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Brief Report

PD-L1 and epithelial-mesenchymal transition in circulating tumor cells from non-small cell lung cancer patients: A molecular shield to evade immune system?

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Article: e1315488 | Received 29 Dec 2016, Accepted 30 Mar 2017, Published online: 11 Oct 2017

References

  • Pardoll DM. The blockade of immune checkpoints in cancer immunotherapy. Nat Rev Cancer 2012; 12:252-64; PMID:22437870; https://doi.org/10.1038/nrc3239
  • Patel SP, Kurzrock R. PD-L1 expression as a predictive biomarker in cancer immunotherapy. Mol Cancer Ther 2015; 14:847-56; PMID:25695955; https://doi.org/10.1158/1535-7163.MCT-14-0983
  • Nicolazzo C, Raimondi C, Mancini ML, Caponnetto S, Gradilone A, Gandini O, Mastromartino M, Del Bene G, Prete A, Longo F et al. Monitoring PD-L1 positive circulating tumor cells in non-small cell lung cancer patients treated with the PD-1 inhibitor nivolumab. Sci Rep 2016; 6:31726; PMID:27553175; https://doi.org/10.1038/srep31726
  • Alsuliman A, Colak D, Al-Harazi O, Fitwi H, Tulbah A, Al-Tweigeri T, Al-Alwan M, Ghebeh H. Bidirectional crosstalk between PD-L1 expression and epithelial to mesenchymal transition: Significance in claudin-low breast cancer cells. Mol Cancer 2015; 14:149; PMID:26245467; https://doi.org/10.1186/s12943-015-0421-2
  • Carpino G, Cardinale V, Gentile R, Onori P, Semeraro R, Franchitto A, Wang Y, Bosco D, Iossa A, Napoletano C et al. Evidence for multipotent endodermal stem/progenitor cell populations in human gallbladder. J Hepatol 2014; 60:1194-202; PMID:24530598; https://doi.org/10.1016/j.jhep.2014.01.026
  • Onori P, Wise C, Gaudio E, Franchitto A, Francis H, Carpino G, Lee V, Lam I, Miller T, Dostal DE et al. Secretin inhibits cholangiocarcinoma growth via dysregulation of the cAMP-dependent signaling mechanisms of secretin receptor. Int J Cancer 2010; 127:43-54; PMID:19904746; https://doi.org/10.1002/ijc.25028
  • Yang KR, Mooney SM, Zarif JC, Coffey DS, Taichman RS, Pienta KJ. Niche inheritance: A cooperative pathway to enhance cancer cell fitness through ecosystem engineering. J Cell Biochem 2014; 115:1478-85; PMID:24700698; https://doi.org/10.1002/jcb.24813
  • Casás-Selves M, Degregori J. How cancer shapes evolution, and how evolution shapes cancer. Evolution (N Y) 2011; 4:624-34; PMID:23705033; https://doi.org/10.1007/s12052-011-0373-y
  • Ferrao PT, Behren A, Anderson RL, Thompson EW. Editorial: Cellular and phenotypic plasticity in cancer. Front Oncol 2015; 5:171; PMID:26301202; https://doi.org/10.3389/fonc.2015.00171
  • Friedl P, Alexander S. Cancer invasion and the microenvironment: Plasticity and reciprocity. Cell 2011; 147:992-1009; PMID:22118458; https://doi.org/10.1016/j.cell.2011.11.016
  • Schreiber RD, Old LJ, Smyth MJ. Cancer immunoediting: Integrating immunity's roles in cancer suppression and promotion. Science 2011; 331:1565-70; PMID:21436444; https://doi.org/10.1126/science.1203486
  • Terry S, Chouaib S. EMT in immuno-resistance. Oncoscience 2015; 2:841-2; PMID:26682272; https://doi.org/10.18632/oncoscience.226
  • Chen L, Heymach JV, Qin FX, Gibbons DL. The mutually regulatory loop of epithelial-mesenchymal transition and immunosuppression in cancer progression. Oncoimmunology 2015; 4(5):e1002731; PMID:26155392; https://doi.org/10.1080/2162402X.2014.1002731
  • Chouaib S, Janji B, Tittarelli A, Eggermont A, Thiery JP. Tumor plasticity interferes with anti-tumor immunity. Crit Rev Immunol 2014; 34:91-102; PMID:24940910; https://doi.org/10.1615/CritRevImmunol.2014010183
  • Chen L, Gibbons DL, Goswami S, Cortez MA, Ahn YH, Byers LA, Zhang X, Yi X, Dwyer D, Lin W et al. Metastasis is regulated via microRNA-200/ZEB1 axis control of tumour cell PD-L1 expression and intratumoral immunosuppression. Nat Commun 2014; 5:5241; PMID:25348003; https://doi.org/10.1038/ncomms6241
  • Lou Y, Diao L, Cuentas ER, Denning WL, Chen L, Fan YH, Byers LA, Wang J, Papadimitrakopoulou VA, Behrens C et al. Epithelial-Mesenchymal transition is associated with a distinct tumor microenvironment including elevation of inflammatory signals and multiple immune checkpoints in lung adenocarcinoma. Clin Cancer Res 2016; 22:3630-42; PMID:26851185; https://doi.org/10.1158/1078-0432.CCR-15-1434
  • Datar I, Schalper KA. Epithelial-Mesenchymal transition and immune evasion during lung cancer progression, the chicken or the egg? Clin Cancer Res 2016; 22:3422-4; PMID:27076625; https://doi.org/10.1158/1078-0432.CCR-16-0336
  • Kim S, Koh J, Kim MY, Kwon D, Go H, Kim YA, Jeon YK, Chung DH. PD-L1 expression is associated with epithelial-to-mesenchymal transition in adenocarcinoma of the lung. Hum Pathol 2016; 58:7-14; PMID:27473266; https://doi.org/10.1016/j.humpath.2016.07.007
  • Mazel M, Jacot W, Pantel K, Bartkowiak K, Topart D, Cayrefourcq L, Rossille D, Maudelonde T, Fest T, Alix-Panabières C. Frequent expression of PD-L1 on circulating breast cancer cells. Mol Oncol 2015; 9:1773-82; PMID:26093818; https://doi.org/10.1016/j.molonc.2015.05.009
  • Satelli A, Batth IS, Brownlee Z, Rojas C, Meng QH, Kopetz S, Li S. Potential role of nuclear PD-L1 expression in cell-surface vimentin positive circulating tumor cells as a prognostic marker in cancer patients. Sci Rep 2016; 6:28910; PMID:27363678; https://doi.org/10.1038/srep28910
  • Ghebeh H, Lehe C, Barhoush E, Al-Romaih K, Tulbah A, Al-Alwan M, Hendrayani SF, Manogaran P, Alaiya A, Al-Tweigeri T et al. Doxorubicin downregulates cell surface B7-H1 expression and upregulates its nuclear expression in breast cancer cells: Role of B7-H1 as an anti-apoptotic molecule. Breast Cancer Res 2010; 12(4):R48; PMID:20626886; https://doi.org/10.1186/bcr2605
  • Azuma T, Yao S, Zhu G, Flies AS, Flies SJ, Chen L. B7-H1 is a ubiquitous antiapoptotic receptor on cancer cells. Blood 2008; 111:3635-43; PMID:18223165; https://doi.org/10.1182/blood-2007-11-123141

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