CEACAM1 as a multi-purpose target for cancer immunotherapy

References

• Hanahan D, Weinberg RA. Hallmarks of cancer: the next generation. Cell 2011; 144:646-74; PMID:21376230; https://doi.org/10.1016/j.cell.2011.02.013
   PubMed Web of Science ®Google Scholar
• Beck A, Wurch T, Bailly C, Corvaia N. Strategies and challenges for the next generation of therapeutic antibodies. Nat Rev Immunol 2010; 10:345-52; PMID:20414207; https://doi.org/10.1038/nri2747
   PubMed Web of Science ®Google Scholar
• Ortenberg R, Sapir Y, Raz L, Hershkovitz L, Ben Arav A, Sapoznik S, Barshack I, Avivi C, Berkun Y, Besser MJ et al. Novel immunotherapy for malignant melanoma with a monoclonal antibody that blocks CEACAM1 homophilic interactions. Mol Cancer Ther 2012; 11:1300-10; PMID:22466331; https://doi.org/10.1158/1535-7163.MCT-11-0526
   PubMed Web of Science ®Google Scholar
• Beauchemin N, Draber P, Dveksler G, Gold P, Gray-Owen S, Grunert F, Hammarstrom S, Holmes KV, Karlsson A, Kuroki M et al. Redefined nomenclature for members of the carcinoembryonic antigen family. Exp Cell Res 1999; 252:243-9; PMID:11501563; https://doi.org/10.1006/excr.1999.4610
   PubMed Web of Science ®Google Scholar
• Huang YH, Zhu C, Kondo Y, Anderson AC, Gandhi A, Russell A, Dougan SK, Petersen BS, Melum E, Pertel T et al. CEACAM1 regulates TIM-3-mediated tolerance and exhaustion. Nature 2015; 517:386-90; PMID:25363763; https://doi.org/10.1038/nature13848
   PubMed Web of Science ®Google Scholar
• Gray-Owen SD, Blumberg RS. CEACAM1: contact-dependent control of immunity. Nat Rev Immunol 2006; 6:433-46; PMID:16724098; https://doi.org/10.1038/nri1864
   PubMed Web of Science ®Google Scholar
• Beauchemin N, Arabzadeh A. Carcinoembryonic antigen-related cell adhesion molecules (CEACAMs) in cancer progression and metastasis. Cancer Metastasis Rev 2013; 32:643-71; PMID:23903773; https://doi.org/10.1007/s10555-013-9444-6
   PubMed Web of Science ®Google Scholar
• Beauchemin N, Kunath T, Robitaille J, Chow B, Turbide C, Daniels E, Veillette A. Association of biliary glycoprotein with protein tyrosine phosphatase SHP-1 in malignant colon epithelial cells. Oncogene 1997; 14:783-90; PMID:9047385; https://doi.org/10.1038/sj.onc.1200888
   PubMed Web of Science ®Google Scholar
• Huber M, Izzi L, Grondin P, Houde C, Kunath T, Veillette A, Beauchemin N. The carboxyl-terminal region of biliary glycoprotein controls its tyrosine phosphorylation and association with protein-tyrosine phosphatases SHP-1 and SHP-2 in epithelial cells. J Biol Chem 1999; 274:335-44; PMID:9867848; https://doi.org/10.1074/jbc.274.1.335
   PubMed Web of Science ®Google Scholar
• Kammerer R, Zimmermann W. Coevolution of activating and inhibitory receptors within mammalian carcinoembryonic antigen families. BMC Biol 2010; 8:12; PMID:20132533; https://doi.org/10.1186/1741-7007-8-12
   PubMed Web of Science ®Google Scholar
• Ieda J, Yokoyama S, Tamura K, Takifuji K, Hotta T, Matsuda K, Oku Y, Nasu T, Kiriyama S, Yamamoto N et al. Re-expression of CEACAM1 long cytoplasmic domain isoform is associated with invasion and migration of colorectal cancer. Int J Cancer 2011; 129:1351-61; PMID:21413011; https://doi.org/10.1002/ijc.26072
   PubMed Web of Science ®Google Scholar
• Chen L, Chen Z, Baker K, Halvorsen EM, da Cunha AP, Flak MB, Gerber G, Huang YH, Hosomi S, Arthur JC et al. The short isoform of the CEACAM1 receptor in intestinal T cells regulates mucosal immunity and homeostasis via Tfh cell induction. Immunity 2012; 37:930-46; PMID:23123061; https://doi.org/10.1016/j.immuni.2012.07.016
   PubMed Web of Science ®Google Scholar
• Markel G, Achdout H, Katz G, Ling KL, Salio M, Gruda R, Gazit R, Mizrahi S, Hanna J, Gonen-Gross T et al. Biological function of the soluble CEACAM1 protein and implications in TAP2-deficient patients. Euro J Immunol 2004; 34:2138-48; PMID:15259011; https://doi.org/10.1002/eji.200425021
   PubMed Web of Science ®Google Scholar
• Markel G, Ortenberg R, Seidman R, Sapoznik S, Koren-Morag N, Besser MJ, Bar J, Shapira R, Kubi A, Nardini G et al. Systemic dysregulation of CEACAM1 in melanoma patients. Cancer immunol Immunother 2010; 59:215-30; PMID:19633846; https://doi.org/10.1007/s00262-009-0740-5
   PubMed Web of Science ®Google Scholar
• Simeone DM, Ji B, Banerjee M, Arumugam T, Li D, Anderson MA, Bamberger AM, Greenson J, Brand RE, Ramachandran V et al. CEACAM1, a novel serum biomarker for pancreatic cancer. Pancreas 2007; 34:436-43; PMID:17446843; https://doi.org/10.1097/MPA.0b013e3180333ae3
   PubMed Web of Science ®Google Scholar
• Tilki D, Singer BB, Shariat SF, Behrend A, Fernando M, Irmak S, Buchner A, Hooper AT, Stief CG, Reich O et al. CEACAM1: a novel urinary marker for bladder cancer detection. Euro Urol 2010; 57:648-54; PMID:19487071; https://doi.org/10.1016/j.eururo.2009.05.040
   PubMed Web of Science ®Google Scholar
• Wojtowicz ME, Dunn BK, Umar A. Immunologic approaches to cancer prevention-current status, challenges, and future perspectives. Semin Oncol 2016; 43:161-72; PMID:26970135; https://doi.org/10.1053/j.seminoncol.2015.11.001
   PubMed Web of Science ®Google Scholar
• Mahoney KM, Rennert PD, Freeman GJ. Combination cancer immunotherapy and new immunomodulatory targets. Nat Rev Drug Discov 2015; 14:561-84; PMID:26228759; https://doi.org/10.1038/nrd4591
   PubMed Web of Science ®Google Scholar
• Beck A, Goetsch L, Dumontet C, Corvaia N. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov 2017; 16(5):315-37; PMID:28303026; https://doi.org/10.1038/nrd.2016.268
   PubMed Web of Science ®Google Scholar
• Moller MJ, Kammerer R, Grunert F, von Kleist S. Biliary glycoprotein (BGP) expression on T cells and on a natural-killer-cell sub-population. Int J Cancer 1996; 65:740-5; PMID:8631584; https://doi.org/10.1002/(SICI)1097-0215(19960315)65:6%3c740::AID-IJC5%3e3.0.CO;2-Z
   PubMed Web of Science ®Google Scholar
• Kammerer R, Hahn S, Singer BB, Luo JS, von Kleist S. Biliary glycoprotein (CD66a), a cell adhesion molecule of the immunoglobulin superfamily, on human lymphocytes: structure, expression and involvement in T cell activation. Eur J Immunol 1998; 28:3664-74; PMID:9842909; https://doi.org/10.1002/(SICI)1521-4141(199811)28:11%3c3664::AID-IMMU3664%3e3.0.CO;2-D
   PubMed Web of Science ®Google Scholar
• Nakajima A, Iijima H, Neurath MF, Nagaishi T, Nieuwenhuis EE, Raychowdhury R, Glickman J, Blau DM, Russell S, Holmes KV et al. Activation-induced expression of carcinoembryonic antigen-cell adhesion molecule 1 regulates mouse T lymphocyte function. J Immunol (Baltimore, Md.: 1950) 2002; 168:1028-35; PMID:11801635; https://doi.org/10.4049/jimmunol.168.3.1028
   PubMed Web of Science ®Google Scholar
• Morales VM, Christ A, Watt SM, Kim HS, Johnson KW, Utku N, Texieira AM, Mizoguchi A, Mizoguchi E, Russell GJ et al. Regulation of human intestinal intraepithelial lymphocyte cytolytic function by biliary glycoprotein (CD66a). J Immunol (Baltimore, Md.: 1950) 1999; 163:1363-70; PMID:10415036
   PubMed Web of Science ®Google Scholar
• Donda A, Mori L, Shamshiev A, Carena I, Mottet C, Heim MH, Beglinger C, Grunert F, Rochlitz C, Terracciano L et al. Locally inducible CD66a (CEACAM1) as an amplifier of the human intestinal T cell response. Euro J Immunol 2000; 30:2593-603; PMID:11009093; https://doi.org/10.1002/1521-4141(200009)30:9%3c2593::AID-IMMU2593%3e3.0.CO;2-0
   PubMed Web of Science ®Google Scholar
• Chen D, Iijima H, Nagaishi T, Nakajima A, Russell S, Raychowdhury R, Morales V, Rudd CE, Utku N, Blumberg RS. Carcinoembryonic antigen-related cellular adhesion molecule 1 isoforms alternatively inhibit and costimulate human T cell function. J Immunol (Baltimore, Md.: 1950) 2004; 172:3535-43; PMID:15004154; https://doi.org/10.4049/jimmunol.172.6.3535
   PubMed Web of Science ®Google Scholar
• Singer BB, Scheffrahn I, Heymann R, Sigmundsson K, Kammerer R, Obrink B. Carcinoembryonic antigen-related cell adhesion molecule 1 expression and signaling in human, mouse, and rat leukocytes: evidence for replacement of the short cytoplasmic domain isoform by glycosylphosphatidylinositol-linked proteins in human leukocytes. J Immunol (Baltimore, Md.: 1950) 2002; 168:5139-46; PMID:11994468; https://doi.org/10.4049/jimmunol.168.10.5139
   PubMed Web of Science ®Google Scholar
• Staub E, Rosenthal A, Hinzmann B. Systematic identification of immunoreceptor tyrosine-based inhibitory motifs in the human proteome. Cell Signal 2004; 16:435-56; PMID:14709333; https://doi.org/10.1016/j.cellsig.2003.08.013
   PubMed Web of Science ®Google Scholar
• Chen Z, Chen L, Qiao SW, Nagaishi T, Blumberg RS. Carcinoembryonic antigen-related cell adhesion molecule 1 inhibits proximal TCR signaling by targeting ZAP-70. J Immunol (Baltimore, Md.: 1950) 2008; 180:6085-93; PMID:18424730; https://doi.org/10.4049/jimmunol.180.9.6085
   PubMed Web of Science ®Google Scholar
• Lee HS, Ostrowski MA, Gray-Owen SD. CEACAM1 dynamics during Neisseria gonorrhoeae suppression of CD4+ T lymphocyte activation. J Immunol (Baltimore, Md.: 1950) 2008; 180:6827-35; PMID:18453603; https://doi.org/10.4049/jimmunol.180.10.6827
   PubMed Web of Science ®Google Scholar
• Iijima H, Neurath MF, Nagaishi T, Glickman JN, Nieuwenhuis EE, Nakajima A, Chen D, Fuss IJ, Utku N, Lewicki DN et al. Specific regulation of T helper cell 1-mediated murine colitis by CEACAM1. J Exp Med 2004; 199:471-82; PMID:14970176; https://doi.org/10.1084/jem.20030437
   PubMed Web of Science ®Google Scholar
• Dery KJ, Gaur S, Gencheva M, Yen Y, Shively JE, Gaur RK. Mechanistic control of carcinoembryonic antigen-related cell adhesion molecule-1 (CEACAM1) splice isoforms by the heterogeneous nuclear ribonuclear proteins hnRNP L, hnRNP A1, and hnRNP M. J Biol Chem 2011; 286:16039-51; PMID:21398516; https://doi.org/10.1074/jbc.M110.204057
   PubMed Web of Science ®Google Scholar
• Nagaishi T, Pao L, Lin SH, Iijima H, Kaser A, Qiao SW, Chen Z, Glickman J, Najjar SM, Nakajima A et al. SHP1 phosphatase-dependent T cell inhibition by CEACAM1 adhesion molecule isoforms. Immunity 2006; 25:769-81; PMID:17081782; https://doi.org/10.1016/j.immuni.2006.08.026
   PubMed Web of Science ®Google Scholar
• Jin Y, Lin Y, Lin L, Sun Y, Zheng C. Carcinoembryonic antigen related cellular adhesion molecule 1 alleviates dextran sulfate sodium-induced ulcerative colitis in mice. Life Sci 2016; 149:120-8; PMID:26898127; https://doi.org/10.1016/j.lfs.2016.02.065
   PubMed Web of Science ®Google Scholar
• Fujita M, Otsuka T, Mizuno M, Tomi C, Yamamura T, Miyake S. Carcinoembryonic antigen-related cell adhesion molecule 1 modulates experimental autoimmune encephalomyelitis via an iNKT cell-dependent mechanism. Am J Pathol 2009; 175:1116-23; PMID:19700760; https://doi.org/10.2353/ajpath.2009.090265
   PubMed Web of Science ®Google Scholar
• Watanabe N, Kaminuma O, Kitamura N, Hiroi T. Induced treg cells augment the Th17-mediated intestinal inflammatory response in a CTLA4-dependent manner. PloS One 2016; 11:e0150244; PMID:26950218; https://doi.org/10.1371/journal.pone.0150244
   PubMed Web of Science ®Google Scholar
• Song MY, Hong CP, Park SJ, Kim JH, Yang BG, Park Y, Kim SW, Kim KS, Lee JY, Lee SW et al. Protective effects of Fc-fused PD-L1 on two different animal models of colitis. Gut 2015; 64:260-71; PMID:24902766; https://doi.org/10.1136/gutjnl-2014-307311
   PubMed Web of Science ®Google Scholar
• Costello CM, Mah N, Hasler R, Rosenstiel P, Waetzig GH, Hahn A, Lu T, Gurbuz Y, Nikolaus S, Albrecht M et al. Dissection of the inflammatory bowel disease transcriptome using genome-wide cDNA microarrays. PLoS Med 2005; 2:e199; PMID:16107186; https://doi.org/10.1371/journal.pmed.0020199
   PubMed Web of Science ®Google Scholar
• Dooley TP, Curto EV, Reddy SP, Davis RL, Lambert GW, Wilborn TW, Elson CO. Regulation of gene expression in inflammatory bowel disease and correlation with IBD drugs: screening by DNA microarrays. Inflamm Bowel Dis 2004; 10:1-14; PMID:15058520; https://doi.org/10.1097/00054725-200401000-00001
   PubMed Web of Science ®Google Scholar
• Li Y, Shively JE. CEACAM1 regulates Fas-mediated apoptosis in Jurkat T-cells via its interaction with beta-catenin. Exp Cell Res 2013; 319:1061-72; PMID:23499736; https://doi.org/10.1016/j.yexcr.2013.02.020
   PubMed Web of Science ®Google Scholar
• Anderson AC, Joller N, Kuchroo VK. Lag-3, Tim-3, and TIGIT: co-inhibitory receptors with specialized functions in immune regulation. Immunity 2016; 44:989-1004; PMID:27192565; https://doi.org/10.1016/j.immuni.2016.05.001
   PubMed Web of Science ®Google Scholar
• Sada-Ovalle I, Chavez-Galan L, Torre-Bouscoulet L, Nava-Gamino L, Barrera L, Jayaraman P, Torres-Rojas M, Salazar-Lezama MA, Behar SM. The Tim3-galectin 9 pathway induces antibacterial activity in human macrophages infected with Mycobacterium tuberculosis. J Immunol (Baltimore, Md.: 1950) 2012; 189:5896-902; PMID:23180819; https://doi.org/10.4049/jimmunol.1200990
   PubMed Web of Science ®Google Scholar
• Cho JL, Roche MI, Sandall B, Brass AL, Seed B, Xavier RJ, Medoff BD. Enhanced Tim3 activity improves survival after influenza infection. J Immunol (Baltimore, Md.: 1950) 2012; 189:2879-89; PMID:22875804; https://doi.org/10.4049/jimmunol.1102483
   PubMed Web of Science ®Google Scholar
• Huang YH, Zhu C, Kondo Y, Anderson AC, Gandhi A, Russell A, Dougan SK, Petersen BS, Melum E, Pertel T et al. Corrigendum: CEACAM1 regulates TIM-3-mediated tolerance and exhaustion. Nature 2016; 536:359; PMID:26982724; https://doi.org/10.1038/nature17421
   PubMed Web of Science ®Google Scholar
• Zhang Y, Cai P, Li L, Shi L, Chang P, Liang T, Yang Q, Liu Y, Wang L, Hu L. Co-expression of TIM-3 and CEACAM1 promotes T cell exhaustion in colorectal cancer patients. Int Immunopharmacol 2016; 43:210-8; PMID:28038383; https://doi.org/10.1016/j.intimp.2016.12.024
   PubMed Web of Science ®Google Scholar
• Marquez-Rodas I, Cerezuela P, Soria A, Berrocal A, Riso A, Gonzalez-Cao M, Martin-Algarra S. Immune checkpoint inhibitors: therapeutic advances in melanoma. Ann Transl Med 2015; 3:267; PMID:26605313; https://doi.org/10.3978/j.issn.2305-5839.2015.10.27
   PubMed Web of Science ®Google Scholar
• Vivier E, Raulet DH, Moretta A, Caligiuri MA, Zitvogel L, Lanier LL, Yokoyama WM, Ugolini S. Innate or adaptive immunity? The example of natural killer cells. Science (New York, N.Y.) 2011; 331:44-9; PMID:21212348; https://doi.org/10.1126/science.1198687
   PubMed Web of Science ®Google Scholar
• Morvan MG, Lanier LL. NK cells and cancer: you can teach innate cells new tricks. Nat Rev Cancer 2015; 16:7-19; PMID:26694935; https://doi.org/10.1038/nrc.2015.5
   PubMed Web of Science ®Google Scholar
• Markel G, Lieberman N, Katz G, Arnon TI, Lotem M, Drize O, Blumberg RS, Bar-Haim E, Mader R, Eisenbach L et al. CD66a interactions between human melanoma and NK cells: a novel class I MHC-independent inhibitory mechanism of cytotoxicity. J Immunol (Baltimore, Md.: 1950) 2002; 168:2803-10; PMID:11884449; https://doi.org/10.4049/jimmunol.168.6.2803
   PubMed Web of Science ®Google Scholar
• Dupuis ML, Fiori V, Soriani A, Ricci B, Dominici S, Moricoli D, Ascione A, Santoni A, Magnani M, Cianfriglia M. The human antibody fragment DIATHIS1 specific for CEACAM1 enhances natural killer cell cytotoxicity against melanoma cell lines in vitro. J Immunother (Hagerstown, Md.: 1997) 2015; 38:357-70; PMID:26448580; https://doi.org/10.1097/CJI.0000000000000100
   PubMed Web of Science ®Google Scholar
• Markel G, Mussaffi H, Ling KL, Salio M, Gadola S, Steuer G, Blau H, Achdout H, de Miguel M, Gonen-Gross T et al. The mechanisms controlling NK cell autoreactivity in TAP2-deficient patients. Blood 2004; 103:1770-8; PMID:14604968; https://doi.org/10.1182/blood-2003-06-2114
   PubMed Web of Science ®Google Scholar
• Ndhlovu LC, Lopez-Verges S, Barbour JD, Jones RB, Jha AR, Long BR, Schoeffler EC, Fujita T, Nixon DF, Lanier LL. Tim-3 marks human natural killer cell maturation and suppresses cell-mediated cytotoxicity. Blood 2012; 119:3734-43; PMID:22383801; https://doi.org/10.1182/blood-2011-11-392951
   PubMed Web of Science ®Google Scholar
• Stern N, Markel G, Arnon TI, Gruda R, Wong H, Gray-Owen SD, Mandelboim O. Carcinoembryonic antigen (CEA) inhibits NK killing via interaction with CEA-related cell adhesion molecule 1. J Immunol (Baltimore, Md.: 1950) 2005; 174:6692-701; PMID:15905509; https://doi.org/10.4049/jimmunol.174.11.6692
   PubMed Web of Science ®Google Scholar
• Markel G, Gruda R, Achdout H, Katz G, Nechama M, Blumberg RS, Kammerer R, Zimmermann W, Mandelboim O. The critical role of residues 43R and 44Q of carcinoembryonic antigen cell adhesion molecules-1 in the protection from killing by human NK cells. J Immunol (Baltimore, Md.: 1950) 2004; 173:3732-9; PMID:15356119; https://doi.org/10.4049/jimmunol.173.6.3732
   PubMed Web of Science ®Google Scholar
• Stern-Ginossar N, Nedvetzki S, Markel G, Gazit R, Betser-Cohen G, Achdout H, Aker M, Blumberg RS, Davis DM, Appelmelk B et al. Intercellular transfer of carcinoembryonic antigen from tumor cells to NK cells. J Immunol (Baltimore, Md.: 1950) 2007; 179:4424-34; PMID:17878338; https://doi.org/10.4049/jimmunol.179.7.4424
   PubMed Web of Science ®Google Scholar
• Chen Z, Chen L, Baker K, Olszak T, Zeissig S, Huang YH, Kuo TT, Mandelboim O, Beauchemin N, Lanier LL et al. CEACAM1 dampens antitumor immunity by down-regulating NKG2D ligand expression on tumor cells. J Exp Med 2011; 208:2633-40; PMID:22143889; https://doi.org/10.1084/jem.20102575
   PubMed Web of Science ®Google Scholar
• Ullrich N, Heinemann A, Nilewski E, Scheffrahn I, Klode J, Scherag A, Schadendorf D, Singer BB, Helfrich I. CEACAM1-3S drives melanoma cells into NK cell-mediated cytolysis and enhances patient survival. Cancer Res 2015; 75:1897-907; PMID:25744717; https://doi.org/10.1158/0008-5472.CAN-14-1752
   PubMed Web of Science ®Google Scholar
• Hosomi S, Chen Z, Baker K, Chen L, Huang YH, Olszak T, Zeissig S, Wang JH, Mandelboim O, Beauchemin N et al. CEACAM1 on activated NK cells inhibits NKG2D-mediated cytolytic function and signaling. Eur J Immunol 2013; 43:2473-83; PMID:23696226; https://doi.org/10.1002/eji.201242676
   PubMed Web of Science ®Google Scholar
• Blake SJ, Stannard K, Liu J, Allen S, Yong MC, Mittal D, Aguilera AR, Miles JJ, Lutzky VP, de Andrade LF et al. Suppression of metastases using a new lymphocyte checkpoint target for cancer immunotherapy. Cancer Discov 2016; 6:446-59; PMID:26787820; https://doi.org/10.1158/2159-8290.CD-15-0944
   PubMed Web of Science ®Google Scholar
• Zitvogel L, Kroemer G. Cancer: antibodies regulate antitumour immunity. Nature 2015; 521:35-37; PMID:25924066; https://doi.org/10.1038/nature14388
   PubMed Web of Science ®Google Scholar
• Chen T, Zimmermann W, Parker J, Chen I, Maeda A, Bolland S. Biliary glycoprotein (BGPa, CD66a, CEACAM1) mediates inhibitory signals. J Leukoc Biol 2001; 70:335-40; PMID:11493628
   PubMed Web of Science ®Google Scholar
• Greicius G, Severinson E, Beauchemin N, Obrink B, Singer BB. CEACAM1 is a potent regulator of B cell receptor complex-induced activation. J Leukoc Biol 2003; 74:126-34; PMID:12832451; https://doi.org/10.1189/jlb.1202594
   PubMed Web of Science ®Google Scholar
• Khairnar V, Duhan V, Maney SK, Honke N, Shaabani N, Pandyra AA, Seifert M, Pozdeev V, Xu HC, Sharma P et al. CEACAM1 induces B-cell survival and is essential for protective antiviral antibody production. Nat Commun 2015; 6:6217; PMID:25692415; https://doi.org/10.1038/ncomms7217
   PubMed Web of Science ®Google Scholar
• Lobo EO, Zhang Z, Shively JE. Pivotal advance: CEACAM1 is a negative coreceptor for the B cell receptor and promotes CD19-mediated adhesion of B cells in a PI3K-dependent manner. J Leukoc Biol 2009; 86:205-18; PMID:19454653; https://doi.org/10.1189/jlb.0109037
   PubMed Web of Science ®Google Scholar
• Pan H, Shively JE. Carcinoembryonic antigen-related cell adhesion molecule-1 regulates granulopoiesis by inhibition of granulocyte colony-stimulating factor receptor. Immunity 2010; 33:620-31; PMID:21029969; https://doi.org/10.1016/j.immuni.2010.10.009
   PubMed Web of Science ®Google Scholar
• Sica A, Larghi P, Mancino A, Rubino L, Porta C, Totaro MG, Rimoldi M, Biswas SK, Allavena P, Mantovani A. Macrophage polarization in tumour progression. Semin cancer Biol 2008; 18:349-55; PMID:18467122; https://doi.org/10.1016/j.semcancer.2008.03.004
   PubMed Web of Science ®Google Scholar
• Noy R, Pollard JW. Tumor-associated macrophages: from mechanisms to therapy. Immunity 2014; 41:49-61; PMID:25035953; https://doi.org/10.1016/j.immuni.2014.06.010
   PubMed Web of Science ®Google Scholar
• Yu Q, Chow EM, Wong H, Gu J, Mandelboim O, Gray-Owen SD, Ostrowski MA. CEACAM1 (CD66a) promotes human monocyte survival via a phosphatidylinositol 3-kinase- and AKT-dependent pathway. J Biol Chem 2006; 281:39179-93; PMID:17071610; https://doi.org/10.1074/jbc.M608864200
   PubMed Web of Science ®Google Scholar
• Satoh T, Nakagawa K, Sugihara F, Kuwahara R, Ashihara M, Yamane F, Minowa Y, Fukushima K, Ebina I, Yoshioka Y et al. Identification of an atypical monocyte and committed progenitor involved in fibrosis. Nature 2017; 541:96-101; PMID:28002407; https://doi.org/10.1038/nature20611
   PubMed Web of Science ®Google Scholar
• Radisky DC, Kenny PA, Bissell MJ. Fibrosis and cancer: do myofibroblasts come also from epithelial cells via EMT? J Cell Biochem 2007; 101:830-9; PMID:17211838; https://doi.org/10.1002/jcb.21186
   PubMed Web of Science ®Google Scholar
• Nieto MA, Huang RY, Jackson RA, Thiery JP. EMT: 2016. Cell 2016; 166:21-45; PMID:27368099; https://doi.org/10.1016/j.cell.2016.06.028
   PubMed Web of Science ®Google Scholar
• Horst AK, Bickert T, Brewig N, Ludewig P, van Rooijen N, Schumacher U, Beauchemin N, Ito WD, Fleischer B, Wagener C et al. CEACAM1+ myeloid cells control angiogenesis in inflammation. Blood 2009; 113:6726-36; PMID:19273835; https://doi.org/10.1182/blood-2008-10-184556
   PubMed Web of Science ®Google Scholar
• Samineni S, Zhang Z, Shively JE. Carcinoembryonic antigen-related cell adhesion molecule 1 negatively regulates granulocyte colony-stimulating factor production by breast tumor-associated macrophages that mediate tumor angiogenesis. Int J Cancer 2013; 133:394-407; PMID:23319418; https://doi.org/10.1002/ijc.28036
   PubMed Web of Science ®Google Scholar
• Liang W, Ferrara N. The complex role of neutrophils in tumor angiogenesis and metastasis. Cancer Immunol Res 2016; 4:83-91; PMID:26839309; https://doi.org/10.1158/2326-6066.CIR-15-0313
   PubMed Web of Science ®Google Scholar
• Ducker TP, Skubitz KM. Subcellular localization of CD66, CD67, and NCA in human neutrophils. J Leukoc Biol 1992; 52:11-6; PMID:1640165
   PubMed Web of Science ®Google Scholar
• Jantscheff P, Nagel G, Thompson J, Kleist SV, Embleton MJ, Price MR, Grunert F. A CD66a-specific, activation-dependent epitope detected by recombinant human single chain fragments (scFvs) on CHO transfectants and activated granulocytes. J Leukoc Biol 1996; 59:891-901; PMID:8691075
   PubMed Web of Science ®Google Scholar
• Gray-Owen SD, Dehio C, Haude A, Grunert F, Meyer TF. CD66 carcinoembryonic antigens mediate interactions between Opa-expressing Neisseria gonorrhoeae and human polymorphonuclear phagocytes. EMBO J 1997; 16:3435-45; PMID:9218786; https://doi.org/10.1093/emboj/16.12.3435
   PubMed Web of Science ®Google Scholar
• Sintsova A, Sarantis H, Islam EA, Sun CX, Amin M, Chan CH, Stanners CP, Glogauer M, Gray-Owen SD. Global analysis of neutrophil responses to Neisseria gonorrhoeae reveals a self-propagating inflammatory program. PLoS Pathog 2014; 10:e1004341; PMID:25188454; https://doi.org/10.1371/journal.ppat.1004341
   PubMed Web of Science ®Google Scholar
• Sarantis H, Gray-Owen SD. Defining the roles of human carcinoembryonic antigen-related cellular adhesion molecules during neutrophil responses to Neisseria gonorrhoeae. Infect Immun 2012; 80:345-58; PMID:22064717; https://doi.org/10.1128/IAI.05702-11
   PubMed Web of Science ®Google Scholar
• Singer BB, Opp L, Heinrich A, Schreiber F, Binding-Liermann R, Berrocal-Almanza LC, Heyl KA, Muller MM, Weimann A, Zweigner J et al. Soluble CEACAM8 interacts with CEACAM1 inhibiting TLR2-triggered immune responses. PloS One 2014; 9:e94106; PMID:24743304; https://doi.org/10.1371/journal.pone.0094106
   PubMed Web of Science ®Google Scholar
• Singer BB, Klaile E, Scheffrahn I, Muller MM, Kammerer R, Reutter W, Obrink B, Lucka L. CEACAM1 (CD66a) mediates delay of spontaneous and Fas ligand-induced apoptosis in granulocytes. Eur J Immunol 2005; 35:1949-59; PMID:15909305; https://doi.org/10.1002/eji.200425691
   PubMed Web of Science ®Google Scholar
• Arabzadeh A, Chan C, Nouvion AL, Breton V, Benlolo S, DeMarte L, Turbide C, Brodt P, Ferri L, Beauchemin N. Host-related carcinoembryonic antigen cell adhesion molecule 1 promotes metastasis of colorectal cancer. Oncogene 2013; 32:849-60; PMID:22469976; https://doi.org/10.1038/onc.2012.112
   PubMed Web of Science ®Google Scholar
• Lu R, Kujawski M, Pan H, Shively JE. Tumor angiogenesis mediated by myeloid cells is negatively regulated by CEACAM1. Cancer Res 2012; 72:2239-50; PMID:22406619; https://doi.org/10.1158/0008-5472.CAN-11-3016
   PubMed Web of Science ®Google Scholar
• Wang N, Feng Y, Wang Q, Liu S, Xiang L, Sun M, Zhang X, Liu G, Qu X, Wei F. Neutrophils infiltration in the tongue squamous cell carcinoma and its correlation with CEACAM1 expression on tumor cells. PloS One 2014; 9:e89991; PMID:24587171; https://doi.org/10.1371/journal.pone.0089991
   PubMed Web of Science ®Google Scholar
• Lustberg MB. Management of neutropenia in cancer patients. Clin Adv Hematol Oncol 2012; 10:825-6; PMID:23271355
   PubMedGoogle Scholar
• Spiegel A, Brooks MW, Houshyar S, Reinhardt F, Ardolino M, Fessler E, Chen MB, Krall JA, DeCock J, Zervantonakis IK et al. Neutrophils suppress intraluminal NK cell-mediated tumor cell clearance and enhance extravasation of disseminated carcinoma cells. Cancer Discov 2016; 6(6):630-49; PMID:27072748; https://doi.org/10.1158/2159-8290.CD-15-1157
   PubMed Web of Science ®Google Scholar
• Najjar SM, Russo L. CEACAM1 loss links inflammation to insulin resistance in obesity and non-alcoholic steatohepatitis (NASH). Semin Immunopathol 2014; 36:55-71; PMID:24258517; https://doi.org/10.1007/s00281-013-0407-3
   PubMed Web of Science ®Google Scholar
• Najjar SM, Philippe N, Suzuki Y, Ignacio GA, Formisano P, Accili D, Taylor SI. Insulin-stimulated phosphorylation of recombinant pp120/HA4, an endogenous substrate of the insulin receptor tyrosine kinase. Biochemistry 1995; 34:9341-9; PMID:7626603; https://doi.org/10.1021/bi00029a009
   PubMed Web of Science ®Google Scholar
• Li Calzi S, Choice CV, Najjar SM. Differential effect of pp120 on insulin endocytosis by two variant insulin receptor isoforms. Am J Physiol 1997; 273:E801-8; PMID:9357811
   PubMed Web of Science ®Google Scholar
• Formisano P, Najjar SM, Gross CN, Philippe N, Oriente F, Kern-Buell CL, Accili D, Gorden P. Receptor-mediated internalization of insulin. Potential role of pp120/HA4, a substrate of the insulin receptor kinase. J Biol Chem 1995; 270:24073-7; PMID:7592607; https://doi.org/10.1074/jbc.270.41.24073
   PubMed Web of Science ®Google Scholar
• Najjar SM, Choice CV, Soni P, Whitman CM, Poy MN. Effect of pp120 on receptor-mediated insulin endocytosis is regulated by the juxtamembrane domain of the insulin receptor. J Biol Chem 1998; 273:12923-8; PMID:9582324; https://doi.org/10.1074/jbc.273.21.12923
   PubMed Web of Science ®Google Scholar
• Poy MN, Ruch RJ, Fernstrom MA, Okabayashi Y, Najjar SM. Shc and CEACAM1 interact to regulate the mitogenic action of insulin. J Biol Chem 2002; 277:1076-84; PMID:11694516; https://doi.org/10.1074/jbc.M108415200
   PubMed Web of Science ®Google Scholar
• Ursini-Siegel J, Muller WJ. The ShcA adaptor protein is a critical regulator of breast cancer progression. Cell Cycle (Georgetown, Tex.) 2008; 7:1936-43; PMID:18604176; https://doi.org/10.4161/cc.7.13.6205
   PubMed Web of Science ®Google Scholar
• Poy MN, Yang Y, Rezaei K, Fernstrom MA, Lee AD, Kido Y, Erickson SK, Najjar SM. CEACAM1 regulates insulin clearance in liver. Nat Genet 2002; 30:270-6; PMID:11850617; https://doi.org/10.1038/ng840
   PubMed Web of Science ®Google Scholar
• Xu E, Dubois MJ, Leung N, Charbonneau A, Turbide C, Avramoglu RK, DeMarte L, Elchebly M, Streichert T, Levy E et al. Targeted disruption of carcinoembryonic antigen-related cell adhesion molecule 1 promotes diet-induced hepatic steatosis and insulin resistance. Endocrinology 2009; 150:3503-12; PMID:19406938; https://doi.org/10.1210/en.2008-1439
   PubMed Web of Science ®Google Scholar
• Ghosh S, Kaw M, Patel PR, Ledford KJ, Bowman TA, McInerney MF, Erickson SK, Bourey RE, Najjar SM. Mice with null mutation of Ceacam I develop nonalcoholic steatohepatitis. Hepat Med 2010; 2010:69-78; PMID:21949477; https://doi.org/10.2147/HMER.S8902
   PubMedGoogle Scholar
• Heinrich G, Russo L, Castaneda TR, Pfeiffer V, Ghadieh HE, Ghanem SS, Wu J, Faulkner LD, Ergun S, McInerney MF et al. Leptin resistance contributes to obesity in mice with null mutation of carcinoembryonic antigen cell adhesion molecule 1. J Biol Chem 2016; 291(21):11124-32; PMID:27002145; https://doi.org/10.1074/jbc.M116.716431
   PubMed Web of Science ®Google Scholar
• Lee W. The CEACAM1 expression is decreased in the liver of severely obese patients with or without diabetes. Diagn Pathol 2011; 6:40; PMID:21569294; https://doi.org/10.1186/1746-1596-6-40
   PubMed Web of Science ®Google Scholar
• Baron A, Migita T, Tang D, Loda M. Fatty acid synthase: a metabolic oncogene in prostate cancer? J Cell Biochem 2004; 91:47-53; PMID:14689581; https://doi.org/10.1002/jcb.10708
   PubMed Web of Science ®Google Scholar
• Dubois MJ, Bergeron S, Kim HJ, Dombrowski L, Perreault M, Fournes B, Faure R, Olivier M, Beauchemin N, Shulman GI et al. The SHP-1 protein tyrosine phosphatase negatively modulates glucose homeostasis. Nat Med 2006; 12:549-56; PMID:16617349; https://doi.org/10.1038/nm1397
   PubMed Web of Science ®Google Scholar
• Wu C, Sun M, Liu L, Zhou GW. The function of the protein tyrosine phosphatase SHP-1 in cancer. Gene 2003; 306:1-12; PMID:12657462; https://doi.org/10.1016/S0378-1119(03)00400-1
   PubMed Web of Science ®Google Scholar
• Al-Share QY, DeAngelis AM, Lester SG, Bowman TA, Ramakrishnan SK, Abdallah SL, Russo L, Patel PR, Kaw MK, Raphael CK et al. Forced hepatic overexpression of CEACAM1 curtails diet-induced insulin resistance. Diabetes 2015; 64:2780-90; PMID:25972571; https://doi.org/10.2337/db14-1772
   PubMed Web of Science ®Google Scholar
• Lester SG, Russo L, Ghanem SS, Khuder SS, DeAngelis AM, Esakov EL, Bowman TA, Heinrich G, Al-Share QY, McInerney MF et al. Hepatic CEACAM1 over-expression protects against diet-induced fibrosis and inflammation in white adipose tissue. Front Endocrinol 2015; 6:116; PMID:26284027; https://doi.org/10.3389/fendo.2015.00116
   PubMed Web of Science ®Google Scholar
• Balasubramanian P, Varde PA, Abdallah SL, Najjar SM, MohanKumar PS, MohanKumar SM. Differential effects of prenatal stress on metabolic programming in diet-induced obese and dietary-resistant rats. Am J Physiol Endocrinol Metab 2015; 309:E582-8; PMID:26219866; https://doi.org/10.1152/ajpendo.00167.2015
   PubMed Web of Science ®Google Scholar
• DeAngelis AM, Heinrich G, Dai T, Bowman TA, Patel PR, Lee SJ, Hong EG, Jung DY, Assmann A, Kulkarni RN et al. Carcinoembryonic antigen-related cell adhesion molecule 1: a link between insulin and lipid metabolism. Diabetes 2008; 57:2296-303; PMID:18544705; https://doi.org/10.2337/db08-0379
   PubMed Web of Science ®Google Scholar
• Argiles JM, Busquets S, Stemmler B, Lopez-Soriano FJ. Cancer cachexia: understanding the molecular basis. Nat Rev Cancer 2014; 14:754-62; PMID:25291291; https://doi.org/10.1038/nrc3829
   PubMed Web of Science ®Google Scholar
• Rueckschloss U, Kuerten S, Ergun S. The role of CEA-related cell adhesion molecule-1 (CEACAM1) in vascular homeostasis. Histochem Cell Biol 2016; 146:657-71; PMID:27695943; https://doi.org/10.1007/s00418-016-1505-9
   PubMed Web of Science ®Google Scholar
• Sawa H, Kamada K, Sato H, Sendo S, Kondo A, Saito I, Edlund M, Obrink B. C-CAM expression in the developing rat central nervous system. Brain Res Dev Brain Res 1994; 78:35-43; PMID:8004772; https://doi.org/10.1016/0165-3806(94)90006-X
   PubMedGoogle Scholar
• rgun S, Kilik N, Ziegeler G, Hansen A, Nollau P, Gotze J, Wurmbach JH, Horst A, Weil J, Fernando M et al. CEA-related cell adhesion molecule 1: a potent angiogenic factor and a major effector of vascular endothelial growth factor. Mol Cell 2000; 5:311-20; PMID:10882072; https://doi.org/10.1016/S1097-2765(00)80426-8
   PubMed Web of Science ®Google Scholar
• Kilic N, Oliveira-Ferrer L, Wurmbach JH, Loges S, Chalajour F, Neshat-Vahid S, Weil J, Fernando M, Ergun S. Pro-angiogenic signaling by the endothelial presence of CEACAM1. J Biol Chem 2005; 280:2361-69; PMID:15536067; https://doi.org/10.1074/jbc.M409407200
   PubMed Web of Science ®Google Scholar
• Tilki D, Irmak S, Oliveira-Ferrer L, Hauschild J, Miethe K, Atakaya H, Hammerer P, Friedrich MG, Schuch G, Galalae R et al. CEA-related cell adhesion molecule-1 is involved in angiogenic switch in prostate cancer. Oncogene 2006; 25:4965-74; PMID:16568082; https://doi.org/10.1038/sj.onc.1209514
   PubMed Web of Science ®Google Scholar
• Gu A, Tsark W, Holmes KV, Shively JE. Role of Ceacam1 in VEGF induced vasculogenesis of murine embryonic stem cell-derived embryoid bodies in 3D culture. Exp Cell Res 2009; 315:1668-82; PMID:19285068; https://doi.org/10.1016/j.yexcr.2009.02.026
   PubMed Web of Science ®Google Scholar
• Zengin E, Chalajour F, Gehling UM, Ito WD, Treede H, Lauke H, Weil J, Reichenspurner H, Kilic N, Ergun S. Vascular wall resident progenitor cells: a source for postnatal vasculogenesis. Development (Cambridge, England) 2006; 133:1543-51; PMID:16524930; https://doi.org/10.1242/dev.02315
   PubMed Web of Science ®Google Scholar
• Horst AK, Ito WD, Dabelstein J, Schumacher U, Sander H, Turbide C, Brummer J, Meinertz T, Beauchemin N, Wagener C. Carcinoembryonic antigen-related cell adhesion molecule 1 modulates vascular remodeling in vitro and in vivo. J Clin Invest 2006; 116:1596-605; PMID:16680193; https://doi.org/10.1172/JCI24340
   PubMed Web of Science ®Google Scholar
• Gerstel D, Wegwitz F, Jannasch K, Ludewig P, Scheike K, Alves F, Beauchemin N, Deppert W, Wagener C, Horst AK. CEACAM1 creates a pro-angiogenic tumor microenvironment that supports tumor vessel maturation. Oncogene 2011; 30:4275-88; PMID:21532628; https://doi.org/10.1038/onc.2011.146
   PubMed Web of Science ®Google Scholar
• Najjar SM, Ledford KJ, Abdallah SL, Paus A, Russo L, Kaw MK, Ramakrishnan SK, Muturi HT, Raphael CK, Lester SG et al. Ceacam1 deletion causes vascular alterations in large vessels. Am J Physiol Endocrinol Metab 2013; 305:E519-29; PMID:23800882; https://doi.org/10.1152/ajpendo.00266.2013
   PubMed Web of Science ®Google Scholar
• Nouvion AL, Oubaha M, Leblanc S, Davis EC, Jastrow H, Kammerer R, Breton V, Turbide C, Ergun S, Gratton JP et al. CEACAM1: a key regulator of vascular permeability. J Cell Sci 2010; 123:4221-30; PMID:21081647; https://doi.org/10.1242/jcs.073635
   PubMed Web of Science ®Google Scholar
• Huang J, Ledford KJ, Pitkin WB, Russo L, Najjar SM, Siragy HM. Targeted deletion of murine CEACAM 1 activates PI3K-Akt signaling and contributes to the expression of (Pro)renin receptor via CREB family and NF-kappaB transcription factors. Hypertension 2013; 62:317-23; PMID:23734002; https://doi.org/10.1161/HYPERTENSIONAHA.113.01324
   PubMed Web of Science ®Google Scholar
• Li C, Culver SA, Quadri S, Ledford KL, Al-Share QY, Ghadieh HE, Najjar SM, Siragy HM. High-fat diet amplifies renal renin angiotensin system expression, blood pressure elevation, and renal dysfunction caused by Ceacam1 null deletion. Am J Physiol Endocrinol Metab 2015; 309:E802-10; PMID:26374765; https://doi.org/10.1152/ajpendo.00158.2015
   PubMed Web of Science ®Google Scholar
• Folkman J. Angiogenesis: an organizing principle for drug discovery? Nat Rev Drug Discov 2007; 6:273-86; PMID:17396134; https://doi.org/10.1038/nrd2115
   PubMed Web of Science ®Google Scholar
• Wang Y, Chen Y, Yan Y, Li X, Chen G, He N, Shen S, Chen G, Zhang C, Liao W et al. Loss of CEACAM1, a tumor-associated factor, attenuates post-infarction cardiac remodeling by inhibiting apoptosis. Sci Rep 2016; 6:21972; PMID:26911181; https://doi.org/10.1038/srep21972
   PubMed Web of Science ®Google Scholar
• Markel G, Imazio M, Koren-Morag N, Galore-Haskel G, Schachter J, Besser M, Cumetti D, Maestroni S, Altman A, Shoenfeld Y et al. CEACAM1 and MICA as novel serum biomarkers in patients with acute and recurrent pericarditis. Oncotarget 2016; 7(14):17885-95; PMID:26909604; https://doi.org/10.18632/oncotarget.7530
   PubMed Web of Science ®Google Scholar
• Thies A, Moll I, Berger J, Wagener C, Brummer J, Schulze HJ, Brunner G, Schumacher U. CEACAM1 expression in cutaneous malignant melanoma predicts the development of metastatic disease. J Clin Oncol 2002; 20:2530-6; PMID:12011132; https://doi.org/10.1200/JCO.2002.05.033
   PubMed Web of Science ®Google Scholar
• Thom I, Schult-Kronefeld O, Burkholder I, Schuch G, Andritzky B, Kastendieck H, Edler L, Wagener C, Bokemeyer C, Schumacher U et al. Expression of CEACAM-1 in pulmonary adenocarcinomas and their metastases. Anticancer Res 2009; 29:249-54; PMID:19331157
   PubMed Web of Science ®Google Scholar
• Thies A, Berlin A, Brunner G, Schulze HJ, Moll I, Pfuller U, Wagener C, Schachner M, Altevogt P, Schumacher U. Glycoconjugate profiling of primary melanoma and its sentinel node and distant metastases: implications for diagnosis and pathophysiology of metastases. Cancer Lett 2007; 248:68-80; PMID:16822608; https://doi.org/10.1016/j.canlet.2006.05.020
   PubMed Web of Science ®Google Scholar
• Kluger HM, Hoyt K, Bacchiocchi A, Mayer T, Kirsch J, Kluger Y, Sznol M, Ariyan S, Molinaro A, Halaban R. Plasma markers for identifying patients with metastatic melanoma. Clin Cancer Res 2011; 17:2417-25; PMID:21487066; https://doi.org/10.1158/1078-0432.CCR-10-2402
   PubMed Web of Science ®Google Scholar
• Khatib N, Pe'er J, Ortenberg R, Schachter J, Frenkel S, Markel G, Amer R. Carcinoembryonic antigen cell adhesion molecule-1 (CEACAM1) in posterior uveal melanoma: correlation with clinical and histological survival markers. Invest Ophthalmol Vis Sci 2011; 52:9368-72; PMID:22039239; https://doi.org/10.1167/iovs.10-6006
   PubMed Web of Science ®Google Scholar
• Gambichler T, Grothe S, Rotterdam S, Altmeyer P, Kreuter A. Protein expression of carcinoembryonic antigen cell adhesion molecules in benign and malignant melanocytic skin lesions. Am J Clin Pathol 2009; 131:782-7; PMID:19461083; https://doi.org/10.1309/AJCP24KXJVBZXENS
   PubMed Web of Science ®Google Scholar
• Ortenberg R, Galore-Haskel G, Greenberg I, Zamlin B, Sapoznik S, Greenberg E, Barshack I, Avivi C, Feiler Y, Zan-Bar I et al. CEACAM1 promotes melanoma cell growth through Sox-2. Neoplasia (New York, N.Y.) 2014; 16:451-60; PMID:24931667; https://doi.org/10.1016/j.neo.2014.05.003
   PubMed Web of Science ®Google Scholar
• Sivan S, Suzan F, Rona O, Tamar H, Vivian B, Tamar P, Jacob S, Gal M, Michal L. Serum CEACAM1 correlates with disease progression and survival in malignant melanoma patients. Clin Dev Immunol 2012; 2012:290536; PMID:22291846; https://doi.org/10.1155/2012/290536
   PubMed Web of Science ®Google Scholar
• Ortenberg R, Sapoznik S, Zippel D, Shapira-Frommer R, Itzhaki O, Kubi A, Zikich D, Besser MJ, Schachter J, Markel G. Serum CEACAM1 elevation correlates with melanoma progression and failure to respond to adoptive cell transfer immunotherapy. J Immunol Res 2015; 2015:902137; PMID:26688824; https://doi.org/10.1155/2015/902137
   PubMed Web of Science ®Google Scholar
• Shahabi V, Berman D, Chasalow SD, Wang L, Tsuchihashi Z, Hu B, Panting L, Jure-Kunkel M, Ji RR. Gene expression profiling of whole blood in ipilimumab-treated patients for identification of potential biomarkers of immune-related gastrointestinal adverse events. J Transl Med 2013; 11:75; PMID:23521917; https://doi.org/10.1186/1479-5876-11-75
   PubMed Web of Science ®Google Scholar
• Markel G, Seidman R, Stern N, Cohen-Sinai T, Izhaki O, Katz G, Besser M, Treves AJ, Blumberg RS, Loewenthal R et al. Inhibition of human tumor-infiltrating lymphocyte effector functions by the homophilic carcinoembryonic cell adhesion molecule 1 interactions. J Immunol (Baltimore, Md.: 1950) 2006; 177:6062-71; PMID:17056532; https://doi.org/10.4049/jimmunol.177.9.6062
   PubMed Web of Science ®Google Scholar
• Takahashi H, Okai Y, Paxton RJ, Hefta LJ, Shively JE. Differential regulation of carcinoembryonic antigen and biliary glycoprotein by gamma-interferon. Cancer Res 1993; 53:1612-9; PMID:8453631
   PubMed Web of Science ®Google Scholar
• Markel G, Seidman R, Cohen Y, Besser MJ, Sinai TC, Treves AJ, Orenstein A, Berger R, Schachter J. Dynamic expression of protective CEACAM1 on melanoma cells during specific immune attack. Immunology 2009; 126:186-200; PMID:18557789; https://doi.org/10.1111/j.1365-2567.2008.02888.x
   PubMed Web of Science ®Google Scholar
• Gold P, Freedman SO. Specific carcinoembryonic antigens of the human digestive system. J Exp Med 1965; 122:467-81; PMID:4953873; https://doi.org/10.1084/jem.122.3.467
   PubMed Web of Science ®Google Scholar
• Neumaier M, Paululat S, Chan A, Matthaes P, Wagener C. Biliary glycoprotein, a potential human cell adhesion molecule, is down-regulated in colorectal carcinomas. Proc Natl Acad Sci U S A 1993; 90:10744-8; PMID:7504281; https://doi.org/10.1073/pnas.90.22.10744
   PubMed Web of Science ®Google Scholar
• Kunath T, Ordonez-Garcia C, Turbide C, Beauchemin N. Inhibition of colonic tumor cell growth by biliary glycoprotein. Oncogene 1995; 11:2375-82; PMID:8570189
   PubMed Web of Science ®Google Scholar
• Nollau P, Scheller H, Kona-Horstmann M, Rohde S, Hagenmuller F, Wagener C, Neumaier M. Expression of CD66a (human C-CAM) and other members of the carcinoembryonic antigen gene family of adhesion molecules in human colorectal adenomas. Cancer Res 1997; 57:2354-57; PMID:9192807
   PubMed Web of Science ®Google Scholar
• Turbide C, Kunath T, Daniels E, Beauchemin N. Optimal ratios of biliary glycoprotein isoforms required for inhibition of colonic tumor cell growth. Cancer Res 1997; 57:2781-8; PMID:9205090
   PubMed Web of Science ®Google Scholar
• Izzi L, Turbide C, Houde C, Kunath T, Beauchemin N. cis-Determinants in the cytoplasmic domain of CEACAM1 responsible for its tumor inhibitory function. Oncogene 1999; 18:5563-72; PMID:10523833; https://doi.org/10.1038/sj.onc.1202935
   PubMed Web of Science ®Google Scholar
• Yeatman TJ, Mao W, Karl RC. Biliary glycoprotein is overexpressed in human colon cancer cells with high metastatic potential. J Gastrointest Sur 1997; 1:292-8; PMID:9834361; https://doi.org/10.1016/S1091-255X(97)80123-0
   PubMedGoogle Scholar
• Kang WY, Chen WT, Wu MT, Chai CY. The expression of CD66a and possible roles in colorectal adenoma and adenocarcinoma. Int J Colorectal Dis 2007; 22:869-74; PMID:17143599; https://doi.org/10.1007/s00384-006-0247-x
   PubMed Web of Science ®Google Scholar
• Song JH, Cao Z, Yoon JH, Nam SW, Kim SY, Lee JY, Park WS. Genetic alterations and expression pattern of CEACAM1 in colorectal adenomas and cancers. Pathol Oncol Res 2011; 17:67-74; PMID:20524097; https://doi.org/10.1007/s12253-010-9282-6
   PubMed Web of Science ®Google Scholar
• Ou G, Baranov V, Lundmark E, Hammarstrom S, Hammarstrom ML. Contribution of intestinal epithelial cells to innate immunity of the human gut––studies on polarized monolayers of colon carcinoma cells. Scand J Immunol 2009; 69:150-61; PMID:19170965; https://doi.org/10.1111/j.1365-3083.2008.02208.x
   PubMed Web of Science ®Google Scholar
• Arabzadeh A, Dupaul-Chicoine J, Breton V, Haftchenary S, Yumeen S, Turbide C, Saleh M, McGregor K, Greenwood CM, Akavia UD et al. Carcinoembryonic Antigen Cell Adhesion Molecule 1 long isoform modulates malignancy of poorly differentiated colon cancer cells. Gut 2016; 65:821-9; PMID:25666195; https://doi.org/10.1136/gutjnl-2014-308781
   PubMed Web of Science ®Google Scholar
• Ilantzis C, DeMarte L, Screaton RA, Stanners CP. Deregulated expression of the human tumor marker CEA and CEA family member CEACAM6 disrupts tissue architecture and blocks colonocyte differentiation. Neoplasia (New York, N.Y.) 2002; 4:151-63; PMID:11896570; https://doi.org/10.1038/sj.neo.7900201
   PubMed Web of Science ®Google Scholar
• Ordonez C, Screaton RA, Ilantzis C, Stanners CP. Human carcinoembryonic antigen functions as a general inhibitor of anoikis. Cancer Res 2000; 60:3419-24; PMID:10910050
   PubMed Web of Science ®Google Scholar
• Camacho-Leal P, Stanners CP. The human carcinoembryonic antigen (CEA) GPI anchor mediates anoikis inhibition by inactivation of the intrinsic death pathway. Oncogene 2008; 27:1545-53; PMID:17891182; https://doi.org/10.1038/sj.onc.1210789
   PubMed Web of Science ®Google Scholar
• Zhou MQ, Du Y, Liu YW, Wang YZ, He YQ, Yang CX, Wang WJ, Gao F. Clinical and experimental studies regarding the expression and diagnostic value of carcinoembryonic antigen-related cell adhesion molecule 1 in non-small-cell lung cancer. BMC Cancer 2013; 13:359; PMID:23885995; https://doi.org/10.1186/1471-2407-13-359
   PubMed Web of Science ®Google Scholar
• Dango S, Sienel W, Schreiber M, Stremmel C, Kirschbaum A, Pantel K, Passlick B. Elevated expression of carcinoembryonic antigen-related cell adhesion molecule 1 (CEACAM-1) is associated with increased angiogenic potential in non-small-cell lung cancer. Lung Cancer (Amsterdam, Netherlands) 2008; 60:426-33; PMID:18215438; https://doi.org/10.1016/j.lungcan.2007.11.015
   PubMed Web of Science ®Google Scholar
• Laack E, Nikbakht H, Peters A, Kugler C, Jasiewicz Y, Edler L, Brummer J, Schumacher U, Hossfeld DK. Expression of CEACAM1 in adenocarcinoma of the lung: a factor of independent prognostic significance. J Clin Oncol 2002; 20:4279-84; PMID:12409325; https://doi.org/10.1200/JCO.2002.08.067
   PubMed Web of Science ®Google Scholar
• Sienel W, Dango S, Woelfle U, Morresi-Hauf A, Wagener C, Brummer J, Mutschler W, Passlick B, Pantel K. Elevated expression of carcinoembryonic antigen-related cell adhesion molecule 1 promotes progression of non-small cell lung cancer. Clin Cancer Res 2003; 9:2260-6; PMID:12796394
   PubMed Web of Science ®Google Scholar
• Wang L, Lin SH, Wu WG, Kemp BL, Walsh GL, Hong WK, Mao L. C-CAM1, a candidate tumor suppressor gene, is abnormally expressed in primary lung cancers. Clin Cancer Res 2000; 6:2988-93; PMID:10955775
   PubMed Web of Science ®Google Scholar
• Nolen BM, Lomakin A, Marrangoni A, Velikokhatnaya L, Prosser D, Lokshin AE. Urinary protein biomarkers in the early detection of lung cancer. Cancer Prev Res (Phila) 2015; 8:111-9; PMID:25416410; https://doi.org/10.1158/1940-6207.CAPR-14-0210
   PubMed Web of Science ®Google Scholar
• Zhang L, Wang J, Wei F, Wang K, Sun Q, Yang F, Jin H, Zheng Y, Zhao H, Wang L et al. Profiling the dynamic expression of checkpoint molecules on cytokine-induced killer cells from non-small-cell lung cancer patients. Oncotarget 2016; 7:43604-15; PMID:27283895; https://doi.org/10.18632/oncotarget.9871
   PubMed Web of Science ®Google Scholar
• Santabarbara G, Maione P, Rossi A, Palazzolo G, Gridelli C. The role of pembrolizumab in the treatment of advanced non-small cell lung cancer. Ann Transl Med 2016; 4:215; PMID:27386489; https://doi.org/10.21037/atm.2016.05.64
   PubMed Web of Science ®Google Scholar
• Gong DY, Fu HX, Peng Y, You YQ, Li ZP. Diagnostic value of serum CEACAM1 in patients with pancreatic cancer. Nan Fang Yi Ke Da Xue Xue Bao J Southern Med University 2011; 31:164-6; PMID:21269981
   PubMedGoogle Scholar
• Giulietti M, Occhipinti G, Principato G, Piva F. Weighted gene co-expression network analysis reveals key genes involved in pancreatic ductal adenocarcinoma development. Cell Oncol (Dordrecht) 2016; 39:379-88; PMID:27240826; https://doi.org/10.1007/s13402-016-0283-7
   PubMed Web of Science ®Google Scholar
• Gebauer F, Wicklein D, Horst J, Sundermann P, Maar H, Streichert T, Tachezy M, Izbicki JR, Bockhorn M, Schumacher U. Carcinoembryonic antigen-related cell adhesion molecules (CEACAM) 1, 5 and 6 as biomarkers in pancreatic cancer. PloS One 2014; 9:e113023; PMID:25409014; https://doi.org/10.1371/journal.pone.0113023
   PubMed Web of Science ®Google Scholar
• `Farren MR, Mace TA, Geyer S, Mikhail S, Wu C, Ciombor K, Tahiri S, Ahn D, Noonan AM, Villalona-Calero M et al. Systemic immune activity predicts overall survival in treatment-naïve patients with metastatic pancreatic cancer. Clin Cancer Res 2016; 22:2565-74; PMID:26719427; https://doi.org/10.1158/1078-0432.CCR-15-1732
   PubMed Web of Science ®Google Scholar
• Oliveira-Ferrer L, Tilki D, Ziegeler G, Hauschild J, Loges S, Irmak S, Kilic E, Huland H, Friedrich M, Ergun S. Dual role of carcinoembryonic antigen-related cell adhesion molecule 1 in angiogenesis and invasion of human urinary bladder cancer. Cancer Res 2004; 64:8932-8; PMID:15604255; https://doi.org/10.1158/0008-5472.CAN-04-0505
   PubMed Web of Science ®Google Scholar
• Kleinerman DI, Dinney CP, Zhang WW, Lin SH, Van NT, Hsieh JT. Suppression of human bladder cancer growth by increased expression of C-CAM1 gene in an orthotopic model. Cancer Res 1996; 56:3431-5; PMID:8758907
   PubMed Web of Science ®Google Scholar
• Yang M, Yu Q, Liu J, Fu W, Cao Y, Yu L, Shao S, Wang X, Niu H, Wang Y. T-cell immunoglobulin mucin-3 expression in bladder urothelial carcinoma: clinicopathologic correlations and association with survival. J Surg Oncol 2015; 112:430-5; PMID:26265374; https://doi.org/10.1002/jso.24012
   PubMed Web of Science ®Google Scholar
• Zibelman M, Plimack ER. Systemic therapy for bladder cancer finally comes into a new age. Future Oncol (London, England) 2016; 12(19):2227-42; PMID:27402371; https://doi.org/10.2217/fon-2016-0135
   PubMed Web of Science ®Google Scholar