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OncoImmunology Volume 5, 2016 - Issue 5
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Unraveling the molecular pathways of DNA-methylation inhibitors: human endogenous retroviruses induce the innate immune response in tumors

Reiner StrickDepartment of Gynecology and Obstetrics, Laboratory for Molecular Medicine, Friedrich-Alexander University Erlangen-Nürnberg (FAU), University-Clinic Erlangen, Erlangen, GermanyCorrespondence[email protected]
,
Pamela L. StrisselDepartment of Gynecology and Obstetrics, Laboratory for Molecular Medicine, Friedrich-Alexander University Erlangen-Nürnberg (FAU), University-Clinic Erlangen, Erlangen, Germany
,
Stephen B. BaylinDepartment of Oncology, The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, MD, USA
&
Katherine B. ChiappinelliDepartment of Oncology, The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, MD, USA
Article: e1122160 | Received 12 Nov 2015, Accepted 17 Nov 2015, Published online: 29 Apr 2016

References

  • Postow MA, Callahan MK, Wolchok JD. Immune Checkpoint Blockade in Cancer Therapy. J Clin Oncol 2015; 33:1974-82; PMID:25605845; http://dx.doi.org/10.1200/JCO.2014.59.4358
  • Li H, Chiappinelli KB, Guzzetta AA, Easwaran H, Yen RW, Vatapalli R, Topper MJ, Luo J, Connolly RM, Azad NS et al. Immune regulation by low doses of the DNA methyltransferase inhibitor 5-azacitidine in common human epithelial cancers. Oncotarget 2014; 5:587-98; PMID:24583822; http://dx.doi.org/10.18632/oncotarget.1782
  • Chiappinelli KB, Strissel PL, Desrichard A, Li H, Henke C, Akman B, Hein A, Rote NS, Cope LM, Snyder A et al. Inhibiting DNA Methylation Causes an Interferon Response in Cancer via dsRNA Including Endogenous Retroviruses. Cell 2015; 162:974-86; PMID:26317466; http://dx.doi.org/10.1016/j.cell.2015.07.011
  • Roulois D, Loo Yau H, Singhania R, Wang Y, Danesh A, Shen SY, Han H, Liang G, Jones PA, Pugh TJ et al. DNA-Demethylating Agents Target Colorectal Cancer Cells by Inducing Viral Mimicry by Endogenous Transcripts. Cell 2015; 162:961-73; PMID:26317465; http://dx.doi.org/10.1016/j.cell.2015.07.056
  • O'Neill LAJ, Golenbock D, Bowie AG. The history of Toll-like receptors — redefining innate immunity. Nat Rev Immunol 2013; 13:453-60; PMID:23681101; http://dx.doi.org/10.1038/nri3446
  • De Nardo D. Toll-like receptors: Activation, signalling and transcriptional modulation. Cytokine 2015; 74:181-9; PMID:25846205; http://dx.doi.org/10.1016/j.cyto.2015.02.025
  • Caskey M, Lefebvre F, Filali-Mouhim A, Cameron MJ, Goulet JP, Haddad EK, Breton G, Trumpfheller C, Pollak S, Shimeliovich I et al. Synthetic double-stranded RNA induces innate immune responses similar to a live viral vaccine in humans. J Exp Med 2011; 208:2357-66; PMID:22065672; http://dx.doi.org/10.1084/jem.20111171
  • Yu P, Lübben W, Slomka H, Gebler J, Konert M, Cai C, Neubrandt L, Prazeres da Costa O, Paul S et al. Nucleic acid-sensing Toll-like receptors are essential for the control of endogenous retrovirus viremia and ERV-induced tumors. Immunity 2012; 37:867-79; PMID:23142781; http://dx.doi.org/10.1016/j.immuni.2012.07.018
  • Reikine S, Nguyen JB, Modis Y. Pattern Recognition and Signaling Mechanisms of RIG-I and MDA5. Front Immunol 2014; 5:342; PMID:25101084; http:10.3389/fimmu.2014.00342.
  • Bruns AM, Leser GP, Lamb RA, Horvath CM. The innate immune sensor LGP2 activates antiviral signaling by regulating MDA5-RNA interaction and filament assembly. Mol Cell 2014; 55:771-81; PMID:25127512; http://dx.doi.org/10.1016/j.molcel.2014.07.003

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