Myeloid PTEN deficiency impairs tumor-immune surveillance via immune-checkpoint inhibition

References

• Cantley LC. The phosphoinositide 3-kinase pathway. Science 2002; 296:1655-7; PMID:12040186; http://dx.doi.org/10.1126/science.296.5573.1655
   PubMed Web of Science ®Google Scholar
• Luyendyk JP, Schabbauer GA, Tencati M, Holscher T, Pawlinski R, Mackman N. Genetic analysis of the role of the PI3K-Akt pathway in lipopolysaccharide-induced cytokine and tissue factor gene expression in monocytes/macrophages. J Immunol 2008; 180:4218-26; PMID:18322234; http://dx.doi.org/10.4049/jimmunol.180.6.4218
   PubMed Web of Science ®Google Scholar
• Gunzl P, Bauer K, Hainzl E, Matt U, Dillinger B, Mahr B, Knapp S, Binder BR, Schabbauer G. Anti-inflammatory properties of the PI3K pathway are mediated by IL-10/DUSP regulation. J Leukoc Biol 2010; 88:1259-69; PMID:20884649; http://dx.doi.org/10.1189/jlb.0110001
   PubMed Web of Science ®Google Scholar
• Schabbauer G, Matt U, Gunzl P, Warszawska J, Furtner T, Hainzl E, Elbau I, Mesteri I, Doninger B, Binder BR et al. Myeloid PTEN promotes inflammation but impairs bactericidal activities during murine pneumococcal pneumonia. J Immunol 2010; 185:468-76; PMID:20505137; http://dx.doi.org/10.4049/jimmunol.0902221
   PubMed Web of Science ®Google Scholar
• Yue S, Rao J, Zhu J, Busuttil RW, Kupiec-Weglinski JW, Lu L, Wang X, Zhai Y. Myeloid PTEN deficiency protects livers from ischemia reperfusion injury by facilitating M2 macrophage differentiation. J Immunol 2014; 192:5343-53; PMID:24771857; http://dx.doi.org/10.4049/jimmunol.1400280
   PubMed Web of Science ®Google Scholar
• Miething C, Scuoppo C, Bosbach B, Appelmann I, Nakitandwe J, Ma J, Wu G, Lintault L, Auer M, Premsrirut PK et al. PTEN action in leukaemia dictated by the tissue microenvironment. Nature 2014; 510:402-6; PMID:24805236; http://dx.doi.org/10.1038/nature13239
   PubMed Web of Science ®Google Scholar
• Sathaliyawala T, O'Gorman WE, Greter M, Bogunovic M, Konjufca V, Hou ZE, Nolan GP, Miller MJ, Merad M, Reizis B. Mammalian target of rapamycin controls dendritic cell development downstream of Flt3 ligand signaling. Immunity 2010; 33:597-606; PMID:20933441; http://dx.doi.org/10.1016/j.immuni.2010.09.012
   PubMed Web of Science ®Google Scholar
• Wang Y, Chi H. mTOR Signaling and Dendritic Cell Biology. J Immunol Clin Res 2014.
   Google Scholar
• Weichhart T, Costantino G, Poglitsch M, Rosner M, Zeyda M, Stuhlmeier KM, Kolbe T, Stulnig TM, Horl WH, Hengstschlager M et al. The TSC-mTOR signaling pathway regulates the innate inflammatory response. Immunity 2008; 29:565-77; PMID:18848473; http://dx.doi.org/10.1016/j.immuni.2008.08.012
   PubMed Web of Science ®Google Scholar
• Sahin E, Brunner JS, Kral JB, Kuttke M, Hanzl L, Datler H, Paar H, Neuwinger N, Saferding V, Zinser E et al. Loss of Phosphatase and Tensin Homolog in APCs Impedes Th17-Mediated Autoimmune Encephalomyelitis. J Immunol 2015; PMID:26246144; http://dx.doi.org/10.4049/jimmunol.1402511
   PubMed Web of Science ®Google Scholar
• Rosborough B.R, Raich-Regue DM, Matta BM, Lee K, Gan B, DePinho RA, Hackstein H, Boothby M, Turnquist HR, Thomson AW. Murine dendritic cell rapamycin-resistant and rictor-independent mTOR controls IL-10, B7-H1, and regulatory T-cell induction. Blood 2013; 121(18):3619-30; PMID:23444404; http://dx.doi.org/10.1182/blood-2012-08-448290
   PubMed Web of Science ®Google Scholar
• Loke P, Allison JP. PD-L1 and PD-L2 are differentially regulated by Th1 and Th2 cells. Proc Natl Acad Sci U S A 2003; 100:5336-41; PMID:12697896; http://dx.doi.org/10.1073/pnas.0931259100
   PubMed Web of Science ®Google Scholar
• Noman MZ, Desantis G, Janji B, Hasmim M, Karray S, Dessen P, Bronte V, Chouaib S. PD-L1 is a novel direct target of HIF-1alpha, and its blockade under hypoxia enhanced MDSC-mediated T cell activation. J Exp Med 2014; 211:781-90; PMID:24778419; http://dx.doi.org/10.1084/jem.20131916
   PubMed Web of Science ®Google Scholar
• Mildner A, Jung S. Development and function of dendritic cell subsets. Immunity 2014; 40:642-56; PMID:24837101; http://dx.doi.org/10.1016/j.immuni.2014.04.016
   PubMed Web of Science ®Google Scholar
• Crncec I, Pathria P, Svinka J, Eferl R. Induction of colorectal cancer in mice and histomorphometric evaluation of tumors. Methods Mol Biol 2015; 1267:145-64; PMID:25636468; http://dx.doi.org/10.1007/978-1-4939-2297-0_7
   PubMedGoogle Scholar
• Ruijter JM, Ramakers C, Hoogaars WM, Karlen Y, Bakker O, van den Hoff MJ, Moorman AF. Amplification efficiency: linking baseline and bias in the analysis of quantitative PCR data. Nucleic Acids Res 2009; 37:e45; PMID:19237396; http://dx.doi.org/10.1093/nar/gkp045
   PubMed Web of Science ®Google Scholar
• Huang da W, Sherman BT, Lempicki RA. Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources. Nat Protoc 2009; 4:44-57; PMID:19131956; http://dx.doi.org/10.1038/nprot.2008.211
   PubMed Web of Science ®Google Scholar
• Huang da W, Sherman BT, Lempicki RA. Bioinformatics enrichment tools: paths toward the comprehensive functional analysis of large gene lists. Nucleic Acids Res 2009; 37:1-13; PMID:19033363; http://dx.doi.org/10.1093/nar/gkn923
   PubMed Web of Science ®Google Scholar
• Latchman Y, Wood C, Chernova T, Chaudhary D, Borde M, Chernova I, Iwai Y, Long A, Brown J, Nunes R et al. PD-L2 is a second ligand for PD-1 and inhibits T cell activation. Nat Immunol 2001; 2(3):261-8; PMID:11224527; http://dx.doi.org/10.1038/85330
   PubMed Web of Science ®Google Scholar
• Jakubzick C, Bogunovic M, Bonito AJ, Kuan EL, Merad M, Randolph GJ. Lymph-migrating, tissue-derived dendritic cells are minor constituents within steady-state lymph nodes. J Exp Med 2008; 205:2839-50; PMID:18981237; http://dx.doi.org/10.1084/jem.20081430
   PubMed Web of Science ®Google Scholar
• Zhang R, Ito S, Nishio N, Cheng Z, Suzuki H, Isobe KI. Dextran sulphate sodium increases splenic Gr1(+)CD11b(+) cells which accelerate recovery from colitis following intravenous transplantation. Clin Exp Immunol 2011; 164:417-27; PMID:21413942; http://dx.doi.org/10.1111/j.1365-2249.2011.04374.x
   PubMed Web of Science ®Google Scholar
• Hildner K, Edelson BT, Purtha WE, Diamond M, Matsushita H, Kohyama M, Calderon B, Schraml BU, ER U, Diamond MS et al. Batf3 Deficiency Reveals a Critical Role for CD8a+ Dendritic Cells in Cytotoxic T Cell Immunity. Science 2008; 322(5904):1097-100; PMID:19008445; http://dx.doi.org/10.1126/science.1164206
   PubMed Web of Science ®Google Scholar
• Carrasco A, Mane J, Santaolalla R, Pedrosa E, Mallolas J, Loren V, Fernandez M, Fernandez-Banares F, Rosinach M, Loras C et al. Comparison of lymphocyte isolation methods for endoscopic biopsy specimens from the colonic mucosa. J Immunol Methods 2013; 389:29-37; PMID:23279944; http://dx.doi.org/10.1016/j.jim.2012.12.006
   PubMed Web of Science ®Google Scholar
• Betts MR, Brenchley JM, Price DA, De Rosa SC, Douek DC, Roederer M, Koup RA. Sensitive and viable identification of antigen-specific CD8+ T cells by a flow cytometric assay for degranulation. J Immunol Methods 2003; 281:65-78; PMID:14580882; http://dx.doi.org/10.1016/S0022-1759(03)00265-5
   PubMed Web of Science ®Google Scholar
• Alter G, Malenfant JM, Altfeld M. CD107a as a functional marker for the identification of natural killer cell activity. J Immunol Methods 2004; 294:15-22; PMID:15604012; http://dx.doi.org/10.1016/j.jim.2004.08.008
   PubMed Web of Science ®Google Scholar
• Schabbauer G, Luyendyk J, Crozat K, Jiang Z, Mackman N, Bahram S, Georgel P. TLR4/CD14-mediated PI3K activation is an essential component of interferon-dependent VSV resistance in macrophages. Mol Immunol 2008; 45:2790-6; PMID:18339426; http://dx.doi.org/10.1016/j.molimm.2008.02.001
   PubMed Web of Science ®Google Scholar
• Sahin E, Haubenwallner S, Kuttke M, Kollmann I, Halfmann A, Dohnal AM, Chen L, Cheng P, Hoesel B, Einwallner E et al. Macrophage PTEN regulates expression and secretion of arginase I modulating innate and adaptive immune responses. J Immunol 2014; 193:1717-27; PMID:25015834; http://dx.doi.org/10.4049/jimmunol.1302167
   PubMed Web of Science ®Google Scholar
• Bluml S, Sahin E, Saferding V, Goncalves-Alves E, Hainzl E, Niederreiter B, Hladik A, Lohmeyer T, Brunner JS, Bonelli M et al. Phosphatase and tensin homolog (PTEN) in antigen-presenting cells controls Th17-mediated autoimmune arthritis. Arthritis Res Ther 2015; 17:230; PMID:26307404; http://dx.doi.org/10.1186/s13075-015-0742-y
   PubMed Web of Science ®Google Scholar
• Knobbe CB, Lapin V, Suzuki A, Mak TW. The roles of PTEN in development, physiology and tumorigenesis in mouse models: a tissue-by-tissue survey. Oncogene 2008; 27:5398-415; PMID:18794876; http://dx.doi.org/10.1038/onc.2008.238
   PubMed Web of Science ®Google Scholar
• Suzuki A, Kaisho T, Ohishi M, Tsukio-Yamaguchi M, Tsubata T, Koni PA, Sasaki T, Mak TW, Nakano T. Critical roles of Pten in B cell homeostasis and immunoglobulin class switch recombination. J Exp Med 2003; 197:657-67; PMID:12615906; http://dx.doi.org/10.1084/jem.20021101
   PubMed Web of Science ®Google Scholar
• Weichhart T, Hengstschlager M, Linke M. Regulation of innate immune cell function by mTOR. Nat Rev Immunol 2015; 15:599-614; PMID:26403194; http://dx.doi.org/10.1038/nri3901
   PubMed Web of Science ®Google Scholar
• Arranz A, Doxaki C, Vergadi E, Martinez de la Torre Y, Vaporidi K, Lagoudaki ED, Ieronymaki E, Androulidaki A, Venihaki M, Margioris AN et al. Akt1 and Akt2 protein kinases differentially contribute to macrophage polarization. Proc Natl Acad Sci U S A 2012; 109:9517-22; PMID:22647600; http://dx.doi.org/10.1073/pnas.1119038109
   PubMed Web of Science ®Google Scholar
• Perse M, Cerar A. Dextran sodium sulphate colitis mouse model: traps and tricks. J Biomed Biotechnol 2012; 2012:718617; PMID:22665990; http://dx.doi.org/10.1155/2012/718617
   PubMedGoogle Scholar
• Zhan Y, Chen PJ, Sadler WD, Wang F, Poe S, Nunez G, Eaton KA, Chen GY. Gut microbiota protects against gastrointestinal tumorigenesis caused by epithelial injury. Cancer Res 2013; 73:7199-210; PMID:24165160; http://dx.doi.org/10.1158/0008-5472.CAN-13-0827
   PubMed Web of Science ®Google Scholar
• Diehl GE, Longman RS, Zhang JX, Breart B, Galan C, Cuesta A, Schwab SR, Littman DR. Microbiota restricts trafficking of bacteria to mesenteric lymph nodes by CX(3)CR1(hi) cells. Nature 2013; 494:116-20; PMID:23334413; http://dx.doi.org/10.1038/nature11809
   PubMed Web of Science ®Google Scholar
• Shim JO. Gut microbiota in inflammatory bowel disease. Pediatr Gastroenterol Hepatol Nutr 2013; 16:17-21; PMID:24010101; http://dx.doi.org/10.5223/pghn.2013.16.1.17
   PubMedGoogle Scholar
• Zeller G, Tap J, Voigt AY, Sunagawa S, Kultima JR, Costea PI, Amiot A, Bohm J, Brunetti F, Habermann N et al. Potential of fecal microbiota for early-stage detection of colorectal cancer. Mol Syst Biol 2014; 10:766; PMID:25432777; http://dx.doi.org/10.15252/msb.20145645
   PubMed Web of Science ®Google Scholar
• Belz GT, Behrens GMN, Smith CM, Miller JFAP, Jones C, Lejon K, Fathman CG, Mueller SN, Shortman K, Carbone FR et al. The CD8 + Dendritic Cell Is Responsible for Inducing Peripheral Self-Tolerance to Tissue-associated Antigens. J Exp Med 2002; 196:1099-104; PMID:12391021; http://dx.doi.org/10.1084/jem.20020861
   PubMed Web of Science ®Google Scholar
• Ganguly D, Haak S, Sisirak V, Reizis B. The role of dendritic cells in autoimmunity. Nat Rev Immunol 2013; 13:566-77; PMID:23827956; http://dx.doi.org/10.1038/nri3477
   PubMed Web of Science ®Google Scholar
• Shortman K, Heath WR. The CD8+ dendritic cell subset. Immunol Rev 2010; 234(1):18-31; PMID:20193009; http://dx.doi.org/10.1111/j.0105-2896.2009.00870.x
   PubMed Web of Science ®Google Scholar
• Woo SR, Corrales L, Gajewski TF. Innate immune recognition of cancer. Annu Rev Immunol 2015; 33:445-74; PMID:25622193; http://dx.doi.org/10.1146/annurev-immunol-032414-112043
   PubMed Web of Science ®Google Scholar
• Liu K, Iyoda T, Saternus M, Kimura Y, Inaba K, Steinman RM. Immune tolerance after delivery of dying cells to dendritic cells in situ. J Exp Med 2002; 196:1091-7; PMID:12391020; http://dx.doi.org/10.1084/jem.20021215
   PubMed Web of Science ®Google Scholar
• Iyoda T, Shimoyama S, Liu K, Omatsu Y, Akiyama Y, Maeda Y, Takahara K, Steinman RM, Inaba K. The CD8+ dendritic cell subset selectively endocytoses dying cells in culture and in vivo. J Exp Med 2002; 195:1289-302; PMID:12021309; http://dx.doi.org/10.1084/jem.20020161
   PubMed Web of Science ®Google Scholar
• Clausen BE, Burkhardt C, Reith W, Renkawitz R, I F. Conditional gene targeting in macrophages and granulocytes using LysMcre mice. Transgenic Res 1999; 8(4):265-77; PMID:10621974
   PubMed Web of Science ®Google Scholar
• Ehrchen JM, Sunderkotter C, Foell D, Vogl T, Roth J. The endogenous Toll-like receptor 4 agonist S100A8/S100A9 (calprotectin) as innate amplifier of infection, autoimmunity, and cancer. J Leukoc Biol 2009; 86:557-66; PMID:19451397; http://dx.doi.org/10.1189/jlb.1008647
   PubMed Web of Science ®Google Scholar
• Cheng P, Corzo CA, Luetteke N, Yu B, Nagaraj S, Bui MM, Ortiz M, Nacken W, Sorg C, Vogl T et al. Inhibition of dendritic cell differentiation and accumulation of myeloid-derived suppressor cells in cancer is regulated by S100A9 protein. J Exp Med 2008; 205:2235-49; PMID:18809714; http://dx.doi.org/10.1084/jem.20080132
   PubMed Web of Science ®Google Scholar
• Hanahan D, Weinberg RA. Hallmarks of cancer: the next generation. Cell 2011; 144:646-74; PMID:21376230; http://dx.doi.org/10.1016/j.cell.2011.02.013
   PubMed Web of Science ®Google Scholar
• Xu D, Liu H, Komai-Koma M, Campbell C, McSharry C, Alexander J, Liew FY. CD4+CD25+ regulatory T cells suppress differentiation and functions of Th1 and Th2 cells, Leishmania major infection, and colitis in mice. J Immunol 2003; 170:394-9; PMID:12496424; http://dx.doi.org/10.4049/jimmunol.170.1.394
   PubMed Web of Science ®Google Scholar
• Borrego F, Robertson MJ, Ritz J, Pena J, Solana R. CD69 is a stimulatory receptor for natural killer cell and its cytotoxic effect is blocked by CD94 inhibitory receptor. Immunology 1999; 97:159-65; PMID:10447727; http://dx.doi.org/10.1046/j.1365-2567.1999.00738.x
   PubMed Web of Science ®Google Scholar
• Ziegler SF, Ramsdell F, Alderson MR. The activation antigen CD69. Stem Cells 1994; 12:456-65; PMID:7804122; http://dx.doi.org/10.1002/stem.5530120502
   PubMed Web of Science ®Google Scholar
• Fazekas de St Groth B, Smith A, Higgins C. T cell activation: in vivo veritas. Immunol Cell Biol 2004; 82(3):260-8; PMID:15186257; http://dx.doi.org/10.1111/j.0818-9641.2004.01243.x
   PubMed Web of Science ®Google Scholar
• Shinoda K, Tokoyoda K, Hanazawa A, Hayashizaki K, Zehentmeier S, Hosokawa H, Iwamura C, Koseki H, Tumes DJ, Radbruch A et al. Type II membrane protein CD69 regulates the formation of resting T-helper memory. Proc Natl Acad Sci U S A 2012; 109:7409-14; PMID:22474373; http://dx.doi.org/10.1073/pnas.1118539109
   PubMed Web of Science ®Google Scholar
• Hull CC, Galloway P, Gordon N, Gerson SL, Hawkins N, Stellato TA. Splenectomy and the induction of murine colon cancer. Arch Surg 1988; 123:462-4; PMID:3348737; http://dx.doi.org/10.1001/archsurg.1988.01400280072012
   PubMed Web of Science ®Google Scholar
• Yamagishi H, Pellis NR, Kahan BD. Effect of splenectomy upon tumor growth: characterization of splenic tumor-enhancing cells in vivo. Surgery 1980; 87:655-61; PMID:6445603
   PubMed Web of Science ®Google Scholar
• Soda K, Kawakami M, Takagi S, Kashii A, Miyata M. Splenectomy before tumor inoculation prolongs the survival time of cachectic mice. Cancer Immunol Immunother 1995; 41:203-9; PMID:7489562; http://dx.doi.org/10.1007/BF01516994
   PubMed Web of Science ®Google Scholar
• Kristinsson SY, Gridley G, Hoover RN, Check D, Landgren O. Long-term risks after splenectomy among 8,149 cancer-free American veterans: a cohort study with up to 27 years follow-up. Haematologica 2014; 99:392-8; PMID:24056815; http://dx.doi.org/10.3324/haematol.2013.092460
   PubMed Web of Science ®Google Scholar