No evidence for TSLP pathway activity in human breast cancer

References

• Chen DS, Mellman I. Oncology meets immunology: the cancer-immunity cycle. Immunity 2013; 39:1-10; PMID:23890059; http://dx.doi.org/10.1016/j.immuni.2013.07.012
   PubMed Web of Science ®Google Scholar
• Luo JL, Maeda S, Hsu LC, Yagita H, Karin M. Inhibition of NF-kappaB in cancer cells converts inflammation- induced tumor growth mediated by TNFalpha to TRAIL-mediated tumor regression. Cancer Cell 2004; 6:297-305; PMID:15380520; http://dx.doi.org/10.1016/j.ccr.2004.08.012
   PubMed Web of Science ®Google Scholar
• Song EY, Shurin MR, Tourkova IL, Chatta G, Shurin GV. Human renal cell carcinoma inhibits dendritic cell maturation and functions. Urologe A 2004; 43 Suppl 3:S128-130; PMID:15150693; http://dx.doi.org/10.1007/s00120-004-0599-1
   PubMedGoogle Scholar
• Balkwill F. Tumour necrosis factor and cancer. Nat Rev Cancer 2009; 9:361-71; PMID:19343034; http://dx.doi.org/10.1038/nrc2628
   PubMed Web of Science ®Google Scholar
• Ghirelli C, Reyal F, Jeanmougin M, Zollinger R, Sirven P, Michea P, Caux C, Bendriss-Vermare N, Donnadieu MH, Caly M et al. Breast cancer cell-derived GM-CSF licenses regulatory Th2 induction by plasmacytoid predendritic cells in aggressive disease subtypes. Cancer Res 2015; 75:2775-87; PMID:25977333; http://dx.doi.org/10.1158/0008-5472.CAN-14-2386
   PubMed Web of Science ®Google Scholar
• Soumelis V, Reche PA, Kanzler H, Yuan W, Edward G, Homey B, Gilliet M, Ho S, Antonenko S, Lauerma A et al. Human epithelial cells trigger dendritic cell mediated allergic inflammation by producing TSLP. Nat Immunol 2002; 3:673-80; PMID:12055625; http://dx.doi.org/10.1038/nrm910
   PubMed Web of Science ®Google Scholar
• Liu YJ, Soumelis V, Watanabe N, Ito T, Wang YH, Malefyt Rde W, Omori M, Zhou B, Ziegler SF. TSLP: an epithelial cell cytokine that regulates T cell differentiation by conditioning dendritic cell maturation. Annu Rev Immunol 2007; 25:193-219; PMID:17129180; http://dx.doi.org/10.1146/annurev.immunol.25.022106.141718
   PubMed Web of Science ®Google Scholar
• Shikotra A, Choy DF, Ohri CM, Doran E, Butler C, Hargadon B, Shelley M, Abbas AR, Austin CD, Jackman J et al. Increased expression of immunoreactive thymic stromal lymphopoietin in patients with severe asthma. J Allergy Clin Immunol 2012; 129:104-11 e101-109; PMID:21975173; http://dx.doi.org/10.1016/j.jaci.2011.08.031
   PubMed Web of Science ®Google Scholar
• Ying S, O'Connor B, Ratoff J, Meng Q, Mallett K, Cousins D, Robinson D, Zhang G, Zhao J, Lee TH et al. Thymic stromal lymphopoietin expression is increased in asthmatic airways and correlates with expression of Th2-attracting chemokines and disease severity. J Immunol 2005; 174:8183-90; PMID:15944327; http://dx.doi.org/10.4049/jimmunol.174.12.8183
   PubMed Web of Science ®Google Scholar
• Volpe E, Pattarini L, Martinez-Cingolani C, Meller S, Donnadieu MH, Bogiatzi SI, Fernandez MI, Touzot M, Bichet JC, Reyal F et al. Thymic stromal lymphopoietin links keratinocytes and dendritic cell-derived IL-23 in patients with psoriasis. J Allergy Clin Immunol 2014; 134:373-81; PMID:24910175; http://dx.doi.org/10.1016/j.jaci.2014.04.022
   PubMed Web of Science ®Google Scholar
• De Monte L, Reni M, Tassi E, Clavenna D, Papa I, Recalde H, Braga M, Di Carlo V, Doglioni C, Pia Protti M. Intratumor T helper type 2 cell infiltrate correlates with cancer-associated fibroblast thymic stromal lymphopoietin production and reduced survival in pancreatic cancer. J Exp Med 2011; 208:469-78; PMID:21339327; http://dx.doi.org/10.1084/jem.20101876
   PubMed Web of Science ®Google Scholar
• Olkhanud PB, Rochman Y, Bodogai M, Malchinkhuu E, Wejksza K, Xu M, Gress RE, Hesdorffer C, Leonard WJ, Biragyn A. Thymic stromal lymphopoietin is a key mediator of breast cancer progression. J Immunol 2011; 186:5656-62; PMID:21490155; http://dx.doi.org/10.4049/jimmunol.1100463
   PubMed Web of Science ®Google Scholar
• Pedroza-Gonzalez A, Xu K, Wu TC, Aspord C, Tindle S, Marches F, Gallegos M, Burton EC, Savino D, Hori T et al. Thymic stromal lymphopoietin fosters human breast tumor growth by promoting type 2 inflammation. J Exp Med 2011; 208:479-90; PMID:21339324; http://dx.doi.org/10.1084/jem.20102131
   PubMed Web of Science ®Google Scholar
• Wu TC, Xu K, Banchereau R, Marches F, Yu CI, Martinek J, Anguiano E, Pedroza-Gonzalez A, Snipes GJ, O'Shaughnessy J et al. Reprogramming tumor-infiltrating dendritic cells for CD103+ CD8+ mucosal T-cell differentiation and breast cancer rejection. Cancer Immunol Res 2014; 2:487-500; PMID:24795361; http://dx.doi.org/10.1158/2326-6066.CIR-13-0217
   PubMed Web of Science ®Google Scholar
• Lo Kuan E, Ziegler SF. Thymic stromal lymphopoietin and cancer. J Immunol 2014; 193:4283-8; PMID:25326546; http://dx.doi.org/10.4049/jimmunol.1400864
   PubMed Web of Science ®Google Scholar
• Demehri S, Cunningham TJ, Manivasagam S, Ngo KH, Moradi Tuchayi S, Reddy R, Meyers MA, DeNardo DG, Yokoyama WM. Thymic stromal lymphopoietin blocks early stages of breast carcinogenesis. J Clin Invest 2016; 126:1458-70; PMID:26927668; http://dx.doi.org/10.1172/JCI83724
   PubMed Web of Science ®Google Scholar
• Di Piazza M, Nowell CS, Koch U, Durham AD, Radtke F. Loss of cutaneous TSLP-dependent immune responses skews the balance of inflammation from tumor protective to tumor promoting. Cancer Cell 2012; 22:479-93; PMID:23079658; http://dx.doi.org/10.1016/j.ccr.2012.08.016
   PubMed Web of Science ®Google Scholar
• Demehri S, Cunningham TJ, Manivasagam S, Ngo KH, Moradi Tuchayi S, Reddy R, Meyers MA, DeNardo DG, Yokoyama WM. Elevated epidermal thymic stromal lymphopoietin levels establish an antitumor environment in the skin. Cancer Cell 2012; 22:494-505; PMID:23079659; http://dx.doi.org/10.1016/j.ccr.2012.08.017
   PubMed Web of Science ®Google Scholar
• Reche PA, Soumelis V, Gorman DM, Clifford T, Liu Mr, Travis M, Zurawski SM, Johnston J, Liu YJ, Spits H et al. Human thymic stromal lymphopoietin preferentially stimulates myeloid cells. J Immunol 2001; 167:336-43; PMID:11418668; http://dx.doi.org/10.4049/jimmunol.167.1.336
   PubMed Web of Science ®Google Scholar
• Barretina J, Caponigro G, Stransky N, Venkatesan K, Margolin AA, Kim S, Wilson CJ, Lehár J, Kryukov GV, Sonkin D et al. The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity. Nature 2012; 483:603-7; PMID:22460905; http://dx.doi.org/10.1038/nature11003
   PubMed Web of Science ®Google Scholar
• Cancer Genome Atlas N. Comprehensive molecular portraits of human breast tumours. Nature 2012; 490:61-70; PMID:23000897; http://dx.doi.org/10.1038/nature11412
   PubMed Web of Science ®Google Scholar
• Bogiatzi SI, Fernandez I, Bichet JC, Marloie-Provost MA, Volpe E, Sastre X, Soumelis V. Cutting Edge: Proinflammatory and Th2 cytokines synergize to induce thymic stromal lymphopoietin production by human skin keratinocytes. J Immunol 2007; 178:3373-7; PMID:17339431; http://dx.doi.org/10.4049/jimmunol.178.6.3373
   PubMed Web of Science ®Google Scholar
• Fontenot D, He H, Hanabuchi S, Nehete PN, Zhang M, Chang M, Nehete B, Wang YH, Wang YH, Ma ZM et al. TSLP production by epithelial cells exposed to immunodeficiency virus triggers DC-mediated mucosal infection of CD4+ T cells. Proc Natl Acad Sci U S A 2009; 106:16776-81; PMID:19805372; http://dx.doi.org/10.1073/pnas.0907347106
   PubMed Web of Science ®Google Scholar
• Macfarlane TV, Seager AL, Moller M, Morgan G, Thornton CA. Thymic stromal lymphopoietin is present in human breast milk. Pediatr Allergy Immunol 2010; 21:e454-456; PMID:20444169; http://dx.doi.org/10.1111/j.1399-3038.2009.00916.x
   Google Scholar
• Thornton CA, Morgan G. Innate and adaptive immune pathways to tolerance. Nestle Nutr Workshop Ser Pediatr Program 2009; 64:45-57; discussion 57-61, 251-257; PMID:19710514; http://dx.doi.org/10.1159/000235782
   PubMedGoogle Scholar
• Luo Y, Zhou B, Zhao M, Tang J, Lu Q. Promoter demethylation contributes to TSLP overexpression in skin lesions of patients with atopic dermatitis. Clin Exp Dermatol 2014; 39:48-53; PMID:24341479; http://dx.doi.org/10.1111/ced.12206
   PubMed Web of Science ®Google Scholar
• Briot A, Deraison C, Lacroix M, Bonnart C, Robin A, Besson C, Dubus P, Hovnanian A. Kallikrein 5 induces atopic dermatitis-like lesions through PAR2-mediated thymic stromal lymphopoietin expression in Netherton syndrome. J Exp Med 2009; 206:1135-47; PMID:19414552; http://dx.doi.org/10.1084/jem.20082242
   PubMed Web of Science ®Google Scholar
• Truneh A, Albert F, Golstein P, Schmitt-Verhulst AM. Early steps of lymphocyte activation bypassed by synergy between calcium ionophores and phorbol ester. Nature 1985; 313:318-20; PMID:3918270; http://dx.doi.org/10.1038/313318a0
   PubMed Web of Science ®Google Scholar
• Kim TK, St John LS, Wieder ED, Khalili J, Ma Q, Komanduri KV. Human late memory CD8+ T cells have a distinct cytokine signature characterized by CC chemokine production without IL-2 production. J Immunol 2009; 183:6167-74; PMID:19841187; http://dx.doi.org/10.4049/jimmunol.0902068
   PubMed Web of Science ®Google Scholar
• Kobayashi M, Kobayashi H, Pollard RB, Suzuki F. A pathogenic role of Th2 cells and their cytokine products on the pulmonary metastasis of murine B16 melanoma. J Immunol 1998; 160:5869-73; PMID:9637498
   PubMed Web of Science ®Google Scholar
• Berzofsky JA, Terabe M. A novel immunoregulatory axis of NKT cell subsets regulating tumor immunity. Cancer Immunol Immunother 2008; 57:1679-83; PMID:18369622; http://dx.doi.org/10.1007/s00262-008-0495-4
   PubMed Web of Science ®Google Scholar
• DeNardo DG, Barreto JB, Andreu P, Vasquez L, Tawfik D, Kolhatkar N, Coussens LM. CD4(+) T cells regulate pulmonary metastasis of mammary carcinomas by enhancing protumor properties of macrophages. Cancer Cell 2009; 16:91-102; PMID:19647220; http://dx.doi.org/10.1016/j.ccr.2009.06.018
   PubMed Web of Science ®Google Scholar
• Zhang Q, Qin J, Zhong L, Gong L, Zhang B, Zhang Y, Gao WQ. CCL5-mediated Th2 immune polarization promotes metastasis in luminal breast cancer. Cancer Res 2015; 75:4312-21; PMID:26249173; http://dx.doi.org/10.1158/0008-5472.CAN-14-3590
   PubMed Web of Science ®Google Scholar
• Koboldt DC, Fulton RS, McLellan MD, Schmidt H, Kalicki-Veizer J, McMichael JF, Fulton LL, Dooling DJ, Ding L, Mardis ER, et al. Comprehensive molecular portraits of human breast tumours. Nature 2012; 490:61-70; PMID:23000897; http://dx.doi.org/10.1038/nature11412
   PubMed Web of Science ®Google Scholar