tang H, Guan Y et al. Activation of STAT6 by STING is critical for antiviral innate immunity. Cell 2011; 147:436-46; PMID:22000020; http://dx.doi.org/10.1016/j.cell.2011.09.022
   PubMed Web of Science ®Google Scholar
• Qin Z. The use of THP-1 cells as a model for mimicking the function and regulation of monocytes and macrophages in the vasculature. Atherosclerosis 2012; 221:2-11; PMID:21978918; http://dx.doi.org/10.1016/j.atherosclerosis.2011.09.003
   PubMed Web of Science ®Google Scholar
• Daniel L, Fakhouri F, Joly D, Mouthon L, Nusbaum P, Grunfeld JP, Schifferli J, Guillevin L, Lesavre P, Halbwachs-Mecarelli L. Increase of circulating neutrophil and platelet microparticles during acute vasculitis and hemodialysis. Kidney Int 2006; 69:1416-23; PMID:16531979; http://dx.doi.org/10.1038/sj.ki.5000306
   PubMed Web of Science ®Google Scholar
• Pitanga TN, de Aragao Franca L, Rocha VC, Meirelles T, Borges VM, Goncalves MS, Pontes-de-Carvalho LC, Noronha-Dutra AA, dos-Santos WL. Neutrophil-derived microparticles induce myeloperoxidase-mediated damage of vascular endothelial cells. BMC Cell Biol 2014; 15:21; PMID:24915973; http://dx.doi.org/10.1186/1471-2121-15-21
   PubMed Web of Science ®Google Scholar
• Siljander P, Carpen O, Lassila R. Platelet-derived microparticles associate with fibrin during thrombosis. Blood 1996; 87:4651-63; PMID:8639834
   PubMed Web of Science ®Google Scholar
• Kanazawa S, Nomura S, Kuwana M, Muramatsu M, Yamaguchi K, Fukuhara S. Monocyte-derived microparticles may be a sign of vascular complication in patients with lung cancer. Lung Cancer 2003; 39:145-9; PMID:12581566; http://dx.doi.org/10.1016/S0169-5002(02)00441-5
   PubMed Web of Science ®Google Scholar
• Kim HK, Song KS, Park YS, Kang YH, Lee YJ, Lee KR, Kim HK, Ryu KW, Bae JM, Kim S. Elevated levels of circulating platelet microparticles, VEGF, IL-6 and RANTES in patients with gastric cancer: possible role of a metastasis predictor. Eur J Cancer 2003; 39:184-91; PMID:12509950; http://dx.doi.org/10.1016/S0959-8049(02)00596-8
   PubMed Web of Science ®Google Scholar
• Huang B, Zhao J, Unkeless JC, Feng ZH, Xiong H. TLR signaling by tumor and immune cells: a double-edged sword. Oncogene 2008; 27:218-24; PMID:18176603; http://dx.doi.org/10.1038/sj.onc.1210904
   PubMed Web of Science ®Google Scholar
• Settembre C, Fraldi A, Medina DL, Ballabio A. Signals from the lysosome: a control centre for cellular clearance and energy metabolism. Nat Rev Mol Cell Biol 2013; 14:283-96; PMID:23609508; http://dx.doi.org/10.1038/nrm3565
   PubMed Web of Science ®Google Scholar
• Settembre C, Ballabio A. Lysosome: regulator of lipid degradation pathways. Trends Cell Biol 2014; 24:743-50; PMID:25061009; http://dx.doi.org/10.1016/j.tcb.2014.06.006
   PubMed Web of Science ®Google Scholar
• Zhitomirsky B, Assaraf YG. Lysosomal sequestration of hydrophobic weak base chemotherapeutics triggers lysosomal biogenesis and lysosome-dependent cancer multidrug resistance. Oncotarget 2015; 6:1143-56; PMID:25544758; http://dx.doi.org/10.18632/oncotarget.2732
   PubMed Web of Science ®Google Scholar
• Groth-Pedersen L, Jaattela M. Combating apoptosis and multidrug resistant cancers by targeting lysosomes. Cancer Lett 2013; 332:265-74; PMID:20598437; http://dx.doi.org/10.1016/j.canlet.2010.05.021
   PubMed Web of Science ®Google Scholar
• Winchester B. Lysosomal metabolism of glycoproteins. Glycobiology 2005; 15:1R-15R; PMID:15647514; http://dx.doi.org/10.1093/glycob/cwi041
   PubMed Web of Science ®Google Scholar
• Schneider DL. ATP-dependent acidification of intact and disrupted lysosomes. Evidence for an ATP-driven proton pump. J Biol Chem 1981; 256:3858-64; PMID:7217060
   PubMed Web of Science ®Google Scholar
• Mindell JA. Lysosomal acidification mechanisms. Annu Rev Physiol 2012; 74:69-86; PMID:22335796; http://dx.doi.org/10.1146/annurev-physiol-012110-142317
   PubMed Web of Science ®Google Scholar
• van Furth R, Cohn ZA. The origin and kinetics of mononuclear phagocytes. J Exp Med 1968; 128:415-35; PMID:5666958; http://dx.doi.org/10.1084/jem.128.3.415
   PubMed Web of Science ®Google Scholar
• van oud Alblas AB, van Furth R. Origin, Kinetics, and characteristics of pulmonary macrophages in the normal steady state. J Exp Med 1979; 149:1504-18; PMID:448291; http://dx.doi.org/10.1084/jem.149.6.1504
   PubMed Web of Science ®Google Scholar
• Umemura N, Saio M, Suwa T, Kitoh Y, Bai J, Nonaka K, Ouyang GF, Okada M, Balazs M, Adany R et al. Tumor-infiltrating myeloid-derived suppressor cells are pleiotropic-inflamed monocytes/macrophages that bear M1- and M2-type characteristics. J Leukoc Biol 2008; 83:1136-44; PMID:18285406; http://dx.doi.org/10.1189/jlb.0907611
   PubMed Web of Science ®Google Scholar
• Murdoch C, Giannoudis A, Lewis CE. Mechanisms regulating the recruitment of macrophages into hypoxic areas of tumors and other ischemic tissues. Blood 2004; 104:2224-34; PMID:15231578; http://dx.doi.org/10.1182/blood-2004-03-1109
   PubMed Web of Science ®Google Scholar
• Huang B, Pan PY, Li Q, Sato AI, Levy DE, Bromberg J, Divino CM, Chen SH. Gr-1+CD115+ immature myeloid suppressor cells mediate the development of tumor-induced T regulatory cells and T-cell anergy in tumor-bearing host. Cancer Res 2006; 66:1123-31; PMID:16424049; http://dx.doi.org/10.1158/0008-5472.CAN-05-1299
   PubMed Web of Science ®Google Scholar
• Li X, Shu C, Yi G, Chaton CT, Shelton CL, Diao J, Zuo X, Kao CC, Herr AB, Li P. Cyclic GMP-AMP synthase is activated by double-stranded DNA-induced oligomerization. Immunity 2013; 39:1019-31; PMID:24332030; http://dx.doi.org/10.1016/j.immuni.2013.10.019
   PubMed Web of Science ®Google Scholar
• Bhat N, Fitzgerald KA. Recognition of cytosolic DNA by cGAS and other STING-dependent sensors. Eur J Immunol 2014; 44:634-40; PMID:24356864; http://dx.doi.org/10.1002/eji.201344127
   PubMed Web of Science ®Google Scholar
• Lam E, Stein S, Falck-Pedersen E. Adenovirus detection by the cGAS/STING/TBK1 DNA sensing cascade. J Virol 2014; 88:974-81; PMID:24198409; http://dx.doi.org/10.1128/JVI.02702-13
   PubMed Web of Science ®Google Scholar
• Zhang X, Shi H, Wu J, Zhang X, Sun L, Chen C, Chen ZJ. Cyclic GMP-AMP containing mixed phosphodiester linkages is an endogenous high-affinity ligand for STING. Mol Cell 2013; 51:226-35; PMID:23747010; http://dx.doi.org/10.1016/j.molcel.2013.05.022
   PubMed Web of Science ®Google Scholar
• Cui TX, Kryczek I, Zhao L, Zhao E, Kuick R, Roh MH, Vatan L, Szeliga W, Mao Y, Thomas DG et al. Myeloid-derived suppressor cells enhance stemness of cancer cells by inducing microRNA101 and suppressing the corepressor CtBP2. Immunity 2013; 39:611-21; PMID:24012420; http://dx.doi.org/10.1016/j.immuni.2013.08.025
   PubMed Web of Science ®Google Scholar
• Laoui D, Van Overmeire E, De Baetselier P, Van Ginderachter JA, Raes G. Functional Relationship between Tumor-Associated Macrophages and Macrophage Colony-Stimulating Factor as Contributors to Cancer Progression. Front Immunol 2014; 5:489; PMID:25339957; http://dx.doi.org/10.3389/fimmu.2014.00489
   PubMed Web of Science ®Google Scholar
• Mosser DM, Edwards JP. Exploring the full spectrum of macrophage activation. Nat Rev Immunol 2008; 8:958-69; PMID:19029990; http://dx.doi.org/10.1038/nri2448
   PubMed Web of Science ®Google Scholar
• Mantovani A, Biswas SK, Galdiero MR, Sica A, Locati M. Macrophage plasticity and polarization in tissue repair and remodelling. J Pathol 2013; 229:176-85; PMID:23096265; http://dx.doi.org/10.1002/path.4133
   PubMed Web of Science ®Google Scholar
• Kaplan RN, Riba RD, Zacharoulis S, Bramley AH, Vincent L, Costa C, MacDonald DD, Jin DK, Shido K, Kerns SA et al. VEGFR1-positive haematopoietic bone marrow progenitors initiate the pre-metastatic niche. Nature 2005; 438:820-7; PMID:16341007; http://dx.doi.org/10.1038/nature04186
   PubMed Web of Science ®Google Scholar
• Obenauf AC, Zou Y, Ji AL, Vanharanta S, Shu W, Shi H, Kong X, Bosenberg MC, Wiesner T, Rosen N et al. Therapy-induced tumour secretomes promote resistance and tumour progression. Nature 2015; 520:368-72; PMID:25807485; http://dx.doi.org/10.1038/nature14336
   PubMed Web of Science ®Google Scholar