AIM2 inflammasome mediates Arsenic-induced secretion of IL-1 β and IL-18

References

• Karagas MR, Stukel TA, Tosteson TD. Assessment of cancer risk and environmental levels of arsenic in New Hampshire. Int J Hyg Environ Health 2002; 205:85-94; PMID:12018020
   PubMed Web of Science ®Google Scholar
• Swann JB, Vesely MD, Silva A, Sharkey J, Akira S, Schreiber RD, Smyth MJ. Demonstration of inflammation-induced cancer and cancer immunoediting during primary tumorigenesis. Proc Natl Acad Sci U S A 2008; 105:652-6; PMID:18178624; http://dx.doi.org/10.1073/pnas.0708594105
   PubMed Web of Science ®Google Scholar
• Grivennikov SI, Greten FR, Karin M. Immunity, inflammation, and cancer. Cell 2010; 140:883-99; PMID:20303878; http://dx.doi.org/10.1016/j.cell.2010.01.025
   PubMed Web of Science ®Google Scholar
• Mantovani A, Garlanda C, Allavena P. Molecular pathways and targets in cancer-related inflammation. Ann Med 2010; 42:161-70; PMID:20384432; http://dx.doi.org/10.3109/07853890903405753
   PubMed Web of Science ®Google Scholar
• Balkwill F. Tumour necrosis factor and cancer. Nat Rev Cancer 2009; 9:361-71; PMID:19343034; http://dx.doi.org/10.1038/nrc2628
   PubMed Web of Science ®Google Scholar
• Bromberg J, Wang TC. Inflammation and cancer: IL-6 and STAT3 complete the link. Cancer Cell 2009; 15:79-80; PMID:19185839; http://dx.doi.org/10.1016/j.ccr.2009.01.009
   PubMed Web of Science ®Google Scholar
• Krelin Y, Voronov E, Dotan S, Elkabets M, Reich E, Fogel M, Huszar M, Iwakura Y, Segal S, Dinarello CA et al. Interleukin-1beta-driven inflammation promotes the development and invasiveness of chemical carcinogen-induced tumors. Cancer Res 2007; 67:1062-71; PMID:17283139; http://dx.doi.org/10.1158/0008-5472.CAN-06-2956
   PubMed Web of Science ®Google Scholar
• Mizutani H, Black R, Kupper TS. Human keratinocytes produce but do not process pro-interleukin-1 (IL-1) β. Different strategies of IL-1 production and processing in monocytes and keratinocytes. J Clin Invest 1991; 87:1066-71; PMID:1999487; http://dx.doi.org/10.1172/JCI115067
   PubMed Web of Science ®Google Scholar
• Yazdi AS, Drexler SK. Regulation of interleukin 1alpha secretion by inflammasomes. Ann Rheum Dis 2013; 72 Suppl 2:ii96-9; PMID:23253918; http://dx.doi.org/10.1136/annrheumdis-2012-202252
   PubMed Web of Science ®Google Scholar
• Kolb R, Liu GH, Janowski AM, Sutterwala FS, Zhang W. Inflammasomes in cancer: a double-edged sword. Protein Cell 2014; 5:12-20; PMID:24474192; http://dx.doi.org/10.1007/s13238-013-0001-4
   PubMed Web of Science ®Google Scholar
• Clemens MJ. PKR–a protein kinase regulated by double-stranded RNA. Int J Biochem Cell Biol 1997; 29:945-9; PMID:9375375
   PubMed Web of Science ®Google Scholar
• Lu B, Nakamura T, Inouye K, Li J, Tang Y, Lundback P, Valdes-Ferrer SI, Olofsson PS, Kalb T, Roth J et al. Novel role of PKR in inflammasome activation and HMGB1 release. Nature 2012; 488:670-4; PMID:22801494; http://dx.doi.org/10.1038/nature11290
   PubMed Web of Science ®Google Scholar
• Abraham N, Stojdl DF, Duncan PI, Methot N, Ishii T, Dube M, Vanderhyden BC, Atkins HL, Gray DA, McBurney MW et al. Characterization of transgenic mice with targeted disruption of the catalytic domain of the double-stranded RNA-dependent protein kinase, PKR. J Biol Chem 1999; 274:5953-62; PMID:10026221; http://dx.doi.org/10.1074/jbc.274.9.5953
   PubMed Web of Science ®Google Scholar
• Dinarello CA. Immunological and inflammatory functions of the interleukin-1 family. Annu Rev Immunol 2009; 27:519-50; PMID:19302047; http://dx.doi.org/10.1146/annurev.immunol.021908.132612
   PubMed Web of Science ®Google Scholar
• Zitvogel L, Kepp O, Galluzzi L, Kroemer G. Inflammasomes in carcinogenesis and anticancer immune responses. Nat Immunol 2012; 13:343-51; PMID:22430787; http://dx.doi.org/10.1038/ni.2224
   PubMed Web of Science ®Google Scholar
• Voronov E, Shouval DS, Krelin Y, Cagnano E, Benharroch D, Iwakura Y, Dinarello CA, Apte RN. IL-1 is required for tumor invasiveness and angiogenesis. Proc Natl Acad Sci U S A 2003; 100:2645-50; PMID:12598651; http://dx.doi.org/10.1073/pnas.0437939100
   PubMed Web of Science ®Google Scholar
• Zepter K, Haffner A, Soohoo LF, De Luca D, Tang HP, Fisher P, Chavinson J, Elmets CA. Induction of biologically active IL-1 β-converting enzyme and mature IL-1 β in human keratinocytes by inflammatory and immunologic stimuli. J Immunol 1997; 159:6203-8.
   PubMed Web of Science ®Google Scholar
• Watanabe H, Gaide O, Petrilli V, Martinon F, Contassot E, Roques S, Kummer JA, Tschopp J, French LE. Activation of the IL-1beta-processing inflammasome is involved in contact hypersensitivity. J Invest Dermatol 2007; 127:1956-63; PMID:17429439; http://dx.doi.org/10.1038/sj.jid.5700819
   PubMed Web of Science ®Google Scholar
• Gueniche A, Viac J, Lizard G, Charveron M, Schmitt D. Effect of nickel on the activation state of normal human keratinocytes through interleukin 1 and intercellular adhesion molecule 1 expression. Br J Dermatol 1994; 131:250-6; PMID:7917990; http://dx.doi.org/10.1111/j.1365-2133.1994.tb08500.x
   PubMed Web of Science ®Google Scholar
• Cho D, Kim TG, Lee W, Hwang YI, Cho HI, Han H, Kwon O, Kim D, Park H, Houh D. Interleukin-18 and the costimulatory molecule B7-1 have a synergistic anti-tumor effect on murine melanoma; implication of combined immunotherapy for poorly immunogenic malignancy. J Invest Dermatol 2000; 114:928-34; PMID:10771473; http://dx.doi.org/10.1038/sj.jid.5600685
   PubMed Web of Science ®Google Scholar
• Maier NK, Crown D, Liu J, Leppla SH, Moayeri M. Arsenic trioxide and other arsenical compounds inhibit the NLRP1, NLRP3, and NAIP5/NLRC4 inflammasomes. J Immunol 2014; 192:763-70; PMID:24337744; http://dx.doi.org/10.4049/jimmunol.1301434.
   PubMed Web of Science ®Google Scholar
• Fang R, Hara H, Sakai S, Hernandez-Cuellar E, Mitsuyama M, Kawamura I, Tsuchiya K. Type I interferon signaling regulates activation of the absent in melanoma 2 inflammasome during Streptococcus pneumoniae infection. Infect Immun 2014; 82:2310-7; PMID:24643540; http://dx.doi.org/10.1128/IAI.01572-14
   PubMed Web of Science ®Google Scholar
• Sorrentino R, Terlizzi M, Di Crescenzo VG, Popolo A, Pecoraro M, Perillo G, Galderisi A, Pinto A. Human lung cancer-derived immunosuppressive plasmacytoid dendritic cells release IL-1alpha in an AIM2 inflammasome-dependent manner. Am J Pathol 2015; 185:3115-24; PMID:26506473; http://dx.doi.org/10.1016/j.ajpath.2015.07.009
   PubMed Web of Science ®Google Scholar
• Shah S, Bohsali A, Ahlbrand SE, Srinivasan L, Rathinam VA, Vogel SN, Fitzgerald KA, Sutterwala FS, Briken V. Cutting edge: Mycobacterium tuberculosis but not nonvirulent mycobacteria inhibits IFN-β and AIM2 inflammasome-dependent IL-1beta production via its ESX-1 secretion system. J Immunol 2013; 191:3514-8; PMID:24643540; http://dx.doi.org/10.4049/jimmunol.1301331
   PubMed Web of Science ®Google Scholar
• McAllister CS, Taghavi N, Samuel CE. Protein kinase PKR amplification of interferon β induction occurs through initiation factor eIF-2alpha-mediated translational control. J Biol Chem 2012; 287:36384-92; PMID:22948139; http://dx.doi.org/10.1074/jbc.M112.390039
   PubMed Web of Science ®Google Scholar
• Ponomareva L, Liu H, Duan X, Dickerson E, Shen H, Panchanathan R, Choubey D. AIM2, an IFN-inducible cytosolic DNA sensor, in the development of benign prostate hyperplasia and prostate cancer. Mol Cancer Res 2013; 11:1193-202; PMID:23864729; http://dx.doi.org/10.1158/1541-7786.MCR-13-0145
   PubMed Web of Science ®Google Scholar
• Hornung V, Ablasser A, Charrel-Dennis M, Bauernfeind F, Horvath G, Caffrey DR, Latz E, Fitzgerald KA. AIM2 recognizes cytosolic dsDNA and forms a caspase-1-activating inflammasome with ASC. Nature 2009; 458:514-8; PMID:19158675; http://dx.doi.org/10.1038/nature07725
   PubMed Web of Science ®Google Scholar
• Kozul CD, Hampton TH, Davey JC, Gosse JA, Nomikos AP, Eisenhauer PL, Weiss DJ, Thorpe JE, Ihnat MA, Hamilton JW. Chronic exposure to arsenic in the drinking water alters the expression of immune response genes in mouse lung. Environ Health Perspect 2009; 117:1108-15; PMID:19654921; http://dx.doi.org/10.1289/ehp.0800199
   PubMed Web of Science ®Google Scholar
• Waalkes MP, Qu W, Tokar EJ, Kissling GE, Dixon D. Lung tumors in mice induced by “whole-life” inorganic arsenic exposure at human-relevant doses. Arch Toxicol 2014; 88:1619-29; PMID:25005685; http://dx.doi.org/10.1007/s00204-014-1305-8
   PubMed Web of Science ®Google Scholar
• Cui X, Wakai T, Shirai Y, Hatakeyama K, Hirano S. Chronic oral exposure to inorganic arsenate interferes with methylation status of p16INK4a and RASSF1A and induces lung cancer in A/J mice. Toxicol Sci 2006; 91:372-81; PMID:16543296
   PubMed Web of Science ®Google Scholar
• Qi Y, Zhang M, Li H, Frank JA, Dai L, Liu H, Zhang Z, Wang C, Chen G. Autophagy Inhibition by Sustained Overproduction of IL6 Contributes to Arsenic Carcinogenesis. Cancer Res 2014; 74(14):3740-52; PMID:24830721
   PubMed Web of Science ®Google Scholar
• Chen G, Ma C, Bower KA, Ke Z, Luo J. Interaction between RAX and PKR modulates the effect of ethanol on protein synthesis and survival of neurons. J Biol Chem 2006; 281:15909-15; PMID:16574643
   PubMed Web of Science ®Google Scholar