Innate γδT17 cells play a protective role in DSS-induced colitis via recruitment of Gr-1⁺CD11b⁺ myeloid suppressor cells

References

• Colombel JF, Narula N, Peyrin-Biroulet L. Management strategies to improve outcomes of patients with inflammatory bowel diseases. Gastroenterology 2017; 152:351-61; PMID:27720840; https://doi.org/10.1053/j.gastro.2016.09.046
   PubMed Web of Science ®Google Scholar
• Ahmed I, Roy BC, Khan SA, Septer S, Umar S. Microbiome, metabolome and inflammatory bowel disease. Microorganisms 2016; 4:pii: E20; PMID:27681914; https://doi.org/10.3390/microorganisms4020020
   PubMed Web of Science ®Google Scholar
• Cai Y, Shen X, Ding C, Qi C, Li K, Li X, Jala VR, Zhang HG, Wang T, Zheng J et al. Pivotal role of dermal IL-17-producing gammadelta T cells in skin inflammation. Immunity 2011; 35:596-610; PMID:21982596; https://doi.org/10.1016/j.immuni.2011.08.001
   PubMed Web of Science ®Google Scholar
• Becher B, Pantelyushin S. Hiding under the skin: Interleukin-17-producing gammadelta T cells go under the skin? Nat Med 2012; 18:1748-50; PMID:23223063; https://doi.org/10.1038/nm.3016
   PubMed Web of Science ®Google Scholar
• Pagliari D, Urgesi R, Frosali S, Riccioni ME, Newton EE, Landolfi R, Pandolfi F, Cianci R. The interaction among microbiota, immunity, and genetic and dietary factors is the Condicio Sine Qua Non Celiac disease can develop. J Immunol Res 2015; 2015:123653; PMID:26090475; https://doi.org/10.1155/2015/123653
   PubMed Web of Science ®Google Scholar
• Dhawan S, De Palma G, Willemze RA, Hilbers FW, Verseijden C, Luyer MD, Nuding S, Wehkamp J, Souwer Y, de Jong EC et al. Acetylcholine-producing T cells in the intestine regulate antimicrobial peptide expression and microbial diversity. Am J Physiol Gastrointest Liver Physiol 2016; 311:G920-33; PMID:27514477; https://doi.org/10.1152/ajpgi.00114.2016
   PubMed Web of Science ®Google Scholar
• Ishikawa H, Li Y, Abeliovich A, Yamamoto S, Kaufmann SH, Tonegawa S. Cytotoxic and interferon gamma-producing activities of gamma delta T cells in the mouse intestinal epithelium are strain dependent. Proc Natl Acad Sci USA 1993; 90:8204-8; PMID:8367483; https://doi.org/10.1073/pnas.90.17.8204
   PubMed Web of Science ®Google Scholar
• Lahn M, Kanehiro A, Takeda K, Joetham A, Schwarze J, Köhler G, O'Brien R, Gelfand EW, Born W. Negative regulation of airway responsiveness that is dependent on gammadelta T cells and independent of alphabeta T cells. Nat Med 1999; 5:1150-6; PMID:10502818; https://doi.org/10.1038/13476
   PubMed Web of Science ®Google Scholar
• Carding SR, Egan PJ. The importance of gamma delta T cells in the resolution of pathogen-induced inflammatory immune responses. Immunol Rev 2000; 173:98-108; PMID:10719671; https://doi.org/10.1034/j.1600-065X.2000.917302.x
   PubMed Web of Science ®Google Scholar
• Lee JS, Tato CM, Joyce-Shaikh B, Gulen MF, Cayatte C, Chen Y, Blumenschein WM, Judo M, Ayanoglu G, McClanahan TK et al. Interleukin-23-independent IL-17 production regulates intestinal epithelial permeability. Immunity 2015; 43:727-38; PMID:26431948; https://doi.org/10.1016/j.immuni.2015.09.003
   PubMed Web of Science ®Google Scholar
• Pantelyushin S, Haak S, Ingold B, Kulig P, Heppner FL, Navarini AA, Becher B. Rorgammat+ innate lymphocytes and gammadelta T cells initiate psoriasiform plaque formation in mice. J Clin Invest 2012; 122:2252-6; PMID:22546855; https://doi.org/10.1172/JCI61862
   PubMed Web of Science ®Google Scholar
• Wu P, Wu D, Ni C, Ye J, Chen W, Hu G, Wang Z, Wang C, Zhang Z, Xia W et al. gammadeltaT17 cells promote the accumulation and expansion of myeloid-derived suppressor cells in human colorectal cancer. Immunity 2014; 40:785-800; PMID:24816404; https://doi.org/10.1016/j.immuni.2014.03.013
   PubMed Web of Science ®Google Scholar
• Fujihashi K, McGhee JR, Kweon MN, Cooper MD, Tonegawa S, Takahashi I, Hiroi T, Mestecky J, Kiyono H. gamma/delta T cell-deficient mice have impaired mucosal immunoglobulin A responses. J Exp Med 1996; 183:1929-35; PMID:8666951; https://doi.org/10.1084/jem.183.4.1929
   PubMed Web of Science ®Google Scholar
• Chen Y, Chou K, Fuchs E, Havran WL, Boismenu R. Protection of the intestinal mucosa by intraepithelial gamma delta T cells. Proc Natl Acad Sci USA 2002; 99:14338-43; PMID:12376619; https://doi.org/10.1073/pnas.212290499
   PubMed Web of Science ®Google Scholar
• Tsuchiya T, Fukuda S, Hamada H, Nakamura A, Kohama Y, Ishikawa H, Tsujikawa K, Yamamoto H. Role of gamma delta T cells in the inflammatory response of experimental colitis mice. J Immunol 2003; 171:5507-13; PMID:14607957; https://doi.org/10.4049/jimmunol.171.10.5507
   PubMed Web of Science ®Google Scholar
• Yeung MM, Melgar S, Baranov V, Oberg A, Danielsson A, Hammarström S, Hammarström ML. Characterisation of mucosal lymphoid aggregates in ulcerative colitis: immune cell phenotype and TcR-gammadelta expression. Gut 2000; 47:215-27; PMID:10896913; https://doi.org/10.1136/gut.47.2.215
   PubMed Web of Science ®Google Scholar
• McVay LD, Li B, Biancaniello R, Creighton MA, Bachwich D, Lichtenstein G, Rombeau JL, Carding SR. Changes in human mucosal gamma delta T cell repertoire and function associated with the disease process in inflammatory bowel disease. Mol Med 1997; 3:183-203; PMID:9100225
   PubMed Web of Science ®Google Scholar
• Kumar V, Patel S, Tcyganov E, Gabrilovich DI. The nature of myeloid-derived suppressor cells in the tumor microenvironment. Trends Immunol 2016; 37:208-20; PMID:26858199; https://doi.org/10.1016/j.it.2016.01.004
   PubMed Web of Science ®Google Scholar
• Ma G, Pan PY, Eisenstein S, Divino CM, Lowell CA, Takai T, Chen SH. Paired immunoglobin-like receptor-B regulates the suppressive function and fate of myeloid-derived suppressor cells. Immunity 2011; 34:385-95; PMID:21376641; https://doi.org/10.1016/j.immuni.2011.02.004
   PubMed Web of Science ®Google Scholar
• Cai Y, Xue F, Fleming C, Yang J, Ding C, Ma Y, Liu M, Zhang HG, Zheng J, Xiong N et al. Differential developmental requirement and peripheral regulation for dermal Vgamma4 and Vgamma6T17 cells in health and inflammation. Nat Commun 2014; 5:3986; PMID:24909159; https://doi.org/10.1038/ncomms4986
   PubMed Web of Science ®Google Scholar
• Rutkowski MR, Stephen TL, Svoronos N, Allegrezza MJ, Tesone AJ, Perales-Puchalt A, Brencicova E, Escovar-Fadul X, Nguyen JM, Cadungog MG et al. Microbially driven TLR5-dependent signaling governs distal malignant progression through tumor-promoting inflammation. Cancer Cell 2015; 27:27-40; PMID:25533336; https://doi.org/10.1016/j.ccell.2014.11.009
   PubMed Web of Science ®Google Scholar
• Meehan TF, Witherden DA, Kim CH, Sendaydiego K, Ye I, Garijo O, Komori HK, Kumanogoh A, Kikutani H, Eckmann L et al. Protection against colitis by CD100-dependent modulation of intraepithelial gammadelta T lymphocyte function. Mucosal Immunol 2014; 7:134-42; PMID:23695512; https://doi.org/10.1038/mi.2013.32
   PubMed Web of Science ®Google Scholar
• Chien YH, Meyer C, Bonneville M. Gammadelta T cells: first line of defense and beyond. Annu Rev Immunol 2014; 32:121-55; PMID:24387714; https://doi.org/10.1146/annurev-immunol-032713-120216
   PubMed Web of Science ®Google Scholar
• Vantourout P, Hayday A. Six-of-the-best: unique contributions of gammadelta T cells to immunology. Nat Rev Immunol 2013; 13:88-100; PMID:23348415; https://doi.org/10.1038/nri3384
   PubMed Web of Science ®Google Scholar
• Wang Y, Tian J, Tang X, Rui K, Tian X, Ma J, Ma B, Xu H, Lu L, Wang S. Exosomes released by granulocytic myeloid-derived suppressor cells attenuate DSS-induced colitis in mice. Oncotarget 2016; 7:15356-68; PMID:26885611; https://doi.org/10.18632/oncotarget.7324
   PubMed Web of Science ®Google Scholar
• Ratsimandresy RA, Indramohan M, Dorfleutner A, Stehlik C. The AIM2 inflammasome is a central regulator of intestinal homeostasis through the IL-18/IL-22/STAT3 pathway. Cell Mol Immunol 2016; 14:127-142; PMID:27524110; https://doi.org/10.1038/cmi.2016.35
   PubMed Web of Science ®Google Scholar
• Kryczek I, Wang L, Wu K, Li W, Zhao E, Cui T, Wei S, Liu Y, Wang Y, Vatan L et al. Inflammatory regulatory T cells in the microenvironments of ulcerative colitis and colon carcinoma. Oncoimmunology 2016; 5:e1105430; PMID:27622054; https://doi.org/10.1080/2162402X.2015.1105430
   PubMed Web of Science ®Google Scholar
• Xu Y, Hunt NH, Bao S. The role of granulocyte macrophage-colony-stimulating factor in acute intestinal inflammation. Cell Res 2008; 18:1220-9; PMID:19030026; https://doi.org/10.1038/cr.2008.310
   PubMed Web of Science ®Google Scholar
• Funderburg NT, Stubblefield Park SR, Sung HC, Hardy G, Clagett B, Ignatz-Hoover J, Harding CV, Fu P, Katz JA, Lederman MM et al. Circulating CD4(+) and CD8(+) T cells are activated in inflammatory bowel disease and are associated with plasma markers of inflammation. Immunology 2013; 140:87-97; PMID:23600521; https://doi.org/10.1111/imm.12114
   PubMed Web of Science ®Google Scholar
• Zhao Y, Wu T, Shao S, Shi B, Zhao Y. Phenotype, development, and biological function of myeloid-derived suppressor cells. Oncoimmunology 2016; 5:e1004983; PMID:27057424; https://doi.org/10.1080/2162402X.2015.1004983
   PubMed Web of Science ®Google Scholar
• Dupaul-Chicoine J, Yeretssian G, Doiron K, Bergstrom KS, McIntire CR, LeBlanc PM, Meunier C, Turbide C, Gros P, Beauchemin N et al. Control of intestinal homeostasis, colitis, and colitis-associated colorectal cancer by the inflammatory caspases. Immunity 2010; 32:367-78; PMID:20226691; https://doi.org/10.1016/j.immuni.2010.02.012
   PubMed Web of Science ®Google Scholar
• Zaki MH, Boyd KL, Vogel P, Kastan MB, Lamkanfi M, Kanneganti TD. The NLRP3 inflammasome protects against loss of epithelial integrity and mortality during experimental colitis. Immunity 2010; 32:379-91; PMID:20303296; https://doi.org/10.1016/j.immuni.2010.03.003
   PubMed Web of Science ®Google Scholar
• Lim HX, Hong HJ, Cho D, Kim TS. IL-18 enhances immunosuppressive responses by promoting differentiation into monocytic myeloid-derived suppressor cells. J Immunol 2014; 193:5453-60; PMID:25362180; https://doi.org/10.4049/jimmunol.1401282
   PubMed Web of Science ®Google Scholar
• Nowarski R, Jackson R, Gagliani N, de Zoete MR, Palm NW, Bailis W, Low JS, Harman CC, Graham M, Elinav E et al. Epithelial IL-18 equilibrium controls barrier function in colitis. Cell 2015; 163:1444-56; PMID:26638073; https://doi.org/10.1016/j.cell.2015.10.072
   PubMed Web of Science ®Google Scholar
• Ostrand-Rosenberg S, Sinha P. Myeloid-derived suppressor cells: linking inflammation and cancer. J Immunol 2009; 182:4499-506; PMID:19342621; https://doi.org/10.4049/jimmunol.0802740
   PubMed Web of Science ®Google Scholar
• Peng G, Wang HY, Peng W, Kiniwa Y, Seo KH, Wang RF. Tumor-infiltrating gammadelta T cells suppress T and dendritic cell function via mechanisms controlled by a unique toll-like receptor signaling pathway. Immunity 2007; 27:334-48; PMID:17656116; https://doi.org/10.1016/j.immuni.2007.05.020
   PubMed Web of Science ®Google Scholar
• Ye J, Ma C, Hsueh EC, Eickhoff CS, Zhang Y, Varvares MA, Hoft DF, Peng G. Tumor-derived gammadelta regulatory T cells suppress innate and adaptive immunity through the induction of immunosenescence. J Immunol 2013; 190:2403-14; PMID:23355732; https://doi.org/10.4049/jimmunol.1202369
   PubMed Web of Science ®Google Scholar
• Daley D, Zambirinis CP, Seifert L, Akkad N, Mohan N, Werba G, Barilla R, Torres-Hernandez A, Hundeyin M, Mani VR et al. gammadelta T cells support pancreatic oncogenesis by restraining alphabeta T Cell activation. Cell 2016; 166:1485-99 e15; PMID:27569912; https://doi.org/10.1016/j.cell.2016.07.046
   PubMed Web of Science ®Google Scholar
• Cheng M, Qian L, Shen G, Bian G, Xu T, Xu W, Shen G, Hu S. Microbiota modulate tumoral immune surveillance in lung through a gammadeltaT17 immune cell-dependent mechanism. Cancer Res 2014; 74:4030-41; PMID:24947042; https://doi.org/10.1158/0008-5472.CAN-13-2462
   PubMed Web of Science ®Google Scholar
• Matsuoka K, Kanai T. The gut microbiota and inflammatory bowel disease. Semin Immunopathol 2015; 37:47-55; PMID:25420450; https://doi.org/10.1007/s00281-014-0454-4
   PubMed Web of Science ®Google Scholar
• Colman RJ, Rubin DT. Histological inflammation increases the risk of colorectal neoplasia in ulcerative colitis: a systematic review. Intest Res 2016; 14:202-10; PMID:27433141; https://doi.org/10.5217/ir.2016.14.3.202
   PubMed Web of Science ®Google Scholar
• Axelrad JE, Lichtiger S, Yajnik V. Inflammatory bowel disease and cancer: the role of inflammation, immunosuppression, and cancer treatment. World J Gastroenterol 2016; 22:4794-801; PMID:27239106; https://doi.org/10.3748/wjg.v22.i20.4794
   PubMed Web of Science ®Google Scholar
• Katoh H, Wang D, Daikoku T, Sun H, Dey SK, Dubois RN. CXCR2-expressing myeloid-derived suppressor cells are essential to promote colitis-associated tumorigenesis. Cancer Cell 2013; 24:631-44; PMID:24229710; https://doi.org/10.1016/j.ccr.2013.10.009
   PubMed Web of Science ®Google Scholar
• Yan J, Huang J. Innate gammadeltaT17 cells convert cancer-elicited inflammation into immunosuppression through myeloid-derived suppressor cells. Oncoimmunology 2014; 3:e953423; PMID:25610744; https://doi.org/10.4161/21624011.2014.953423
   PubMed Web of Science ®Google Scholar
• Kim JJ, Shajib MS, Manocha MM, Khan WI. Investigating intestinal inflammation in DSS-induced model of IBD. J Vis Exp 2012;Feb 1; (60). pii:3678; PMID:22331082; https://doi.org/10.3791/3678
   PubMed Web of Science ®Google Scholar